2024
Intense exercise increases dopamine transporter and neuromelanin concentrations in the substantia nigra in Parkinson’s disease
de Laat B, Hoye J, Stanley G, Hespeler M, Ligi J, Mohan V, Wooten D, Zhang X, Nguyen T, Key J, Colonna G, Huang Y, Nabulsi N, Patel A, Matuskey D, Morris E, Tinaz S. Intense exercise increases dopamine transporter and neuromelanin concentrations in the substantia nigra in Parkinson’s disease. Npj Parkinson's Disease 2024, 10: 34. PMID: 38336768, PMCID: PMC10858031, DOI: 10.1038/s41531-024-00641-1.Peer-Reviewed Original ResearchDopamine transporterSubstantia nigraDopaminergic neuronsDopamine transporter availabilityNeuroprotective effects of exerciseDopaminergic systemClinical progression of PDEarly PDSubstantiaNeuromelanin contentNigraLoss of dopaminergic neuronsEffects of exerciseNM-MRIDopamineSystem of patientsProgressive loss of dopaminergic neuronsParkinson's diseaseClinical progressionProgression of PDNeuroprotective effectsClinical trialsIntensity exercisePET imagingProgressive loss
2023
Differential impact of resilience on demoralization and depression in Parkinson disease
de Figueiredo J, Zhu B, Patel A, Kohn R, Koo B, Louis E. Differential impact of resilience on demoralization and depression in Parkinson disease. Frontiers In Psychiatry 2023, 14: 1207019. PMID: 37559912, PMCID: PMC10408307, DOI: 10.3389/fpsyt.2023.1207019.Peer-Reviewed Original Research
2022
Mental imagery content is associated with disease severity and specific brain functional connectivity changes in patients with Parkinson’s disease
Cherry J, Kamel S, Elfil M, Aravala S, Bayoumi A, Patel A, Sinha R, Tinaz S. Mental imagery content is associated with disease severity and specific brain functional connectivity changes in patients with Parkinson’s disease. Brain Imaging And Behavior 2022, 17: 161-171. PMID: 36434490, PMCID: PMC10050121, DOI: 10.1007/s11682-022-00749-z.Peer-Reviewed Original ResearchConceptsImagery trainingFunctional connectivity changesMild Parkinson's diseaseVisual imagery trainingMental imagery trainingComplex cognitive processesConnectivity changesMotor imagery trainingBrain functional connectivity changesFunctional connectivity characteristicsExecutive processesMental imageryCognitive processesPerceptual experienceNeural correlatesBrain mechanismsImagery practiceImagery contentSensorimotor processesNeuropsychiatric patient populationsMotor functionMotor actsMotor enhancementBrain areasParkinson's disease
2020
Deep Brain Stimulation Target Selection in Co-Morbid Essential Tremor and Parkinson’s Disease
Wadhwa A, Schaefer S, Gerrard J, Deeb W, Okun MS, Patel A. Deep Brain Stimulation Target Selection in Co-Morbid Essential Tremor and Parkinson’s Disease. Tremor And Other Hyperkinetic Movements 2020, 10: 17. PMID: 32775031, PMCID: PMC7394224, DOI: 10.5334/tohm.62.Peer-Reviewed Original ResearchConceptsDeep brain stimulationParkinson's diseaseEssential tremorHead trialsDBS targetsAction tremorSubthalamic nucleus (STN) DBSThalamus deep brain stimulationLimited evidenceDBS target selectionVentral intermediate nucleusBilateral STNPD patientsDBS treatmentEquivalent efficacyRest tremorMild improvementCurrent evidenceET patientsET tremorBrain stimulationComparative efficacyPatientsExpert consensusTremor reduction
2019
Dorsal GPi/GPe Stimulation Induced Dyskinesia in a Patient with Parkinson’s Disease
Elkouzi A, Tsuboi T, Burns M, Eisinger R, Patel A, Deeb W. Dorsal GPi/GPe Stimulation Induced Dyskinesia in a Patient with Parkinson’s Disease. Tremor And Other Hyperkinetic Movements 2019, 9 DOI: 10.5334/tohm.496.Peer-Reviewed Original ResearchStimulation-induced dyskinesiasParkinson's diseaseGPi DBSBilateral GPi DBSGPi stimulationMotor fluctuationsPD patientsTherapeutic benefitSide effectsVentral contactVolume of tissuePatientsDiseaseMore studiesDyskinesiaMotor controlDiffusion tensorSpecific tractsPotential strategyStimulationTherapyTractMRI
2017
Deep Brain Stimulation Target Selection in an Advanced Parkinson’s Disease Patient with Significant Tremor and Comorbid Depression
Patel AS. Deep Brain Stimulation Target Selection in an Advanced Parkinson’s Disease Patient with Significant Tremor and Comorbid Depression. Tremor And Other Hyperkinetic Movements 2017, 7: 447. PMID: 28428905, PMCID: PMC5395677, DOI: 10.7916/d8kd23nz.Peer-Reviewed Original ResearchGlobus pallidus internaSTN stimulationDisease patientsSubthalamic nucleusParkinson's diseaseAdvanced Parkinson's disease (PD) patientsSignificant short-term improvementsAdvanced Parkinson's diseasePD motor symptomsParkinson's disease patientsShort-term improvementSignificant tremor reductionSTN-DBSMotor symptomsPD patientsRefractory tremorComorbid depressionDBS targetsPD tremorMood disordersBilateral DBSInsufficient evidencePatientsTremor reductionSignificant depressionDeep Brain Stimulation Target Selection in an Advanced Parkinson’s Disease Patient with Significant Tremor and Comorbid Depression
Patel A. Deep Brain Stimulation Target Selection in an Advanced Parkinson’s Disease Patient with Significant Tremor and Comorbid Depression. Tremor And Other Hyperkinetic Movements 2017, 7: 447. DOI: 10.5334/tohm.369.Peer-Reviewed Original ResearchGlobus pallidus internaSTN stimulationDisease patientsSubthalamic nucleusParkinson's diseaseAdvanced Parkinson's disease (PD) patientsSignificant short-term improvementsAdvanced Parkinson's diseasePD motor symptomsParkinson's disease patientsShort-term improvementSignificant tremor reductionSTN-DBSMotor symptomsPD patientsRefractory tremorComorbid depressionDBS targetsPD tremorMood disordersBilateral DBSInsufficient evidencePatientsTremor reductionSignificant depression