2023
Effect of Alteplase on Ischemic Stroke Mortality Is Dependent on Stroke Severity
de Havenon A, Abbasi M, Yaghi S, Delic A, Bangad A, Johnston K, Tirschwell D, Sheth K. Effect of Alteplase on Ischemic Stroke Mortality Is Dependent on Stroke Severity. Annals Of Neurology 2023, 93: 1106-1116. PMID: 36852919, DOI: 10.1002/ana.26621.Peer-Reviewed Original ResearchConceptsIV-tPAHigher NIHSSIschemic strokeAtrial fibrillationNational Inpatient Sample (NIS) 2016Non-Hispanic white raceOlder ageBaseline National InstitutesDEFUSE-3 trialsHealth Stroke ScalePost-stroke mortalityIschemic stroke mortalityEffect of alteplaseRisk of mortalityLogistic regression modelsAnn NeurolFAST-MAGIMS IIISevere ISHospital mortalityIntravenous alteplaseSevere strokeStroke ScaleStroke severityFunctional outcome
2021
MR Perfusion in the Evaluation of Mechanical Thrombectomy Candidacy
Muddasani V, de Havenon A, McNally JS, Baradaran H, Alexander MD. MR Perfusion in the Evaluation of Mechanical Thrombectomy Candidacy. Topics In Magnetic Resonance Imaging 2021, 30: 197-204. PMID: 34397969, PMCID: PMC8371677, DOI: 10.1097/rmr.0000000000000277.Peer-Reviewed Original ResearchMeSH KeywordsBrain IschemiaDiffusion Magnetic Resonance ImagingHumansMagnetic Resonance ImagingPerfusionStrokeThrombectomyThrombolytic TherapyConceptsMagnetic resonance imagingIschemic strokeComputed tomographyMR perfusionCore infarctDiffusion-weighted magnetic resonance imagingPerfusion-diffusion mismatchDegree of ischemiaNoncontrast Computed TomographyImproved imaging techniquesSalvageable brainSuperior diagnostic informationIschemic penumbraSymptom onsetAcute evaluationAppropriate imagingPatient selectionStroke therapyThrombolytic therapyPoor outcomePrognostic valueLeading causeEffective treatmentBetter outcomesEarly identificationEndovascular therapy with or without intravenous thrombolysis in acute stroke with tandem occlusion
Anadani M, Marnat G, Consoli A, Papanagiotou P, Nogueira RG, Spiotta AM, Bourcier R, Kyheng M, Labreuche J, Siddiqui AH, Ribo M, de Havenon A, Fischer U, Sibon I, Dargazanli C, Arquizan C, Cognard C, Olivot JM, Anxionnat R, Audibert G, Mazighi M, Blanc R, Lapergue B, Richard S, Gory B, Investigators T. Endovascular therapy with or without intravenous thrombolysis in acute stroke with tandem occlusion. Journal Of NeuroInterventional Surgery 2021, 14: 314-320. PMID: 33911016, DOI: 10.1136/neurintsurg-2020-017202.Peer-Reviewed Original ResearchMeSH KeywordsBrain IschemiaEndovascular ProceduresFibrinolytic AgentsHumansIschemic StrokeStrokeThrombectomyThrombolytic TherapyTreatment OutcomeConceptsCervical internal carotid arteryIntravenous thrombolysisAcute ischemic strokeTandem occlusionsEndovascular therapyInternal carotid arteryFavorable outcomeAcute strokeIschemic strokeCarotid arteryHigher oddsAnterior circulation tandem occlusionAcute tandem occlusionIschemic Stroke RegistrySignificant hemorrhagic complicationsIVT treatmentHemorrhagic complicationsStroke RegistrySuccessful reperfusionRankin ScaleConsecutive patientsIPTW analysisPrimary outcomeEndovascular treatmentPuncture time
2020
Pulse pressure variability is associated with unfavorable outcomes in acute ischaemic stroke patients treated with intravenous thrombolysis
Katsanos A, Alexandrov A, Mandava P, Köhrmann M, Soinne L, Barreto A, Sharma V, Mikulik R, Muir K, Rothlisberger T, Grotta J, Levi C, Molina C, Saqqur M, Palaiodimou L, Psaltopoulou T, Vosko M, Moreira T, Fiebach J, Rubiera M, Sandset E, de Havenon A, Kent T, Alexandrov A, Schellinger P, Tsivgoulis G, Investigators F. Pulse pressure variability is associated with unfavorable outcomes in acute ischaemic stroke patients treated with intravenous thrombolysis. European Journal Of Neurology 2020, 27: 2453-2462. PMID: 32697894, DOI: 10.1111/ene.14447.Peer-Reviewed Original ResearchConceptsPatients treated with intravenous thrombolysisAcute ischaemic strokeIndependent functional outcomePulse pressure variabilityIntravenous thrombolysisIntracranial bleedingAssociated with adverse short-termFunctional outcomesBlood pressureStroke patients treated with intravenous thrombolysisTissue plasminogen activator bolusSystemic tissue plasminogen activatorAssociated with unfavorable outcomesAssociated with worse neurological outcomeSymptomatic intracranial bleedingLong-term functional outcomeSafety end pointPulse pressureAcute ischaemic stroke patientsAdverse short-termLysis of thrombiPressure variabilityTissue plasminogen activatorCombined Lysis of ThrombusIntravenous thrombolysis administrationAcute stroke care in a New York City comprehensive stroke center during the COVID-19 pandemic
Agarwal S, Scher E, Rossan-Raghunath N, Marolia D, Butnar M, Torres J, Zhang C, Kim S, Sanger M, Humbert K, Tanweer O, Shapiro M, Raz E, Nossek E, Nelson PK, Riina HA, de Havenon A, Wachs M, Farkas J, Tiwari A, Arcot K, Parella DT, Liff J, Wu T, Wittman I, Caldwell R, Frontera J, Lord A, Ishida K, Yaghi S. Acute stroke care in a New York City comprehensive stroke center during the COVID-19 pandemic. Journal Of Stroke And Cerebrovascular Diseases 2020, 29: 105068. PMID: 32807471, PMCID: PMC7305900, DOI: 10.1016/j.jstrokecerebrovasdis.2020.105068.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBetacoronavirusComprehensive Health CareCoronavirus InfectionsCOVID-19Critical PathwaysDelivery of Health Care, IntegratedFemaleHumansMaleMiddle AgedNew York CityPandemicsPatient Care TeamPneumonia, ViralQuality ImprovementQuality Indicators, Health CareRegistriesRetrospective StudiesSARS-CoV-2StrokeThrombectomyThrombolytic TherapyTime FactorsTime-to-TreatmentTreatment OutcomeWorkflowConceptsComprehensive stroke centerAcute ischemic strokePre-pandemic groupAIS patientsStroke centersTransient ischemic attack/strokeAcute stroke processDefect-free careLonger median doorEmergency health care servicesAcute stroke careConsecutive AIS patientsQuality improvement registrySuccessful recanalization rateLong-term outcomesQuality of careHealth care servicesCOVID-19 screeningAcute strokeIschemic strokeLonger doorMechanical thrombectomyMedian doorStroke severityDischarge outcomesIntracranial Atherosclerosis Treatment
Flusty B, de Havenon A, Prabhakaran S, Liebeskind DS, Yaghi S. Intracranial Atherosclerosis Treatment. Stroke 2020, 51: e49-e53. PMID: 32078441, PMCID: PMC7041867, DOI: 10.1161/strokeaha.119.028528.Peer-Reviewed Original Research
2019
Diurnal Variations in the First 24/7 Mobile Stroke Unit
Zaidat OO, Changal KH, Sultan-Qurraie A, de Havenon A, Calderon VJ, Goins-Whitmore J, Patterson MS, Lin E. Diurnal Variations in the First 24/7 Mobile Stroke Unit. Stroke 2019, 50: 1911-1914. PMID: 31104620, DOI: 10.1161/strokeaha.119.024950.Peer-Reviewed Original ResearchConceptsStroke unitResults One hundred ninetyEvening shiftsMorning shiftPrehospital stroke careMobile stroke unitMSU patientsProspective databaseIntravenous thrombolyticsMechanical thrombectomyPatient characteristicsStroke treatmentStroke careTreatment metricsTherapeutic interventionsNocturnal shiftPatients