2019
Epigenetic Associations With Estimated Glomerular Filtration Rate Among Men With Human Immunodeficiency Virus Infection
Chen J, Huang Y, Hui Q, Mathur R, Gwinn M, So-Armah K, Freiberg MS, Justice AC, Xu K, Marconi VC, Sun YV. Epigenetic Associations With Estimated Glomerular Filtration Rate Among Men With Human Immunodeficiency Virus Infection. Clinical Infectious Diseases 2019, 70: 667-673. PMID: 30893429, PMCID: PMC7319269, DOI: 10.1093/cid/ciz240.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseHuman immunodeficiency virus (HIV) infectionImmunodeficiency virus infectionGlomerular filtration rateKidney functionFiltration rateVirus infectionVeterans Aging Cohort StudyPeripheral blood mononuclear cellsAging Cohort StudyHIV-positive participantsBlood mononuclear cellsMechanisms of HIVCKD riskCohort studyKidney diseaseMononuclear cellsHigh riskHIVPooled populationEGFREpigenetic associationsSignificant CpG sitesGuanine dinucleotide sitesPotential epigenetic mechanismsPodocyte histone deacetylase activity regulates murine and human glomerular diseases
Inoue K, Gan G, Ciarleglio M, Zhang Y, Tian X, Pedigo CE, Cavanaugh C, Tate J, Wang Y, Cross E, Groener M, Chai N, Wang Z, Justice A, Zhang Z, Parikh CR, Wilson FP, Ishibe S. Podocyte histone deacetylase activity regulates murine and human glomerular diseases. Journal Of Clinical Investigation 2019, 129: 1295-1313. PMID: 30776024, PMCID: PMC6391095, DOI: 10.1172/jci124030.Peer-Reviewed Original ResearchConceptsEarly growth response 1Histone deacetylase 1Proteinuric patientsKidney diseaseHDAC2 activityValproic acidVeterans Aging Cohort StudyEnd-stage kidney diseaseDegree of proteinuriaGlomerular filtration rateAging Cohort StudyInhibition of HDAC1Proteinuric kidney diseaseHuman glomerular diseasesGlomerular disease modelsConnectivity Map databaseCohort studyFiltration rateGlomerular diseaseHistone deacetylase activityProteinuric kidneysHDAC inhibitorsProteinuriaMRNA expressionGenetic ablation
2017
Multimorbidity Among Persons Living with Human Immunodeficiency Virus in the United States
Wong C, Gange SJ, Moore RD, Justice AC, Buchacz K, Abraham AG, Rebeiro PF, Koethe JR, Martin JN, Horberg MA, Boyd CM, Kitahata MM, Crane HM, Gebo KA, Gill MJ, Silverberg MJ, Palella FJ, Patel P, Samji H, Thorne J, Rabkin CS, Mayor A, Althoff KN, Freeman A, Cescon A, Rachlis A, Rogers B, Rodriguez B, Grasso C, Benson C, Drozd D, Fiellin D, Haas D, Kirk G, Willig J, Globerman J, Brooks J, Eron J, Montaner J, Gabler K, Anastos K, Mayer K, Jacobson L, Kopansky-Giles M, Klein M, Turner M, Mugavero M, Saag M, Harrigan P, Dubrow R, Hunter-Mellado R, Hogg R, Bosch R, McKaig R, Bebawy S, Rourke S, Napravnik S, Boswell S, Sterling T. Multimorbidity Among Persons Living with Human Immunodeficiency Virus in the United States. Clinical Infectious Diseases 2017, 66: 1230-1238. PMID: 29149237, PMCID: PMC5889007, DOI: 10.1093/cid/cix998.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsBlack PeopleCohort StudiesDiabetes Mellitus, Type 2FemaleHeterosexualityHIVHIV InfectionsHomosexuality, MaleHumansHypercholesterolemiaHypertensionLongitudinal StudiesMaleMiddle AgedMultimorbidityRenal Insufficiency, ChronicSexual and Gender MinoritiesUnited StatesWhite PeopleConceptsHuman immunodeficiency virusAdjusted prevalence ratiosAge-associated conditionsImmunodeficiency virusMultimorbidity prevalenceClinical careNorth American AIDS Cohort CollaborationEnd-stage liver diseaseMedian baseline ageHIV outpatient clinicChronic kidney diseaseRobust error varianceConfidence intervalsComplex healthcare needsDemographic subgroupsCohort CollaborationComorbidity preventionCohort studyDiabetes mellitusLiver diseaseOutpatient clinicKidney diseasePrevalence ratiosBaseline ageCare complexity
2016
First Occurrence of Diabetes, Chronic Kidney Disease, and Hypertension Among North American HIV-Infected Adults, 2000–2013
Wong C, Gange SJ, Buchacz K, Moore RD, Justice AC, Horberg MA, Gill MJ, Koethe JR, Rebeiro PF, Silverberg MJ, Palella FJ, Patel P, Kitahata MM, Crane HM, Abraham AG, Samji H, Napravnik S, Ahmed T, Thorne JE, Bosch RJ, Mayor AM, Althoff KN, Research and Design F. First Occurrence of Diabetes, Chronic Kidney Disease, and Hypertension Among North American HIV-Infected Adults, 2000–2013. Clinical Infectious Diseases 2016, 64: 459-467. PMID: 28172581, PMCID: PMC5850614, DOI: 10.1093/cid/ciw804.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseHuman immunodeficiency virusDiabetes mellitusAntiretroviral therapyCumulative incidenceKidney diseaseNoncommunicable diseasesNorth American AIDS Cohort CollaborationOccurrence of DMType 2 diabetes mellitusRisk of deathDemographic subgroupsNon-black womenCohort CollaborationHIV populationImmunodeficiency virusTreatment optionsHypertensionAge 70Poisson regressionRacial disparitiesDiseaseBlack womenIncidenceCare
2013
Hepatitis C Viremia and the Risk of Chronic Kidney Disease in HIV-Infected Individuals
Lucas G, Jing Y, Sulkowski M, Abraham A, Estrella M, Atta M, Fine D, Klein M, Silverberg M, Gill M, Moore R, Gebo K, Sterling T, Butt A, for the NA-ACCORD of the IeDEA, Kirk G, Benson C, Bosch R, Collier A, Boswell S, Grasso C, Mayer K, Hogg R, Harrigan R, Montaner J, Cescon A, Brooks J, Buchacz K, Gebo K, Moore R, Carey J, Rodriguez B, Horberg M, Silverberg M, Horberg M, Thorne J, Goedert J, Jacobson L, Klein M, Rourke S, Burchell A, Rachlis A, Rico P, Hunter-Mellado R, Mayor A, Gill M, Deeks S, Martin J, Patel P, Brooks J, Saag M, Mugavero M, Willig J, Eron J, Napravnik S, Kitahata M, Crane H, Justice A, Dubrow R, Fiellin D, Sterling T, Haas D, Bebawy S, Turner M, Gange S, Anastos K, Moore R, Saag M, Gange S, Kitahata M, McKaig R, Justice A, Freeman A, Moore R, Freeman A, Lent C, Kitahata M, Van Rompaey S, Crane H, Webster E, Morton L, Simon B, Gange S, Althoff K, Abraham A, Lau B, Zhang J, Jing J, Golub E, Modur S, Hanna D, Rebeiro P, Wong C, Mendes A. Hepatitis C Viremia and the Risk of Chronic Kidney Disease in HIV-Infected Individuals. The Journal Of Infectious Diseases 2013, 208: 1240-1249. PMID: 23904290, PMCID: PMC3778973, DOI: 10.1093/infdis/jit373.Peer-Reviewed Original ResearchConceptsStage 3 CKDStage 5 CKDProgressive CKDAviremic subjectsHazard ratioGlomerular filtration rate decreaseChronic kidney disease riskHepatitis C virus replicationHCV seronegative subjectsHCV viremic subjectsAdjusted hazard ratioChronic kidney diseaseHepatitis C viremiaKidney disease riskConfidence intervalsC virus replicationAdvanced CKDAviremic individualsCKD incidenceHCV-viremicSeronegative subjectsC viremiaViremic subjectsKidney diseaseCKD
2012
Comorbid Diabetes and the Risk of Progressive Chronic Kidney Disease in HIV-Infected Adults
Medapalli RK, Parikh CR, Gordon K, Brown ST, Butt AA, Gibert CL, Rimland D, Rodriguez-Barradas MC, Chang CC, Justice AC, He JC, Wyatt CM. Comorbid Diabetes and the Risk of Progressive Chronic Kidney Disease in HIV-Infected Adults. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2012, 60: 393-399. PMID: 22592587, PMCID: PMC3392432, DOI: 10.1097/qai.0b013e31825b70d9.Peer-Reviewed Original ResearchConceptsCKD risk factorsTraditional CKD risk factorsRisk factorsBaseline eGFRChronic kidney disease progressionProgressive chronic kidney diseaseChronic kidney diseaseKidney disease progressionGlomerular filtration rateMean baseline eGFRRisk of CKDRate of progressionCox proportional hazardsVeterans Healthcare AdministrationUse of cARTBaseline HIVCKD progressionComorbid diabetesAdjunctive therapyDiabetes statusGlycemic controlKidney diseaseProgressive CKDComplex comorbiditiesFiltration rate
2010
The Association Between Alcohol Consumption and Prevalent Cardiovascular Diseases Among HIV-Infected and HIV-Uninfected Men
Freiberg MS, McGinnis KA, Kraemer K, Samet JH, Conigliaro J, Ellison R, Bryant K, Kuller LH, Justice AC. The Association Between Alcohol Consumption and Prevalent Cardiovascular Diseases Among HIV-Infected and HIV-Uninfected Men. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2010, 53: 247-253. PMID: 20009766, PMCID: PMC2858978, DOI: 10.1097/qai.0b013e3181c6c4b7.Peer-Reviewed Original ResearchConceptsPrevalent cardiovascular diseaseCardiovascular diseaseAlcohol consumptionHigh prevalenceAlcohol abuseHazardous drinkingRisk factorsOdds ratioModerate drinkingTraditional CVD risk factorsVeterans Aging Cohort StudyCVD risk factorsTraditional risk factorsAging Cohort StudyHIV-uninfected (HIV-) menHIV-InfectedSimilar HIVAntiretroviral therapyCD4 countCohort studyProspective cohortPast drinkersKidney diseaseHIVLogistic regressionHepatitis C and the Risk of Kidney Disease and Mortality in Veterans With HIV
Fischer MJ, Wyatt CM, Gordon K, Gibert CL, Brown ST, Rimland D, Rodriguez-Barradas MC, Justice AC, Parikh CR. Hepatitis C and the Risk of Kidney Disease and Mortality in Veterans With HIV. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2010, 53: 222-226. PMID: 20104121, PMCID: PMC3032564, DOI: 10.1097/qai.0b013e3181b980d4.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseHepatitis C virusKidney diseaseMortality rateGlomerular filtration rateAdjusted mortality rateLevels of eGFRVeterans Healthcare AdministrationHepatitis CCoinfected subjectsC virusFiltration rateNational cohortIndependent associationHIVHigh mortalityPoisson regressionMortalityGraduated increaseVeteransCohortHigh rateEGFRDiseaseHealthcare administration