2011
Angiotensin(1–7) increases survival of stroke‐prone spontaneously hypertensive rats
Regenhardt R, Ritucci‐Chinni P, Desland F, Mecca A, Sumners C. Angiotensin(1–7) increases survival of stroke‐prone spontaneously hypertensive rats. The FASEB Journal 2011, 25: 650.10-650.10. DOI: 10.1096/fasebj.25.1_supplement.650.10.Peer-Reviewed Original ResearchHemorrhagic strokeCerebroprotective actionHypertensive ratsSystemic arterial pressureNovel therapeutic targetArtificial cerebrospinal fluidWeeks of ageAngiotensin systemIschemic strokeSalt dietArterial pressureSpontaneous hypertensionTherapeutic optionsAngiotensin IIINOS expressionStroke occurrenceCerebrospinal fluidTherapeutic targetOsmotic pumpHemorrhagic stroke occurrenceStrokeRatsSignificant increaseWeeksSurvivalCentral and Peripheral Administration of Compound 21 Elicits Cerebroprotective Effects in Ischemic Stroke
Joseph J, Regenhardt R, Mecca A, Patel N, Steckelings U, Unger T, Katovich M, Sumners C. Central and Peripheral Administration of Compound 21 Elicits Cerebroprotective Effects in Ischemic Stroke. The FASEB Journal 2011, 25: lb576-lb576. DOI: 10.1096/fasebj.25.1_supplement.lb576.Peer-Reviewed Original ResearchMiddle cerebral artery occlusionIpsilateral gray matterArtificial cerebrospinal fluidInfarct sizeMCAO inductionIschemic strokeNeurological deficitsControl ratsAdult male Sprague-Dawley ratsAngiotensin type 2 receptorGray matterMale Sprague-Dawley ratsSpecific AT2R agonistCerebral artery occlusionExert beneficial actionsSprague-Dawley ratsType 2 receptorACSF controlsCerebroprotective effectArtery occlusionPeripheral administrationAT2R agonistIP administrationEndothelin-1Intracerebroventricular infusion
2009
Cerebroprotective action of angiotensin 1‐7 in a rat model of ischemic stroke
Mecca A, O'Connor T, Dooies K, Katovich M, Sumners C. Cerebroprotective action of angiotensin 1‐7 in a rat model of ischemic stroke. The FASEB Journal 2009, 23: 947.1-947.1. DOI: 10.1096/fasebj.23.1_supplement.947.1.Peer-Reviewed Original ResearchMiddle cerebral artery occlusionAngiotensin-Converting Enzyme 2Ang-1Artificial cerebrospinal fluidControl ratsIschemic strokeNeurological deficitsInfarct sizeAngiotensin 1Rat modelArtificial cerebrospinal fluid controlsIpsilateral gray matterCerebral artery occlusionLateral ventricular cannulasConverting enzyme 2Cerebrospinal fluid controlsCerebroprotective propertiesMCAO inductionArtery occlusionCerebroprotective actionEndothelin-1Ventricular cannulaEnzyme 2Cerebrospinal fluidET-1