Hyojin Park
Associate Research ScientistCards
About
Research
Publications
2023
Genetic or therapeutic neutralization of ALK1 reduces LDL transcytosis and atherosclerosis in mice
Lee S, Schleer H, Park H, Jang E, Boyer M, Tao B, Gamez-Mendez A, Singh A, Folta-Stogniew E, Zhang X, Qin L, Xiao X, Xu L, Zhang J, Hu X, Pashos E, Tellides G, Shaul P, Lee W, Fernandez-Hernando C, Eichmann A, Sessa W. Genetic or therapeutic neutralization of ALK1 reduces LDL transcytosis and atherosclerosis in mice. Nature Cardiovascular Research 2023, 2: 438-448. PMID: 39196046, PMCID: PMC11358031, DOI: 10.1038/s44161-023-00266-2.Peer-Reviewed Original ResearchLDL transcytosisLDL receptor knockout miceReceptor knockout miceAtherosclerotic cardiovascular diseaseLow-density lipoprotein accumulationHigh-fat dietPromising therapeutic strategyTherapeutic neutralizationMacrophage infiltrationTriglyceride levelsLDL entryCardiovascular diseaseSelective monoclonal antibodiesLipoprotein accumulationTherapeutic strategiesKnockout micePlaque formationAtherosclerosis initiationType 1Genetic deletionArterial wallMonoclonal antibodiesEndothelial cellsLDL accumulationMice
2022
Traffic Patterns of the Migrating Endothelium: How Force Transmission Regulates Vascular Malformation and Functional Shunting During Angiogenic Remodelling
Edgar LT, Park H, Crawshaw JR, Osborne JM, Eichmann A, Bernabeu MO. Traffic Patterns of the Migrating Endothelium: How Force Transmission Regulates Vascular Malformation and Functional Shunting During Angiogenic Remodelling. Frontiers In Cell And Developmental Biology 2022, 10: 840066. PMID: 35663401, PMCID: PMC9160721, DOI: 10.3389/fcell.2022.840066.Peer-Reviewed Original ResearchCell polarityCell-cell adherens junctionsAngiogenic remodellingEndothelial cellsAggregation of cellsMixed populationRearrangement of cellsVascular patterningAdherens junctionsForce transmissionALK1 receptorCell migrationAbnormal remodellingNew targetsEC dynamicsCellsMouse retinaRemodellingMigrationPolarityPopulationMutations
2021
Specialized endothelial tip cells guide neuroretina vascularization and blood-retina-barrier formation
Zarkada G, Howard JP, Xiao X, Park H, Bizou M, Leclerc S, Künzel SE, Boisseau B, Li J, Cagnone G, Joyal JS, Andelfinger G, Eichmann A, Dubrac A. Specialized endothelial tip cells guide neuroretina vascularization and blood-retina-barrier formation. Developmental Cell 2021, 56: 2237-2251.e6. PMID: 34273276, PMCID: PMC9951594, DOI: 10.1016/j.devcel.2021.06.021.Peer-Reviewed Original ResearchConceptsSuperficial retinal vascular plexusRetinal vascular plexusTGF-β receptor IRetinal vascular developmentEndothelial tip cellsMouse neuroretinaIschemic retinopathyRetinal revascularizationVascular malformationsAngiogenic therapyReceptor IUnique transcriptional signatureVascular plexusNeural functionPericyte differentiationTranscriptional signatureComplex branching patternsRevascularizationEndothelial deletionPlexus formationSmad effectorsTissue vascularizationPrimary targetVascular developmentBranching patternDefective Flow-Migration Coupling Causes Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia
Park H, Furtado J, Poulet M, Chung M, Yun S, Lee S, Sessa WC, Franco CA, Schwartz MA, Eichmann A. Defective Flow-Migration Coupling Causes Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia. Circulation 2021, 144: 805-822. PMID: 34182767, PMCID: PMC8429266, DOI: 10.1161/circulationaha.120.053047.Peer-Reviewed Original ResearchConceptsActivin receptor-like kinase 1Hereditary hemorrhagic telangiectasiaHemorrhagic telangiectasiaVascular malformationsArteriovenous malformationsBlood flowGrowth factor receptor 2Endothelial growth factor receptor 2Vascular endothelial growth factor receptor 2Factor receptor 2Receptor-like kinase 1New potential targetsYAP/TAZ nuclear translocationDeficient miceTransmembrane serine-threonine kinase receptorsDevastating disorderAlk1 deletionReceptor 2Pharmacologic inhibitionCre linesPostnatal retinaMalformationsSerine-threonine kinase receptorsEndothelial cell migrationNuclear translocation
2019
MicroRNA-148a/b-3p regulates angiogenesis by targeting neuropilin-1 in endothelial cells.
Kim H, Ko Y, Park H, Zhang H, Jeong Y, Kim Y, Noh M, Park S, Kim YM, Kwon YG. MicroRNA-148a/b-3p regulates angiogenesis by targeting neuropilin-1 in endothelial cells. Exp Mol Med 2019, 51: 1-11. PMID: 31723119, DOI: 10.1038/s12276-019-0344-x.Peer-Reviewed Original Research
2017
Integrative analysis of DNA methylation and mRNA expression during differentiation of umbilical cord blood derived mononuclear cells to endothelial cells.
Jeong Y, Jun Y, Kim J, Park H, Choi KS, Zhang H, Park JA, Kwon JY, Kim YM, Lee S, Kwon YG. Integrative analysis of DNA methylation and mRNA expression during differentiation of umbilical cord blood derived mononuclear cells to endothelial cells. Gene 2017, 635: 48-60. PMID: 28887159, DOI: 10.1016/j.gene.2017.09.006.Peer-Reviewed Original ResearchSac-1004, a vascular leakage blocker, reduces cerebral ischemia-reperfusion injury by suppressing blood-brain barrier disruption and inflammation.
Zhang H, Park JH, Maharjan S, Park JA, Choi KS, Park H, Jeong Y, Ahn JH, Kim IH, Lee JC, Cho JH, Lee IK, Lee CH, Hwang IK, Kim YM, Suh YG, Won MH, Kwon YG. Sac-1004, a vascular leakage blocker, reduces cerebral ischemia-reperfusion injury by suppressing blood-brain barrier disruption and inflammation. J Neuroinflammation 2017, 14: 122. PMID: 28645333, DOI: 10.1186/s12974-017-0897-3.Peer-Reviewed Original ResearchCarbohydrate-binding protein CLEC14A regulates VEGFR-2- and VEGFR-3-dependent signals during angiogenesis and lymphangiogenesis.
Lee S, Rho SS, Park H, Park JA, Kim J, Lee IK, Koh GY, Mochizuki N, Kim YM, Kwon YG. Carbohydrate-binding protein CLEC14A regulates VEGFR-2- and VEGFR-3-dependent signals during angiogenesis and lymphangiogenesis. J Clin Invest 2017, 127: 457-471. PMID: 27991863, DOI: 10.1172/JCI85145.Peer-Reviewed Original Research
2015
AMIGO2, a novel membrane anchor of PDK1, controls cell survival and angiogenesis via Akt activation.
Park H, Lee S, Shrestha P, Kim J, Park JA, Ko Y, Ban YH, Park DY, Ha SJ, Koh GY, Hong VS, Mochizuki N, Kim YM, Lee W, Kwon YG. AMIGO2, a novel membrane anchor of PDK1, controls cell survival and angiogenesis via Akt activation. J Cell Biol 2015, 211: 619-37. PMID: 26553931, DOI: 10.1083/jcb.201503113.Peer-Reviewed Original ResearchBMP9 Induces Cord Blood-Derived Endothelial Progenitor Cell Differentiation and Ischemic Neovascularization via ALK1.
Kim J, Kim M, Jeong Y, Lee WB, Park H, Kwon JY, Kim YM, Hwang D, Kwon YG. BMP9 Induces Cord Blood-Derived Endothelial Progenitor Cell Differentiation and Ischemic Neovascularization via ALK1. Arterioscler Thromb Vasc Biol 2015, 35: 2020-31. PMID: 26229139, DOI: 10.1161/ATVBAHA.115.306142.Peer-Reviewed Original Research