2024
Polypharmacy in elective lumbar spinal surgery for degenerative conditions with 24-month follow-up
Dietz N, Kumar C, Elsamadicy A, Bjurström M, Wong K, Jamieson A, Sharma M, Wang D, Ugiliweneza B, Drazin D, Boakye M. Polypharmacy in elective lumbar spinal surgery for degenerative conditions with 24-month follow-up. Scientific Reports 2024, 14: 25340. PMID: 39455709, PMCID: PMC11511981, DOI: 10.1038/s41598-024-76248-6.Peer-Reviewed Original ResearchConceptsDegenerative lumbar pathologySurgical site infectionSpinal surgeryPolypharmacy groupSite infectionLumbar pathologyFollow-upMedical complicationsElective lumbar spinal surgeryLumbar spinal surgeryUrinary tract infectionDegenerative lumbar conditionsReturn to the emergency departmentTract infectionsNon-polypharmacy groupSurgical patientsLumbar conditionsSurgeryPatientsComplicationsPolypharmacyEmergency departmentPrescribed medicationsMarketScan datasetDegenerative conditions
2022
Geriatric relationship with inpatient opioid consumption and hospital outcomes after open posterior spinal fusion for adult spine deformity
Elsamadicy A, Sandhu M, Reeves B, Sherman J, Craft S, Williams M, Shin J, Sciubba D. Geriatric relationship with inpatient opioid consumption and hospital outcomes after open posterior spinal fusion for adult spine deformity. Clinical Neurology And Neurosurgery 2022, 224: 107532. PMID: 36436433, DOI: 10.1016/j.clineuro.2022.107532.Peer-Reviewed Original ResearchConceptsNon-routine dischargeHealthcare resource utilizationAdverse eventsGeriatric cohortMME useGeriatric patientsSpinal fusionSpine deformityMultivariate logistic regression analysisInpatient narcotic consumptionInpatient opioid consumptionInpatient opioid usePremier Healthcare DatabasePoor surgical outcomesPatient risk stratificationPosterior spinal fusionAdult spinal deformityAdult spine deformityICD-10-CM codesGreater proportionLogistic regression analysisGreater resource utilizationNon-Hispanic whitesOlder CohortOpioid consumptionAssociation of inpatient opioid consumption on postoperative outcomes after open posterior spinal fusion for adult spine deformity
Elsamadicy A, Sandhu M, Reeves B, Freedman I, Koo A, Jayaraj C, Hengartner A, Havlik J, Hersh A, Pennington Z, Lo S, Shin J, Mendel E, Sciubba D. Association of inpatient opioid consumption on postoperative outcomes after open posterior spinal fusion for adult spine deformity. Spine Deformity 2022, 11: 439-453. PMID: 36350557, DOI: 10.1007/s43390-022-00609-2.Peer-Reviewed Original ResearchConceptsAdult spinal deformityInpatient opioid useProportion of patientsOpioid useAdverse eventsHigher MMESpinal fusionHospital costsMME consumptionPostoperative outcomesDischarge dispositionHospital admissionRisk factorsMultivariate analysisLong-term opioid useMethodsA retrospective cohort studyHigh opioid useInpatient opioid consumptionOpioid-related disordersPremier Healthcare DatabasePostoperative adverse eventsPostoperative opioid useRetrospective cohort studyHealthcare resource utilizationNon-routine dischargeAssessment of Spinal Metastases Surgery Risk Stratification Tools in Breast Cancer by Molecular Subtype
Duvall J, Massaad E, Siraj L, Kiapour A, Connolly I, Hadzipasic M, Elsamadicy A, Williamson T, Shankar G, Schoenfeld A, Fourman M, Shin J. Assessment of Spinal Metastases Surgery Risk Stratification Tools in Breast Cancer by Molecular Subtype. Neurosurgery 2022, 92: 83-91. PMID: 36305664, PMCID: PMC10158884, DOI: 10.1227/neu.0000000000002180.Peer-Reviewed Original ResearchConceptsHuman epidermal growth factor receptor 2Epidermal growth factor receptor 2Triple-negative breast cancerGrowth factor receptor 2Factor receptor 2Breast cancerHazard ratioSpine metastasesMolecular subtypesReceptor 2Retrospective multi-institutional studyHormone receptorsBreast cancer molecular subtypesPostoperative systemic therapySystemic treatment plansPoor physical activityRisk stratification toolSpinal metastasis surgeryCancer molecular subtypesMulti-institutional studyMassachusetts General HospitalMolecular featuresPostoperative chemotherapyBrain metastasesEndocrine therapy
2021
Comprehensive Genomic Characterization of A Case of Granular Cell Tumor of the Posterior Pituitary Gland: A Case Report
Hong CS, Elsamadicy AA, Fisayo A, Inzucchi SE, Gopal PP, Vining EM, Erson-Omay EZ, Omay S. Comprehensive Genomic Characterization of A Case of Granular Cell Tumor of the Posterior Pituitary Gland: A Case Report. Frontiers In Endocrinology 2021, 12: 762095. PMID: 34925233, PMCID: PMC8671743, DOI: 10.3389/fendo.2021.762095.Peer-Reviewed Original ResearchConceptsGranular cell tumorPosterior pituitary glandCell tumorsPituitary glandComprehensive genomic characterizationWhole-exome sequencingImmune checkpoint inhibitorsPoor clinical outcomePituitary gland tumorsHistone deacetylase inhibitorsInstitutional review boardRadiographic compressionUnderwent resectionCheckpoint inhibitorsMedical therapyPituitary massClinical outcomesOptic nerveSignificant morbidityResidual diseaseCase reportCentral hypothyroidismPharmacologic agentsGland tumorsTherapeutic targetingEffects of preoperative nutritional status on complications and readmissions after posterior lumbar decompression and fusion for spondylolisthesis: A propensity-score analysis
Elsamadicy AA, Havlik J, Reeves BC, Koo AB, Sherman J, Lo SL, Shin JH, Sciubba DM. Effects of preoperative nutritional status on complications and readmissions after posterior lumbar decompression and fusion for spondylolisthesis: A propensity-score analysis. Clinical Neurology And Neurosurgery 2021, 211: 107017. PMID: 34781222, DOI: 10.1016/j.clineuro.2021.107017.Peer-Reviewed Original ResearchConceptsUnplanned readmissionAdverse eventsSpine surgerySurgeons National Surgical Quality Improvement Program databaseNational Surgical Quality Improvement Program databaseOccurrence of AEsPreoperative serum albumin levelQuality Improvement Program databaseMultivariate logistic regression analysisPosterior lumbar decompressionPreoperative nutritional statusHigh rateImprovement Program databaseRetrospective cohort studySerum albumin levelSignificant independent predictorsEffects of malnutritionLogistic regression analysisPropensity score analysisPropensity-score matchingMalnourished cohortMalnourished patientsPerioperative complicationsPostoperative complicationsLumbar decompressionUtility of expanded anterior column resection versus decompression-alone for local control in the management of carcinomatous vertebral column metastases undergoing adjuvant stereotactic radiotherapy
Pennington Z, Pairojboriboon S, Chen X, Sacino A, Elsamadicy AA, de la Garza Ramos R, Patel J, Elder BD, Kleinberg LR, Sciubba DM, Redmond KJ, Lo SL. Utility of expanded anterior column resection versus decompression-alone for local control in the management of carcinomatous vertebral column metastases undergoing adjuvant stereotactic radiotherapy. The Spine Journal 2021, 22: 835-846. PMID: 34718175, DOI: 10.1016/j.spinee.2021.10.016.Peer-Reviewed Original ResearchConceptsStereotactic body radiotherapyLong-term local controlLocal recurrenceLocal controlAnterior columnTumor pathologyCommon primary tumor typesSingle comprehensive cancer centerAdjuvant stereotactic radiotherapySpinal column metastasesVertebral Column MetastasesRetrospective cohort studyLocal control ratePrimary tumor typeLocal tumor recurrenceComprehensive cancer centerKaplan-Meier functionInvasive surgical techniquesEpidural removalAdjuvant radiotherapySurgical debulkingCohort studyDisease resectionSpinal metastasesTumor involvementPatient- and hospital-related risk factors for non-routine discharge after lumbar decompression and fusion for spondylolisthesis
Elsamadicy AA, Freedman IG, Koo AB, David W, Hengartner AC, Havlik J, Reeves BC, Hersh A, Pennington Z, Kolb L, Laurans M, Shin JH, Sciubba DM. Patient- and hospital-related risk factors for non-routine discharge after lumbar decompression and fusion for spondylolisthesis. Clinical Neurology And Neurosurgery 2021, 209: 106902. PMID: 34481141, DOI: 10.1016/j.clineuro.2021.106902.Peer-Reviewed Original ResearchConceptsNon-routine dischargeDependent functional statusAdverse eventsIndependent predictorsUnplanned readmissionLonger LOSSpinal decompressionLumbar spondylolisthesisFemale sexFunctional statusSurgeons National Surgical Quality Improvement Program databaseNational Surgical Quality Improvement Program databaseNon-Hispanic black race/ethnicityHospital-related risk factorsQuality Improvement Program databaseNon-Hispanic black raceICD-9-CM diagnosisBlack race/ethnicityMultivariate logistic regression modelNon-home dischargeHospital-related factorsImprovement Program databaseRetrospective cohort studyLength of stayProcedural Coding SystemA Web-Based Calculator for Predicting the Occurrence of Wound Complications, Wound Infection, and Unplanned Reoperation for Wound Complications in Patients Undergoing Surgery for Spinal Metastases
Hersh AM, Feghali J, Hung B, Pennington Z, Schilling A, Antar A, Patel J, Ehresman J, Cottrill E, Lubelski D, Elsamadicy AA, Goodwin CR, Lo SL, Sciubba DM. A Web-Based Calculator for Predicting the Occurrence of Wound Complications, Wound Infection, and Unplanned Reoperation for Wound Complications in Patients Undergoing Surgery for Spinal Metastases. World Neurosurgery 2021, 155: e218-e228. PMID: 34403800, DOI: 10.1016/j.wneu.2021.08.041.Peer-Reviewed Original ResearchConceptsLow platelet countWound complicationsPlatelet countUnplanned reoperationWound infectionRevision surgeryWeb-based calculatorIncision lengthHigher CCIHigher Charlson comorbidity indexSingle comprehensive cancer centerKarnofsky Performance Scale scoreLonger incision lengthCharlson Comorbidity IndexWound-related complicationsIndependent predictive factorsSurgical site infectionMultivariable logistic regressionPerformance Scale scoreComprehensive cancer centerOptimism-corrected areaPoor health statusComorbidity indexIndex surgeryMetastasis surgeryImpact of Frailty on Morbidity and Mortality in Adult Patients Presenting with an Acute Traumatic Cervical Spinal Cord Injury
Elsamadicy AA, Sandhu MRS, Freedman IG, Reeves BC, Koo AB, Hengartner A, Havlik J, Sherman J, Maduka R, Agboola IK, Johnson DC, Kolb L, Laurans M. Impact of Frailty on Morbidity and Mortality in Adult Patients Presenting with an Acute Traumatic Cervical Spinal Cord Injury. World Neurosurgery 2021, 153: e408-e418. PMID: 34224881, DOI: 10.1016/j.wneu.2021.06.130.Peer-Reviewed Original ResearchConceptsCervical spinal cord injurySpinal cord injuryAcute cervical spinal cord injuryNational Trauma DatabaseAdverse eventsHospital mortalityFrailty scoreAdult patientsIndependent predictorsCord injuryAcute traumatic cervical spinal cord injuryTraumatic cervical spinal cord injuryRisk of AEsComplete spinal cord injuryMultivariate logistic regression analysisCentral cord syndromeHospital adverse eventsImpact of frailtyRetrospective cohort studyProportion of patientsType of injuryProcedural Coding SystemLogistic regression analysisRegression analysisMultivariate regression analysisIndependent Association of Obesity and Nonroutine Discharge Disposition After Elective Anterior Cervical Discectomy and Fusion for Cervical Spondylotic Myelopathy
Koo AB, Elsamadicy AA, Sarkozy M, David WB, Reeves BC, Hong CS, Boylan A, Laurans M, Kolb L. Independent Association of Obesity and Nonroutine Discharge Disposition After Elective Anterior Cervical Discectomy and Fusion for Cervical Spondylotic Myelopathy. World Neurosurgery 2021, 151: e950-e960. PMID: 34020060, DOI: 10.1016/j.wneu.2021.05.022.Peer-Reviewed Original ResearchConceptsCervical spondylotic myelopathyNonroutine discharge dispositionAnterior cervical discectomyElective anterior cervical discectomyDischarge dispositionSpondylotic myelopathyCervical discectomyElective ACDFComplication rateNational Inpatient Sample databaseElective spine surgeryOverall complication ratePrevalence of obesityShort-term outcomesLength of stayHospital bed sizeMultivariate regression analysisHealth care coverageMore comorbiditiesNonroutine dischargeDischarge weightIndependent predictorsElixhauser comorbiditiesGreater proportionPrimary diagnosisFenestrated pedicle screws for thoracolumbar instrumentation in patients with poor bone quality: Case series and systematic review of the literature
Ehresman J, Pennington Z, Elsamadicy AA, Hersh A, Lubelski D, Lehner K, Cottrill E, Schilling A, Lakomkin N, Ahmed AK, Lo SF, Sciubba DM. Fenestrated pedicle screws for thoracolumbar instrumentation in patients with poor bone quality: Case series and systematic review of the literature. Clinical Neurology And Neurosurgery 2021, 206: 106675. PMID: 34020324, DOI: 10.1016/j.clineuro.2021.106675.Peer-Reviewed Original ResearchConceptsPulmonary cement embolismFenestrated pedicle screwsCement leakageBone qualityCement embolismInstrumented fusionHardware looseningOsteoporotic fracturesPedicle screwsSystematic reviewSymptomatic pulmonary cement embolismNon-augmented patientsSingle-surgeon seriesDegenerative spine diseaseHigh-quality evidencePoor bone qualityEndpoints of interestLow reported ratesPathologic fractureCase seriesSpine metastasesFenestrated screwsSpine diseasePRISMA guidelinesPatientsRace Is an Independent Predictor for Nonroutine Discharges After Spine Surgery for Spinal Intradural/Cord Tumors
Elsamadicy AA, Koo AB, David WB, Reeves BC, Freedman IG, Pennington Z, Ehresman J, Kolb L, Laurans M, Shin JH, Sciubba DM. Race Is an Independent Predictor for Nonroutine Discharges After Spine Surgery for Spinal Intradural/Cord Tumors. World Neurosurgery 2021, 151: e707-e717. PMID: 33940256, DOI: 10.1016/j.wneu.2021.04.085.Peer-Reviewed Original ResearchConceptsNonroutine discharge dispositionIndependent predictorsNonroutine dischargeDischarge dispositionCord tumorsAA raceSurgical interventionNational Inpatient Sample databaseMultivariable logistic regression analysisStepwise multivariable logistic regression analysisBackward stepwise multivariable logistic regression analysisAfrican AmericansPostoperative complication rateRetrospective cohort studyClinical Modification diagnosisLength of hospitalizationProcedural Coding SystemLogistic regression analysisHealth care costsRegression analysisMultivariate regression analysisAA/BlackPostoperative complicationsCohort studyComplication ratePatient Risk Factors Associated With 30- and 90-Day Readmission After Ventriculoperitoneal Shunt Placement for Idiopathic Normal Pressure Hydrocephalus in Elderly Patients: A Nationwide Readmission Study
Koo AB, Elsamadicy AA, Lin IH, David WB, Reeves BC, Santarosa C, Cord B, Malhotra A, Kahle KT, Matouk CC. Patient Risk Factors Associated With 30- and 90-Day Readmission After Ventriculoperitoneal Shunt Placement for Idiopathic Normal Pressure Hydrocephalus in Elderly Patients: A Nationwide Readmission Study. World Neurosurgery 2021, 152: e23-e31. PMID: 33862298, DOI: 10.1016/j.wneu.2021.04.010.Peer-Reviewed Original ResearchConceptsIdiopathic normal pressure hydrocephalusVP shunt surgeryShunt surgeryElderly patientsNormal pressure hydrocephalusPressure hydrocephalusNationwide Readmissions DatabaseVentriculoperitoneal shunt surgeryPatient risk factorsVentriculoperitoneal shunt placementQuality of careMultivariate regression analysisIndex admissionUnplanned readmissionReadmission ratesRenal failureMechanical complicationsPostoperative infectionShunt placementNinth RevisionFemale sexRisk factorsSubdural hemorrhageClinical ModificationReadmissionCost and Health Care Resource Utilization Differences After Spine Surgery for Bony Spine versus Primary Intradural Spine Tumors
Elsamadicy AA, Koo AB, Reeves BC, Freedman IG, Pennington Z, David WB, Ehresman J, Hengartner A, Laurans M, Kolb L, Shin JH, Sciubba DM. Cost and Health Care Resource Utilization Differences After Spine Surgery for Bony Spine versus Primary Intradural Spine Tumors. World Neurosurgery 2021, 151: e286-e298. PMID: 33866030, DOI: 10.1016/j.wneu.2021.04.015.Peer-Reviewed Original ResearchConceptsLength of stayPrimary intradural spinal tumorsIntradural spinal tumorsSpine tumorsSpine surgeryPerioperative complicationsSpinal tumorsNational Inpatient Sample databaseMultivariable logistic regression analysisStepwise multivariable logistic regression analysisBackward stepwise multivariable logistic regression analysisIntradural spinal neoplasmsIntradural spine tumorsRetrospective cohort studyLogistic regression analysisHealth care resourcesMore comorbiditiesAdult patientsCohort studyDischarge dispositionIntraoperative variablesPatient demographicsComplication rateHospital admissionIndependent predictors
2020
Predictors of Extended Length of Stay Following Treatment of Unruptured Adult Cerebral Aneurysms: A Study of The National Inpatient Sample
Koo AB, Elsamadicy AA, Lin IH, David WB, Sujijantarat N, Santarosa C, Cord BJ, Zetchi A, Hebert R, Bahrassa F, Malhotra A, Matouk CC. Predictors of Extended Length of Stay Following Treatment of Unruptured Adult Cerebral Aneurysms: A Study of The National Inpatient Sample. Journal Of Stroke And Cerebrovascular Diseases 2020, 29: 105230. PMID: 33066916, DOI: 10.1016/j.jstrokecerebrovasdis.2020.105230.Peer-Reviewed Original ResearchMeSH KeywordsAgedComorbidityDatabases, FactualEndovascular ProceduresFemaleHospital CostsHumansInpatientsIntracranial AneurysmLength of StayMaleMicrosurgeryMiddle AgedOutcome and Process Assessment, Health CarePatient AdmissionPostoperative ComplicationsQuality Indicators, Health CareRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeUnited StatesConceptsLOS cohortExtended LOSMultivariate logistic regressionUnruptured cerebral aneurysmsCerebral aneurysmsPreadmission comorbiditiesInpatient complicationsHospital stayMore patientsOdds ratioUnruptured aneurysmsHealthcare costsMultiple patient-specific factorsLogistic regressionOverall complication rateHospital-level factorsNon-routine dischargePatient-level factorsNational Inpatient SamplePatient-specific factorsOverall healthcare costsChoice of procedureIndex admissionPostoperative complicationsComplication rateWithdrawal of Life-supporting Treatment in Severe Traumatic Brain Injury
Williamson T, Ryser MD, Ubel PA, Abdelgadir J, Spears CA, Liu B, Komisarow J, Lemmon ME, Elsamadicy A, Lad SP. Withdrawal of Life-supporting Treatment in Severe Traumatic Brain Injury. JAMA Surgery 2020, 155: 723-731. PMID: 32584926, PMCID: PMC7301301, DOI: 10.1001/jamasurg.2020.1790.Peer-Reviewed Original ResearchConceptsSevere traumatic brain injuryLife-supporting treatmentTraumatic brain injuryBrain injurySurgeons Trauma Quality Improvement Program databaseTrauma Quality Improvement Program databaseLower Glasgow Coma Scale scoreHigher Injury Severity ScoreQuality Improvement Program databaseGlasgow Coma Scale scoreImprovement Program databaseInjury Severity ScoreSelf-pay patientsDependent health statusOlder patientsAdult patientsClinical factorsWhite patientsBlack patientsMultivariable analysisTrauma centerDisseminated cancerSeverity scoreProgram databaseRetrospective analysisLaser interstitial thermal therapy (LITT) vs. bevacizumab for radiation necrosis in previously irradiated brain metastases
Sujijantarat N, Hong CS, Owusu KA, Elsamadicy AA, Antonios JP, Koo AB, Baehring JM, Chiang VL. Laser interstitial thermal therapy (LITT) vs. bevacizumab for radiation necrosis in previously irradiated brain metastases. Journal Of Neuro-Oncology 2020, 148: 641-649. PMID: 32602021, DOI: 10.1007/s11060-020-03570-0.Peer-Reviewed Original ResearchConceptsLaser interstitial thermal therapyLonger overall survivalRadiation necrosisInterstitial thermal therapyBrain metastasesOverall survivalMedian volume decreaseMedian volume increaseBrain metastasis patientsPre-treatment patient characteristicsRetrospective chart reviewResultsTwenty-five patientsPre-treatment factorsBevacizumab patientsChart reviewMetastasis patientsLocal recurrencePatient characteristicsTreatment optionsTreatment responseBevacizumabPatientsLesional volumeThermal therapyStatistical significancePortending Influence of Racial Disparities on Extended Length of Stay after Elective Anterior Cervical Discectomy and Interbody Fusion for Cervical Spondylotic Myelopathy
Elsamadicy AA, Koo AB, David WB, Sarkozy M, Freedman IG, Reeves BC, Laurans M, Kolb L, Sciubba DM. Portending Influence of Racial Disparities on Extended Length of Stay after Elective Anterior Cervical Discectomy and Interbody Fusion for Cervical Spondylotic Myelopathy. World Neurosurgery 2020, 142: e173-e182. PMID: 32599203, DOI: 10.1016/j.wneu.2020.06.155.Peer-Reviewed Original ResearchMeSH KeywordsAgedBlack or African AmericanCerebrospinal Fluid LeakCervical VertebraeCohort StudiesComorbidityDiskectomyElective Surgical ProceduresFemaleHealthcare DisparitiesHumansIntraoperative ComplicationsLength of StayMaleMiddle AgedPostoperative ComplicationsPrevalenceRetrospective StudiesSpinal Cord CompressionSpinal FusionSpondylosisUnited StatesWhite PeopleConceptsCervical spondylotic myelopathyElective anterior cervical discectomyAnterior cervical discectomyAA cohortSpondylotic myelopathyCervical discectomyExtended LOSC cohortSignificant independent risk factorsNational Inpatient Sample databaseLonger hospital stayPrevalence of comorbiditiesRetrospective cohort studyIndependent risk factorNumber of complicationsAfrican AmericansElective ACDFNonroutine dischargeAA raceC patientsHospital stayAdult patientsCohort studyIndependent predictorsAA patientsAssociated risk factors for extended length of stay following anterior cervical discectomy and fusion for cervical spondylotic myelopathy
Elsamadicy AA, Koo AB, Lee M, David WB, Kundishora AJ, Robert SM, Kuzmik GA, Coutinho PO, Kolb L, Laurans M, Abbed K. Associated risk factors for extended length of stay following anterior cervical discectomy and fusion for cervical spondylotic myelopathy. Clinical Neurology And Neurosurgery 2020, 195: 105883. PMID: 32428797, DOI: 10.1016/j.clineuro.2020.105883.Peer-Reviewed Original ResearchConceptsCervical spondylotic myelopathyHospital-level factorsLOS cohortAnterior cervical discectomyExtended LOSMultivariate logistic regressionSpondylotic myelopathyPostoperative complicationsCervical discectomyBlood transfusionOdds ratioNational Inpatient Sample databaseLogistic regressionFurther investigational studiesOverall complication rateNon-routine dischargeAssociated risk factorsNational cohort studyNumber of complicationsRisk-adjusted LOSGreater overall costsLow socioeconomic statusPaucity of literatureHospital LOSHospital stay