Single-cell analysis of targeted transcriptome predicts drug sensitivity of single cells within human myeloma tumors
Mitra A, Mukherjee U, Harding T, Jang J, Stessman H, Li Y, Abyzov A, Jen J, Kumar S, Rajkumar V, Van Ness B. Single-cell analysis of targeted transcriptome predicts drug sensitivity of single cells within human myeloma tumors. Leukemia 2015, 30: 1094-1102. PMID: 26710886, DOI: 10.1038/leu.2015.361.Peer-Reviewed Original ResearchConceptsSingle cellsIndividual cellsSignificant genetic diversitySingle-cell analysisGene expression profile signaturesSingle-cell levelGenetic diversityTranscriptome analysisDrug responseCellular responsesDrug sensitivityBulk populationInhibitor sensitivitySubclonal architectureProfiling studiesPCR analysisPrediction programsCell linesMyeloma cell linesTumor progressionCellsIntratumor heterogeneityProfile signaturesProteasome inhibitor sensitivitySubclonal level