2022
Accelerated cortical thinning precedes and predicts conversion to psychosis: The NAPLS3 longitudinal study of youth at clinical high-risk
Collins M, Ji J, Chung Y, Lympus C, Afriyie-Agyemang Y, Addington J, Goodyear B, Bearden C, Cadenhead K, Mirzakhanian H, Tsuang M, Cornblatt B, Carrión R, Keshavan M, Stone W, Mathalon D, Perkins D, Walker E, Woods S, Powers A, Anticevic A, Cannon T. Accelerated cortical thinning precedes and predicts conversion to psychosis: The NAPLS3 longitudinal study of youth at clinical high-risk. Molecular Psychiatry 2022, 28: 1182-1189. PMID: 36434057, PMCID: PMC10005940, DOI: 10.1038/s41380-022-01870-7.Peer-Reviewed Original ResearchConceptsCHR-NCPercent thickness changeCortical thinningPsychosis onsetHealth controlsProgressive grey matter lossNorth American Prodrome Longitudinal StudyClinical high-risk individualsGray matter lossHigh-risk individualsLongitudinal studyGreater percent decreaseNovel treatment targetsParietal cortical regionsTargeted early interventionsCortical thicknessCortical areasMRI scansCHR individualsTreatment targetsEarly interventionCortical regionsLeft hemisphere regionsROC analysisHC participants
2020
Paracingulate Sulcus Length Is Shorter in Voice-Hearers Regardless of Need for Care
Powers AR, van Dyck LI, Garrison JR, Corlett PR. Paracingulate Sulcus Length Is Shorter in Voice-Hearers Regardless of Need for Care. Schizophrenia Bulletin 2020, 46: 1520-1523. PMID: 32432706, PMCID: PMC7707078, DOI: 10.1093/schbul/sbaa067.Peer-Reviewed Original ResearchConceptsAuditory verbal hallucinationsPsychotic disordersParacingulate sulcusT1-weighted structural MRI scansMedial prefrontal cortexStructural MRI scansClinical stateClinical careMRI scansAVH phenomenologyMental illnessClinical counterpartPrefrontal cortexClinical populationsDisordersVerbal hallucinationsHallucinationsIllnessPsychosisSulcus lengthCareGroups of participantsCurrent studyParticipantsNonclinical populations