2010
Treatment Choice and Outcome In Diffuse Large B Cell Lymphoma (DLBCL) Patients 75 Years and Older
Toomey C, Muzikanksy A, Lee A, Barnes J, Michaelson J, Abramson J, Hochberg E. Treatment Choice and Outcome In Diffuse Large B Cell Lymphoma (DLBCL) Patients 75 Years and Older. Blood 2010, 116: 733. DOI: 10.1182/blood.v116.21.733.733.Peer-Reviewed Original ResearchDiffuse large B-cell lymphomaCharlson Comorbidity IndexPatients age 75Patients 75 yearsUse of anthracyclinesComorbidity indexAge 75Elderly patientsOverall survivalPerformance statusPrognostic factorsSpeakers bureauModern chemotherapyAdvanced stageMedian Charlson comorbidity indexOutcome of DLBCLDiagnosis of DLBCLDischarge summariesLarge B-cell lymphomaExtranodal disease sitesHealth-related comorbiditiesECOG performance statusMedian overall survivalPatients 80 yearsAnn Arbor stage
2009
Rituximab Does Not Improve Progression Free (PFS) or Overall Survival (OS) in Patients with Limited Stage Diffuse Large B Cell Lymphoma (DLBCL).
Hochberg E, Birrer N, Toomey C, Barnes J, Lee A, LaCasce A, Abramson J. Rituximab Does Not Improve Progression Free (PFS) or Overall Survival (OS) in Patients with Limited Stage Diffuse Large B Cell Lymphoma (DLBCL). Blood 2009, 114: 3755. DOI: 10.1182/blood.v114.22.3755.3755.Peer-Reviewed Original ResearchLimited stage diffuse large B-cell lymphomaDiffuse large B-cell lymphomaLarge B-cell lymphomaUse of rituximabOverall survivalB-cell lymphomaSpeakers bureauCell lymphomaYounger low-risk patientsPrimary diffuse large B-cell lymphomaDana-Farber Cancer InstituteBenefit of rituximabGood-prognosis populationMultiple retrospective analysesAnthracycline-containing chemotherapyOverall survival benefitPatients 18 yearsLow-risk patientsAdvanced-stage patientsCD20 monoclonal antibodyLarge multicenter trialsTumor registry dataYears of ageMassachusetts General HospitalCurative intent
2008
Early Interim FDG-PET Scan Predicts Outcome in Non-Bulky Limited Stage Hodgkin Lymphoma, but may Not Guide Use of Consolidative Radiotherapy.
Barnes J, LaCasce A, Toomey C, Hochberg E, Lee A, Canellos G, Abramson J. Early Interim FDG-PET Scan Predicts Outcome in Non-Bulky Limited Stage Hodgkin Lymphoma, but may Not Guide Use of Consolidative Radiotherapy. Blood 2008, 112: 1453. DOI: 10.1182/blood.v112.11.1453.1453.Peer-Reviewed Original ResearchInterim PET scanNegative interim PET scanPositive interim PETConsolidative radiotherapyPrimary treatment failureStage Hodgkin lymphomaLimited stage Hodgkin lymphomaEnd of therapyTreatment failureInterim PETPET scansOverall survivalHodgkin's lymphomaComplete remissionCR patientsLimited-stage Hodgkin lymphomaAchievement of CRComplete response rateCompletion of chemotherapyCycles of chemotherapyInterim FDG-PETLimited stage diseaseLimited stage patientsNegative interim PETAnthracycline-based chemotherapy