2004
Qualitatively differential regulation of T cell activation and apoptosis by T cell receptor ζ chain ITAMs and their tyrosine residues
Chae WJ, Lee HK, Han JH, Kim SW, Bothwell AL, Morio T, Lee SK. Qualitatively differential regulation of T cell activation and apoptosis by T cell receptor ζ chain ITAMs and their tyrosine residues. International Immunology 2004, 16: 1225-1236. PMID: 15302845, DOI: 10.1093/intimm/dxh120.Peer-Reviewed Original ResearchConceptsMitogen-activated protein kinaseTCR zeta chainTyrosine phosphorylated proteinsTyrosine residuesZeta chainPhosphorylated proteinsT cell activationCell deathFirst tyrosine residueCell activationInfluence of mutationsActivation-induced cell deathProtein kinaseDistinctive regulationIntracellular signalsDifferential regulationITAMMAPK phosphorylationTCR stimulationStepwise deletionJurkat transfectantsDistinct signalsActivation signalsMutationsResidues
2002
Cutting Edge: Internalization of Transduced E-Selectin by Cultured Human Endothelial Cells: Comparison of Dermal Microvascular and Umbilical Vein Cells and Identification of a Phosphoserine-Type Di-leucine Motif
Kluger MS, Shiao SL, Bothwell AL, Pober JS. Cutting Edge: Internalization of Transduced E-Selectin by Cultured Human Endothelial Cells: Comparison of Dermal Microvascular and Umbilical Vein Cells and Identification of a Phosphoserine-Type Di-leucine Motif. The Journal Of Immunology 2002, 168: 2091-2095. PMID: 11859093, DOI: 10.4049/jimmunol.168.5.2091.Peer-Reviewed Original ResearchConceptsHuman dermal microvascular endothelial cellsRate of internalizationAspartic acid substitutionSurface protein expressionEndothelial cell behaviorLeucine motifProtein internalizationCytoplasmic regionSurface expression levelsType motifSelectin surface expressionEndothelial cellsMutational analysisHuman endothelial cellsUmbilical vein cellsAcid substitutionsDermal microvascular endothelial cellsCell behaviorCultured human endothelial cellsCytokine inductionExpression levelsVein cellsInternalization processProtein expressionMotif