2023
Development of Expert-Level Classification of Seizures and Rhythmic and Periodic Patterns During EEG Interpretation
Jing J, Ge W, Hong S, Fernandes M, Lin Z, Yang C, An S, Struck A, Herlopian A, Karakis I, Halford J, Ng M, Johnson E, Appavu B, Sarkis R, Osman G, Kaplan P, Dhakar M, Arcot Jayagopal L, Sheikh Z, Taraschenko O, Schmitt S, Haider H, Kim J, Swisher C, Gaspard N, Cervenka M, Rodriguez Ruiz A, Lee J, Tabaeizadeh M, Gilmore E, Nordstrom K, Yoo J, Holmes M, Herman S, Williams J, Pathmanathan J, Nascimento F, Fan Z, Nasiri S, Shafi M, Cash S, Hoch D, Cole A, Rosenthal E, Zafar S, Sun J, Westover M. Development of Expert-Level Classification of Seizures and Rhythmic and Periodic Patterns During EEG Interpretation. Neurology 2023, 100: e1750-e1762. PMID: 36878708, PMCID: PMC10136013, DOI: 10.1212/wnl.0000000000207127.Peer-Reviewed Original Research
2022
Interrater Reliability of Expert Electroencephalographers Identifying Seizures and Rhythmic and Periodic Patterns in EEGs
Jing J, Ge W, Struck A, Fernandes M, Hong S, An S, Fatima S, Herlopian A, Karakis I, Halford J, Ng M, Johnson E, Appavu B, Sarkis R, Osman G, Kaplan P, Dhakar M, Jayagopal L, Sheikh Z, Taraschenko O, Schmitt S, Haider H, Kim J, Swisher C, Gaspard N, Cervenka M, Rodriguez Ruiz A, Lee J, Tabaeizadeh M, Gilmore E, Nordstrom K, Yoo J, Holmes M, Herman S, Williams J, Pathmanathan J, Nascimento F, Fan Z, Nasiri S, Shafi M, Cash S, Hoch D, Cole A, Rosenthal E, Zafar S, Sun J, Westover M. Interrater Reliability of Expert Electroencephalographers Identifying Seizures and Rhythmic and Periodic Patterns in EEGs. Neurology 2022, 100: e1737-e1749. PMID: 36460472, PMCID: PMC10136018, DOI: 10.1212/wnl.0000000000201670.Peer-Reviewed Original ResearchConceptsGeneralized rhythmic delta activityLateralized rhythmic delta activityLateralized periodic dischargesRhythmic delta activityDelta activityPeriodic dischargesClass II evidencePrimary outcome measureMassachusetts General HospitalContributions of biasCritical illnessSecondary outcomesMedian ageInterrater reliability studyClinical indicationsGeneral HospitalMedian numberOutcome measuresProspective analysisExpert consensusSeizuresBrain monitoringInterrater reliabilityBrain activitySelection biasMeasuring expertise in identifying interictal epileptiform discharges
Harid NM, Jing J, Hogan J, Nascimento FA, Ouyang A, Zheng W, Ge W, Zafar SF, Kim JA, Alice DL, Herlopian A, Maus D, Karakis I, Ng M, Hong S, Yu Z, Kaplan PW, Cash S, Shafi M, Martz G, Halford JJ, Westover MB. Measuring expertise in identifying interictal epileptiform discharges. Epileptic Disorders 2022, 24: 496-506. PMID: 35770748, PMCID: PMC9340812, DOI: 10.1684/epd.2021.1409.Peer-Reviewed Original ResearchElectroencephalographic changes in purified pharmaceutical cannabidiol therapy
Herlopian A, Barnett JR, Nascimento FA, Lee H, Thiele EA. Electroencephalographic changes in purified pharmaceutical cannabidiol therapy. Epilepsy & Behavior 2022, 128: 108558. PMID: 35078115, DOI: 10.1016/j.yebeh.2022.108558.Peer-Reviewed Original ResearchConceptsInterictal epileptiform dischargesElectroencephalographic changesCBD treatmentIctal findingsSleep architectureEEG changesInvestigational New Drug programPredominant seizure typeNew drug programPre-treatment EEGYears of ageSubjective cognitive improvementElectrographic findingsElectrographic improvementRefractory epilepsySeizure typesClinical outcomesElectrographic changesEpileptiform dischargesPatientsCognitive improvementDrug programsSubstantial associationEEG studiesTreatment
2020
Deep active learning for Interictal Ictal Injury Continuum EEG patterns
Ge W, Jing J, An S, Herlopian A, Ng M, Struck AF, Appavu B, Johnson EL, Osman G, Haider HA, Karakis I, Kim JA, Halford JJ, Dhakar MB, Sarkis RA, Swisher CB, Schmitt S, Lee JW, Tabaeizadeh M, Rodriguez A, Gaspard N, Gilmore E, Herman ST, Kaplan PW, Pathmanathan J, Hong S, Rosenthal ES, Zafar S, Sun J, Westover M. Deep active learning for Interictal Ictal Injury Continuum EEG patterns. Journal Of Neuroscience Methods 2020, 351: 108966. PMID: 33131680, PMCID: PMC8135050, DOI: 10.1016/j.jneumeth.2020.108966.Peer-Reviewed Original ResearchConceptsConvolutional neural networkIll patientsActive learningLarge labeled datasetExpert-level performanceDeep active learningLarge EEG datasetsPseudo-labeled dataUse of ALElectroencephalography patternsPatient careQuery criteriaLabeled datasetLabel spreadingEEG patternsPatientsExpert labelsClass balancingNeural networkAvailable labelsVector representationQueriesInformative examplesAL approachEEG datasetCannabidiol in treatment of refractory epileptic spasms: An open-label study
Herlopian A, Hess EJ, Barnett J, Geffrey AL, Pollack SF, Skirvin L, Bruno P, Sourbron J, Thiele EA. Cannabidiol in treatment of refractory epileptic spasms: An open-label study. Epilepsy & Behavior 2020, 106: 106988. PMID: 32169600, DOI: 10.1016/j.yebeh.2020.106988.Peer-Reviewed Original ResearchConceptsRefractory epileptic spasmsEpileptic spasmsResponder rateAdjunctive therapyCBD treatmentInvestigational new drug trialsOpen-label studyMonths of treatmentSafe adjunctive therapyNew drug trialsInstitutional review boardSubjective reportsBaseline medicationsCBD initiationElectrographic findingsHypsarrhythmia patternClinical responseSeizure frequencyAdverse eventsClinical efficacyElectrographic changesSubjective improvementTarget dosageDrug trialsInitial dosageDevelopment of Expert-Level Automated Detection of Epileptiform Discharges During Electroencephalogram Interpretation
Jing J, Sun H, Kim JA, Herlopian A, Karakis I, Ng M, Halford JJ, Maus D, Chan F, Dolatshahi M, Muniz C, Chu C, Sacca V, Pathmanathan J, Ge W, Dauwels J, Lam A, Cole AJ, Cash SS, Westover MB. Development of Expert-Level Automated Detection of Epileptiform Discharges During Electroencephalogram Interpretation. JAMA Neurology 2020, 77: 103-108. PMID: 31633740, PMCID: PMC6806668, DOI: 10.1001/jamaneurol.2019.3485.Peer-Reviewed Original ResearchInterrater Reliability of Experts in Identifying Interictal Epileptiform Discharges in Electroencephalograms
Jing J, Herlopian A, Karakis I, Ng M, Halford JJ, Lam A, Maus D, Chan F, Dolatshahi M, Muniz C, Chu C, Sacca V, Pathmanathan J, Ge W, Sun H, Dauwels J, Cole AJ, Hoch DB, Cash SS, Westover MB. Interrater Reliability of Experts in Identifying Interictal Epileptiform Discharges in Electroencephalograms. JAMA Neurology 2020, 77: 49-57. PMID: 31633742, PMCID: PMC6806666, DOI: 10.1001/jamaneurol.2019.3531.Peer-Reviewed Original ResearchConceptsInterictal epileptiform dischargesPercentage of agreementEpileptiform dischargesNumber of IEDsMultivariate logistic regression modelPrimary outcome measureMassachusetts General HospitalLogistic regression modelsPhase 1Secondary outcomesInterrater reliability studyRoutine electroencephalogramMedical recordsGeneral HospitalOutcome measuresMAIN OUTCOMEProspective analysisClinical neurophysiologySubspecialty trainingIndividualized thresholdsSubstantial reliabilityInterrater reliabilityNegative controlPhase 2Electroencephalogram
2018
EEG findings in CAR T-cell therapy-related encephalopathy
Herlopian A, Dietrich J, Abramson JS, Cole AJ, Westover MB. EEG findings in CAR T-cell therapy-related encephalopathy. Neurology 2018, 91: 227-229. PMID: 29959264, PMCID: PMC6093761, DOI: 10.1212/wnl.0000000000005910.Peer-Reviewed Original Research
2017
Predictive Value of Electrocorticography in Patients With Mesial Temporal Lobe Epilepsy Undergoing Selective Amygdalohippocampectomy
Herlopian A, Shihabuddin B. Predictive Value of Electrocorticography in Patients With Mesial Temporal Lobe Epilepsy Undergoing Selective Amygdalohippocampectomy. Journal Of Clinical Neurophysiology 2017, 34: 370-374. PMID: 28306691, DOI: 10.1097/wnp.0000000000000376.Peer-Reviewed Original ResearchConceptsMesial temporal lobe epilepsyMesial temporal sclerosisTemporal lobe epilepsyPostoperative seizure freedomSelective amygdalohippocampectomyLobe epilepsyIntraoperative electrocorticographySeizure freedomPredictive valueStandard temporal lobectomyNormal brain MRIElectrocorticography findingsSeizure outcomeTemporal sclerosisPostoperative outcomesConsecutive patientsTemporal lobectomyMean durationSingle neurosurgeonRetrospective analysisBrain MRIPatientsEpilepsySeizuresElectrocorticography