Mark Perazella, MD
Professor Emeritus of MedicineDownloadHi-Res Photo
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Appointments
Nephrology
Primary
Additional Titles
Director, Acute Dialysis Unit
Medical Director, Yale Physician Associate Program
Medical Director, Yale PA Online Program
Contact Info
Appointments
Nephrology
Primary
Additional Titles
Director, Acute Dialysis Unit
Medical Director, Yale Physician Associate Program
Medical Director, Yale PA Online Program
Contact Info
Appointments
Nephrology
Primary
Additional Titles
Director, Acute Dialysis Unit
Medical Director, Yale Physician Associate Program
Medical Director, Yale PA Online Program
Contact Info
About
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Titles
Professor Emeritus of Medicine
Director, Acute Dialysis Unit; Medical Director, Yale Physician Associate Program; Medical Director, Yale PA Online Program
Appointments
Nephrology
EmeritusPrimary
Other Departments & Organizations
- All Institutions
- Internal Medicine
- Nephrology
- Yale Ventures
Education & Training
- MD
- New York Medical College (1988)
- Resident
- St. Mary's Hospital
- Fellow
- Yale University School of Medicine
Research
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Overview
Medical Research Interests
Dialysis; Drug-Related Side Effects and Adverse Reactions; Hemodialysis Units, Hospital; HIV; Hypotension; Kidney Diseases; Kidney Failure, Chronic; Nephrogenic Fibrosing Dermopathy; Nephrology
ORCID
0000-0002-6994-2659
Research at a Glance
Yale Co-Authors
Frequent collaborators of Mark Perazella's published research.
Publications Timeline
A big-picture view of Mark Perazella's research output by year.
Research Interests
Research topics Mark Perazella is interested in exploring.
Dennis G Moledina, MD, PhD, FASN
F. Perry Wilson, MD, MSCE
Randy Luciano, MD, PhD
Chirag Parikh, MD, PhD, FACP
Megan Leila Baker, MD
Ali Abu-Alfa, MD, FASN, FAHA
179Publications
6,773Citations
Kidney Failure, Chronic
Kidney Diseases
Drug-Related Side Effects and Adverse Reactions
Hypotension
Nephrology
Publications
2026
Conventional cytotoxic chemotherapy-associated nephrotoxicity
Perazella M, Forni L, Lentini P, Cosmai L, Whitman A, Jaimes E. Conventional cytotoxic chemotherapy-associated nephrotoxicity. Kidney International 2026 PMID: 41881107, DOI: 10.1016/j.kint.2026.01.037.Peer-Reviewed Original ResearchAltmetricConceptsCytotoxic chemotherapyKidney injuryClinical manifestationsCancer therapyConventional cytotoxic chemotherapyCytotoxic chemotherapy drugsManagement of kidney injuryPredisposing Risk FactorsChronic kidney injuryMechanisms of nephrotoxicityAnti-cancer effectsManifestation of nephrotoxicityPatient survivalRenal complicationsTargeted agentsOnco-NephrologyChemotherapy drugsNephrotoxicityRisk factorsMitomycin C.ChemotherapyTherapyInjuryImmunotherapyPemetrexedCancer Therapy and the Kidney
Izzedine H, Perazella M, Kuruvada K, Jhaveri K. Cancer Therapy and the Kidney. Kidney International 2026 PMID: 41866123, DOI: 10.1016/j.kint.2026.01.036.Peer-Reviewed Original ResearchAltmetricConceptsAnti-cancer therapyAcute kidney injuryChronic kidney diseasePatients' qualityConventional cytotoxic chemotherapyModern cancer therapyKidney related complicationsPatients' quality of lifeVulnerable patient populationCytotoxic chemotherapyDose reductionRenal outcomesRenal toxicityRelated complicationsTargeted agentsElectrolyte disordersKidney injuryKidney functionPathophysiological mechanismsPatient populationKidney diseaseCancer therapyTherapyCancer treatmentQuality of life
2025
Biology of drug-induced acute nephrotoxicity: focus on the tubulointerstitium
Krishnan N, Perazella M. Biology of drug-induced acute nephrotoxicity: focus on the tubulointerstitium. Nephrology Dialysis Transplantation 2025, gfaf266. PMID: 41395877, DOI: 10.1093/ndt/gfaf266.Peer-Reviewed Original ResearchCitationsAltmetricConceptsAcute kidney injuryChronic kidney diseaseKidney injuryMechanism of injuryTubulointerstitial injuryDrug exposureHigh indexHigh index of clinical suspicionDegree of drug exposureDrug-related toxic effectsCase of acute tubulointerstitial nephritisIndex of clinical suspicionSusceptibility to renal injuryRisk factorsMonitoring of kidney functionResponse to drug exposureAcute tubulointerstitial nephritisAcute tubular injuryAcute tubulointerstitial injuryChronic kidney injuryDrug-induced nephrotoxicityIndependent of doseClinical suspicionTubulointerstitial nephritisClinical characteristicsThe nephrotoxic effects of anti-cancer therapies: consensus report of the 34th Acute Disease Quality Initiative workgroup
Renaghan A, Ostermann M, Ronco C, Ballen K, Cosmai L, Fenoglio R, Floris M, Forni L, Gladstone D, Glezerman I, Goldstein S, Gupta S, Herrmann S, Jaimes E, Jhaveri K, Karam S, Kitchlu A, Landau H, Latcha S, Leaf D, Lentini P, Małyszko J, Markowitz G, Murakami N, Pani A, Perazella M, Rashidi A, Roccatello D, Sharon E, Sprangers B, Tesař V, Torres V, Wanchoo R, Whitman A, Workeneh B, Zepeda-Orozco D, Rosner M. The nephrotoxic effects of anti-cancer therapies: consensus report of the 34th Acute Disease Quality Initiative workgroup. Nature Reviews Nephrology 2025, 22: 283-300. PMID: 41361704, DOI: 10.1038/s41581-025-01031-3.Peer-Reviewed Original ResearchCitationsAltmetricConceptsKidney diseaseNephrotoxic effectsDrug doseChimeric antigen receptor T-cell therapyEffects of anti-cancer therapyEarly detection of nephrotoxicityEffective conventional chemotherapyImmune-based therapiesT-cell therapyHaematopoietic cell transplantationOptimal drug doseDetection of nephrotoxicityEarly detectionAnti-cancer therapyKidney replacement therapyChronic kidney diseaseLife-saving therapyAcute kidney diseaseKidney function estimationInternational panel of expertsTherapy toxicityConventional chemotherapyCell transplantationTargeted therapyReplacement therapyOnco-nephrology education marches on: Highlights from the Turin Onco-Nephrology Congress
Rashidi A, Perazella M. Onco-nephrology education marches on: Highlights from the Turin Onco-Nephrology Congress. Journal Of Onco-Nephrology 2025 DOI: 10.1177/23993693251398908.Peer-Reviewed Original ResearchCitationsUrine Microscopy
Cavanaugh C, Perazella M. Urine Microscopy. Kidney360 2025, 6: 1837-1839. PMID: 41264406, PMCID: PMC12626671, DOI: 10.34067/kid.0000000985.Peer-Reviewed Original ResearchNephrotoxicity of conventional chemotherapeutics: part 1—platinum compounds and antimetabolite agents
Kelly A, Sharma S, Mamlouk O, Hassanein M, Chowdhury R, Gupta S, Troung H, Bonilla M, Kalra K, Wanchoo R, Pariswala T, Turcotte A, Zaveri I, Dernell C, Ibrahim M, Patel M, Eskander S, Gudsoorkar P, Jhaveri K, Perazella M, Hanna P. Nephrotoxicity of conventional chemotherapeutics: part 1—platinum compounds and antimetabolite agents. Nephrology Dialysis Transplantation 2025, gfaf251. PMID: 41247096, DOI: 10.1093/ndt/gfaf251.Peer-Reviewed Original ResearchAltmetricNephrotoxicity of conventional chemotherapeutics: part II—non-platinum agents and miscellaneous nephrotoxic drugs
Kelly A, Sharma S, Mamlouk O, Hassanein M, Chowdhury R, Gupta S, Truong H, Bonilla M, Kalra K, Wanchoo R, Pariswala T, Turcotte A, Zaveri I, Dernell C, Ibrahim M, Patel M, Eskander S, Gudsoorkar P, Jhaveri K, Perazella M, Hanna P. Nephrotoxicity of conventional chemotherapeutics: part II—non-platinum agents and miscellaneous nephrotoxic drugs. Nephrology Dialysis Transplantation 2025, gfaf220. PMID: 41105138, DOI: 10.1093/ndt/gfaf220.Peer-Reviewed Original ResearchAltmetricConceptsKidney-protective strategiesAdverse kidney outcomesOncological benefitNephrotoxic drugsPredictive biomarkersKidney outcomesToxicity profileCytotoxic drugsChemotherapeutic agentsKidney functionRenal implicationsAnticancer therapyNephrotoxic effectsSide effectsAlkylating agentsNephrotoxicityPatientsCancerKidneyDrugPreventive measuresAgentsAssociation of Kidney Interstitial Infiltrate with and Without Tubulitis with Histological Acute Tubulointerstitial Nephritis
Mukherjee J, Sadarangani S, Shelton K, Shaw M, Liang C, Koval E, Kent C, Perazella M, Luciano R, Turner J, Moeckel G, Kuperman M, Rosenberg A, Kumar D, Wilson F, Parikh C, Moledina D. Association of Kidney Interstitial Infiltrate with and Without Tubulitis with Histological Acute Tubulointerstitial Nephritis. Journal Of The American Society Of Nephrology 2025, 36: 10.1681/asn.2025555bfcpt. DOI: 10.1681/asn.2025555bfcpt.Peer-Reviewed Original ResearchUrinary CXCL9 as a Predictive Biomarker of Corticosteroid Responsiveness in Acute Tubulointerstitial Nephritis
Sadarangani S, Obeid W, Moeckel G, Kuperman M, Kumar D, Rosenberg A, Perazella M, Turner J, Luciano R, Parikh C, Moledina D. Urinary CXCL9 as a Predictive Biomarker of Corticosteroid Responsiveness in Acute Tubulointerstitial Nephritis. Journal Of The American Society Of Nephrology 2025, 36: 10.1681/asn.20258762wsmf. DOI: 10.1681/asn.20258762wsmf.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
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Activities
activity American Society of Nephrology
07/01/2015 - PresentMeeting Planning and ParticipationDirectorDetailsASN Education Co-Director, Board Review Course and Update (BRCU)activity National Kidney Foundation
05/01/2019 - PresentMeeting Planning and ParticipationChairDetailsChair of the NKF Spring Clinical Meeting 2020 (Co-Chair for the meeting in 2019)activity American Society of Nephrology
07/01/2019 - PresentJournal ServiceEditorDetailsDeputy Editor for ASN journal Kidney360activity Italian Society of Nephrology
07/01/2017 - PresentJournal ServiceEditorDetailsCo-Editor-in-Chief for the Journal of Onco-Nephrologyactivity American Society of Nephrology
11/01/2013 - 11/01/2017Meeting Planning and ParticipationChairDetailsChair of the ASN Onco-Nephology Forum
Honors
honor Robert G. Narins Lifetime Achievement Award in Education
07/07/2022National AwardAmerican Society of NephrologyDetailsUnited Stateshonor Donald W. Seldin Distinguished Award
10/02/2020National AwardNational Kidney FoundationDetailsUnited Stateshonor Department of Medicine Faculty Achievement Award in Education
07/01/2005Yale School of Medicine AwardYale University, Department of MedicineDetailsUnited States
News
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News
- December 01, 2023
Dr. Mark Perazella, Internationally Renowned Nephrologist, Retires at Year End
- October 24, 2023
Yale Contributions Shape ASN Kidney Week 2023
- May 25, 2023
YSM PA Online Graduates Celebrated for "Fierce Advocacy"
- May 11, 2023
Discoveries & Impact (May 2023)
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