2020
Artery to vein configuration of arteriovenous fistula improves hemodynamics to increase maturation and patency
Bai H, Sadaghianloo N, Gorecka J, Liu S, Ono S, Ramachandra AB, Bonnet S, Mazure NM, Declemy S, Humphrey JD, Dardik A. Artery to vein configuration of arteriovenous fistula improves hemodynamics to increase maturation and patency. Science Translational Medicine 2020, 12 PMID: 32817365, PMCID: PMC7705473, DOI: 10.1126/scitranslmed.aax7613.Peer-Reviewed Original ResearchConceptsArteriovenous fistulaHemodialysis accessNeointimal hyperplasiaEndothelial nitric oxide synthaseDurable surgical optionUremic male ratsRadial-cephalic arteriovenous fistulaKruppel-like factor 2Nitric oxide synthasePeak systolic velocityLong-term patencyReintervention rateSecondary patencyImproved hemodynamicsFemale patientsReimplantation techniqueSurgical optionsSystolic velocityMale ratsOxide synthaseFistula modelPatencyHemodynamicsDifferent hemodynamicsFemale animalsAltered hemodynamics during arteriovenous fistula remodeling leads to reduced fistula patency in female mice
Kudze T, Ono S, Fereydooni A, Gonzalez L, Isaji T, Hu H, Yatsula B, Taniguchi R, Koizumi J, Nishibe T, Dardik A. Altered hemodynamics during arteriovenous fistula remodeling leads to reduced fistula patency in female mice. JVS Vascular Science 2020, 1: 42-56. PMID: 32754721, PMCID: PMC7402599, DOI: 10.1016/j.jvssci.2020.03.001.Peer-Reviewed Original ResearchInfrarenal inferior vena cavaArteriovenous fistulaFemale miceMale miceHuman AVF maturationAVF maturationAVF patencyVascular cell adhesion molecule-1Superior long-term outcomesEndothelial nitric oxide synthaseCell adhesion molecule-1Male C57BL/6 miceLong-term outcomesInferior vena cavaNitric oxide synthaseAdhesion molecule-1Krüppel-like factor 2Significant differencesSex-specific differential expressionMessenger RNAAVF remodelingAVF utilizationFistula utilizationAortocaval fistulaFistula patency
1998
Shear stress and the endothelium.
Ballermann B, Dardik A, Eng E, Liu A. Shear stress and the endothelium. Kidney International Supplement 1998, 67: s100-8. PMID: 9736263, DOI: 10.1046/j.1523-1755.1998.06720.x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsEndothelial nitric oxide synthaseChronic shear stressEndothelial cellsBlood flowGrowth factorWall distentionNitric oxide synthaseTranscription factor nuclear factorPlatelet-derived growth factorVascular endothelial cellsAcute shear stressInflammatory cytokinesMCP-1Oxide synthaseICAM-1Cyclooxygenase IIAcute releaseStructural remodelingTissue factorNitric oxideNuclear factorTransmural pressureC-fosVascular prosthesesEvidence of differentiationShear stress and the endothelium
Ballermann B, Dardik A, Eng E, Liu A. Shear stress and the endothelium. Kidney International 1998, 54: s100-s108. DOI: 10.1046/j.1523-1755.1998.06720.x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsEndothelial nitric oxide synthaseChronic shear stressEndothelial cellsBlood flowGrowth factorWall distentionTranscription factor nuclear factorNitric oxide synthasePlatelet-derived growth factorVascular endothelial cellsAcute shear stressInflammatory cytokinesMCP-1Oxide synthaseICAM-1Cyclooxygenase IIAcute releaseStructural remodelingTissue factorNitric oxideNuclear factorTransmural pressureC-fosRapid cytoskeletal remodelingVascular prostheses