2023
Incretin effect determines glucose trajectory and insulin sensitivity in youths with obesity
Galderisi A, Tricò D, Lat J, Samuels S, Weiss R, Van Name M, Pierpont B, Santoro N, Caprio S. Incretin effect determines glucose trajectory and insulin sensitivity in youths with obesity. JCI Insight 2023, 8: e165709. PMID: 37847560, PMCID: PMC10721315, DOI: 10.1172/jci.insight.165709.Peer-Reviewed Original ResearchConceptsOral glucose tolerance testΒ-cell functionIncretin effectBeta-cell functionInsulin sensitivityInsulin secretionGlucose levelsCell functionIsoglycemic intravenous glucose infusionGreater insulin sensitivityIntravenous glucose infusionPubertal transitionGlucose tolerance testGLP-17Glucagon suppressionGlucose infusionObesityLongitudinal increaseBaselineOGTTEffect groupGreater increaseLongitudinal trajectoriesSecretionGroupGlucose pattern in children with classical congenital adrenal hyperplasia: evidence from continuous glucose monitoring
Galderisi A, Kariyawasam D, Stoupa A, Quoc A, Pinto G, Viaud M, Brabant S, Beltrand J, Polak M, Samara-Boustani D. Glucose pattern in children with classical congenital adrenal hyperplasia: evidence from continuous glucose monitoring. European Journal Of Endocrinology 2023, 189: k19-k24. PMID: 37952170, DOI: 10.1093/ejendo/lvad147.Peer-Reviewed Original ResearchConceptsClassical congenital adrenal hyperplasiaClassical CAHCongenital adrenal hyperplasiaContinuous glucose monitoringLower cortisol concentrationsGlucose patternsAdrenal hyperplasiaCortisol concentrationsGlucose monitoringFludrocortisone replacement therapySensor glucose valuesHydrocortisone doseAcute illnessAsymptomatic hypoglycemiaWhole cohortNighttime hypoglycemiaReplacement therapyPercentage of timeObservational studyGlucose profilesGlycemic patternsSerial measuresGlucose valuesDaily cortisolHypoglycemiaSumatriptan, a serotonin 5HT1B receptor agonist, acutely reduces insulin secretion and sensitivity and glucose effectiveness in overweight humans: A double‐blinded placebo‐controlled cross‐over trial
Golubic R, Ismail M, Josipovic M, Kennet J, Galderisi A, Evans M. Sumatriptan, a serotonin 5HT1B receptor agonist, acutely reduces insulin secretion and sensitivity and glucose effectiveness in overweight humans: A double‐blinded placebo‐controlled cross‐over trial. Diabetes Obesity And Metabolism 2023, 25: 3059-3063. PMID: 37312648, DOI: 10.1111/dom.15176.Peer-Reviewed Original ResearchConceptsPlacebo-controlled cross-over trialIntravenous glucose tolerance testGlucose tolerance testCross-over trialGlucose effectivenessTolerance testInsulin sensitivityInsulin secretionHyperinsulinaemic euglycaemic clampControl blood glucoseGlucoregulatory roleOverweight adultsOverweight humansEuglycaemic clampInsulin levelsGlucose excursionsBlood glucoseReceptor agonistMouse modelGlucose homeostasisSumatriptanPlaceboSecretionTrialsHumansScreening strategies for glucose tolerance abnormalities and diabetes in people with cystic fibrosis
Weiss L, Reix P, Mosnier-Pudar H, Ronsin O, Beltrand J, Reynaud Q, Mely L, Burgel P, Stremler N, Rakotoarisoa L, Galderisi A, Perge K, Bendelac N, Abely M, Kessler L. Screening strategies for glucose tolerance abnormalities and diabetes in people with cystic fibrosis. Diabetes & Metabolism 2023, 49: 101444. PMID: 37030530, DOI: 10.1016/j.diabet.2023.101444.Peer-Reviewed Original ResearchConceptsGlucose tolerance abnormalitiesCystic fibrosis-related diabetesTolerance abnormalitiesCystic fibrosisAnnual oral glucose tolerance testOral glucose tolerance testGlucose tolerance testLong asymptomatic periodStage of diabetesNew comorbiditiesAsymptomatic periodClinical profileTolerance testNew diagnostic toolsPathophysiological knowledgeDiabetesNutritional outcomesPatientsFibrosisAbnormalitiesScreening strategyLife expectancyDiagnostic toolScreening methodComorbidities
2022
Glucose-to-lactate ratio and neurodevelopment in infants with hypoxic-ischemic encephalopathy: an observational study
Galderisi A, Tordin M, Suppiej A, Cainelli E, Baraldi E, Trevisanuto D. Glucose-to-lactate ratio and neurodevelopment in infants with hypoxic-ischemic encephalopathy: an observational study. European Journal Of Pediatrics 2022, 182: 837-844. PMID: 36484862, PMCID: PMC9899169, DOI: 10.1007/s00431-022-04694-3.Peer-Reviewed Original ResearchConceptsHypoxic-ischemic encephalopathyTherapeutic hypothermiaNeurodevelopmental outcomesLactate ratioDay 1Severe hypoxic-ischemic encephalopathyNew risk markerSevere hypoNeonatal hypoglycemiaMetabolic outcomesRisk markersObservational studyMetabolic variablesDay 2InfantsLactate concentrationEncephalopathyLactate kineticsNeurodevelopmentMetabolic fuelsNeonatesStrongest predictorHypothermiaOutcomesGlucoseGlucose variability increases during minimally invasive procedures in very preterm infants
Galderisi A, Res G, Guiducci S, Savio F, Brigadoi S, Forlani L, Mastrandrea B, Moschino L, Lolli E, Priante E, Trevisanuto D, Baraldi E. Glucose variability increases during minimally invasive procedures in very preterm infants. European Journal Of Pediatrics 2022, 182: 89-94. PMID: 36201017, PMCID: PMC9829573, DOI: 10.1007/s00431-022-04641-2.Peer-Reviewed Original ResearchConceptsVery preterm infantsContinuous glucose monitoringPreterm infantsGlucose variabilityNeonatal stressNappy changeInvasive proceduresMedian glucoseGlucose monitoringNon-invasive procedurePrimary outcomeAbsence of changesHeel prickMean glucoseNeonatal proceduresCare proceduresDay 2InfantsParental presenceGlucose variationCGM dataGlucoseSDNeonatesPrickMechanistic Insights Into the Heterogeneity of Glucose Response Classes in Youths With Obesity: A Latent Class Trajectory Approach
Tricò D, McCollum S, Samuels S, Santoro N, Galderisi A, Groop L, Caprio S, Shabanova V. Mechanistic Insights Into the Heterogeneity of Glucose Response Classes in Youths With Obesity: A Latent Class Trajectory Approach. Diabetes Care 2022, 45: 1841-1851. PMID: 35766976, PMCID: PMC9346992, DOI: 10.2337/dc22-0110.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBlood GlucoseGlucoseGlucose IntoleranceHumansInsulinInsulin ResistanceObesityConceptsOral glucose tolerance testΒ-cell functionΒ-cell glucose sensitivityInsulin sensitivityGenetic risk profileMultiple oral glucose tolerance testsDifferent genetic risk profilesRisk profileMin oral glucose tolerance testLatent class trajectory analysisGlucose tolerance testImpaired insulin sensitivityPlasma glucose responseGlucose sensitivityClass 3Model-predicted probabilityClass 1Tolerance testProgressive impairmentMultiethnic cohortGlucose responseLongitudinal changesObesityTransient reductionInsulin kineticsA low n‐6 to n‐3 polyunsaturated fatty acid ratio diet improves hyperinsulinaemia by restoring insulin clearance in obese youth
Tricò D, Galderisi A, Van Name MA, Caprio S, Samuels S, Li Z, Galuppo BT, Savoye M, Mari A, Feldstein AE, Santoro N. A low n‐6 to n‐3 polyunsaturated fatty acid ratio diet improves hyperinsulinaemia by restoring insulin clearance in obese youth. Diabetes Obesity And Metabolism 2022, 24: 1267-1276. PMID: 35297549, PMCID: PMC9177628, DOI: 10.1111/dom.14695.Peer-Reviewed Original ResearchConceptsOral glucose tolerance testΒ-cell glucose sensitivityInsulin clearanceΒ-cell functionObese youthInsulin secretionRatio dietGlucose-dependent insulin secretionAbdominal magnetic resonance imagingWhole-body insulin sensitivityImpaired insulin clearancePostload insulin levelsWorse metabolic profileGlucose tolerance testHepatic fat contentDietary-induced changesGlucose sensitivityMagnetic resonance imagingInsulin levelsHepatic fatInsulin resistancePlasma insulinTolerance testInsulin sensitivityC-peptide
2020
Metabolic and Genetic Determinants of Glucose Shape After Oral Challenge in Obese Youths: A Longitudinal Study
Galderisi A, Tricò D, Man C, Santoro N, Pierpont B, Groop L, Cobelli C, Caprio S. Metabolic and Genetic Determinants of Glucose Shape After Oral Challenge in Obese Youths: A Longitudinal Study. The Journal Of Clinical Endocrinology & Metabolism 2020, 105: dgz207. PMID: 31972003, PMCID: PMC6977541, DOI: 10.1210/clinem/dgz207.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAllelesChildCross-Sectional StudiesDiabetes Mellitus, Type 2FemaleGenetic Predisposition to DiseaseGenotypeGlucoseGlucose IntoleranceGlucose Tolerance TestHumansInsulin SecretionInsulin-Secreting CellsLongitudinal StudiesMalePediatric ObesityPrediabetic StateTime FactorsTranscription Factor 7-Like 2 ProteinYoung AdultConceptsOral glucose tolerance testTCF7L2 rs7903146 variantΒ-cell responsivenessObese youthT risk alleleDisposition indexGlucose peakRs7903146 variantTCF7L2 rs7903146Lower disposition indexGlucose tolerance testOral minimal modelGlucose toleranceOral challengeDiabetes riskTolerance testInsulin sensitivityHigh glucose concentrationsLate peak groupMetabolic phenotypeGlucose concentrationLongitudinal studyReproducible markerPrevalenceRs7903146
2019
Fructose Consumption Contributes to Hyperinsulinemia in Adolescents With Obesity Through a GLP-1–Mediated Mechanism
Galderisi A, Giannini C, Van Name M, Caprio S. Fructose Consumption Contributes to Hyperinsulinemia in Adolescents With Obesity Through a GLP-1–Mediated Mechanism. The Journal Of Clinical Endocrinology & Metabolism 2019, 104: 3481-3490. PMID: 30938760, PMCID: PMC6599430, DOI: 10.1210/jc.2019-00161.Peer-Reviewed Original ResearchConceptsLean adolescentsGLP-1Insulin responseFructose consumptionBaseline oral glucose tolerance testGlucagon-like peptide-1 secretionOral glucose tolerance testGlucose-dependent insulinotropic polypeptideHigher GLP-1Plasma glucose excursionsGLP-1 responsePeptide-1 secretionGlucose tolerance testIngestion of glucoseΒ-cell functionMeasures of glucoseEligible subjectsGlucose ingestionGlucose toleranceLean adultsAnorexic effectFructose challengeGreater insulinInsulinotropic polypeptideLean group