2023
Utility of Gadolinium-Based Contrast in Initial Evaluation of Seizures in Children Presenting Emergently
Andrijauskis D, Woolf G, Kuehne A, Al-Dasuqi K, Silva C, Payabvash S, Malhotra A. Utility of Gadolinium-Based Contrast in Initial Evaluation of Seizures in Children Presenting Emergently. American Journal Of Neuroradiology 2023, 44: 1208-1211. PMID: 37652579, PMCID: PMC10549952, DOI: 10.3174/ajnr.a7976.Peer-Reviewed Original ResearchConceptsSeizure presentationMR imagingConsecutive pediatric patientsNew-onset seizuresEvaluation of seizuresIschemic/hypoxicImaging of patientsBrain MR imagingGadolinium-based contrast agentsNoncontrast studyAcute onsetHippocampal sclerosisPediatric seizuresPatient agePediatric patientsNormal findingsIntracranial hemorrhageEmergency departmentVascular anomaliesInpatient unitGadolinium contrastPatientsNeurodevelopmental lesionAdditive benefitSeizuresAssociation of Body Mass Index and Waist Circumference With Imaging Metrics of Brain Integrity and Functional Connectivity in Children Aged 9 to 10 Years in the US, 2016-2018
Kaltenhauser S, Weber C, Lin H, Mozayan A, Malhotra A, Constable R, Acosta J, Falcone G, Taylor S, Ment L, Sheth K, Payabvash S. Association of Body Mass Index and Waist Circumference With Imaging Metrics of Brain Integrity and Functional Connectivity in Children Aged 9 to 10 Years in the US, 2016-2018. JAMA Network Open 2023, 6: e2314193. PMID: 37200030, PMCID: PMC10196880, DOI: 10.1001/jamanetworkopen.2023.14193.Peer-Reviewed Original ResearchConceptsBody mass indexHigher body mass indexWaist circumferenceBMI z-scoreCross-sectional studyBrain healthCross-sectional analysisFunctional connectivityMass indexMean ageInterval developmentCorpus callosumAssociation of BMIHigher baseline body mass indexBaseline cross-sectional analysisBaseline body mass indexBrain integrityResting-state functional connectivityLongitudinal analysisFuture treatment trialsABCD studyLower microstructural integrityCognitive Development StudyAdolescent Brain Cognitive Development (ABCD) studyCardiovascular implications
2020
Septic cavernous sinus thrombosis—Case series and review of the literature
Geng B, Wu X, Malhotra A. Septic cavernous sinus thrombosis—Case series and review of the literature. Clinical Neurology And Neurosurgery 2020, 197: 106092. PMID: 32693341, DOI: 10.1016/j.clineuro.2020.106092.Peer-Reviewed Original ResearchConceptsCavernous sinus thrombosisAcademic tertiary care centerSeptic cavernous sinus thrombosisExtension of thrombosisTertiary care centerInternal jugular veinTransverse-sigmoid sinusLife-threatening diseaseSource of infectionCST patientsInfectious thrombosisSinus thrombosisPatient demographicsPseudo aneurysmReported complicationsIntracranial complicationsSubdural empyemaBilateral narrowingHigh morbidityTreatment coursePersistent narrowingRadiology databaseCare centerUnilateral narrowingJugular veinA Rare Case of a Pediatric Medullary Intracranial Germinoma
Seifert K, Huttner A, Malhotra A. A Rare Case of a Pediatric Medullary Intracranial Germinoma. World Neurosurgery 2020, 138: 137-140. PMID: 32147555, DOI: 10.1016/j.wneu.2020.02.147.Peer-Reviewed Original Research
2019
Neuroimaging of Pediatric Arteriopathies
Goyal P, Malhotra A, Almast J, Sapire J, Gupta S, Mangla M, Mangla R. Neuroimaging of Pediatric Arteriopathies. Journal Of Neuroimaging 2019, 29: 287-308. PMID: 30920080, DOI: 10.1111/jon.12614.Peer-Reviewed Original ResearchConceptsIschemic strokeMajor prognostic implicationsPediatric ischemic strokeSecondary stroke preventionAcute ischemic strokeFocal neurologic deficitsAdult stroke populationSmall vessel arteriopathyNoninflammatory etiologiesRecurrent strokeStroke preventionSystemic complicationsCerebral arteriopathyNeurologic deficitsStroke etiologyAcute managementPrompt diagnosisStroke populationNeuropsychiatric symptomsClinical manifestationsClinical symptomsPrognostic implicationsPredominant vesselRisk factorsSchool-aged children
2018
Pediatric Congenital Cerebrovascular Anomalies
Goyal P, Mangla R, Gupta S, Malhotra A, Almast J, Sapire J, Kolar B. Pediatric Congenital Cerebrovascular Anomalies. Journal Of Neuroimaging 2018, 29: 165-181. PMID: 30378722, DOI: 10.1111/jon.12575.Peer-Reviewed Original ResearchConceptsVascular malformationsCerebrovascular anomaliesCentral nervous system vascular malformationsMultiple developmental venous anomaliesPersistent carotid-vertebrobasilar anastomosesFamilial associationAssociated vascular malformationCarotid-vertebrobasilar anastomosesDevelopmental venous anomaliesPediatric age groupMultiple cavernous malformationsSturge-Weber syndromeCongenital vascular malformationsHereditary hemorrhagic telangiectasiaArterial anomaliesSinus thrombosisVenous anomaliesVenous malformationsVascular abnormalitiesVascular tumorsVascular lesionsDiverse etiologiesArteriovenous malformationsSystemic conditionsFurther managementCost-Effectiveness Analysis of Intracapsular Tonsillectomy and Total Tonsillectomy for Pediatric Obstructive Sleep Apnea
Bagwell K, Wu X, Baum ED, Malhotra A. Cost-Effectiveness Analysis of Intracapsular Tonsillectomy and Total Tonsillectomy for Pediatric Obstructive Sleep Apnea. Applied Health Economics And Health Policy 2018, 16: 527-535. PMID: 29797301, DOI: 10.1007/s40258-018-0396-4.Peer-Reviewed Original ResearchConceptsProbabilistic sensitivity analysesIncremental cost-effectiveness ratioDeterministic sensitivity analysesMedicaid Services perspectiveResultsBase-case analysisCost-effectiveness analysisCost-effectiveness ratioSensitivity analysisBase-case analysisRelative cost effectivenessEconomic evaluationMedicare ValueDecision modelOSA recurrenceRevision tonsillectomyPartial intracapsular tonsillectomyDecision tree modelCost-effective strategyQALYCase analysisService perspectiveCostCost effectivenessConclusionStudy resultsDisutilityGrading of oligodendroglial tumors of the brain with apparent diffusion coefficient, magnetic resonance spectroscopy, and dynamic susceptibility contrast imaging
Naveed MA, Goyal P, Malhotra A, Liu X, Gupta S, Mangla M, Mangla R. Grading of oligodendroglial tumors of the brain with apparent diffusion coefficient, magnetic resonance spectroscopy, and dynamic susceptibility contrast imaging. The Neuroradiology Journal 2018, 31: 379-385. PMID: 29469659, PMCID: PMC6111423, DOI: 10.1177/1971400918757217.Peer-Reviewed Original Research
2017
Letter to the Editor
Malhotra A, Wu X. Letter to the Editor. Journal Of Pediatric Surgery 2017, 53: 855. PMID: 29373107, DOI: 10.1016/j.jpedsurg.2017.11.064.Peer-Reviewed Original ResearchMRI findings of optic pathway involvement in Miller Fisher syndrome in 3 pediatric patients and a review of the literature
Malhotra A, Zhang M, Wu X, Jindal S, Durand D, Makhani N. MRI findings of optic pathway involvement in Miller Fisher syndrome in 3 pediatric patients and a review of the literature. Journal Of Clinical Neuroscience 2017, 39: 63-67. PMID: 28209311, DOI: 10.1016/j.jocn.2016.12.049.Peer-Reviewed Original ResearchConceptsMiller Fisher syndromeOptic pathway involvementGuillain-Barré syndromeCranial nerve enhancementPediatric patientsFisher syndromeNerve enhancementPathway involvementCranial nerve involvementNerve involvementAcute illnessDemyelinating conditionMRI findingsBrighton criteriaClinical manifestationsOptic pathwayCase reportCranial nervesBrain MRIPatientsSyndromeInvolvementFindingsNerveIllnessScreening for pediatric blunt cerebrovascular injury
Wu X, Malhotra A. Screening for pediatric blunt cerebrovascular injury. Journal Of Trauma And Acute Care Surgery 2017, 82: 226-227. PMID: 27805989, DOI: 10.1097/ta.0000000000001271.Peer-Reviewed Original Research
2015
Screening for Pediatric Blunt Cerebrovascular Injury: Review of Literature and a Cost-Effectiveness Analysis
Malhotra A, Wu X, Kalra VB, Goodman TR, Schindler J, Forman HP. Screening for Pediatric Blunt Cerebrovascular Injury: Review of Literature and a Cost-Effectiveness Analysis. Journal Of Pediatric Surgery 2015, 50: 1751-1757. PMID: 26546389, DOI: 10.1016/j.jpedsurg.2015.05.005.Peer-Reviewed Original ResearchConceptsBlunt cerebrovascular injuryPediatric blunt cerebrovascular injurySelective computed tomography angiographyComputed tomography angiographyOptimal imaging strategyCost-effectiveness analysisAnticoagulation therapyCerebrovascular injuryManagement of BCVIAppropriate anticoagulation therapyHigh-risk patientsHigh-risk factorsImaging strategiesPossible screening strategiesReview of literatureSelective anticoagulationPediatric patientsAnticoagulation complicationsTomography angiographySystematic reviewPatientsSocietal perspectiveCost-effective strategyData extractionScreening strategy
2014
Individual exome analysis in diagnosis and management of paediatric liver failure of indeterminate aetiology
Vilarinho S, Choi M, Jain D, Malhotra A, Kulkarni S, Pashankar D, Phatak U, Patel M, Bale A, Mane S, Lifton RP, Mistry PK. Individual exome analysis in diagnosis and management of paediatric liver failure of indeterminate aetiology. Journal Of Hepatology 2014, 61: 1056-1063. PMID: 25016221, PMCID: PMC4203706, DOI: 10.1016/j.jhep.2014.06.038.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceBase SequenceCarboxylic Ester HydrolasesChildCholestasisDNA Mutational AnalysisEnd Stage Liver DiseaseExomeFatal OutcomeFemaleGenes, RecessiveHepatolenticular DegenerationHeterozygoteHomozygoteHumansInfant, NewbornLiver FailureLiver Failure, AcuteMaleMembrane ProteinsMitochondrial ProteinsMolecular Sequence DataPedigreeReceptor, Notch2RNA Splice SitesSequence Homology, Amino AcidConceptsFatal acute liver failureWhole-exome sequencingAdvanced liver diseaseAcute liver failureIndeterminate etiologyYear old femaleLiver failureLiver diseaseMetabolic liver diseasePatient 3Treatment optionsPhenotypic spectrumPediatric liver failureDecompensated liver cirrhosisManagement of childrenOptimal treatment optionsAge 3 monthsNovel inborn errorLiver transplantAtypical presentationLiver cirrhosisHepatocerebral mitochondrial DNA depletion syndromePatient 1Patient 2Unknown etiology
2013
Radiology Quiz Case 1
Gilbert JW, Kalra VB, Malhotra A. Radiology Quiz Case 1. JAMA Otolaryngology - Head & Neck Surgery 2013, 139: 419-419. PMID: 23599081, DOI: 10.1001/jamaoto.2013.125a.Peer-Reviewed Original Research
2008
Simultaneous Gastric and Small Intestinal Trichobezoars
Malhotra A, Jones L, Drugas G. Simultaneous Gastric and Small Intestinal Trichobezoars. Pediatric Emergency Care 2008, 24: 774-776. PMID: 19018222, DOI: 10.1097/pec.0b013e31818c2891.Peer-Reviewed Original Research