Sameer Nagpal, MD
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Cardiovascular Medicine
Primary
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Assistant Professor
Biography
Dr. Nagpal is an Interventional Cardiologist with additional specialized training in peripheral vascular interventions. His path into medicine began at Amherst College where he graduated cum laude, majoring in Neuroscience and receiving the honor for best thesis. He then went on to medical school at Emory University School of Medicine where he decided to pursue a career in Interventional Cardiology. He completed his Internal Medicine Residency at Yale New Haven Hospital and was selected to be a Chief Medicine Resident for an additional year. He continued his training at Yale in Cardiology, Peripheral Vascular Interventions, and Interventional Cardiology and is currently a faculty member in the Section of Cardiovascular Medicine.
Appointments
Cardiovascular Medicine
Assistant ProfessorPrimary
Other Departments & Organizations
Education & Training
- Interventional Cardiology Fellow
- Yale University School of Medicine (2019)
- Cardiovascular Medicine Fellow
- Yale University School of Medicine (2018)
- Peripheral Vascular Medicine Fellow
- Yale University School of Medicine (2018)
- Chief Medical Resident
- Yale University School of Medicine (2015)
- Internal Medicine Resident
- Yale University School of Medicine (2014)
- MD
- Emory University (2011)
- BA
- Amherst College, Neuroscience (2006)
Research
Research at a Glance
Yale Co-Authors
Frequent collaborators of Sameer Nagpal's published research.
Publications Timeline
A big-picture view of Sameer Nagpal's research output by year.
Kim Germaine Emiel Smolderen, PhD, MSc
Carlos Mena-Hurtado, MD, FACC, FSCAI, FAHA
Christopher Regan, MD, FACC, FSCAI
Alexandra Lansky, MD, FACC, FAHA, FESC
Edouard Aboian, MD
S. Elissa Altin, MD
30Publications
119Citations
Publications
2024
Sex-specific analysis of intravascular lithotripsy for peripheral artery disease from the Disrupt PAD III observational study
Nagpal S, Altin S, McGinigle K, Mangalmurti S, Adams G, Shammas N, Mehrle A, Soukas P, Bertolet B, Lansky A. Sex-specific analysis of intravascular lithotripsy for peripheral artery disease from the Disrupt PAD III observational study. European Journal Of Vascular And Endovascular Surgery 2024, 67: e22-e23. DOI: 10.1016/j.ejvs.2024.01.026.Peer-Reviewed Original Research
2023
Sex-specific analysis of intravascular lithotripsy for peripheral artery disease from the Disrupt PAD III observational study
Nagpal S, Altin S, McGinigle K, Mangalmurti S, Adams G, Shammas N, Mehrle A, Soukas P, Bertolet B, Lansky A. Sex-specific analysis of intravascular lithotripsy for peripheral artery disease from the Disrupt PAD III observational study. Journal Of Vascular Surgery 2023, 79: 358-365. PMID: 37925039, DOI: 10.1016/j.jvs.2023.10.058.Peer-Reviewed Original ResearchCitationsAltmetricConceptsPeripheral artery diseaseLower extremity peripheral artery diseaseIntravascular lithotripsyResidual stenosisArtery diseaseAcute safetyObservational studyLow ankle-brachial indexUse of IVLChronic limb-threatening ischemiaFinal residual stenosisPeripheral intravascular lithotripsySevere lesion calcificationAnkle-brachial indexLimb-threatening ischemiaReference vessel sizeAbrupt vessel closureHigh complication rateRates of diabetesFisher's exact testSex-specific analysesAngiographic complicationsAtherectomy useIVL treatmentEfficacy outcomesWireless pulmonary artery sensor implantation in a unilateral lung transplant recipient
Kelly R, Bae J, Mansour A, Nagpal S, Hahn S, Murugiah K. Wireless pulmonary artery sensor implantation in a unilateral lung transplant recipient. Journal Of Cardiology Cases 2023, 28: 216-220. PMID: 38024115, PMCID: PMC10658300, DOI: 10.1016/j.jccase.2023.08.004.Peer-Reviewed Case Reports and Technical NotesAltmetricConceptsPulmonary artery pressure monitorLung transplant recipientsLung transplantationCardioMEMS deviceTransplant recipientsHeart failurePressure monitorPulmonary artery injuryPulmonary artery pressureDevice-related complicationsSelective pulmonary angiographyFirst such caseArtery pressureVentricular failureArtery injuryHemodynamic managementPost transplantationHemodynamic assessmentPulmonary angiographyRight PAInvasive monitoringTransplantationSignificant tortuositySmall caliberTwo yearsIntravascular Imaging Use by Intermediate to High-Volume US Operators – A Medicare Data Analysis
See C, Sawano M, Nagpal S, Chamie D, Curtis J, Murugiah K. Intravascular Imaging Use by Intermediate to High-Volume US Operators – A Medicare Data Analysis. Journal Of The Society For Cardiovascular Angiography & Interventions 2023, 2: 100977. PMID: 37854494, PMCID: PMC10584013, DOI: 10.1016/j.jscai.2023.100977.Peer-Reviewed Original ResearchCitationsAltmetricCommunity distress and risk of adverse outcomes after peripheral vascular intervention
Schenck C, Strand E, Smolderen K, Romain G, Nagpal S, Cleman J, Blume P, Mena-Hurtado C. Community distress and risk of adverse outcomes after peripheral vascular intervention. Journal Of Vascular Surgery 2023, 78: 166-174.e3. PMID: 36944389, PMCID: PMC11146282, DOI: 10.1016/j.jvs.2023.03.027.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPeripheral vascular interventionsDistressed Communities IndexMajor amputationRisk of mortalityAdverse outcomesVascular interventionsVascular Quality Initiative databaseDCI scoresCommunity distressCox regression modelTime-dependent receiverCharacteristic curve analysisClinical characteristicsFinal cohortPrimary outcomeClinical outcomesCardiovascular diseasePatientsAmputationZip code dataMortalityRisk categoriesCurve analysisInitiative databaseOutcomes- Nagpal S, Altin SE, McGinigle K, Mangalmurti SS, Adams G, Shammas NW, Mehrle A, Soukas P, Bertolet B, Lansky AJ. Sex-specific analysis of intravascular lithotripsy for peripheral artery disease from the Disrupt PAD III Observational Study. J Vasc Surg. In pressPeer-Reviewed Original Research In Press
2022
Real‐world VASCADE closure device versus manual compression use and outcomes in patients with severe common femoral artery disease
Nagpal S, Scierka LE, Castro‐Dominguez Y, Kansal D, Kunnirickal S, Hussain Y, Love K, Aboian E, Smolderen KG, Mena‐Hurtado C. Real‐world VASCADE closure device versus manual compression use and outcomes in patients with severe common femoral artery disease. Catheterization And Cardiovascular Interventions 2022, 100: 776-784. PMID: 36129818, DOI: 10.1002/ccd.30405.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPeripheral vascular interventionsManual compressionClosure deviceCommon femoral artery diseaseVascular Quality Initiative databaseFemoral artery diseasePropensity-matched cohortPseudoaneurysm rateRetroperitoneal bleedingArtery diseaseRetrospective reviewMean ageBaseline variablesInstitutional databaseNonsignificant reductionNonsignificant decreaseVascular interventionsMortality ratePatientsCompression useCollagen plugDiseaseInitiative databaseProcedural metricsDevice useTCT-207 Intravascular Lithotripsy for Calcified Peripheral Artery Disease (PAD) in Female vs Male Patients: Sex-Specific Analysis From the Disrupt PAD III Observational Study
Nagpal S, McGinigle K, Mangalmurti S, Adams G, Shammas N, Soukas P, Bertolet B, Lansky A. TCT-207 Intravascular Lithotripsy for Calcified Peripheral Artery Disease (PAD) in Female vs Male Patients: Sex-Specific Analysis From the Disrupt PAD III Observational Study. Journal Of The American College Of Cardiology 2022, 80: b83-b84. DOI: 10.1016/j.jacc.2022.08.244.Peer-Reviewed Original ResearchAntiplatelet regimens following carotid artery revascularization
Lee M, Ahmed ZV, Huang J, Brice A, Arham A, Castro-Dominguez Y, Aboian E, Nagpal S, Smolderen KG, Mena-Hurtado C. Antiplatelet regimens following carotid artery revascularization. American Heart Journal 2022, 253: 48-52. PMID: 35863439, DOI: 10.1016/j.ahj.2022.07.004.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsDual antiplatelet therapySingle antiplatelet therapyCarotid artery stentingCarotid endarterectomyAntiplatelet therapyReal-world clinical practiceCarotid artery revascularizationLow adherence ratesArtery revascularizationArtery stentingAdherence ratesClinical practicePatientsTherapyEngland dataHigh percentageRevascularizationAntiplateletEndarterectomyStentingThe shifting care and outcomes for patients with endangered limbs – Critical limb ischemia (SCOPE-CLI) registry overview of study design and rationale
Scierka LE, Mena-Hurtado C, Shishehbor MH, Spertus JA, Nagpal S, Babrowski T, Bunte MC, Politano A, Humphries M, Chung J, Kirksey L, Alabi O, Soukas P, Parikh S, Faizer R, Fitridge R, Provance J, Romain G, McMillan N, Stone N, Scott K, Fuss C, Pacheco CM, Gosch K, Harper-Brooks A, Smolderen KG, Consortium O. The shifting care and outcomes for patients with endangered limbs – Critical limb ischemia (SCOPE-CLI) registry overview of study design and rationale. IJC Heart & Vasculature 2022, 39: 100971. PMID: 35198727, PMCID: PMC8850321, DOI: 10.1016/j.ijcha.2022.100971.Peer-Reviewed Original ResearchCitationsAltmetricConceptsCritical limb ischemiaTreatment preferencesPeripheral artery diseaseProspective observational registryPatient-centered outcomesPatterns of carePoor wound healingHealth status outcomesProcess of careCLI careObservational registryLimb ischemiaPatient characteristicsArtery diseaseVascular centersVital statusMean agePatient preferencesPatient's perspectiveSevere formPatientsPsychosocial factorsStatus outcomesHealth statusCare experiences
Clinical Trials
Current Trials
CRUSH PAD: Real-world Outcomes Following Use of the Shockwave Intravascular Lithotripsy (IVL) Technology in Calcified Common Femoral Lesions
HIC ID2000031113RoleSub InvestigatorPrimary Completion Date12/31/2023Recruiting ParticipantsGenderBothAge18+ years
Academic Achievements and Community Involvement
activity Reviewer
Peer Review Groups and Grant Study SectionsJournal of Society of Cardiovascular Angiography and InterventionsDetails07/01/2023 - PresentDescriptionPeer-review for manuscript submissions to JSCAIactivity Intravascular Lithotripsy for Symptomatic Calcified Peripheral Artery Disease: Sex-Specific Analysis From the Disrupt PAD III Observational STudy
Oral PresentationTCTDetails10/24/2023 - PresentBoston, MA, United Statesactivity Intravascular Lithotripsy for Treatment of Coronary and Peripheral Artery Disease
LectureCardiac Catheterization ConferenceDetails01/11/2023 - 01/11/2023New Haven, CT, United StatesSponsored by Yale University School of Medicineactivity Physiology Guided Peripheral Vascular Interventions
Oral PresentationYale Interventional Cardiology CME ProgramDetails11/18/2022 - PresentNew Haven, CT, United Stateshonor 2nd place poster case presentation
Regional AwardAmerican College of Cardiology CT ChapterDetails03/08/2021United States
Clinical Care
Overview
Sameer Nagpal, MD, is an interventional cardiologist with specialized training in peripheral vascular interventions, or PVIs. PVIs are procedures used to treat peripheral artery disease or atherosclerosis by restoring blood flow to the lower extremities and eliminating numbness, pain, and the need for amputation.
Dr. Nagpal’s research has explored the use of the VASCADE closure device (VCD) system to treat severe peripheral artery disease compared to the standard treatment of manual compression. In a study published in the journal Catheterization and Cardiovascular Interventions, Dr. Nagpal and fellow researchers found that the 30-day mortality rates were similar between the two patient groups and there was no difference in minor or major complications.
He earned his medical degree from Emory University and is an assistant professor of medicine (interventional cardiology) at Yale School of Medicine.
Clinical Specialties
Interventional Cardiology; Cardiovascular Medicine
Fact Sheets
Peripheral Vascular Disease (PVD)
Learn More on Yale MedicinePheochromocytoma
Learn More on Yale MedicineEndovascular Brain Surgery
Learn More on Yale MedicinePeripheral Artery Disease (PAD)
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News
- May 01, 2024
Yale Department of Internal Medicine Faculty Promotions and Appointments (May 2024)
- November 21, 2022
Most-read Content of November: Analysis of patient-focused web pages about LAAO, PROMPT-LIPID, and antiplatelet regimens
- September 22, 2022
VASCADE Closure Device: Patient Characteristics and Outcomes Similar to Standard of Care
- November 10, 2021
10th Annual Update on Interventional Cardiology Meeting Recap
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