2017
Pre- and postoperative anemia, acute kidney injury, and mortality after coronary artery bypass grafting surgery: a retrospective observational study
Oprea AD, Del Rio JM, Cooter M, Green CL, Karhausen JA, Nailer P, Guinn NR, Podgoreanu MV, Stafford-Smith M, Schroder JN, Fontes ML, Kertai MD. Pre- and postoperative anemia, acute kidney injury, and mortality after coronary artery bypass grafting surgery: a retrospective observational study. Journal Canadien D'anesthésie 2017, 65: 46-59. PMID: 29098634, DOI: 10.1007/s12630-017-0991-0.Peer-Reviewed Original ResearchConceptsAcute kidney injuryPostoperative acute kidney injuryCoronary artery bypassPostoperative anemiaDay of surgerySerum hemoglobin concentrationPreoperative anemiaHemoglobin concentrationArtery bypassCABG surgeryKidney injuryGlobal Outcomes (KDIGO) Clinical Practice GuidelineIncidence of AKIMultivariable Cox proportional hazards analysisSingle large academic medical centerCox proportional hazards analysisPostoperative hemoglobin concentrationPostoperative hemoglobin levelsLong-term mortalityTenth postoperative dayProportional hazards analysisRetrospective observational studyLarge academic medical centerClinical practice guidelinesPotential risk factors
2016
Baseline Pulse Pressure, Acute Kidney Injury, and Mortality After Noncardiac Surgery
Oprea AD, Lombard FW, Liu WW, White WD, Karhausen JA, Li YJ, Miller TE, Aronson S, Gan TJ, Fontes ML, Kertai MD. Baseline Pulse Pressure, Acute Kidney Injury, and Mortality After Noncardiac Surgery. Anesthesia & Analgesia 2016, 123: 1480-1489. PMID: 27607474, DOI: 10.1213/ane.0000000000001557.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAcute Kidney InjuryAdultAgedAged, 80 and overArterial PressureChi-Square DistributionFemaleHumansHypertensionIncidenceLogistic ModelsMaleMiddle AgedMultivariate AnalysisNorth CarolinaOdds RatioRetrospective StudiesRisk AssessmentRisk FactorsSeverity of Illness IndexSurgical Procedures, OperativeTime FactorsTreatment OutcomeConceptsPostoperative acute kidney injuryAcute kidney injuryBaseline pulse pressureNoncardiac surgeryPulse pressureKidney injuryIncidence of AKIAdvanced stageBaseline arterial blood pressureMultivariable logistic regression analysisDuke University Medical CenterPreoperative pulse pressurePerioperative risk factorsArterial blood pressureImportant independent predictorLogistic regression analysisUniversity Medical CenterRisk-adjusted modelsCardiovascular outcomesAdult patientsBlood pressureCardiac surgeryIndependent predictorsRisk factorsMedical Center
2015
The influence of clopidogrel on ischemia diagnosed by myocardial perfusion stress testing
Jovin IS, Ebisu KA, Oprea AD, Brandt CA, Natale D, Finta LA, Dziura J, Wackers FJ. The influence of clopidogrel on ischemia diagnosed by myocardial perfusion stress testing. Journal Of Nuclear Cardiology 2015, 23: 773-779. PMID: 26338428, DOI: 10.1007/s12350-015-0268-3.Peer-Reviewed Original ResearchConceptsReversible perfusion defectsOdds ratioPerfusion defectsMyocardial perfusion stress testMyocardial perfusion stress testingStress testStress myocardial perfusion scansMyocardial single photon emissionAdenosine stress testInfluence of clopidogrelLikelihood of ischemiaMyocardial perfusion testingUse of clopidogrelCoronary vascular toneExercise stress testMyocardial perfusion scanMyocardial perfusion imagingSingle photon emissionAdenosine receptor antagonistDiagnosis of ischemiaPerfusion scanPerfusion testingVascular toneReceptor antagonistTomography scan
2012
Left Ventricular Ejection Fraction and Left Ventricular End‐Diastolic Volume in Patients With Diastolic Dysfunction
Jovin IS, Ebisu K, Liu Y, Finta LA, Oprea AD, Brandt CA, Dziura J, Wackers FJ. Left Ventricular Ejection Fraction and Left Ventricular End‐Diastolic Volume in Patients With Diastolic Dysfunction. Congestive Heart Failure 2012, 19: 130-134. PMID: 23241105, DOI: 10.1111/chf.12013.Peer-Reviewed Original ResearchConceptsLVEF of patientsLeft ventricular ejection fractionLower peak filling ratePeak filling rateEnd-diastolic volumeNormal peak filling ratesEquilibrium radionuclide angiocardiographyVentricular ejection fractionDiastolic dysfunctionAsymptomatic patientsEjection fractionLow left ventricular ejection fractionNormal left ventricular ejection fractionVentricular end-diastolic volumeMild systolic dysfunctionNormal systolic functionEDV indexSystolic dysfunctionSystolic functionRadionuclide angiocardiographyPatientsDysfunctionRepeat scansFilling rateAngiocardiography