2024
Polypharmacy in elective lumbar spinal surgery for degenerative conditions with 24-month follow-up
Dietz N, Kumar C, Elsamadicy A, Bjurström M, Wong K, Jamieson A, Sharma M, Wang D, Ugiliweneza B, Drazin D, Boakye M. Polypharmacy in elective lumbar spinal surgery for degenerative conditions with 24-month follow-up. Scientific Reports 2024, 14: 25340. PMID: 39455709, PMCID: PMC11511981, DOI: 10.1038/s41598-024-76248-6.Peer-Reviewed Original ResearchConceptsDegenerative lumbar pathologySurgical site infectionSpinal surgeryPolypharmacy groupSite infectionLumbar pathologyFollow-upMedical complicationsElective lumbar spinal surgeryLumbar spinal surgeryUrinary tract infectionDegenerative lumbar conditionsReturn to the emergency departmentTract infectionsNon-polypharmacy groupSurgical patientsLumbar conditionsSurgeryPatientsComplicationsPolypharmacyEmergency departmentPrescribed medicationsMarketScan datasetDegenerative conditions
2021
Patient Risk Factors Associated With 30- and 90-Day Readmission After Ventriculoperitoneal Shunt Placement for Idiopathic Normal Pressure Hydrocephalus in Elderly Patients: A Nationwide Readmission Study
Koo AB, Elsamadicy AA, Lin IH, David WB, Reeves BC, Santarosa C, Cord B, Malhotra A, Kahle KT, Matouk CC. Patient Risk Factors Associated With 30- and 90-Day Readmission After Ventriculoperitoneal Shunt Placement for Idiopathic Normal Pressure Hydrocephalus in Elderly Patients: A Nationwide Readmission Study. World Neurosurgery 2021, 152: e23-e31. PMID: 33862298, DOI: 10.1016/j.wneu.2021.04.010.Peer-Reviewed Original ResearchConceptsIdiopathic normal pressure hydrocephalusVP shunt surgeryShunt surgeryElderly patientsNormal pressure hydrocephalusPressure hydrocephalusNationwide Readmissions DatabaseVentriculoperitoneal shunt surgeryPatient risk factorsVentriculoperitoneal shunt placementQuality of careMultivariate regression analysisIndex admissionUnplanned readmissionReadmission ratesRenal failureMechanical complicationsPostoperative infectionShunt placementNinth RevisionFemale sexRisk factorsSubdural hemorrhageClinical ModificationReadmission
2020
Laser interstitial thermal therapy (LITT) vs. bevacizumab for radiation necrosis in previously irradiated brain metastases
Sujijantarat N, Hong CS, Owusu KA, Elsamadicy AA, Antonios JP, Koo AB, Baehring JM, Chiang VL. Laser interstitial thermal therapy (LITT) vs. bevacizumab for radiation necrosis in previously irradiated brain metastases. Journal Of Neuro-Oncology 2020, 148: 641-649. PMID: 32602021, DOI: 10.1007/s11060-020-03570-0.Peer-Reviewed Original ResearchConceptsLaser interstitial thermal therapyLonger overall survivalRadiation necrosisInterstitial thermal therapyBrain metastasesOverall survivalMedian volume decreaseMedian volume increaseBrain metastasis patientsPre-treatment patient characteristicsRetrospective chart reviewResultsTwenty-five patientsPre-treatment factorsBevacizumab patientsChart reviewMetastasis patientsLocal recurrencePatient characteristicsTreatment optionsTreatment responseBevacizumabPatientsLesional volumeThermal therapyStatistical significance
2018
Correlation of 2-year SRS-22r and ODI patient-reported outcomes with 5-year patient-reported outcomes after complex spinal fusion: a 5-year single-institution study of 118 patients.
Adogwa O, Karikari IO, Elsamadicy AA, Sergesketter AR, Galan D, Bridwell KH. Correlation of 2-year SRS-22r and ODI patient-reported outcomes with 5-year patient-reported outcomes after complex spinal fusion: a 5-year single-institution study of 118 patients. Journal Of Neurosurgery Spine 2018, 29: 422-428. PMID: 29979138, DOI: 10.3171/2018.2.spine171142.Peer-Reviewed Original ResearchConceptsPatient-reported outcomesComplex spinal fusionSpinal fusionLong-term patient-reported outcomesBaseline patient-reported outcomesMental healthSRS-22r domainsSingle-institution studyLack of patientsSRS-22rAdult patientsAmbispective studyIntraoperative variablesPatient demographicsPrimary outcomeGreater absolute changeRevision surgeryRadiographic parametersProspective collectionCobb angleSpinal arthrodesisIliac fixationPatientsPRO dataPRO instruments
2017
Long-term Cost Utility of Spinal Cord Stimulation in Patients with Failed Back Surgery Syndrome.
Farber SH, Han JL, Elsamadicy AA, Hussaini Q, Yang S, Pagadala P, Parente B, Xie J, Lad SP. Long-term Cost Utility of Spinal Cord Stimulation in Patients with Failed Back Surgery Syndrome. Pain Physician 2017, 20: e797-e805. PMID: 28934786, PMCID: PMC8358894, DOI: 10.36076/ppj.20.5.e797.Peer-Reviewed Original ResearchConceptsConventional medical managementSpinal cord stimulationFBSS patientsSurgery syndromeCord stimulationSCS systemCost utilityFailed Back Surgery SyndromeBack surgery syndromePrior back surgeryGEE modelHealth care utilizationRandomized clinical trialsConventional managementLongitudinal GEE modelsTime of implantationLeg painSCS implantationBack painCare utilizationLong followMedical managementSignificant morbidityBack surgeryTreatment optionsProphylactic use of intraoperative vancomycin powder and postoperative infection: an analysis of microbiological patterns in 1200 consecutive surgical cases.
Adogwa O, Elsamadicy AA, Sergesketter A, Vuong VD, Mehta AI, Vasquez RA, Cheng J, Bagley CA, Karikari IO. Prophylactic use of intraoperative vancomycin powder and postoperative infection: an analysis of microbiological patterns in 1200 consecutive surgical cases. Journal Of Neurosurgery Spine 2017, 27: 328-334. PMID: 28665245, DOI: 10.3171/2017.2.spine161310.Peer-Reviewed Original ResearchConceptsSurgical site infectionMean body mass indexIntraoperative vancomycin powderVancomycin powderWound infectionAdult patientsProphylactic useCases of SSIPatients' mean body mass indexMicrobiological patternDirect medical record reviewPostoperative surgical site infectionDuke University Medical CenterDeep wound infectionEmpirical antibiotic therapyHistory of diabetesAdverse clinical outcomesMedical record reviewConsecutive surgical casesDay of surgeryBody mass indexSpinal deformity surgeryUniversity Medical CenterRandomized control trialHealth care system
2016
Do measures of surgical effectiveness at 1 year after lumbar spine surgery accurately predict 2-year outcomes?
Adogwa O, Elsamadicy AA, Han JL, Cheng J, Karikari I, Bagley CA. Do measures of surgical effectiveness at 1 year after lumbar spine surgery accurately predict 2-year outcomes? Journal Of Neurosurgery Spine 2016, 25: 689-696. PMID: 26722957, DOI: 10.3171/2015.8.spine15476.Peer-Reviewed Original ResearchConceptsTransforaminal lumbar interbody fusionLumbar spine surgeryAnterior lumbar interbody fusionLong-term outcomesLateral interbody fusionLumbar interbody fusionSpine surgeryInterbody fusionSurgical effectivenessOutcome measuresSF-36 physical component summary scorePhysical component summary scoreLongitudinal assessmentPatient-reported outcome instrumentsAchievement of MCIDMultiinstitutional prospective studyVAS leg painComponent summary scoresClinical outcome dataPatient-centered measuresLogistic regression modelingIneffective patient careInstitutional registryOutcomes RegistrySF-36
2015
Effects of Psoas Muscle Thickness on Outcomes of Lumbar Fusion Surgery
Verla T, Adogwa O, Elsamadicy A, Moreno JR, Farber H, Cheng J, Bagley CA. Effects of Psoas Muscle Thickness on Outcomes of Lumbar Fusion Surgery. World Neurosurgery 2015, 87: 283-289. PMID: 26619920, DOI: 10.1016/j.wneu.2015.11.022.Peer-Reviewed Original ResearchConceptsPsoas muscle thicknessLumbar fusion surgeryFusion surgeryMuscle thicknessPsoas muscleSpinal stabilizationVisual analog scale pain scoreHip flexor weaknessScale pain scoresPreoperative magnetic resonanceInterbody fusion surgeryLumbar intervertebral spaceSpecific clinical outcomesWarrants further investigationEarly ambulationPain scoresAdult patientsFlexor weaknessPostoperative rehabilitationRetrospective reviewClinical outcomesHospital recordsSurgical optionsLumbar pathologyFunctional outcome