2022
Accelerated cortical thinning precedes and predicts conversion to psychosis: The NAPLS3 longitudinal study of youth at clinical high-risk
Collins M, Ji J, Chung Y, Lympus C, Afriyie-Agyemang Y, Addington J, Goodyear B, Bearden C, Cadenhead K, Mirzakhanian H, Tsuang M, Cornblatt B, Carrión R, Keshavan M, Stone W, Mathalon D, Perkins D, Walker E, Woods S, Powers A, Anticevic A, Cannon T. Accelerated cortical thinning precedes and predicts conversion to psychosis: The NAPLS3 longitudinal study of youth at clinical high-risk. Molecular Psychiatry 2022, 28: 1182-1189. PMID: 36434057, PMCID: PMC10005940, DOI: 10.1038/s41380-022-01870-7.Peer-Reviewed Original ResearchConceptsCHR-NCPercent thickness changeCortical thinningPsychosis onsetHealth controlsProgressive grey matter lossNorth American Prodrome Longitudinal StudyClinical high-risk individualsGray matter lossHigh-risk individualsLongitudinal studyGreater percent decreaseNovel treatment targetsParietal cortical regionsTargeted early interventionsCortical thicknessCortical areasMRI scansCHR individualsTreatment targetsEarly interventionCortical regionsLeft hemisphere regionsROC analysisHC participants
2021
Racial and ethnic differences in perception of provider cultural competence among patients with depression and anxiety symptoms: a retrospective, population-based, cross-sectional analysis
Eken HN, Dee EC, Powers AR, Jordan A. Racial and ethnic differences in perception of provider cultural competence among patients with depression and anxiety symptoms: a retrospective, population-based, cross-sectional analysis. The Lancet Psychiatry 2021, 8: 957-968. PMID: 34563316, PMCID: PMC10688309, DOI: 10.1016/s2215-0366(21)00285-6.Peer-Reviewed Original ResearchConceptsProvider cultural competenceAdjusted odds ratioHispanic ethnicityDepression symptomsHealth statusMultivariable ordinal logistic regressionUS National Health Interview SurveyNational Health Interview SurveySelf-reported health statusOutcome variablesAlaskan NativesPresence of symptomsAssociation of raceCross-sectional studyHealth Interview SurveyMental health statusMental health providersAfrican AmericansCross-sectional analysisMean ageSubgroup analysisOrdinal logistic regressionOdds ratioPatients' viewsCultural competence
2019
Does hallucination perceptual modality impact psychosis risk?
Niles H, Walsh B, Woods S, Powers A. Does hallucination perceptual modality impact psychosis risk? Acta Psychiatrica Scandinavica 2019, 140: 360-370. PMID: 31355420, PMCID: PMC6752971, DOI: 10.1111/acps.13078.Peer-Reviewed Original ResearchConceptsClinical high riskPerceptual abnormalitiesPsychosis riskNon-verbal contentAuditory perceptual abnormalitiesIndividuals ages 12Verbal experienceAuditory experienceCHR individualsThought contentCHR sampleUnusual thought contentPredictive validityAuditory scoresGustatory componentsAge 12Meeting criteriaPsychotic disordersPhenomenological aspectsInterview notesPsychosisConversion riskScoresIndividualsExperience
2017
Lack of Diagnostic Pluripotentiality in Patients at Clinical High Risk for Psychosis: Specificity of Comorbidity Persistence and Search for Pluripotential Subgroups
Woods SW, Powers AR, Taylor JH, Davidson CA, Johannesen JK, Addington J, Perkins DO, Bearden CE, Cadenhead KS, Cannon TD, Cornblatt BA, Seidman LJ, Tsuang MT, Walker EF, McGlashan TH. Lack of Diagnostic Pluripotentiality in Patients at Clinical High Risk for Psychosis: Specificity of Comorbidity Persistence and Search for Pluripotential Subgroups. Schizophrenia Bulletin 2017, 44: 254-263. PMID: 29036402, PMCID: PMC5814797, DOI: 10.1093/schbul/sbx138.Peer-Reviewed Original ResearchConceptsCHR syndromeDiagnostic outcomesCHR subgroupsClinical high-risk syndromeHigh-risk syndromeOnset of psychosisClinical high riskPersistence of anxietyEmergent psychosisCHR patientsRisk syndromeObservational studyCHR casesHigh riskNonpsychotic disordersComorbid disordersComparison subjectsBipolar disorderDiagnostic InterviewSyndromeDSM-IVPatientsPsychosisDiagnostic specificityComparison groupPavlovian conditioning–induced hallucinations result from overweighting of perceptual priors
Powers AR, Mathys C, Corlett PR. Pavlovian conditioning–induced hallucinations result from overweighting of perceptual priors. Science 2017, 357: 596-600. PMID: 28798131, PMCID: PMC5802347, DOI: 10.1126/science.aan3458.Peer-Reviewed Original Research
2016
Varieties of Voice-Hearing: Psychics and the Psychosis Continuum
Powers AR, Kelley MS, Corlett PR. Varieties of Voice-Hearing: Psychics and the Psychosis Continuum. Schizophrenia Bulletin 2016, 43: 84-98. PMID: 28053132, PMCID: PMC5216860, DOI: 10.1093/schbul/sbw133.Peer-Reviewed Original ResearchConceptsPsychotic disordersSerious mental illnessVoice-hearing experiencesControl subjectsStudy populationProminent symptomContinuum of psychosisTreatment of voiceMental illnessProtective factorsPatientsNew study populationPsychosis continuumHelp-seeking groupDisordersHallucinatory experiencesVoice hearingSubjectsAuditory messagesVoice hearersPopulationSymptomsIllnessPsychosisDisease
2015
Ketamine-Induced Hallucinations
Powers A, Gancsos MG, Finn ES, Morgan PT, Corlett PR. Ketamine-Induced Hallucinations. Psychopathology 2015, 48: 376-385. PMID: 26361209, PMCID: PMC4684980, DOI: 10.1159/000438675.Peer-Reviewed Original ResearchConceptsAuditory verbal hallucinationsPerceptual inputVerbal hallucinationsPredictive coding modelDelusion-like ideasPerceptual disruptionsPerceptual expectationsPerceptual environmentCoding modelPhenomenological experienceSensory stimuliStimulation environmentAuditory hallucinationsHealthy participantsHallmark symptomFirst-episode psychosisMusical hallucinationsMRI scannerHallucinationsParticipantsMagnetic resonance imaging (MRI) scannerPsychosisAmotivationPerceptVivid hallucinations
2013
The effects of visual training on multisensory temporal processing
Stevenson RA, Wilson MM, Powers AR, Wallace MT. The effects of visual training on multisensory temporal processing. Experimental Brain Research 2013, 225: 479-489. PMID: 23307155, PMCID: PMC3606590, DOI: 10.1007/s00221-012-3387-y.Peer-Reviewed Original ResearchConceptsMultisensory integrationVisual trainingMultisensory temporal processesMultisensory temporal processingVisual perceptual trainingTemporal visual processingTemporal integration processPerceptual trainingTemporal trainingVisual processingTemporal processingSensory modalitiesTemporal synchronyMultisensoryHuman behaviorSensory inputTemporal offsetFeedback trainingTemporal processesTemporal precisionDifferent modalitiesCurrent studyTrainingTraining processProcessing
2010
Binding of sights and sounds: Age-related changes in multisensory temporal processing
Hillock AR, Powers AR, Wallace MT. Binding of sights and sounds: Age-related changes in multisensory temporal processing. Neuropsychologia 2010, 49: 461-467. PMID: 21134385, PMCID: PMC3140703, DOI: 10.1016/j.neuropsychologia.2010.11.041.Peer-Reviewed Original ResearchConceptsMultisensory temporal processingTemporal processingLong stimulus onset asynchroniesAudiovisual temporal perceptionMultisensory temporal functionAudiovisual temporal asynchronyStimulus onset asynchronyRelatedness of stimuliAge-related differencesSignificant group differencesMultisensory processesMultisensory stimuliMultisensory worldTemporal perceptionOnset asynchronyAuditory cuesAuditory stimuliVisual stimuliTemporal asynchronyAge-related changesGroup differencesExternal eventsStimuliTemporal functionAsynchrony
2009
Perceptual Training Narrows the Temporal Window of Multisensory Binding
Powers AR, Hillock AR, Wallace MT. Perceptual Training Narrows the Temporal Window of Multisensory Binding. Journal Of Neuroscience 2009, 29: 12265-12274. PMID: 19793985, PMCID: PMC2771316, DOI: 10.1523/jneurosci.3501-09.2009.Peer-Reviewed Original ResearchConceptsPerceptual trainingAudiovisual simultaneity judgment taskMultisensory temporal functionMultisensory temporal processingSimultaneity judgment taskPerceptual learning paradigmTemporal windowSame environmental eventAudiovisual simultaneityMultisensory bindingAudiovisual integrationAudiovisual pairsCognitive biasesJudgment taskTemporal processingVisual stimuliBrain's abilityTwo-alternativeLearning paradigmChoice paradigmTwo-intervalTemporal functionEnvironmental eventsTemporal boundsSecond experiment