2024
Emergent Large Vessel Occlusion due to Intracranial Stenosis: Identification, Management, Challenges, and Future Directions
Al Kasab S, Nguyen T, Derdeyn C, Yaghi S, Amin-Hanjani S, Kicielinski K, Zaidat O, de Havenon A. Emergent Large Vessel Occlusion due to Intracranial Stenosis: Identification, Management, Challenges, and Future Directions. Stroke 2024, 55: 355-365. PMID: 38252763, DOI: 10.1161/strokeaha.123.043635.Peer-Reviewed Original ResearchConceptsIntracranial atherosclerotic stenosisVessel occlusionRecurrence riskEarly recurrence riskHigh-risk patientsAggressive medical managementRecurrent stroke riskEndovascular therapyHemodynamic failureTreatment strategiesPerfusion imagingAdvanced ageEndovascular interventionIntracranial stenosisMedical managementRisk factorsHigh riskAdvanced imagingAtherosclerotic stenosisStroke riskOcclusionStenosisPatientsRisk
2023
Recurrence risk in symptomatic intracranial stenosis treated medically in the real world
Yaghi S, Shu L, Goldstein E, Chang A, Kala N, Stretz C, Burton T, Perelstein E, Furie K, Jayaraman M, Torabi R, Moldovan K, de Havenon A, Khatri P, Gebregziabher M, Liebeskind D, Prabhakaran S. Recurrence risk in symptomatic intracranial stenosis treated medically in the real world. Journal Of Stroke And Cerebrovascular Diseases 2023, 32: 107086. PMID: 37030126, DOI: 10.1016/j.jstrokecerebrovasdis.2023.107086.Peer-Reviewed Original ResearchMeSH KeywordsAgedCerebral InfarctionConstriction, PathologicDual Anti-Platelet TherapyFemaleHumansIntracranial ArteriosclerosisIschemic StrokeMaleRecurrenceRisk FactorsStrokeConceptsIntracranial atherosclerotic stenosisSymptomatic intracranial atherosclerotic stenosisClinical trialsRecurrence riskRecurrent strokeInclusion criteriaReal-world settingMaximal medical treatmentRecurrent stroke rateDual antiplatelet therapyAcute ischemic strokeReal-world cohortSymptomatic intracranial stenosisPharmacological treatment strategiesCox regression modelMeeting inclusion criteriaLow event ratesAntiplatelet therapyStroke RegistryIschemic eventsIschemic strokeWorld CohortHospitalized patientsEarly recurrenceIntracranial stenosis
2022
Borderzone infarction and recurrent stroke in intracranial atherosclerosis
Kvernland A, Torres J, Raz E, Nossek E, de Havenon A, Gebregziabher M, Khatri P, Prabhakaran S, Liebeskind D, Yaghi S. Borderzone infarction and recurrent stroke in intracranial atherosclerosis. Journal Of Stroke And Cerebrovascular Diseases 2022, 32: 106897. PMID: 36402094, DOI: 10.1016/j.jstrokecerebrovasdis.2022.106897.Peer-Reviewed Original ResearchConceptsRecurrent cerebrovascular eventsIntracranial stenosisBorderzone infarctsInfarct patternsIschemic strokeBorderzone infarctionRetrospective single-center studyAcute ischemic strokeRecurrent ischemic strokeSingle-center studySymptomatic intracranial stenosisHigh-risk cohortBinary logistic regression analysisDistal blood flowAlternative treatment strategiesLogistic regression analysisLogistic regression modelsCerebrovascular eventsRecurrent strokeIntracranial atherosclerosisPrimary outcomeCenter studyMean ageSurrogate markerTreatment strategies
2021
Impaired Distal Perfusion Predicts Length of Hospital Stay in Patients with Symptomatic Middle Cerebral Artery Stenosis
Yaghi S, de Havenon A, Honda T, Hinman JD, Raychev R, Sharma LK, Kim S, Feldmann E, Romano JG, Prabhakaran S, Liebeskind DS. Impaired Distal Perfusion Predicts Length of Hospital Stay in Patients with Symptomatic Middle Cerebral Artery Stenosis. Journal Of Neuroimaging 2021, 31: 475-479. PMID: 33565162, PMCID: PMC8119309, DOI: 10.1111/jon.12839.Peer-Reviewed Original ResearchConceptsTransient ischemic attackMCA stenosisPerfusion delayPerfusion imagingSymptomatic middle cerebral artery stenosisMiddle cerebral artery stenosisSymptomatic MCA stenosisComprehensive stroke centerSymptomatic intracranial stenosisCerebral artery stenosisContinuous variablesHospital stayIschemic attackIschemic strokeStenosis patientsStroke centersSymptom onsetConsecutive patientsArtery stenosisIntracranial stenosisProspective studyRetrospective studyPredicts LengthInclusion criteriaMismatch volume