2018
Topical application of aminoglycoside antibiotics enhances host resistance to viral infections in a microbiota-independent manner
Gopinath S, Kim MV, Rakib T, Wong PW, van Zandt M, Barry NA, Kaisho T, Goodman AL, Iwasaki A. Topical application of aminoglycoside antibiotics enhances host resistance to viral infections in a microbiota-independent manner. Nature Microbiology 2018, 3: 611-621. PMID: 29632368, PMCID: PMC5918160, DOI: 10.1038/s41564-018-0138-2.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, TopicalAminoglycosidesAnimalsAnti-Bacterial AgentsDisease Models, AnimalGene Expression ProfilingGene Expression RegulationGerm-Free LifeHumansInfluenza A virusMiceMicrobiotaOligonucleotide Array Sequence AnalysisSimplexvirusToll-Like Receptor 3Transcription FactorsVirus DiseasesVirus ReplicationZika VirusConceptsToll-like receptor 3Aminoglycoside treatmentInterferon-stimulated genesViral infectionReceptor 3ISG inductionAminoglycoside antibioticsMicrobiota-independent mannerGerm-free miceAdapter-inducing interferonInterferon regulatory factor 3Herpes simplex virusTopical mucosal applicationRegulatory factor 3Dendritic cellsAntibiotic useAntiviral effectAminoglycoside applicationHost resistanceSimplex virusAntiviral resistanceVaginal mucosaMarked upregulationMucosal applicationTopical application
2015
No Viral Association Found in a Set of Differentiated Vulvar Intraepithelial Neoplasia Cases by Human Papillomavirus and Pan-Viral Microarray Testing
Saglam O, Samayoa E, Somasekar S, Naccache S, Iwasaki A, Chiu CY. No Viral Association Found in a Set of Differentiated Vulvar Intraepithelial Neoplasia Cases by Human Papillomavirus and Pan-Viral Microarray Testing. PLOS ONE 2015, 10: e0125292. PMID: 25894343, PMCID: PMC4404153, DOI: 10.1371/journal.pone.0125292.Peer-Reviewed Original ResearchMeSH KeywordsAgedCarcinoma in SituCyclin-Dependent Kinase Inhibitor p16FemaleHigh-Throughput Nucleotide SequencingHumansMiddle AgedOligonucleotide Array Sequence AnalysisPapillomaviridaeVulvar NeoplasmsConceptsVulvar squamous cell carcinomaVulvar intraepithelial neoplasiaDVIN casesHuman papillomavirusHigh-grade vulvar intraepithelial neoplasiaUsual-type vulvar intraepithelial neoplasiaUsual-type VINSquamous cell carcinomaHPV infectionIntraepithelial neoplasiaCell carcinomaPrecursor lesionsSmall biopsiesInfectious agentsDifferentiated typeGermline mutationsP53 geneInfectionDVINBiopsyCarcinomaPapillomavirusNeoplasiaLesionsCases