2008
Injury Enhances Resistance to Escherichia coli Infection by Boosting Innate Immune System Function
Maung AA, Fujimi S, MacConmara MP, Tajima G, McKenna AM, Delisle AJ, Stallwood C, Onderdonk AB, Mannick JA, Lederer JA. Injury Enhances Resistance to Escherichia coli Infection by Boosting Innate Immune System Function. The Journal Of Immunology 2008, 180: 2450-2458. PMID: 18250454, DOI: 10.4049/jimmunol.180.4.2450.Peer-Reviewed Original ResearchConceptsBurn-injured miceSham miceCecal ligationEnhanced innate immune responseSystemic inflammatory response syndromeInnate immune system functionRelevant sepsis modelSham-injured miceInflammatory response syndromeMac-1 expressionEscherichia coli infectionInnate immune responseSite of infectionImmune system functionPolymicrobial sepsisResponse syndromeOpportunistic infectionsSepsis modelDays postinjuryInjury causesColi infectionImmune responseCommon pathogensMajor injuriesAnimal studies
1998
Expansion of functional NK cells in multiple tissue compartments of mice treated with Flt3-ligand: implications for anti-cancer and anti-viral therapy.
Shaw S, Maung A, Steptoe R, Thomson A, Vujanovic3 N. Expansion of functional NK cells in multiple tissue compartments of mice treated with Flt3-ligand: implications for anti-cancer and anti-viral therapy. The Journal Of Immunology 1998, 161: 2817-24. PMID: 9743341, DOI: 10.4049/jimmunol.161.6.2817.Peer-Reviewed Original ResearchMeSH KeywordsAdjuvants, ImmunologicAnimalsAntineoplastic AgentsAntiviral AgentsCell DifferentiationCytotoxicity, ImmunologicDendritic CellsDose-Response Relationship, ImmunologicHematopoiesisHumansInjections, IntraperitonealInterleukin-2Killer Cells, NaturalKineticsLigandsLymphocyte ActivationLymphocyte CountMembrane ProteinsMiceMice, Inbred C57BLOrgan SpecificityPeptidesT-Lymphocyte SubsetsConceptsNK cellsIL-2Lymphokine-activated killer activityAdherent NK cellsAdministration of Flt3Dendritic cell productionFlt3-L treatmentFunctional NK cellsRecombinant human Flt3 ligandMature NK cellsNK cell developmentNK cell generationNK cell progenitorsAnti-viral therapyCell proliferative responsesTotal cytotoxic activityNK activityTime-dependent increaseDaily i.Multiple tissue compartmentsKiller activityHuman Flt3 ligandProliferative responseVivo effectsViral infection