Interferon-γ Induces X-linked Inhibitor of Apoptosis-associated Factor-1 and Noxa Expression and Potentiates Human Vascular Smooth Muscle Cell Apoptosis by STAT3 Activation*
Bai Y, Ahmad U, Wang Y, Li JH, Choy JC, Kim RW, Kirkiles-Smith N, Maher SE, Karras JG, Bennett CF, Bothwell AL, Pober JS, Tellides G. Interferon-γ Induces X-linked Inhibitor of Apoptosis-associated Factor-1 and Noxa Expression and Potentiates Human Vascular Smooth Muscle Cell Apoptosis by STAT3 Activation*. Journal Of Biological Chemistry 2008, 283: 6832-6842. PMID: 18192275, DOI: 10.1074/jbc.m706021200.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsApoptosisApoptosis Regulatory ProteinsF-Box ProteinsGene Expression RegulationHumansInterferon-gammaIntracellular Signaling Peptides and ProteinsMiceModels, BiologicalMuscle, Smooth, VascularNeoplasm ProteinsProto-Oncogene Proteins c-bcl-2Signal TransductionSTAT3 Transcription FactorTissue TransplantationConceptsVascular smooth muscle cellsInhibitor of apoptosisHuman vascular smooth muscle cellsSTAT3 activationNoxa expressionFactor 1Mouse vascular smooth muscle cellsExpression of XAF1Vascular smooth muscle cell apoptosisSmooth muscle cell apoptosisMuscle cell apoptosisApoptotic stimuliTranscription factorsTranscription (STAT) proteinsGene productsPro-apoptotic effectsHuman coronary artery graftsSignal transducerDeath receptorsMicroarray analysisHuman endothelial cellsChimeric animal modelPhenotypic modulationSTAT1 activationNuclear translocation