2024
Multi-omic network analysis identifies dysregulated neurobiological pathways in opioid addiction
Sullivan K, Kainer D, Lane M, Cashman M, Miller J, Garvin M, Townsend A, Quach B, Willis C, Kruse P, Gaddis N, Mathur R, Corradin O, Maher B, Scacheri P, Sanchez-Roige S, Palmer A, Troiani V, Chesler E, Kember R, Kranzler H, Justice A, Xu K, Aouizerat B, Hancock D, Johnson E, Jacobson D, Program V. Multi-omic network analysis identifies dysregulated neurobiological pathways in opioid addiction. Biological Psychiatry 2024 PMID: 39615775, DOI: 10.1016/j.biopsych.2024.11.013.Peer-Reviewed Original ResearchGenome-wide association studiesSubstance use disordersOpioid use disorderAddiction treatmentOpioid addictionDorsolateral prefrontal cortexOpioid addiction treatmentMulti-omics network analysisPrefrontal cortexPrescription opioid misuseSystems biology approachNeurobiological pathwaysOpioid overdose victimsUse disorderOverdose victimsAddictionAssociation studiesEpigenetic dataOpioid misuseOpioidDlPFCERK pathwayBiology approachMulti-omicsGene targetingImpact of Decarceration Plus Alcohol, Substance Use, and Mental Health Screening on Life Expectancies of Black Sexual Minority Men and Black Transgender Women Living With HIV in the United States: A Simulation Study Based on HPTN 061
Feelemyer J, Bershteyn A, Scheidell J, Brewer R, Dyer T, Cleland C, Hucks-Ortiz C, Justice A, Mayer K, Grawert A, Kaufman J, Braithwaite S, Khan M. Impact of Decarceration Plus Alcohol, Substance Use, and Mental Health Screening on Life Expectancies of Black Sexual Minority Men and Black Transgender Women Living With HIV in the United States: A Simulation Study Based on HPTN 061. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2024, 95: 283-290. PMID: 38032748, PMCID: PMC10922416, DOI: 10.1097/qai.0000000000003354.Peer-Reviewed Original ResearchConceptsLower life expectancyBlack sexual minority menBlack transgender womenReduce incarcerationSubstance useTransgender WomenIncreased LEVeterans Aging Cohort StudyPsychiatric conditionsMental health screeningLinkage to treatmentDisproportionate rates of incarcerationLife expectancyAging Cohort StudyRates of incarcerationHistory of incarcerationSexual minority menImplementing screeningHealth screeningSubstance use disordersTreatment of psychiatric conditionsPositive screenImprove screeningCohort studyDisproportionate ratesA multi-ancestry genetic study of pain intensity in 598,339 veterans
Toikumo S, Vickers-Smith R, Jinwala Z, Xu H, Saini D, Hartwell E, Pavicic M, Sullivan K, Xu K, Jacobson D, Gelernter J, Rentsch C, Stahl E, Cheatle M, Zhou H, Waxman S, Justice A, Kember R, Kranzler H. A multi-ancestry genetic study of pain intensity in 598,339 veterans. Nature Medicine 2024, 30: 1075-1084. PMID: 38429522, DOI: 10.1038/s41591-024-02839-5.Peer-Reviewed Original ResearchPain intensityChronic painTreat chronic painCalcium channel blockersCross-ancestry meta-analysisGenome-wide association studiesExperience of painSamples of European ancestryPain phenotypesFunctional genomics dataGABAergic neuronsCalcium channelsAnalgesic effectB-blockersDrug groupMillion Veteran ProgramPainSubstance use disordersQuality of lifeDrug repurposing analysisOpioid crisisGenetic architectureCausal genesGenetic lociGenomic data
2023
MULTI-ANCESTRY META-ANALYSIS OF TOBACCO USE DISORDERS PRIORITIZES NOVEL CANDIDATE RISK GENES AND REVEALS ASSOCIATIONS WITH NUMEROUS HEALTH OUTCOMES
Sanchez-Roige S, Toikumo S, Jennings M, Pham B, Lee H, Mallard T, Bianchi S, Meredith J, Smoller J, Davis L, Justice A, Kranzler H, Kember R, Sanchez-Roige S. MULTI-ANCESTRY META-ANALYSIS OF TOBACCO USE DISORDERS PRIORITIZES NOVEL CANDIDATE RISK GENES AND REVEALS ASSOCIATIONS WITH NUMEROUS HEALTH OUTCOMES. European Neuropsychopharmacology 2023, 75: s8-s9. DOI: 10.1016/j.euroneuro.2023.08.024.Peer-Reviewed Original ResearchTobacco use disorderUse disordersPrevalent substance use disordersSubstance use disordersRisk genesNumerous health outcomesHIV infectionHeart diseaseSmoking behaviorMedical outcomesGenome-wide association studiesNicotine consumptionHealth outcomesCandidate risk genesPotential risk genesGenetic factorsIndependent risk lociDisordersRisk variantsNovel candidate risk genesRisk lociOutcomesMajority of variantsFunctional genomics toolsPsychiatric traits
2022
Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects in brain regions associated with addiction
Kember RL, Vickers-Smith R, Xu H, Toikumo S, Niarchou M, Zhou H, Hartwell EE, Crist RC, Rentsch CT, Davis L, Justice A, Sanchez-Roige S, Kampman K, Gelernter J, Kranzler H. Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects in brain regions associated with addiction. Nature Neuroscience 2022, 25: 1279-1287. PMID: 36171425, PMCID: PMC9682545, DOI: 10.1038/s41593-022-01160-z.Peer-Reviewed Original ResearchConceptsOpioid use disorderGenome-wide association studiesWide significant lociGene expression enrichmentSignificant genetic correlationsCell type groupSignificant lociAssociation studiesExpression enrichmentMillion Veteran ProgramGenetic correlationsUse disordersLociBrain regionsExonic variantsIntronic variantsSubstance use disordersTraitsBiological basisOpioid epidemicPsychiatric disordersVeteran ProgramBrain diseasesTSNARE1FBXW4
2020
Health System‐Based Unhealthy Alcohol Use Screening and Treatment Comparing Demographically Matched Participants With and Without HIV
Silverberg MJ, Levine‐Hall T, Hood N, Anderson AN, Alexeeff SE, Lam JO, Slome SB, Flamm JA, Hare C, Ross T, Justice A, Sterne JAC, Williams A, Bryant KJ, Weisner CM, Horberg MA, Sterling SA, Satre DD. Health System‐Based Unhealthy Alcohol Use Screening and Treatment Comparing Demographically Matched Participants With and Without HIV. Alcohol Clinical And Experimental Research 2020, 44: 2545-2554. PMID: 33067802, PMCID: PMC7725961, DOI: 10.1111/acer.14481.Peer-Reviewed Original ResearchConceptsUnhealthy alcohol useAlcohol use screeningHIV statusBrief interventionRace/ethnicityAlcohol useSpecialty visitsHazard ratioPrevalence ratiosLarge integrated healthcare systemCharlson Comorbidity IndexSpecialty care visitsProportional hazards modelIntegrated healthcare systemOutcomes of timeSubstance use disordersAddiction specialty careNeighborhood deprivation indexElectronic health recordsComorbidity indexAdult PLWHCare visitsCohort studyOutpatient visitsSignificant morbiditySerious Falls in Middle‐Aged Veterans: Development and Validation of a Predictive Risk Model
Womack JA, Murphy TE, Bathulapalli H, Smith A, Bates J, Jarad S, Redeker NS, Luther SL, Gill TM, Brandt CA, Justice AC. Serious Falls in Middle‐Aged Veterans: Development and Validation of a Predictive Risk Model. Journal Of The American Geriatrics Society 2020, 68: 2847-2854. PMID: 32860222, PMCID: PMC7744431, DOI: 10.1111/jgs.16773.Peer-Reviewed Original ResearchConceptsMiddle-aged veteransVeterans Health AdministrationOpioid useSerious fallsAlcohol Use Disorders Identification Test-Consumption scoresCategory-free net reclassification improvementIllicit substance use disordersMental health comorbiditiesPrescription opioid useMultivariable logistic regressionNet reclassification improvementSubstance use disordersQuality of lifeHazardous alcohol usePredictive risk modelChronic medicationsCohort studyHealth comorbiditiesNinth RevisionReclassification improvementGeriatric healthInjury codesHazardous alcoholInternational ClassificationUse disorders
2018
Duration of opioid prescriptions predicts incident nonmedical use of prescription opioids among U.S. veterans receiving medical care
Barry DT, Marshall BDL, Becker WC, Gordon AJ, Crystal S, Kerns RD, Gaither JR, Gordon KS, Justice AC, Fiellin DA, Edelman EJ. Duration of opioid prescriptions predicts incident nonmedical use of prescription opioids among U.S. veterans receiving medical care. Drug And Alcohol Dependence 2018, 191: 348-354. PMID: 30176548, PMCID: PMC6596307, DOI: 10.1016/j.drugalcdep.2018.07.008.Peer-Reviewed Original ResearchConceptsPrescription opioid receiptPrescription opioidsMedical careOpioid receiptVeterans Health Administration primary careNonmedical useMultivariable Cox modelInfectious disease clinicProspective cohort studyProportional hazards regressionPrescription opioid medicationsPublic health problemSubstance use disordersMedication-related characteristicsOpioid therapyOpioid medicationsOpioid prescriptionsCohort studyDisease clinicMedian ageHazards regressionEligible participantsPrimary careRisk factorsIncidence rate
2017
The effect of substance use disorders on the association between guideline-concordant long-term opioid therapy and all-cause mortality
Gaither J, Goulet J, Becker W, Crystal S, Edelman E, Gordon K, Kerns R, Rimland D, Skanderson M, Justice A, Fiellin D. The effect of substance use disorders on the association between guideline-concordant long-term opioid therapy and all-cause mortality. Drug And Alcohol Dependence 2017, 171: e68. DOI: 10.1016/j.drugalcdep.2016.08.196.Peer-Reviewed Original ResearchLong-term opioid therapySubstance use disordersOpioid therapyCause mortalityUse disordersTherapyMortality
2016
The Effect of Substance Use Disorders on the Association Between Guideline-concordant Long-term Opioid Therapy and All-cause Mortality
Gaither JR, Goulet JL, Becker WC, Crystal S, Edelman EJ, Gordon K, Kerns RD, Rimland D, Skanderson M, Justice AC, Fiellin DA. The Effect of Substance Use Disorders on the Association Between Guideline-concordant Long-term Opioid Therapy and All-cause Mortality. Journal Of Addiction Medicine 2016, 10: 418-428. PMID: 27610580, PMCID: PMC5083184, DOI: 10.1097/adm.0000000000000255.Peer-Reviewed Original ResearchConceptsSubstance use disordersLong-term opioid therapyCause mortalityOpioid therapySUD treatmentUse disordersLower mortalityTime-updated Cox regressionUntreated substance use disordersVeterans Aging Cohort StudyOpioid-prescribing guidelinesGuideline-concordant careSUD statusAging Cohort StudyClinical practice guidelinesSUD treatment servicesOverall sampleHIV patientsCohort studyCox regressionPractice guidelinesPatientsTreatment servicesHigh mortalityMortalityThe Association Between Receipt of Guideline-Concordant Long-Term Opioid Therapy and All-Cause Mortality
Gaither JR, Goulet JL, Becker WC, Crystal S, Edelman EJ, Gordon K, Kerns RD, Rimland D, Skanderson M, Justice AC, Fiellin DA. The Association Between Receipt of Guideline-Concordant Long-Term Opioid Therapy and All-Cause Mortality. Journal Of General Internal Medicine 2016, 31: 492-501. PMID: 26847447, PMCID: PMC4835362, DOI: 10.1007/s11606-015-3571-4.Peer-Reviewed Original ResearchConceptsSubstance use disordersGuideline-concordant careCause mortalityOpioid therapyLong-term opioid therapyUntreated substance use disordersCurrent substance use disorderTerm opioid therapyTime-updated covariatesPrimary care visitsImportant clinical outcomesMulti-modal treatmentUrine drug testingUninfected patientsUntreated patientsCare visitsChronic painClinical outcomesCox regressionDecreased riskHigh comorbidityMortality burdenRehabilitative therapySUD treatmentHigh risk
2014
Guideline-Concordant Management of Opioid Therapy Among Human Immunodeficiency Virus (HIV)-Infected and Uninfected Veterans
Gaither JR, Goulet JL, Becker WC, Crystal S, Edelman EJ, Gordon K, Kerns RD, Rimland D, Skanderson M, Weisberg DF, Justice AC, Fiellin DA. Guideline-Concordant Management of Opioid Therapy Among Human Immunodeficiency Virus (HIV)-Infected and Uninfected Veterans. Journal Of Pain 2014, 15: 1130-1140. PMID: 25152300, PMCID: PMC4253900, DOI: 10.1016/j.jpain.2014.08.004.Peer-Reviewed Original ResearchConceptsCurrent substance use disorderGuideline-concordant careOpioid therapyUrine drug testsHuman immunodeficiency virusSubstance use disordersUninfected patientsImmunodeficiency virusUse disordersPatient/provider characteristicsPrimary care provider visitsVeterans Affairs/DepartmentGuideline-concordant managementDrug testsCare concordantGuideline concordanceUninfected veteransProvider visitsPatient characteristicsPatient groupPrimary careClinical guidelinesPain medicineProvider characteristicsPatients
2012
Antiretroviral Adherence Among Rural Compared to Urban Veterans with HIV Infection in the United States
Ohl ME, Perencevich E, McInnes DK, Kim N, Rimland D, Akgun K, Fiellin DA, Skanderson M, Wang K, Justice A. Antiretroviral Adherence Among Rural Compared to Urban Veterans with HIV Infection in the United States. AIDS And Behavior 2012, 17: 174-180. PMID: 23080359, DOI: 10.1007/s10461-012-0325-8.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-Retroviral AgentsConfidence IntervalsFemaleFollow-Up StudiesHIV InfectionsHumansLogistic ModelsMaleMedication AdherenceMiddle AgedOdds RatioResidence CharacteristicsRetrospective StudiesRural PopulationSocioeconomic FactorsUnited StatesUnited States Department of Veterans AffairsUrban PopulationVeteransConceptsRural-dwelling personsAntiretroviral therapyAntiretroviral adherenceUrban veteransRural-Urban Commuting Area codesVeterans Affairs Healthcare SystemCombination antiretroviral therapyHepatitis C infectionMultivariable logistic regressionSubstance use disordersC infectionHIV infectionRemote residentsHigh adherenceWhite raceVA healthcareUse disordersMedian proportionLogistic regressionAdherenceHealthcare systemRemote settingsTherapyInfectionFace barriers