2020
Investigation of increased platelet alloimmunization screening in the era of pathogen‐reduced platelets treated with psoralen/UV light
Hendrickson JE, Mendoza H, Ross R, Siddon AJ, Gowda L, Hauser RG, Schulz WL, Tormey CA. Investigation of increased platelet alloimmunization screening in the era of pathogen‐reduced platelets treated with psoralen/UV light. Transfusion 2020, 60: 650-651. PMID: 32128834, DOI: 10.1111/trf.15691.Peer-Reviewed Original Research
2019
Chapter Six The chemical and laboratory investigation of hemolysis
Siddon AJ, Tormey CA. Chapter Six The chemical and laboratory investigation of hemolysis. Advances In Clinical Chemistry 2019, 89: 215-258. PMID: 30797470, DOI: 10.1016/bs.acc.2018.12.006.Peer-Reviewed Original ResearchConceptsRed blood cellsSignificant clinical issueDivision of HematologyLaboratory investigationsPathophysiology of hemolysisPrimary disorderDisease processHemolytic disordersClinical issuesPathologic formsClinical pathologyBlood cellsTransfusion medicineClinical interpretationHemolysisClinical laboratoriesClinical chemistryLaboratory basisDisordersAssaysAbnormal breakdownPathophysiologyPathologyHematology
2018
Delayed haemolytic and serologic transfusion reactions
Siddon AJ, Kenney BC, Hendrickson JE, Tormey CA. Delayed haemolytic and serologic transfusion reactions. Current Opinion In Hematology 2018, 25: 459-467. PMID: 30124474, DOI: 10.1097/moh.0000000000000462.Peer-Reviewed Original ResearchConceptsSickle cell diseaseAdverse eventsTransfusion reactionsTransfusion-associated adverse eventsHaemolytic transfusion reactionsSerologic transfusion reactionsGeneral patient groupNovel immunosuppressive agentPractical preventive strategiesEvidence-based approachImmune dysregulationImmunosuppressive agentsPatient groupTransfusion recipientsRisk factorsBasic epidemiologyCell diseasePreventive strategiesRed blood cell deathAntibody detectionDHTRHaemolytic reactionsMultitude of reportsCell deathDHTRs
2016
Antigen modulation as a potential mechanism of anti-KEL immunoprophylaxis in mice
Liu J, Santhanakrishnan M, Natarajan P, Gibb DR, Eisenbarth SC, Tormey CA, Siddon AJ, Stowell SR, Branch DR, Hendrickson JE. Antigen modulation as a potential mechanism of anti-KEL immunoprophylaxis in mice. Blood 2016, 128: 3159-3168. PMID: 27688803, PMCID: PMC5201095, DOI: 10.1182/blood-2016-06-724732.Peer-Reviewed Original ResearchConceptsMechanism of actionKO miceRed blood cell alloimmunizationGlycoprotein antigenMurine RBCsHuman KEL glycoproteinRh immune globulinSingle knockout miceWild-type recipientsImmunoprophylaxis programKO recipientsPrevent alloimmunizationImmune globulinSerious complicationsAntigen modulationMurine modelImmunoprophylaxisFcγ receptorsKEL antigenAlloimmunizationFlow cytometryRapid clearanceWestern blotMiceAntigen