2023
A novel computational approach to pain perception modelling within a Bayesian framework using quantitative sensory testing
Drusko A, Baumeister D, McPhee Christensen M, Kold S, Fisher V, Treede R, Powers A, Graven-Nielsen T, Tesarz J. A novel computational approach to pain perception modelling within a Bayesian framework using quantitative sensory testing. Scientific Reports 2023, 13: 3196. PMID: 36823292, PMCID: PMC9950064, DOI: 10.1038/s41598-023-29758-8.Peer-Reviewed Original ResearchConceptsHierarchical Gaussian FilterPrior expectationsRelevant individual differencesPain perceptionLearning-based interventionsTesting paradigmCognitive processesSensory evidenceIndividual differencesPsychophysical paradigmInferential processesVisual cuesElectrical cutaneous stimulusPrior weightingPerceptionPain stimuliPrior beliefsIndividual levelNociceptive inputBeliefsGreater relianceStimuliStrong weightingAcute pain stimuliParadigm
2022
Relating Glutamate, Conditioned, and Clinical Hallucinations via 1H-MR Spectroscopy
Leptourgos P, Bansal S, Dutterer J, Culbreth A, Powers A, Suthaharan P, Kenney J, Erickson M, Waltz J, Wijtenburg SA, Gaston F, Rowland LM, Gold J, Corlett P. Relating Glutamate, Conditioned, and Clinical Hallucinations via 1H-MR Spectroscopy. Schizophrenia Bulletin 2022, 48: 912-920. PMID: 35199836, PMCID: PMC9212089, DOI: 10.1093/schbul/sbac006.Peer-Reviewed Original ResearchConceptsGlutamate levelsAnterior insulaPrior beliefsCognitive modelPathophysiological theoriesAuditory cortexClinical hallucinationsAnterior cingulateComputational psychiatryNew treatmentsDorsolateral prefrontalVisual cuesPrior expectationsSame participantsHallucinationsInsulaNegative relationshipCurrent experienceMagnetic resonance spectroscopyBeliefsComputational modelingTone