Combined neuromodulation and resection for functional cortex epilepsy: a case series.
Merenzon M, Sivaraju A, Herlopian A, Gerrard J, Quraishi I, Hirsch L, Spencer D, Damisah E. Combined neuromodulation and resection for functional cortex epilepsy: a case series. Journal Of Neurosurgery 2024, 1-9. PMID: 38848588, DOI: 10.3171/2024.3.jns24122.Peer-Reviewed Original ResearchMedically refractory epilepsySeizure onset zoneFunctional cortexSeizure outcomeRefractory epilepsyMonths of follow-up dataMaximal safe resectionMedian follow-upTreated with resectionImprove seizure outcomeFocal neuromodulationFollow-up dataPreservation of functionRetrospective analysis of individualsSafe resectionPartial resectionMedian intervalCase seriesPreoperative assessmentSurgical interventionRNS deviceNeurological deficitsNo significant changesResectionRetrospective analysisNon-dominant, Lesional Parieto-occipital Lobe Epilepsy
Herlopian A. Non-dominant, Lesional Parieto-occipital Lobe Epilepsy. 2024, 221-240. DOI: 10.1007/978-3-031-23828-4_11.Peer-Reviewed Original ResearchFocal cortical dysplasiaCortical dysplasiaSupratentorial cystic lesionsPost-operative outcomesInterictal epileptiform activityPredictors of outcomeAnti-seizure medicationsMechanisms of epileptogenesisVisual evoked potentialsNeocortical epilepsy surgeryResection surgeryCystic lesionsSurgical interventionEpileptiform activityDifferential diagnosisEvoked potentialsPharmacoresistant epilepsyPatient populationNeuroimaging characteristicsEpilepsy surgeryDysplasiaPatientsOccipital lobeSensorimotor cortexSurgeryDominant, Lesional Post-Traumatic Temporal Lobe Epilepsy
Herlopian A. Dominant, Lesional Post-Traumatic Temporal Lobe Epilepsy. 2024, 135-160. DOI: 10.1007/978-3-031-23828-4_7.Peer-Reviewed Original ResearchTraumatic brain injuryImprove medication complianceIntracranial monitoringPatient populationExtent of cerebral injuryAnalysis of patientsNeuroimaging modalitiesPost-traumatic epilepsyMedication adherenceMedication compliancePredictors of outcomeBrain injuryStages of epileptogenesisSurgical outcomesIctal onsetResection surgerySurgical interventionTonic seizuresCerebral injuryHistopathological analysisPatientsVisual phenomenaEpilepsyOutcomesInjuryDominant, Lesional Pediatric-Onset Hemispheric Epilepsy
Knight V, Herlopian A. Dominant, Lesional Pediatric-Onset Hemispheric Epilepsy. 2024, 533-562. DOI: 10.1007/978-3-031-23828-4_22.Peer-Reviewed Original ResearchRasmussen encephalitisCerebrospinal fluid analysis findingsIctal rhythmic dischargesFocal cortical dysplasiaEpilepsia partialis continuaIctal nystagmusPediatric patientsCortical dysplasiaSurgical considerationsStatus epilepticusSurgical interventionPediatric populationCortical myoclonusRhythmic dischargesDevice placementProgressive epilepsyPatientsQuantitative electroencephalographyEncephalitisTechnical considerationsEpilepticusNystagmusNon-dominant, Lesional Posterior Quadrant Epilepsy
Herlopian A. Non-dominant, Lesional Posterior Quadrant Epilepsy. 2024, 633-652. DOI: 10.1007/978-3-031-23828-4_25.Peer-Reviewed Original ResearchArterio-venous malformationsIntracranial monitoringImpact of topiramatePosterior quadrantic epilepsyTreat pharmacoresistant epilepsySurgical outcomesTransient encephalopathyElectrographic seizuresSurgical interventionOutcome predictorsClinical significancePharmacoresistant epilepsyEpileptogenesis mechanismsEpilepsy patientsPatientsWada testAuditory hallucinationsLanguage reorganizationMalformationsEpilepsyCognitive functionOutcomesAuditory illusionTopiramateCongenital, Non-lesional Lennox-Gastaut Syndrome
Herlopian A. Congenital, Non-lesional Lennox-Gastaut Syndrome. 2024, 889-906. DOI: 10.1007/978-3-031-23828-4_35.Peer-Reviewed Original ResearchLennox-Gastaut syndromeVagus nerve stimulationNerve stimulationTreatment of Lennox-Gastaut syndromeTolerability of vagus nerve stimulationCerebellar volume lossPalliative therapyElectroclinical characteristicsSurgical interventionTonic seizuresChronic epilepsyDeep brain stimulationCentromedian nucleusStimulationBrain stimulationVolume lossNon-dominant, Lesional Temporal Lobe Epilepsy
Herlopian A. Non-dominant, Lesional Temporal Lobe Epilepsy. 2024, 361-374. DOI: 10.1007/978-3-031-23828-4_16.Peer-Reviewed Original ResearchMultifocal Epilepsy Due to New-Onset Refractory Status Epilepticus
Herlopian A, Gunawardane N. Multifocal Epilepsy Due to New-Onset Refractory Status Epilepticus. 2024, 497-532. DOI: 10.1007/978-3-031-23828-4_21.Peer-Reviewed Original ResearchRefractory status epilepticusStatus epilepticusNew-onset refractory status epilepticusOnset refractory status epilepticusSuper-refractory status epilepticusSingle pulse electrical stimulationCortico-cortical evoked potentialsResponsive neurostimulation deviceNew-onsetMultifocal epilepsySurgical interventionNeuroimaging characteristicsEpilepticusPulse electrical stimulationEpileptic networkEvaluate functional connectivityPatientsCortical stimulationNeurostimulation devicesElectrical stimulationFunctional connectivityLanguage mappingStimulationAcquired, Lesional Lennox-Gastaut Syndrome
Herlopian A. Acquired, Lesional Lennox-Gastaut Syndrome. 2024, 919-943. DOI: 10.1007/978-3-031-23828-4_37.Peer-Reviewed Original ResearchCentromedian nucleusConfirm electrode placementGeneralized atonic seizuresLennox-Gastaut syndromeCentromedian thalamic nucleusLanguage lateralizationPost-operative language deficitsRare entityLennox-GastautCorpus callosotomySurgical interventionCortical malformationsAtonic seizuresSurgical proceduresThalamic nucleiCorpus callosumEpileptic networkDeep brain stimulation devicesLanguage deficitsNeurostimulation devicesElectrode placementPatientsNeurophysiological recordingsEpilepsyLanguageNon-dominant, Lesional Frontal Lobe Epilepsy Overlapping with Motor Cortex
Herlopian A. Non-dominant, Lesional Frontal Lobe Epilepsy Overlapping with Motor Cortex. 2024, 469-496. DOI: 10.1007/978-3-031-23828-4_20.Peer-Reviewed Original ResearchFocal cortical dysplasiaCortical dysplasiaIntracranial monitoringPredictors of seizure freedomIctal onset patternsPost-operative outcomesSurgical decision-making processFrontal lobe epilepsySensorimotor functionDysplastic cortexResection marginsSurgical interventionSeizure freedomEpileptiform patternsLobe epilepsyPharmacoresistant epilepsyMotor cortexOnset patternsDysplasiaCortexPatientsCircuit organizationEpileptiformEpilepsyRasmussen’s Encephalitis and Focal Cortical Dysplasia
Vadiparati A, Herlopian A. Rasmussen’s Encephalitis and Focal Cortical Dysplasia. 2024, 241-286. DOI: 10.1007/978-3-031-23828-4_12.Peer-Reviewed Original ResearchOccipital lobe epilepsyRasmussen encephalitisSurgical interventionLobe epilepsyVisual field analysisSurgical decision-making processFocal cortical dysplasiaLeft occipital lobeAnterior thalamic nucleiClinical presentationCortical dysplasiaMultifocal epilepsySurgical techniqueIntractable seizuresOutcome predictorsDeep brain stimulationThalamic nucleiNeuromodulation therapiesDiagnostic criteriaOccipital lobeOccipital lobectomyProgressive natureEpilepsyBrain stimulationPatientsNon-dominant, Non-lesional Temporal-Plus Epilepsy
Herlopian A, Percy J, Mattson R. Non-dominant, Non-lesional Temporal-Plus Epilepsy. 2024, 599-631. DOI: 10.1007/978-3-031-23828-4_24.Peer-Reviewed Original Research