2023
National Trends of Cerebral Venous Sinus Stenting for the Treatment of Idiopathic Intracranial Hypertension
Khunte M, Chen H, Colasurdo M, Chaturvedi S, Malhotra A, Gandhi D. National Trends of Cerebral Venous Sinus Stenting for the Treatment of Idiopathic Intracranial Hypertension. Neurology 2023, 101: 402-406. PMID: 36990721, PMCID: PMC10501094, DOI: 10.1212/wnl.0000000000207245.Peer-Reviewed Original ResearchConceptsVenous sinus stentingOptic nerve sheath fenestrationIdiopathic intracranial hypertensionIIH treatmentCSF shuntsIntracranial hypertensionSurgical proceduresCerebral venous sinus stentingNational Inpatient Sample databaseStandard medical treatmentCerebral venous sinusesNew surgical procedureRecent temporal trendsAdult patientsSheath fenestrationSinus stentingHospital characteristicsPractice patternsVenous sinusesMedical treatmentComparative effectivenessProcedure numbersPatientsSample databaseShuntClinical criteria to exclude acute vascular pathology on CT angiogram in patients with dizziness
Tu L, Malhotra A, Venkatesh A, Taylor R, Sheth K, Yaesoubi R, Forman H, Sureshanand S, Navaratnam D. Clinical criteria to exclude acute vascular pathology on CT angiogram in patients with dizziness. PLOS ONE 2023, 18: e0280752. PMID: 36893103, PMCID: PMC9997874, DOI: 10.1371/journal.pone.0280752.Peer-Reviewed Original ResearchConceptsAcute vascular pathologyEmergency departmentVascular pathologyNegative predictive valueDizzy patientsStroke codeCTA headPredictive valueAdult ED encountersTransient ischemic attackHalf of patientsLong-term smokersLarge vessel occlusionCoronary artery diseasePast medical historySeparate validation cohortCross-sectional analysisIschemic attackAnalysis cohortArterial dissectionArtery diseaseClinical factorsED encountersMedication useChief complaint
2022
Associations of Osteoarthritis With Thrombectomy Utilization and Outcomes for Large Vessel Acute Ischemic Stroke
Chen H, Khunte M, Colasurdo M, Jindal G, Malhotra A, Gandhi D, Chaturvedi S. Associations of Osteoarthritis With Thrombectomy Utilization and Outcomes for Large Vessel Acute Ischemic Stroke. Stroke 2022, 54: 518-526. PMID: 36541211, DOI: 10.1161/strokeaha.122.041749.Peer-Reviewed Original ResearchConceptsMultivariable logistic regression modelEndovascular thrombectomyAssociation of osteoarthritisLogistic regression modelsHospital mortalityMedical comorbiditiesIschemic strokeRisk factorsLower oddsLarge vessel acute ischemic strokeNational Inpatient Sample databaseMultivariable logistic regression analysisLarge-vessel ischemic strokeIntravenous thrombolysis treatmentStroke risk factorsAcute ischemic strokeIschemic stroke patientsPresence of osteoarthritisCause of disabilityCross-sectional studyLogistic regression analysisPatient selection practicesLarge-scale cross-sectional studyDirect risk factorEVT treatment
2020
Septic cavernous sinus thrombosis—Case series and review of the literature
Geng B, Wu X, Malhotra A. Septic cavernous sinus thrombosis—Case series and review of the literature. Clinical Neurology And Neurosurgery 2020, 197: 106092. PMID: 32693341, DOI: 10.1016/j.clineuro.2020.106092.Peer-Reviewed Original ResearchConceptsCavernous sinus thrombosisAcademic tertiary care centerSeptic cavernous sinus thrombosisExtension of thrombosisTertiary care centerInternal jugular veinTransverse-sigmoid sinusLife-threatening diseaseSource of infectionCST patientsInfectious thrombosisSinus thrombosisPatient demographicsPseudo aneurysmReported complicationsIntracranial complicationsSubdural empyemaBilateral narrowingHigh morbidityTreatment coursePersistent narrowingRadiology databaseCare centerUnilateral narrowingJugular veinReduced 2-year aneurysm retreatment and costs among patients treated with flow diversion versus non-flow diversion embolization: A Premier Healthcare Database retrospective cohort study
Grandhi R, Karsy M, Taussky P, Ricker CN, Malhotra A. Reduced 2-year aneurysm retreatment and costs among patients treated with flow diversion versus non-flow diversion embolization: A Premier Healthcare Database retrospective cohort study. PLOS ONE 2020, 15: e0234478. PMID: 32555657, PMCID: PMC7302520, DOI: 10.1371/journal.pone.0234478.Peer-Reviewed Original ResearchConceptsPipeline Embolization DeviceEndovascular treatmentRetreatment ratePS matchingIntracranial aneurysmsRetrospective cohort studyRate of readmissionEmergency department visitsLength of stayLower retreatment rateInitial treatment costsUnruptured intracranial aneurysmsPropensity-score matchingTime of treatmentCumulative followCohort studyReadmission costsDepartment visitsPatient subgroupsPED placementCase selection biasSame hospitalAneurysm retreatmentEmbolization DevicePatientsThirty- and 90-Day Readmissions After Treatment of Traumatic Subdural Hematoma: National Trend Analysis
Koo AB, Elsamadicy AA, David WB, Zogg CK, Santarosa C, Sujijantarat N, Robert SM, Kundishora AJ, Cord BJ, Hebert R, Bahrassa F, Malhotra A, Matouk CC. Thirty- and 90-Day Readmissions After Treatment of Traumatic Subdural Hematoma: National Trend Analysis. World Neurosurgery 2020, 139: e212-e219. PMID: 32272271, PMCID: PMC7380544, DOI: 10.1016/j.wneu.2020.03.168.Peer-Reviewed Original ResearchConceptsTraumatic subdural hematomaSubdural hematomaRheumatoid arthritis/collagen vascular diseasesMultivariate logistic regression analysisCollagen vascular diseaseNationwide Readmissions DatabaseCongestive heart failureLikelihood of readmissionPrimary procedure codeTraumatic brain injuryLogistic regression analysisReadmission ratesRenal failureHeart failurePostoperative infectionNinth RevisionSurgical interventionPatient populationVascular diseaseCerebral meningesBrain injuryClinical ModificationPatient managementReadmissionInternational ClassificationDiagnostic Value of CT of Chest, Abdomen, and Pelvis in Patients With Solitary and Multiple Brain Lesions.
Rothman RK, Weinreb J, Zucconi W, Malhotra A. Diagnostic Value of CT of Chest, Abdomen, and Pelvis in Patients With Solitary and Multiple Brain Lesions. American Journal Of Roentgenology 2020, 214: 636-640. PMID: 31939701, DOI: 10.2214/ajr.19.22051.Peer-Reviewed Original ResearchConceptsPrimary neoplasmsBrain lesionsChest CTIntracranial lesionsCT CAPAncillary signsBrain neoplasmsNew intracranial lesionsPrimary brain neoplasmsMultiple brain lesionsMalignant brain neoplasmsLarge academic hospitalPresence of enhancementBrain metastasesLung primaryMetastatic workupSuch patientsPrimary cancerLesion characteristicsAcademic hospitalBenign entityCT scanPatientsMalignant casesNeoplasms
2019
Cost-Effectiveness of Computed Tomography Angiography in Management of Tiny Unruptured Intracranial Aneurysms in the United States
Wu X, Matouk CC, Mangla R, Forman HP, Gandhi D, Sanelli P, Malhotra A. Cost-Effectiveness of Computed Tomography Angiography in Management of Tiny Unruptured Intracranial Aneurysms in the United States. Stroke 2019, 50: 2396-2403. PMID: 31340732, DOI: 10.1161/strokeaha.119.025600.Peer-Reviewed Original ResearchConceptsComputed tomography angiographyUnruptured intracranial aneurysmsIntracranial aneurysmsTomography angiographyCancer riskCTA surveillanceCost-effective strategyRadiation-induced brain tumorsRadiation-induced cancer riskSubsequent magnetic resonanceBrain cancer riskBetter health outcomesAnnual rupture riskProbabilistic sensitivity analysesRupture riskLower healthcare spendingAggressive managementPatients 30Subarachnoid hemorrhageIncidental detectionPrior historyHigh riskBrain tumorsAneurysmsHealth outcomesA comparison of benign positional vertigo and stroke patients presenting to the emergency department with vertigo or dizziness
Hanna J, Malhotra A, Brauer PR, Luryi A, Michaelides E. A comparison of benign positional vertigo and stroke patients presenting to the emergency department with vertigo or dizziness. American Journal Of Otolaryngology 2019, 40: 102263. PMID: 31358317, DOI: 10.1016/j.amjoto.2019.07.007.Peer-Reviewed Original ResearchConceptsBenign paroxysmal positional vertigoStroke risk factorsCT/CTAEmergency departmentBPPV patientsNeurologic symptomsStroke patientsRisk factorsPositional vertigoCT headExam findingsNeurologic exam findingsPosterior circulation strokeProfile of patientsBenign positional vertigoParoxysmal positional vertigoCommon imaging modalityAcute strokeNeurologic examInitial imagingMRI brainDischarge diagnosisComputed tomographyPatientsVertigoRegarding “Cervical spine clearance in the adult obtunded blunt trauma patient: A systematic review”
Malhotra A, Wu X. Regarding “Cervical spine clearance in the adult obtunded blunt trauma patient: A systematic review”. Intensive And Critical Care Nursing 2019, 53: 109. PMID: 31027902, DOI: 10.1016/j.iccn.2019.04.005.Peer-Reviewed Original ResearchMR Angiography Screening and Surveillance for Intracranial Aneurysms in Autosomal Dominant Polycystic Kidney Disease: A Cost-effectiveness Analysis
Malhotra A, Wu X, Matouk CC, Forman HP, Gandhi D, Sanelli P. MR Angiography Screening and Surveillance for Intracranial Aneurysms in Autosomal Dominant Polycystic Kidney Disease: A Cost-effectiveness Analysis. Radiology 2019, 291: 400-408. PMID: 30777807, DOI: 10.1148/radiol.2019181399.Peer-Reviewed Original Research
2018
Progressive T1 Shortening of the Dentate Nucleus in Patients With Multiple Sclerosis: Result of Multiple Administrations of Linear Gadolinium Contrast Agents Versus Intrinsic Disease.
Malhotra A, LeSar B, Wu X, Durand D, Das N, Anzai Y, Sanelli P. Progressive T1 Shortening of the Dentate Nucleus in Patients With Multiple Sclerosis: Result of Multiple Administrations of Linear Gadolinium Contrast Agents Versus Intrinsic Disease. American Journal Of Roentgenology 2018, 211: 1099-1105. PMID: 30160975, DOI: 10.2214/ajr.17.19155.Peer-Reviewed Original ResearchConceptsMacrocyclic agent gadobutrolMultiple sclerosisGlobus pallidusDentate nucleusGadolinium-based contrast agentsGadopentetate dimeglumineIntrinsic diseaseContrast injectionMultiple administrationsRelapsing-remitting multiple sclerosisMultiple contrast injectionsSubsequent MRI studiesUnenhanced T1-weighted imagesT1-weighted imagesIntrinsic T1 hyperintensityPons SI ratioContrast agent administrationRetrospective reviewMore dosesT1 hyperintensitySignal intensity ratioContrast agentsGadolinium contrastMRI studiesPatientsCost-effectiveness of Magnetic Resonance Imaging in Cervical Clearance of Obtunded Blunt Trauma After a Normal Computed Tomographic Finding
Wu X, Malhotra A, Geng B, Kalra VB, Abbed K, Forman HP, Sanelli P. Cost-effectiveness of Magnetic Resonance Imaging in Cervical Clearance of Obtunded Blunt Trauma After a Normal Computed Tomographic Finding. JAMA Surgery 2018, 153: 625-632. PMID: 29541757, PMCID: PMC5875318, DOI: 10.1001/jamasurg.2018.0099.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingBlunt traumaResonance imagingCervical clearanceNeurologic deficitsTomographic findingsHealth benefitsNational Spinal Cord Injury DatabaseSpinal Cord Injury DatabaseCost of MRISpecificity of MRIUse of MRIPermanent neurologic deficitsGroup of patientsComputed tomographic findingsNegative predictive valueProbabilistic sensitivity analysesCost-effectiveness analysisLower health benefitsCervical CTCT findingsInitial CTNormal CTCervical collarCervical spineGrading of oligodendroglial tumors of the brain with apparent diffusion coefficient, magnetic resonance spectroscopy, and dynamic susceptibility contrast imaging
Naveed MA, Goyal P, Malhotra A, Liu X, Gupta S, Mangla M, Mangla R. Grading of oligodendroglial tumors of the brain with apparent diffusion coefficient, magnetic resonance spectroscopy, and dynamic susceptibility contrast imaging. The Neuroradiology Journal 2018, 31: 379-385. PMID: 29469659, PMCID: PMC6111423, DOI: 10.1177/1971400918757217.Peer-Reviewed Original ResearchUtility of MRI for cervical spine clearance in blunt trauma patients after a negative CT
Malhotra A, Durand D, Wu X, Geng B, Abbed K, Nunez DB, Sanelli P. Utility of MRI for cervical spine clearance in blunt trauma patients after a negative CT. European Radiology 2018, 28: 2823-2829. PMID: 29450715, DOI: 10.1007/s00330-017-5285-y.Peer-Reviewed Original ResearchConceptsBlunt trauma evaluationCervical spine CTCervical spine MRIUnstable injuriesBlunt traumaTrauma evaluationSpine CTSpine MRIBlunt cervical spine traumaCervical spine clearanceCT cervical spineAbnormal neurological examinationBlunt trauma patientsPercent of patientsCervical spine traumaCervical spine studiesSoft tissue injuriesUtility of MRICervical CTSpine clearanceAdult patientsSubsequent MRINeurological examinationSpine traumaTrauma patientsManagement of Tiny Unruptured Intracranial Aneurysms: A Comparative Effectiveness Analysis
Malhotra A, Wu X, Forman HP, Matouk CC, Gandhi D, Sanelli P. Management of Tiny Unruptured Intracranial Aneurysms: A Comparative Effectiveness Analysis. JAMA Neurology 2018, 75: 27-34. PMID: 29159405, PMCID: PMC5833486, DOI: 10.1001/jamaneurol.2017.3232.Peer-Reviewed Original ResearchConceptsUnruptured intracranial aneurysmsComparative effectiveness analysisPreventive treatmentAdult patientsAnnual riskIntracranial aneurysmsHealth benefitsFollow-up imagingCurrent clinical practiceBetter health outcomesRisk of ruptureImaging surveillanceTiny aneurysmsMean ageSubarachnoid hemorrhageRoutine treatmentIncidental detectionEffectiveness analysisClinical studiesMAIN OUTCOMEHigh riskGeneral populationPatientsPubMed searchClinical practice
2017
Semicircular canal dehiscence among idiopathic intracranial hypertension patients
Kuo P, Bagwell KA, Mongelluzzo G, Schutt CA, Malhotra A, Khokhar B, Kveton JF. Semicircular canal dehiscence among idiopathic intracranial hypertension patients. The Laryngoscope 2017, 128: 1196-1199. PMID: 28833207, DOI: 10.1002/lary.26795.Peer-Reviewed Original ResearchConceptsRadiographic superior semicircular canal dehiscenceSuperior semicircular canal dehiscenceIdiopathic intracranial hypertensionSemicircular canal dehiscenceOpening pressureCanal dehiscenceIdiopathic intracranial hypertension patientsLogistic regressionIntracranial hypertension patientsBody mass indexRetrospective pilot studyMultivariate logistic regressionComputed tomography (CT) imagingStudent's t-testAverage opening pressureRetrospective cohortConsecutive patientsIntracranial hypertensionHypertension patientsMass indexRetrospective studyLumbar punctureControl cohortTegmental defectsPatientsCost-effectiveness of Magnetic Resonance Imaging in Cervical Spine Clearance of Neurologically Intact Patients With Blunt Trauma
Wu X, Malhotra A, Geng B, Liu R, Abbed K, Forman HP, Sanelli P. Cost-effectiveness of Magnetic Resonance Imaging in Cervical Spine Clearance of Neurologically Intact Patients With Blunt Trauma. Annals Of Emergency Medicine 2017, 71: 64-73. PMID: 28826754, DOI: 10.1016/j.annemergmed.2017.07.006.Peer-Reviewed Original ResearchMeSH KeywordsAdultAftercareCervical VertebraeCost-Benefit AnalysisDecision Support TechniquesHealth Care CostsHumansMagnetic Resonance ImagingMarkov ChainsModels, EconomicQuality-Adjusted Life YearsSensitivity and SpecificitySpinal InjuriesTomography, X-Ray ComputedUnited StatesWounds, NonpenetratingConceptsMagnetic resonance imagingCervical computed tomographyBlunt traumaIntact patientsUnstable injuriesCT resultsResonance imagingCost of MRICervical spine clearanceIncidence of patientsPermanent neurologic deficitsHealth benefitsNegative predictive valueProbabilistic sensitivity analysesInitial CT resultsCervical clearanceSpine clearanceNeurologic deficitsHard collarCord injuryPatient populationAlert patientsComputed tomographyPredictive valuePatients
2016
Cerebral Microhemorrhages and Meningeal Siderosis in Infective Endocarditis
Malhotra A, Schindler J, Grory B, Chu SY, Youn TS, Matouk C, Greer DM, Schrag M. Cerebral Microhemorrhages and Meningeal Siderosis in Infective Endocarditis. Cerebrovascular Diseases 2016, 43: 59-67. PMID: 27871078, DOI: 10.1159/000452718.Peer-Reviewed Original ResearchConceptsCerebral amyloid angiopathyInfective endocarditisSusceptibility-weighted imaging (SWI) sequencesSmall subarachnoid hemorrhageGradient-echo T2Sensitive diagnostic techniquesSWI MRIMycotic aneurysmSevere hypertensionGroups of subjectsAmyloid angiopathyCerebral insultCerebral microhemorrhagesNeurological involvementWorse prognosisSubarachnoid hemorrhageSWI findingsAcademic hospitalSignificant predilectionMicrohemorrhagesPatientsGRE T2HypertensionSiderosisEndocarditisCranial nerve involvement in Charcot–Marie–Tooth Disease
Das N, Kandalaft S, Wu X, Malhotra A. Cranial nerve involvement in Charcot–Marie–Tooth Disease. Journal Of Clinical Neuroscience 2016, 37: 59-62. PMID: 27884603, DOI: 10.1016/j.jocn.2016.10.049.Peer-Reviewed Original ResearchConceptsCranial nerve involvementNerve involvementTooth diseaseCharcot-MarieFacial muscle weaknessSpinal nerve rootsSkull base foraminaGroup of disordersForms of HMSNNerve findingsRight medianClinical featuresClinical presentationCauda equineDisease involvementMuscle weaknessNerve rootsSymmetric enlargementTrigeminal neuralgiaTrigeminal nerveFacial nervePes cavusEmergency roomAbsent responseRare disorder