1999
Physical and Biological Regulation of Proteoglycan Turnover around Chondrocytes in Cartilage Explants: Implications for Tissue Degradation and Repair
QUINN T, MAUNG A, GRODZINSKY A, HUNZIKER E, SANDY J. Physical and Biological Regulation of Proteoglycan Turnover around Chondrocytes in Cartilage Explants: Implications for Tissue Degradation and Repair. Annals Of The New York Academy Of Sciences 1999, 878: 420-441. PMID: 10415746, DOI: 10.1111/j.1749-6632.1999.tb07700.x.Peer-Reviewed Original ResearchConceptsInjurious compressionProteoglycan turnoverIL-1 betaCartilage explantsQuantitative autoradiographyClinical strategiesCartilage injuryMatrix metabolismMatrix degradationProteoglycan depositionTissue degradationBiomechanical pathwaysCell-associated matrixBiomechanical rolePossible new approachCartilage repair strategiesViable chondrocytesAdult bovineChondrocytesCartilage repairChondrocyte phenotypeRepairPG degradationExtracellular matrixCatabolic process
1998
Expansion of functional NK cells in multiple tissue compartments of mice treated with Flt3-ligand: implications for anti-cancer and anti-viral therapy.
Shaw S, Maung A, Steptoe R, Thomson A, Vujanovic3 N. Expansion of functional NK cells in multiple tissue compartments of mice treated with Flt3-ligand: implications for anti-cancer and anti-viral therapy. The Journal Of Immunology 1998, 161: 2817-24. PMID: 9743341, DOI: 10.4049/jimmunol.161.6.2817.Peer-Reviewed Original ResearchMeSH KeywordsAdjuvants, ImmunologicAnimalsAntineoplastic AgentsAntiviral AgentsCell DifferentiationCytotoxicity, ImmunologicDendritic CellsDose-Response Relationship, ImmunologicHematopoiesisHumansInjections, IntraperitonealInterleukin-2Killer Cells, NaturalKineticsLigandsLymphocyte ActivationLymphocyte CountMembrane ProteinsMiceMice, Inbred C57BLOrgan SpecificityPeptidesT-Lymphocyte SubsetsConceptsNK cellsIL-2Lymphokine-activated killer activityAdherent NK cellsAdministration of Flt3Dendritic cell productionFlt3-L treatmentFunctional NK cellsRecombinant human Flt3 ligandMature NK cellsNK cell developmentNK cell generationNK cell progenitorsAnti-viral therapyCell proliferative responsesTotal cytotoxic activityNK activityTime-dependent increaseDaily i.Multiple tissue compartmentsKiller activityHuman Flt3 ligandProliferative responseVivo effectsViral infection