MSB: A mean-shift-based approach for the analysis of structural variation in the genome
Wang LY, Abyzov A, Korbel JO, Snyder M, Gerstein M. MSB: A mean-shift-based approach for the analysis of structural variation in the genome. Genome Research 2008, 19: 106-117. PMID: 19037015, PMCID: PMC2612956, DOI: 10.1101/gr.080069.108.Peer-Reviewed Original ResearchConceptsProbability density functionNumber of segmentsGood parameter initializationLikelihood functionArray CGH experimentsKernel-based approachUnderlying distributionModel parametersParameter initializationParticular assumptionsNonparametric methodsExpectation maximizationComputational methodsConvergenceGlobal criterionLocal gradients