2024
Impact of Baseline Collateral Status Assessed on Perfusion Scans on Patient Outcomes in Acute Ischemic Stroke: A Meta-analysis and Systematic Review (P2-5.001)
Nayar D, Bajaj S, Malhotra A. Impact of Baseline Collateral Status Assessed on Perfusion Scans on Patient Outcomes in Acute Ischemic Stroke: A Meta-analysis and Systematic Review (P2-5.001). Neurology 2024, 102 DOI: 10.1212/wnl.0000000000206669.Peer-Reviewed Original ResearchSex Discrepancies in the Population Incidence of Stroke and Hemorrhage Related to Atrial Fibrillation or Flutter
Khunte M, Chen H, Colasurdo M, Chaturvedi S, Malhotra A, Gandhi D. Sex Discrepancies in the Population Incidence of Stroke and Hemorrhage Related to Atrial Fibrillation or Flutter. Cerebrovascular Diseases 2024, 1-6. PMID: 38432203, DOI: 10.1159/000538108.Peer-Reviewed Original ResearchAF-related ischemic strokeIschemic strokeAssociated with higher stroke riskIschemic stroke hospitalizationsRisk factorsAF-related strokeICD-10 codesRisk of hospitalizationVascular risk factorsRates of anticoagulant useHigher stroke riskIncidence of hospitalizationNational Inpatient SampleHigher stroke severityUnited States Census BureauIncidence of strokeAtrial fibrillationPatient demographic informationStroke hospitalizationsStroke characteristicsRelative riskICD-10Population incidenceRates of large vessel occlusionsRisk of morbidityClinical Applications of Dual‐Energy Computed Tomography for Acute Ischemic Stroke
Chen H, Bodanapally U, Colasurdo M, Malhotra A, Gandhi D. Clinical Applications of Dual‐Energy Computed Tomography for Acute Ischemic Stroke. Stroke Vascular And Interventional Neurology 2024, 4 DOI: 10.1161/svin.123.001193.Peer-Reviewed Original ResearchDual-energy computed tomographyAcute ischemic strokePostinterventional managementIschemic strokeDual-energyClinical applicationPredicting hemorrhagic transformationContext of acute ischemic strokeDiagnostic challengePatient selectionEarly cerebral ischemiaHemorrhagic transformationRecanalization therapyComputed tomographyClinical evidenceDiagnostic accuracyTreatment strategiesAcute stroke triageVascular lesionsNeurological disabilityCerebral ischemiaDiagnostic imagingTomographyStroke triageNarrative reviewTime-driven activity-based costing (TDABC) of direct-to-angiography pathway for acute ischemic stroke patients with suspected large vessel occlusion
Sangha K, White T, Boltyenkov A, Bastani M, Sanmartin M, Katz J, Malhotra A, Rula E, Naidich J, Sanelli P. Time-driven activity-based costing (TDABC) of direct-to-angiography pathway for acute ischemic stroke patients with suspected large vessel occlusion. Journal Of Stroke And Cerebrovascular Diseases 2024, 33: 107516. PMID: 38183964, DOI: 10.1016/j.jstrokecerebrovasdis.2023.107516.Peer-Reviewed Original ResearchAcute ischemic strokeEndovascular treatmentAcute ischemic stroke patientsAppropriate patient selection criteriaNovel care pathwayIschemic stroke patientsLarge vessel occlusionPatient selection criteriaInstitutional patient databaseTime-driven activity-based costingEligible patientsAnterior circulationIschemic strokeClinical outcomesPatient factorsStroke patientsAIS patientsVessel occlusionCare pathwayPatient costsMain cost driversPatientsPatient databaseAngiography suiteCT pathway
2023
Predictors for large vessel recanalization before stroke thrombectomy: the HALT score
Colasurdo M, Chen H, Schrier C, Khalid M, Khunte M, Miller T, Cherian J, Malhotra A, Gandhi D. Predictors for large vessel recanalization before stroke thrombectomy: the HALT score. Journal Of NeuroInterventional Surgery 2023, 16: 237-242. PMID: 37100595, DOI: 10.1136/jnis-2023-020220.Peer-Reviewed Original ResearchLarge-vessel recanalizationEndovascular therapyIndependent predictorsVessel recanalizationAtrial fibrillationVascular occlusionAcute large-vessel ischemic strokeLarge-vessel ischemic strokeIntravenous thrombolysis useComprehensive stroke centerHealth Stroke ScaleRetrospective cohort studyReceiver-operating curveEVT treatmentLVR patientsStroke ScaleClinical characteristicsIschemic strokeStroke centersCohort studyConsecutive patientsStroke thrombectomyThrombolysis usePatient selectionStroke triageLetter to the Editor Re “Endovascular thrombectomy or bridging therapy in minor ischemic stroke with large vessel occlusion”
Malhotra A, Khunte M, Wu X, Radmard M. Letter to the Editor Re “Endovascular thrombectomy or bridging therapy in minor ischemic stroke with large vessel occlusion”. Thrombosis Research 2023, 232: 145. PMID: 36739257, DOI: 10.1016/j.thromres.2023.01.008.Peer-Reviewed Original Research
2022
Associations of Osteoarthritis With Thrombectomy Utilization and Outcomes for Large Vessel Acute Ischemic Stroke
Chen H, Khunte M, Colasurdo M, Jindal G, Malhotra A, Gandhi D, Chaturvedi S. Associations of Osteoarthritis With Thrombectomy Utilization and Outcomes for Large Vessel Acute Ischemic Stroke. Stroke 2022, 54: 518-526. PMID: 36541211, DOI: 10.1161/strokeaha.122.041749.Peer-Reviewed Original ResearchConceptsMultivariable logistic regression modelEndovascular thrombectomyAssociation of osteoarthritisLogistic regression modelsHospital mortalityMedical comorbiditiesIschemic strokeRisk factorsLower oddsLarge vessel acute ischemic strokeNational Inpatient Sample databaseMultivariable logistic regression analysisLarge-vessel ischemic strokeIntravenous thrombolysis treatmentStroke risk factorsAcute ischemic strokeIschemic stroke patientsPresence of osteoarthritisCause of disabilityCross-sectional studyLogistic regression analysisPatient selection practicesLarge-scale cross-sectional studyDirect risk factorEVT treatment
2020
Implications of achieving TICI 2b vs TICI 3 reperfusion in patients with ischemic stroke: a cost-effectiveness analysis
Wu X, Khunte M, Gandhi D, Matouk C, Hughes DR, Sanelli P, Malhotra A. Implications of achieving TICI 2b vs TICI 3 reperfusion in patients with ischemic stroke: a cost-effectiveness analysis. Journal Of NeuroInterventional Surgery 2020, 12: 1161-1165. PMID: 32457225, DOI: 10.1136/neurintsurg-2020-015873.Peer-Reviewed Original ResearchConceptsQuality-adjusted life yearsLarge vessel occlusionTICI 3 reperfusionEndovascular thrombectomyTICI 2bTICI 3Stroke patientsHealth benefitsAge groupsAcute stroke patientsDegree of recanalizationDegree of reperfusionLifetime quality-adjusted life yearsCost-effectiveness analysisDecision analytic studyUnited States settingsIncomplete reperfusionIschemic strokeComplete reperfusionPatient selectionReperfusionPatientsHealth outcomesLife yearsCost savingsCT Angiography for Triage of Patients with Acute Minor Stroke: A Cost-effectiveness Analysis.
Wu X, Hughes DR, Gandhi D, Matouk CC, Sheth K, Schindler J, Wira C, Wintermark M, Sanelli P, Malhotra A. CT Angiography for Triage of Patients with Acute Minor Stroke: A Cost-effectiveness Analysis. Radiology 2020, 294: 580-588. PMID: 31934828, DOI: 10.1148/radiol.2019191238.Peer-Reviewed Original ResearchConceptsLarge vessel occlusionAcute minor strokeBest medical managementMinor strokeCT angiographyMedical managementProbabilistic sensitivity analysesLower health benefitsImmediate thrombectomyHealth benefitsHealth outcomesVascular imagingAcute ischemic strokeMarkov decision-analytic modelWorse health outcomesImproved health outcomesDecision analytic modelNet monetary benefitIntravenous thrombolysisIschemic strokeYounger patientsThrombectomy strategyPatientsAngiographyStroke
2019
Higher Plaque Burden of Middle Cerebral Artery Is Associated With Recurrent Ischemic Stroke
Ran Y, Wang Y, Zhu M, Wu X, Malhotra A, Lei X, Zhang F, Wang X, Xie S, Zhou J, Zhu J, Cheng J, Zhu C. Higher Plaque Burden of Middle Cerebral Artery Is Associated With Recurrent Ischemic Stroke. Stroke 2019, 51: 659-662. PMID: 31856694, DOI: 10.1161/strokeaha.119.028405.Peer-Reviewed Original ResearchConceptsRecurrent ischemic strokeMiddle cerebral arteryMagnetic resonance vessel wall imagingPlaque burdenIschemic strokeVessel wall imagingAcute strokeCerebral arteryRecurrent strokeChronic strokeStroke patientsPlaque characteristicsMiddle cerebral artery plaqueRecurrent acute strokeRecurrent stroke groupRecurrent stroke patientsAcute stroke patientsHigher plaque burdenMethods One hundredDegree of stenosisClinical factorsStroke groupArtery plaquesFemale sexImaging featuresCulprit intracranial plaque without substantial stenosis in acute ischemic stroke on vessel wall MRI: A systematic review
Wang Y, Liu X, Wu X, Degnan AJ, Malhotra A, Zhu C. Culprit intracranial plaque without substantial stenosis in acute ischemic stroke on vessel wall MRI: A systematic review. Atherosclerosis 2019, 287: 112-121. PMID: 31254918, PMCID: PMC6707846, DOI: 10.1016/j.atherosclerosis.2019.06.907.Peer-Reviewed Original ResearchConceptsIschemic stroke patientsVessel wall MRISubstantial stenosisIschemic strokeStroke patientsMagnetic resonance angiographyIntracranial plaquesPlaque featuresAtherosclerotic plaquesSystematic reviewHigh-resolution vessel wall MRIHigh-risk plaque featuresAcute ischemic stroke patientsProgressive motor deficitsAcute ischemic strokeIntracranial atherosclerotic plaquesOverall functional outcomeHigh-risk plaquesRelevant clinical dataArterial atherosclerotic plaquesArticle reference listsAcute strokeCulprit plaquesIntracranial atherosclerosisMotor deficitsComparative Effectiveness of Endovascular Thrombectomy in Elderly Stroke Patients
Malhotra A, Wu X, Payabvash S, Matouk CC, Forman HP, Gandhi D, Sanelli P, Schindler J. Comparative Effectiveness of Endovascular Thrombectomy in Elderly Stroke Patients. Stroke 2019, 50: 963-969. PMID: 30908156, DOI: 10.1161/strokeaha.119.025031.Peer-Reviewed Original ResearchConceptsQuality-adjusted life yearsIntravenous thrombolysisEndovascular thrombectomyLarge vessel occlusionAge 80 yearsEVT strategyVessel occlusionModified Rankin Scale scorePoststroke functional outcomeAcute ischemic strokeRankin Scale scoreElderly stroke patientsMarkov decision-analytic modelYears of ageDecision analytic modelMultiple sensitivity analysesPurpose- StrokeAcute strokeBaseline disabilityElderly patientsIschemic strokeStroke patientsFunctional outcomeHealthy patientsAdvanced ageNeuroimaging of Pediatric Arteriopathies
Goyal P, Malhotra A, Almast J, Sapire J, Gupta S, Mangla M, Mangla R. Neuroimaging of Pediatric Arteriopathies. Journal Of Neuroimaging 2019, 29: 287-308. PMID: 30920080, DOI: 10.1111/jon.12614.Peer-Reviewed Original ResearchConceptsIschemic strokeMajor prognostic implicationsPediatric ischemic strokeSecondary stroke preventionAcute ischemic strokeFocal neurologic deficitsAdult stroke populationSmall vessel arteriopathyNoninflammatory etiologiesRecurrent strokeStroke preventionSystemic complicationsCerebral arteriopathyNeurologic deficitsStroke etiologyAcute managementPrompt diagnosisStroke populationNeuropsychiatric symptomsClinical manifestationsClinical symptomsPrognostic implicationsPredominant vesselRisk factorsSchool-aged children