Pax5 and Linker Histone H1 Coordinate DNA Methylation and Histone Modifications in the 3′ Regulatory Region of the Immunoglobulin Heavy Chain Locus
Giambra V, Volpi S, Emelyanov AV, Pflugh D, Bothwell AL, Norio P, Fan Y, Ju Z, Skoultchi AI, Hardy RR, Frezza D, Birshtein BK. Pax5 and Linker Histone H1 Coordinate DNA Methylation and Histone Modifications in the 3′ Regulatory Region of the Immunoglobulin Heavy Chain Locus. Molecular And Cellular Biology 2008, 28: 6123-6133. PMID: 18644860, PMCID: PMC2547000, DOI: 10.1128/mcb.00233-08.Peer-Reviewed Original ResearchConceptsImmunoglobulin heavy chain locusHeavy chain locusHistone modificationsDNA methylationRegulatory regionsPalindromic regionMurine immunoglobulin heavy chain locusB-cell-specific transcription factor Pax5Chain locusLinker histone H1Multiple DNase IModular patternsTranscription factor Pax5Class switch recombinationMethylation-sensitive restriction sitesActive chromatinHeavy chain allelesHypersensitive sitesHistone H1B cell differentiationDNase ISwitch recombinationPotential insulatorsRestriction sitesHS4