Featured Publications
Cerebellar Hippocampal and Basal Nuclei Transient Edema with Restricted diffusion (CHANTER) Syndrome
Jasne AS, Alsherbini KH, Smith MS, Pandhi A, Vagal A, Kanter D. Cerebellar Hippocampal and Basal Nuclei Transient Edema with Restricted diffusion (CHANTER) Syndrome. Neurocritical Care 2019, 31: 288-296. PMID: 30788708, PMCID: PMC6757017, DOI: 10.1007/s12028-018-00666-4.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcoholic IntoxicationAmphetaminesBasal GangliaBenzodiazepinesBrain EdemaCentral Nervous System StimulantsCerebellar CortexCerebellumCocaineComaFemaleHeroinHippocampusHumansHydrocephalusHydromorphoneMagnetic Resonance ImagingMaleMiddle AgedOpiate AlkaloidsPain, PostoperativeStuporSubstance-Related DisordersSyndromeConceptsCerebellar edemaIschemic strokeObstructive hydrocephalusCerebellar cortexAcute cytotoxic edemaSeries of patientsNeurocritical care unitPatterns of injuryLevel of consciousnessMagnetic resonance imagingClinical characteristicsInitial presentationCare unitSurgical managementHypoxic injuryCytotoxic edemaFavorable outcomeSimilar presentationAnoxic injuryBilateral hippocampusTransient edemaBasal nucleusToxic injuryNovel syndromeAcceptable outcomes
2024
Adjunctive Intravenous Argatroban or Eptifibatide for Ischemic Stroke
Adeoye O, Broderick J, Derdeyn C, Grotta J, Barsan W, Bentho O, Berry S, Concha M, Davis I, Demel S, Elm J, Gentile N, Graves T, Hoffman M, Huang J, Ingles J, Janis S, Jasne A, Khatri P, Levine S, Majjhoo A, Panagos P, Pancioli A, Pizzella S, Ranasinghe T, Sabagha N, Sivakumar S, Streib C, Vagal A, Wilson A, Wintermark M, Yoo A, Barreto A. Adjunctive Intravenous Argatroban or Eptifibatide for Ischemic Stroke. New England Journal Of Medicine 2024, 391: 810-820. PMID: 39231343, PMCID: PMC11528349, DOI: 10.1056/nejmoa2314779.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnticoagulantsArginineCombined Modality TherapyDrug Therapy, CombinationEptifibatideFemaleFibrinolytic AgentsHumansIncidenceInfusions, IntravenousIntracranial HemorrhagesIschemic StrokeMaleMiddle AgedPeptidesPipecolic AcidsPlatelet Aggregation InhibitorsSingle-Blind MethodSulfonamidesThrombectomyThrombolytic TherapyTreatment OutcomeConceptsSymptomatic intracranial hemorrhageIntravenous argatrobanIntravenous thrombolysisAcute ischemic strokeIntracranial hemorrhageIschemic strokeIncidence of symptomatic intracranial hemorrhageSymptom onsetIschemic stroke treated with intravenous thrombolysisAcute ischemic stroke treated with intravenous thrombolysisStroke treated with intravenous thrombolysisAssociated with increased mortalityRankin Scale scoreInitiation of thrombolysisControlled clinical trialsTreatment of acute ischemic strokePlacebo groupEptifibatide groupEfficacy outcomesArgatroban groupStandard treatmentAdjunctive treatmentPlaceboClinical trialsArgatrobanProjections of Endovascular Therapy–Eligible Patients With Stroke for the US Population
Mistry E, Khoury J, Kleindorfer D, Kissela B, Alwell K, Jasne A, Ferioli S, La Rosa F, Coleman E, Demel S, Walsh K, Slavin S, Star M, Haverbusch M, Mackey J, Woo D, Aziz Y, Heldner M, Fischer U, Jadhav A, Jovin T, Albers G, Nogueira R, Khatri P. Projections of Endovascular Therapy–Eligible Patients With Stroke for the US Population. Stroke 2024, 55: 2011-2019. PMID: 38934124, DOI: 10.1161/strokeaha.123.045766.Peer-Reviewed Original ResearchUS populationStudy of stroke incidenceEndovascular thrombectomyNational Institutes of Health Stroke ScalePrevalence of large vessel occlusionHealth Stroke ScaleIschemic strokeEVT-eligible patientsUnited StatesPopulation-basedPrestroke disabilityStroke systemsStroke incidenceYears of ageLarge vessel occlusionEligibility criteriaAcute ischemic strokePost hoc analysisStroke ScaleObservational studyEligibilityAdult patientsTreatment indicationsHospitalized patientsNational InstituteRacial Disparities in Blood Pressure at Time of Acute Ischemic Stroke Presentation: A Population Study
Aziz Y, Sucharew H, Stanton R, Alwell K, Ferioli S, Khatri P, Adeoye O, Flaherty M, Mackey J, La Rosa F, Martini S, Mistry E, Coleman E, Jasne A, Slavin S, Walsh K, Star M, Ridha M, Ades L, Haverbusch M, Demel S, Woo D, Kissela B, Kleindorfer D. Racial Disparities in Blood Pressure at Time of Acute Ischemic Stroke Presentation: A Population Study. Journal Of The American Heart Association 2024, 13: e032645. PMID: 38700029, PMCID: PMC11179936, DOI: 10.1161/jaha.123.032645.Peer-Reviewed Original ResearchConceptsNational Institutes of Health Stroke Scale scoreWhite patientsStroke Scale scoreAcute ischemic strokeBlood pressureGreater Cincinnati/Northern Kentucky Stroke StudyDiastolic BPBlack patientsPopulation-based studyStudy epochInfluence clinical decision-makingScale scoreStroke risk factorsPresenting blood pressureIschemic strokeSubanalysis of patientsBody mass indexNational InstituteHistory of hypertensionMultivariate linear regressionClinical trial eligibilityAcute ischemic stroke presentingClinical decision-makingIschemic stroke presentingRacial disparitiesMediation of Age and Thrombectomy Outcome by Neuroimaging Markers of Frailty in Patients With Stroke
Benali F, Singh N, Fladt J, Jaroenngarmsamer T, Bala F, Ospel J, Buck B, Dowlatshahi D, Field T, Hanel R, Peeling L, Tymianski M, Hill M, Goyal M, Ganesh A, Barber P, Smith E, Bal S, Subramanian S, Peters S, Couillard P, Klein G, Stys P, Coutts S, Wong J, Mitha A, Eesa M, Morrish W, Alqatani S, Kashani N, Venkatesan P, Teleg E, Sitaram A, Graham B, Gaal S, Moussaddy A, Chakraborty D, Maraj N, Lockey A, Chen S, Singh R, Alsultan A, Asunsian R, Tse D, Doshi D, Volny O, Ojha P, Wadhwa A, Marko M, Singh N, Wasyliw S, Ryckborst K, Kenney C, Save S, Jambula A, Newcommon N, Hull G, Blackstock D, Kiszczak S, Zimmel L, Wright M, Jahraus C, Andersen L, Bohn S, Paul J, Buck B, Butcher K, Shuaib A, Jeerakathil T, Jickling G, Emery D, Rempel J, Ower R, Ashforth R, Yeo T, Kotylak T, O;Kelly C, Chow M, Siddiqui M, Saqqur M, D'Souza A, Lloret M, Butt A, Nomani A, Kalashyan H, Thirunavukkarasu S, Jabs J, Fairall P, Piquette L, Phillips S, Green A, Gubitz G, Heidenreich J, Huynh T, Shankar J, Maloney W, Vandorpe R, Schmidt M, Pickett G, Weeks A, Jarrett J, MacDonald D, Arsenault J, Kinnear R, Mandzia J, Mayich M, Boulton M, Bullrich M, Fridman S, Kiwan R, Lee D, Lownie S, Khaw A, Pandey S, Sharma M, Sposato L, Wade K, Beauchamp B, Lambourn L, Amato-Marziali B, Roy D, Deneault N, Deschaintre Y, Gioia L, Jacquin G, Odier C, Stapf C, Iancu D, Raymond J, Weill A, Lapierre M, Jadil N, Jolteus J, Teitelbaum J, Angle M, Hannouche M, Badawy M, Letourneau J, Cortes M, Linnell G, Tampieri D, Vieira L, Legault C, Durcan L, Moore A, Cole E, Magnussen C, Salmon K, Khalil S, Desloges I, Waxman L, Abdon W, Lai S, Dowlatshahi D, Shamy M, Stotts G, Blacquiere D, Lesiuk H, Quateen A, Drake B, Dewar B, Daham Z, Kelly M, Hunter G, Peeling L, Graham B, Whelan R, Garner A, Urroz L, Maley S, Silver F, Casaubon L, Pikula A, Campo M, Schaafsma J, Jaigobin C, Krings T, Pereira V, Agid R, Farb R, Kalman L, Cayley A, Williams J, Stewart T, Misquitta K, Bharatha A, Selchen D, Marotta T, Sarma D, Montanera W, Spears J, Saposnik G, Kostyrko P, Li Y, Parra-Farinas C, Diestro J, Camden M, Verreault S, Mackey A, Audet M, Milot G, Lavoie P, Gariépy J, Collard K, Haché A, Sahlas D, Alshanbari A, Baldwin J, Catanese L, Chen B, Sa Boasquevisque D, Deshmukh A, Knapman J, Lamers S, Larrazabal R, MacMillan S, Mai L, Mattai A, Nayar S, Ng K, Oczkowski W, Perera K, Shawawrah M, Shoamanesh A, Sobhi G, Syed N, Yaher N, Vandervelde C, Wang D, Field T, Van Gaal S, Teal P, Benavente O, Wilson L, Mann S, Yip S, Murphy C, Heran M, Rohr A, Settecase F, Redekop G, Haw C, Maclean G, Murray K, Chiu R, Flexman A, Strecha E, Gayton Y, Yip J, Swartz R, Boulos M, Gladstone D, Yu A, Hopyan J, Khosravani H, Manosalva Alzate H, Southwell A, Kamra M, Lopes K, Kapoor A, da Costa L, Yang V, Dyer E, Shah R, Knowles B, Nichols J, Patterson J, Cope K, Dickerson L, Barton K, Gray K, Massengale T, Miller M, Simpson C, Walker S, Tennyson-Yemm C, Frei D, Bellon R, Atchie B, Kaminsky I, Wilson D, Schraeder N, Arias E, Kodis L, Talley M, Edinger A, Talley T, Dempsey I, Williams L, Williams S, Kupniewski S, Fasbinder B, Snead J, Choe H, Mackenzie L, Weisman D, Kozak O, Shah Q, Gzesh D, Kulandaivel K, Khoury J, Klein B, Bussinger P, Griffin L, DePalmo A, Oliva C, Jadhav A, Jovin T, Kenmuir C, Jankowitz B, Gross B, Rocha M, Starr M, Brown M, Hawkes C, Shah K, Tememe D, Walker G, Patel P, Klein B, Ziayee H, Limaye K, Baxendell L, Glichrist V, Feineigle P, Toseki Haibach K, Van Every C, Desai S, Zulfiqar M, Gibson L, Barrett S, Turkel-Parrella D, Arcot K, DiCrescento S, Farkas J, Filipowski G, Frontera J, Joset D, Liff J, Scher E, McDougall C, Kelly C, Patel A, Monteith S, Starkman S, Atchaneeyasakul K, Burgos A, Anne Y. Chua J, Gaines N, Grunberg I, Guzy J, Liu Z, Maluste N, Ramirez L, Sharma L, Heck D, Brown M, McDonald C, Calderon M, Hargis M, Roels C, Emmady P, Alvi T, Jayaraman M, Cutting S, Smith W, Foley S, Paolucci G, Haas R, Quinn K, Fuller L, Brierley R, Watkins C, Demir N, Lopez G, Vargas A, Osteraas N, Holtz B, Sauvageau E, Aghaebrahim A, Chmayssani M, Naval N, Day J, Dellorso S, Ludwig B, Schemmel D, Ebreo N, Bell K, Lewis L, Delucia M, Haussen D, Frankel M, Bhatt N, Bianchi N, Anderson A, Belagaje S, Liberato B, Rangaraju S, Al-Bayati A, Grossber J, Craft L, Schindler K, Schaad E, Schultz M, Sutherly L, Doppelheuer S, Charlton J, Faggard J, Barbret Z, DukSoo Han E, Walters R, Dolia J, El-Jamal S, Eby B, Saleem Y, Pearl H, Patel K, Rahman H, Butt R, English S, Puri A, Howk M, Singh J, Massari F, DeMacedo Rodrigues K, Kuhn A, English J, Barazangi N, Telischak N, Kim W, Ross J, DeVole N, Redford J, Ferreira M, Ponting K, Shen H, Bedenk A, Patel S, Fernandess J, Ke M, Spokoyny I, Gao B, Tong D, Chen C, Wong C, Choe J, Martin C, Summers D, Boutwell C, Olds K, Crandall S, Eatman J, Akhtar N, Holloway W, Halpin J, Donegan B, Schindler J, Hwang D, Gilmore E, Petersen N, Sheth K, Brown S, Beekman R, George B, Kaddouh F, Falcone G, Wira C, Matouk C, Loomis C, Amin H, Stretz H, Narula R, Jasne A, Sansing L, Agarwal T, Jasak S, Fontaine B, King Z, Kouhn L, Orgass H, Leary M, Nye J, Halbert K, Nystrom K, Neuschatz K, Petrucci D, Coppola A, Joyce T, Hou S, Umekubo M, Nakamura C, Ovando R, Zuniga D, Nien Y, Basto F, Arch A, Jong L, Conrad W, Abbott T, Yao J, Caganap S, Jordan J, Teitelbaum G, Darflinger R, Kelly D, Gupta R, Budzik R, Czerniak J, Groezinger K, Hicks W, Kaskar O, Katz B, Loochtan A, Pema P, Rai V, Vora N, Brown A, Goodman D, Danenbergs B, Gossett M, Bang O, Chung J, Jeon P, Kim K, Lim Y, Hoe Heo J, Nam H, Kim Y, Park H, Hwang I, Ha W, Choi J, Jeong K, Rha J, Park H, Yoon C, Kim B, Sohn S, Kim C, Yoo J, Hong J, Park H, Kim S, Choi M, Bae H, Lee J, Lee J, Jun G, Jeon S, Campbell B, Mitchell P, Yassi N, Davis S, Donnan G, Parsons M, Yan B, Dowling R, Bush S, Wu T, Shan D, Zhao H, Salvaris P, Alemseged F, Ng F, Williams C, Balabanski A, dos Santos A, Ng J, McDonald A, Jackson D, Tsoleridis J, Pesavento L, Kleinig T, Drew R, Cranefield J, Scroop R, Cagi L, Harvey J, Waters M, Thornton J, Brennan R, O'Hare A, Power S, Williams D, Boyle K, Moynihan B, Liddy A, Large M, Cullen A, Walsh R, Martin E, Lynch J, McElroy S, Murphy S, Coveney S, Deegan C, Horgan G, Kelly P, Laffan A, Llamas-Osorio Y, Lynch C, Mac Mahon P, Marnane M, McCabe J, Burns P, Tauro S, Cuddy S, Rennie I, Smyth G, Flynn P, Wiggam I, Kerr E, Gordon P, Fearon P, Roberts G, Patterson C, Adams K, Wells B, McFarland M, Moreira T, Sjöstrand C, Mazya M, Almqvist H, Wahlgren N, Steinberg A, Cooray C, Eriksson E, Thorén M, Keselman B, Ahmed N, Holmberg Å, Axelsson M, Berglund A, Golsari A, Hoppe J, Deb-Chatterji M, Cheng B, Barow E, Schlemm E, Lettow I, Jensen M, Otto D, Jaramillo K, Appelbohm H, Fiehler J, Bester M, Schönfeld M, Brekenfeld C, Holst B, Wortmann G, Koch F, Gerber J, Abramyuk A, Kaiser D, Winzer S, Prakapenia A, Pallesen L, Siepmann T, Barlinn K, Haase K, Sauer A, Psychogios M, Liman J, Brehm A, Maus V, Hollstein N, Reinke A, Neitz G, Schnieder M, Schwarz M, Ibrahim A, Müller J, Meister S, Bäumle B, Chapot R, Pilgram-Pastor S, Wallocha M, Stauder M, Celik E, Stracke P, Müller N, Weber R, Veltkamp R, Nagel S, Ringleb P, Heyse M, Amiri H, Mundiyanapurath S, Chen M, Beyrle E, Beck P, Möhlenbruch M. Mediation of Age and Thrombectomy Outcome by Neuroimaging Markers of Frailty in Patients With Stroke. JAMA Network Open 2024, 7: e2349628. PMID: 38165676, PMCID: PMC10762575, DOI: 10.1001/jamanetworkopen.2023.49628.Peer-Reviewed Original ResearchConceptsMarker of frailtyEndovascular thrombectomyAlteplase treatmentCohort studyESCAPE-NA1 trialAcute ischemic strokeEarly ischemic changesSmall vessel diseaseBest medical managementAcute care hospitalsBrain frailtyFrailty featuresIschemic strokeStroke severityBrain atrophyCare hospitalIschemic changesPrimary outcomeClinical featuresMedical managementPuncture timeThrombectomy outcomesPoor outcomeVessel diseaseFunctional outcome
2023
Acute and subacute neurovascular impact of cryptogenic air emboli
Gummerson C, Parasram M, Peng T, Picard J, Kahn P, Angelus E, Bhatt S, de Havenon A, Jasne A, Magid-Bernstein J. Acute and subacute neurovascular impact of cryptogenic air emboli. Surgical Neurology International 2023, 14: 285. PMID: 37680929, PMCID: PMC10481802, DOI: 10.25259/sni_382_2023.Peer-Reviewed Case Reports and Technical NotesMagnetic resonance imagingCortical diffusion restrictionAir emboliMiddle cerebral artery territoryRight anterior cerebral arterySubsequent magnetic resonance imagingDiffusion restrictionClose neurologic monitoringNeurocritical care managementCerebral air embolismAcute ischemic strokeAnterior cerebral arteryInitial radiographic findingsCerebral air emboliType of injuryComputerized tomography scanCourse of careArtery territoryCerebral edemaIschemic strokeNeurologic monitoringCerebral arteryCortical veinsInitial imagingMechanical ventilationChanging Trends in Demographics, Risk Factors, and Clinical Features of Patients With Infective Endocarditis–Related Stroke, 2005–2015
Ridha M, Flaherty M, Aziz Y, Ades L, Alwell K, Khoury J, Woo D, Ferioli S, Adeoye O, Khatri P, De Los Rios La Rosa F, Mistry E, Demel S, Mackey J, Martini S, Coleman E, Jasne A, Slavin S, Walsh K, Star M, Haverbusch M, Madsen T, Broderick J, Kissela B, Kleindorfer D. Changing Trends in Demographics, Risk Factors, and Clinical Features of Patients With Infective Endocarditis–Related Stroke, 2005–2015. Neurology 2023, 100: e1555-e1564. PMID: 36746635, PMCID: PMC10103121, DOI: 10.1212/wnl.0000000000206865.Peer-Reviewed Original ResearchConceptsRisk factorsOpioid epidemicClinical characteristicsClinical featuresGreater Cincinnati/Northern Kentucky regionStudy periodRetrospective cohort studyRates of hypertensionIntravenous drug useIntravenous drug usersICD-10 codesCochran-Armitage testPerioperative strokeAcute strokeCohort studyDefinite endocarditisDuke criteriaHypertension prevalenceIschemic strokeYounger patientsStroke populationInfective endocarditisAtrial fibrillationEpidemiologic descriptionUnadjusted comparisons
2022
Navigating an Internal Carotid Artery Anatomic Variant During Endovascular Therapy for Acute Ischemic Stroke
Peng T, Sharma R, Antonios J, Hebert R, Jasne A. Navigating an Internal Carotid Artery Anatomic Variant During Endovascular Therapy for Acute Ischemic Stroke. Stroke 2022, 53: e517-e518. PMID: 36106549, DOI: 10.1161/strokeaha.122.040501.Peer-Reviewed Case Reports and Technical Notes