2024
Dominant, Lesional Posterior Quadrant Epilepsy
Herlopian A, Tolba H, Mattson R. Dominant, Lesional Posterior Quadrant Epilepsy. 2024, 757-777. DOI: 10.1007/978-3-031-23828-4_31.Peer-Reviewed Original ResearchIctal high-frequency oscillationsPeriventricular nodular heterotopiaPredicting surgical outcomesSurgical decision-making processFocal cortical dysplasiaPropagation of seizuresInterictal epileptiform dischargesThermoablative therapyNodular heterotopiaSurgical outcomesCortical dysplasiaIctal patternsCortical malformationsEpileptiform dischargesIntracranial monitoringPharmacoresistant epilepsyClonic movementsIctal vocalizationSpeech disturbanceCephalic auraTherapyPatientsHigh-frequency oscillationsNon-dominant, Non-lesional Orbitofrontal-Plus Epilepsy
Herlopian A. Non-dominant, Non-lesional Orbitofrontal-Plus Epilepsy. 2024, 563-598. DOI: 10.1007/978-3-031-23828-4_23.Peer-Reviewed Original ResearchResection surgeryIntracranial monitoringInterictal PET scanIctal onset patternsPost-operative outcomesNon-lesional epilepsySurgical work-upInterictal epileptiform dischargesNon-invasive modalityDelta slowingEEG findingsInvestigative armamentariumTonic seizuresEpileptiform dischargesPET scansIctal propagationWidespread hypometabolismWork-upInsular epilepsyPsychiatric manifestationsOnset patternsSpike rateEpilepsySurgeryPatients
2022
Electroencephalographic changes in purified pharmaceutical cannabidiol therapy
Herlopian A, Barnett JR, Nascimento FA, Lee H, Thiele EA. Electroencephalographic changes in purified pharmaceutical cannabidiol therapy. Epilepsy & Behavior 2022, 128: 108558. PMID: 35078115, DOI: 10.1016/j.yebeh.2022.108558.Peer-Reviewed Original ResearchConceptsInterictal epileptiform dischargesElectroencephalographic changesCBD treatmentIctal findingsSleep architectureEEG changesInvestigational New Drug programPredominant seizure typeNew drug programPre-treatment EEGYears of ageSubjective cognitive improvementElectrographic findingsElectrographic improvementRefractory epilepsySeizure typesClinical outcomesElectrographic changesEpileptiform dischargesPatientsCognitive improvementDrug programsSubstantial associationEEG studiesTreatment
2020
Interrater Reliability of Experts in Identifying Interictal Epileptiform Discharges in Electroencephalograms
Jing J, Herlopian A, Karakis I, Ng M, Halford JJ, Lam A, Maus D, Chan F, Dolatshahi M, Muniz C, Chu C, Sacca V, Pathmanathan J, Ge W, Sun H, Dauwels J, Cole AJ, Hoch DB, Cash SS, Westover MB. Interrater Reliability of Experts in Identifying Interictal Epileptiform Discharges in Electroencephalograms. JAMA Neurology 2020, 77: 49-57. PMID: 31633742, PMCID: PMC6806666, DOI: 10.1001/jamaneurol.2019.3531.Peer-Reviewed Original ResearchConceptsInterictal epileptiform dischargesPercentage of agreementEpileptiform dischargesNumber of IEDsMultivariate logistic regression modelPrimary outcome measureMassachusetts General HospitalLogistic regression modelsPhase 1Secondary outcomesInterrater reliability studyRoutine electroencephalogramMedical recordsGeneral HospitalOutcome measuresMAIN OUTCOMEProspective analysisClinical neurophysiologySubspecialty trainingIndividualized thresholdsSubstantial reliabilityInterrater reliabilityNegative controlPhase 2Electroencephalogram