Voluntary Faculty
Voluntary faculty are typically clinicians or others who are employed outside of the School but make significant contributions to department programs at the medical center or at affiliate institutions.
Voluntary rank detailsSamit Joshi, DO, MPH
Assistant Clinical ProfessorDownloadHi-Res Photo
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Titles
Assistant Clinical Professor
Biography
Dr. Joshi completed his clinical training at the Yale School of Medicine (Internal Medicine and Infectious Diseases) after which his postdoctoral translational research focused on: 1) innate immunosenescence in context of HIV-1 infection and 2) the relationship between the oral microbiome and health-care associated pneumonia.
His ongoing clinical activities as a Clinical Instructor at the Yale School of Medicine / VAMC (West Haven) and a Consultant at Waterbury Hospital continue to complement his research and developmental interests in Infectious Diseases and Immunology.
Last Updated on May 07, 2025.
Appointments
Infectious Diseases
Assistant Clinical ProfessorPrimary
Other Departments & Organizations
Education & Training
- Postdoctoral Fellow
- Yale School of Medicine (2012)
- Fellow
- Yale School of Medicine (2011)
- Resident
- Yale School of Medicine (2008)
- MPH
- Des Moines University (2005)
- DO
- Des Moines University - Osteopathic Medical Center (2005)
- BA
- University of Minnesota (2001)
Research
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Overview
Public Health Interests
HIV/AIDS
ORCID
0000-0002-1332-5918
Research at a Glance
Yale Co-Authors
Frequent collaborators of Samit Joshi's published research.
Publications Timeline
A big-picture view of Samit Joshi's research output by year.
Max Lataillade, MPH, DO
Ruth R Montgomery, PhD
8Publications
990Citations
Publications
2025
Efficacy and safety of the HIV-1 maturation inhibitor GSK3640254 plus dolutegravir as a two-drug regimen in adults naive to antiretroviral therapy (DYNAMIC): 24-week results from a randomised phase 2b study
Joshi S, Masiá M, Mitha E, Castagna A, Cordova E, Ramgopal M, Gaudion A, Karthika S, Oyee J, Bainbridge V, Wynne B, Lataillade M. Efficacy and safety of the HIV-1 maturation inhibitor GSK3640254 plus dolutegravir as a two-drug regimen in adults naive to antiretroviral therapy (DYNAMIC): 24-week results from a randomised phase 2b study. EClinicalMedicine 2025, 89: 103566. PMID: 41357331, PMCID: PMC12675015, DOI: 10.1016/j.eclinm.2025.103566.Peer-Reviewed Original ResearchCitationsAltmetricEfficacy and safety of the HIV-1 maturation inhibitor GSK3640254 plus two NRTIs in adults naive to antiretroviral therapy (DOMINO): 24-week results from a randomised phase 2b study
Joshi S, Cordova E, Mitha E, Castagna A, Ramgopal M, Llibre J, Potthoff A, Chernova O, Nuñez S, Man C, Jeffrey J, Fishman C, Oyee J, Joshi A, Zhang Y, Bainbridge V, Wynne B, Lataillade M. Efficacy and safety of the HIV-1 maturation inhibitor GSK3640254 plus two NRTIs in adults naive to antiretroviral therapy (DOMINO): 24-week results from a randomised phase 2b study. EClinicalMedicine 2025, 89: 103567. PMID: 41357330, PMCID: PMC12675029, DOI: 10.1016/j.eclinm.2025.103567.Peer-Reviewed Original ResearchCitationsAltmetric
2024
Exploring HIV-1 Maturation: A New Frontier in Antiviral Development
McGraw A, Hillmer G, Medehincu S, Hikichi Y, Gagliardi S, Narayan K, Tibebe H, Marquez D, Bose L, Keating A, Izumi C, Peese K, Joshi S, Krystal M, DeCicco-Skinner K, Freed E, Sardo L, Izumi T. Exploring HIV-1 Maturation: A New Frontier in Antiviral Development. Viruses 2024, 16: 1423. PMID: 39339899, PMCID: PMC11437483, DOI: 10.3390/v16091423.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitations
2023
Effects of the HIV‐1 maturation inhibitor GSK3640254 on QT interval in healthy participants
Zhang Y, Bush M, Yazdani P, Zhan J, Wen B, Bainbridge V, Wynne B, Joshi S, Lataillade M. Effects of the HIV‐1 maturation inhibitor GSK3640254 on QT interval in healthy participants. Pharmacology Research & Perspectives 2023, 11: e01151. PMID: 37961928, PMCID: PMC10644204, DOI: 10.1002/prp2.1151.Peer-Reviewed Original Research
2013
Top3β is an RNA topoisomerase that works with fragile X syndrome protein to promote synapse formation
Xu D, Shen W, Guo R, Xue Y, Peng W, Sima J, Yang J, Sharov A, Srikantan S, Yang J, Fox D, Qian Y, Martindale JL, Piao Y, Machamer J, Joshi SR, Mohanty S, Shaw AC, Lloyd TE, Brown GW, Ko MS, Gorospe M, Zou S, Wang W. Top3β is an RNA topoisomerase that works with fragile X syndrome protein to promote synapse formation. Nature Neuroscience 2013, 16: 1238-1247. PMID: 23912945, PMCID: PMC3853347, DOI: 10.1038/nn.3479.Peer-Reviewed Original ResearchCitationsAltmetricMeSH KeywordsAnimalsAnimals, Genetically ModifiedCells, CulturedChickensDNA Topoisomerases, Type IDrosophilaDrosophila ProteinsEmbryo, MammalianEyeFragile X Mental Retardation ProteinGene Expression RegulationHumansMiceMice, Inbred C57BLNerve Tissue ProteinsNeurogenesisNeuromuscular JunctionNeuronsRNA-Binding ProteinsTransfection
2010
Dysregulation of human Toll-like receptor function in aging
Shaw AC, Panda A, Joshi SR, Qian F, Allore HG, Montgomery RR. Dysregulation of human Toll-like receptor function in aging. Ageing Research Reviews 2010, 10: 346-353. PMID: 21074638, PMCID: PMC3633557, DOI: 10.1016/j.arr.2010.10.007.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricAging of the innate immune system
Shaw AC, Joshi S, Greenwood H, Panda A, Lord JM. Aging of the innate immune system. Current Opinion In Immunology 2010, 22: 507-513. PMID: 20667703, PMCID: PMC4034446, DOI: 10.1016/j.coi.2010.05.003.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetric
2009
Pandemic influenza H1N1 2009, innate immunity, and the impact of immunosenescence on influenza vaccine.
Joshi SR, Shaw AC, Quagliarello VJ. Pandemic influenza H1N1 2009, innate immunity, and the impact of immunosenescence on influenza vaccine. The Yale Journal Of Biology And Medicine 2009, 82: 143-51. PMID: 20027279, PMCID: PMC2794489.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetric
Academic Achievements & Community Involvement
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Honors
honor Annual Meeting Travel Award and Special Citation for Oral Abstract
10/06/2011National AwardInfectious Diseases Society of AmericaDetailsUnited Stateshonor John W. Brackett Award for Resident Teacher
06/30/2008Yale School of Medicine AwardYale Primary Care Residency ProgramDetailsUnited Stateshonor Physician Scholar in International Health
06/01/2007Yale School of Medicine AwardYale School of Medicine / Johnson & JohnsonDetailsUnited States
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