Featured Publications
Toward a Clearer Definition of Selection Bias When Estimating Causal Effects
Lu H, Cole S, Howe C, Westreich D. Toward a Clearer Definition of Selection Bias When Estimating Causal Effects. Epidemiology 2022, 33: 699-706. PMID: 35700187, PMCID: PMC9378569, DOI: 10.1097/ede.0000000000001516.Peer-Reviewed Original ResearchRevisiting Overadjustment Bias
Lu H, Cole S, Platt R, Schisterman E. Revisiting Overadjustment Bias. Epidemiology 2021, 32: e22-e23. PMID: 34172691, DOI: 10.1097/ede.0000000000001377.Peer-Reviewed Original ResearchClinical Effectiveness of Integrase Strand Transfer Inhibitor–Based Antiretroviral Regimens Among Adults With Human Immunodeficiency Virus: A Collaboration of Cohort Studies in the United States and Canada
Lu H, Cole S, Westreich D, Hudgens M, Adimora A, Althoff K, Silverberg M, Buchacz K, Li J, Edwards J, Rebeiro P, Lima V, Marconi V, Sterling T, Horberg M, Gill M, Kitahata M, Eron J, Moore R. Clinical Effectiveness of Integrase Strand Transfer Inhibitor–Based Antiretroviral Regimens Among Adults With Human Immunodeficiency Virus: A Collaboration of Cohort Studies in the United States and Canada. Clinical Infectious Diseases 2020, 73: e1408-e1414. PMID: 32780095, PMCID: PMC8492356, DOI: 10.1093/cid/ciaa1037.Peer-Reviewed Original ResearchConceptsIntegrase strand transfer inhibitorsHuman immunodeficiency virusHazard ratioEFV groupAntiretroviral therapyStrand transfer inhibitorsClinical outcomesRisk differenceINSTI groupComposite outcomeImmunodeficiency virusClinical effectivenessNorth American AIDS Cohort CollaborationFirst-line antiretroviral therapyEnd-stage liver diseaseLong-term clinical effectivenessEnd-stage renal diseaseLong-term clinical outcomesComposite clinical outcomeFirst ART regimenInitial ART regimensAdverse clinical outcomesModern antiretroviral therapyTransfer inhibitorsAcute myocardial infarctionFour targets: an enhanced framework for guiding causal inference from observational data.
Lu H, Li F, Lesko CR, Fink DS, Rudolph KE, Harhay MO, Rentsch CT, Fiellin DA, Gonsalves GS. Four targets: an enhanced framework for guiding causal inference from observational data. Int J Epidemiol 2024, 54 PMID: 39868475, DOI: 10.1093/ije/dyaf003.Peer-Reviewed Original ResearchSelection Bias Requires Selection: The Case of Collider Stratification Bias
Lu H, Gonsalves G, Westreich D. Selection Bias Requires Selection: The Case of Collider Stratification Bias. American Journal Of Epidemiology 2023, 193: 407-409. PMID: 37939152, PMCID: PMC10911840, DOI: 10.1093/aje/kwad213.Peer-Reviewed Original Research
2025
Frequency and Intensity of Depressive Symptoms and Frequency of Prescribed Opioid Use Among Older Adults in the United States: Results of a National Survey.
Zhu X, Ge S, Ma W, Wu L, Ma H, Hu J, Lu H, Lin X. Frequency and Intensity of Depressive Symptoms and Frequency of Prescribed Opioid Use Among Older Adults in the United States: Results of a National Survey. J Addict Nurs 2025 PMID: 39919217, DOI: 10.1097/JAN.0000000000000604.Peer-Reviewed Original ResearchSpatiotemporal Trends of Birth Defects in North Carolina, 2003-2015
Lu H, Olshan AF, Serre ML, Anthony KM, Fry RC, Forestieri NE, Keil AP. Spatiotemporal Trends of Birth Defects in North Carolina, 2003-2015. Annals of Epidemiology. Revise & Resubmission.Peer-Reviewed Original Research
2024
Revisiting Representativeness
Lu H, Zivich PN, Rudulph JE, Liew Z, Mukherjee B, Li F. Revisiting Representativeness. International Journal of Epidemiology. Under Review.Peer-Reviewed Original ResearchReducing Information and Selection Bias in EHR-Linked Biobanks via Genetics-Informed Multiple Imputation and Sample Weighting
Salvatore M, Kundu R, Du J, Friese CR, Mondul AM, Hanauer D, Lu H, Pearce CL, Mukherjee B. Reducing Information and Selection Bias in EHR-Linked Biobanks via Genetics-Informed Multiple Imputation and Sample Weighting. Under Review.Peer-Reviewed Original ResearchThe Influence of Perinatal Psychological Changes on Infant Neurodevelopment in Shanghai, China: A Longitudinal Group-based Trajectory Analysis.
Zhang J, Lu H, Sheng Q, Zang E, Zhang Y, Yuan H, Chen B, Tang W. The Influence of Perinatal Psychological Changes on Infant Neurodevelopment in Shanghai, China: A Longitudinal Group-based Trajectory Analysis. J Affect Disord 2024, 361: 291-298. PMID: 38876315, DOI: 10.1016/j.jad.2024.06.029.Peer-Reviewed Original ResearchThe Evolution of Selection Bias in the Recent Epidemiologic Literature—A Selective Overview
Lu H, Howe C, Zivich P, Gonsalves G, Westreich D. The Evolution of Selection Bias in the Recent Epidemiologic Literature—A Selective Overview. American Journal Of Epidemiology 2024, kwae282. PMID: 39136207, DOI: 10.1093/aje/kwae282.Peer-Reviewed Original ResearchSynergistic interaction between pay-it-forward incentives and recreational drug use on hepatitis B virus and hepatitis C virus testing among men who have sex with men in China
Ai W, Xie Y, Lu H, Ai T, Wu D, Zhang Y, Marley G, Ong J, Tucker J, Tang W. Synergistic interaction between pay-it-forward incentives and recreational drug use on hepatitis B virus and hepatitis C virus testing among men who have sex with men in China. Sexually Transmitted Infections 2024, 100: 302-309. PMID: 38862237, PMCID: PMC11283352, DOI: 10.1136/sextrans-2024-056150.Peer-Reviewed Original ResearchHepatitis C virus testingHepatitis C virus testing uptakePay-it-forwardTesting uptakeRecreational drug useStandard-of-care groupIncentive groupPromote hepatitis B virusDrug useHepatitis testingChinese MSMAdditive scaleMSMCommunity connectednessDrug use behaviorsRecreational drugsDonation opportunitiesFree testingParticipantsPooled dataHepatitis B virusHepatitis C virusUse behaviorsMenStudy groupAccessibility of Opioid Treatment Programs Based on Conventional vs Perceived Travel Time Measures
Kim J, Lee J, Thornhill T, Dennett J, Lu H, Howell B, Grau L, Fiellin D, Heimer R, Gonsalves G. Accessibility of Opioid Treatment Programs Based on Conventional vs Perceived Travel Time Measures. JAMA Network Open 2024, 7: e240209. PMID: 38376839, PMCID: PMC10879949, DOI: 10.1001/jamanetworkopen.2024.0209.Peer-Reviewed Original ResearchConceptsTransit travel timeAccessibility metricsTravel timeTravel componentsAccessibility scoresTransportation burdenTravel burdenOut-of-vehicleComponents of travelConventional accessibility measuresSpatial regression modelsTravel time measurementsPublic transitTransit schedulesAccessibility measuresDeparture timeTravel time analysisTrip durationTravelOperating hoursTime analysisCross-sectional studyOpioid use disorderPolicy recommendationsDecision-making
2023
Pay-it-forward incentives for hepatitis virus testing in men who have sex with men: a cluster randomized trial
Zhang Y, Li J, Xie Y, Wu D, Ong J, Marley G, Kamarulzaman A, Lu H, Zou F, Smith J, Tucker J, Fu G, Tang W. Pay-it-forward incentives for hepatitis virus testing in men who have sex with men: a cluster randomized trial. Nature Medicine 2023, 29: 2241-2247. PMID: 37640859, DOI: 10.1038/s41591-023-02519-w.Peer-Reviewed Original ResearchConceptsHepatitis B virusCare armHCV testingVirus testingTwo-arm cluster-randomized trialHepatitis C virus testingHepatitis virus testingCluster-randomized trialProportion of menGroup of menAdverse eventsHBV testPrimary outcomeB virusForward armFree testingHCVMenRapid testingSexTrialsArmActive community participationTestingPersonsDietary Polyphenol Intake and Risk of Hypertension: An 18-y Nationwide Cohort Study in China.
Lin X, Zhao J, Ge S, Lu H, Xiong Q, Guo X, Li L, He S, Wang J, Peng F, Fan Y, Zuo X, Tian C, Ying C. Dietary Polyphenol Intake and Risk of Hypertension: An 18-y Nationwide Cohort Study in China. Am J Clin Nutr 2023, 118: 264-272. PMID: 37146758, DOI: 10.1016/j.ajcnut.2023.05.001.Peer-Reviewed Original ResearchOptimizing Treatment for Human Immunodeficiency Virus to Improve Clinical Outcomes Using Precision Medicine
Jetsupphasuk M, Hudgens M, Lu H, Cole S, Edwards J, Adimora A, Althoff K, Silverberg M, Rebeiro P, Lima V, Marconi V, Sterling T, Horberg M, Gill M, Kitahata M, Moore R, Lang R, Gebo K, Rabkin C, Eron J. Optimizing Treatment for Human Immunodeficiency Virus to Improve Clinical Outcomes Using Precision Medicine. American Journal Of Epidemiology 2023, 192: 1341-1349. PMID: 36922393, PMCID: PMC10666965, DOI: 10.1093/aje/kwad057.Peer-Reviewed Original ResearchConceptsEfavirenz-based regimenAntiretroviral therapyPatient characteristicsComposite outcomeNorth American AIDS Cohort CollaborationFirst-line antiretroviral therapySerious non-AIDS eventsHuman immunodeficiency virus (HIV) treatmentIntegrase strand transfer inhibitorsSame drug regimenBaseline patient characteristicsNon-AIDS eventsAbsolute risk reductionSubgroup of patientsHuman immunodeficiency virusIndividual patient characteristicsImmune deficiency syndromePrecision medicineStrand transfer inhibitorsCohort CollaborationCause mortalityDrug regimenClinical outcomesImmunodeficiency virusDeficiency syndromeGeographic and temporal trends in fentanyl-detected deaths in Connecticut, 2009–2019
Lu H, Crawford F, Gonsalves G, Grau L. Geographic and temporal trends in fentanyl-detected deaths in Connecticut, 2009–2019. Annals Of Epidemiology 2023, 79: 32-38. PMID: 36669599, PMCID: PMC10163838, DOI: 10.1016/j.annepidem.2023.01.009.Peer-Reviewed Original Research
2022
Prescribed opioid use is associated with increased all-purpose emergency department visits and hospitalizations in community-dwelling older adults in the United States.
Ge S, Tian C, Wu L, Liu M, Lu H. Prescribed opioid use is associated with increased all-purpose emergency department visits and hospitalizations in community-dwelling older adults in the United States. Front Psychiatry 2022, 13: 1092199. PMID: 36582257, DOI: 10.3389/fpsyt.2022.1092199.Peer-Reviewed Original ResearchEliminating conversion therapy and promoting LGBTQ-affirmative therapy in China
Li G, Qin S, Lu H, Santtila P, Hall B. Eliminating conversion therapy and promoting LGBTQ-affirmative therapy in China. The Lancet Psychiatry 2022, 9: e25. PMID: 35569506, DOI: 10.1016/s2215-0366(22)00120-1.Peer-Reviewed Original ResearchCorrigendum to: Clinical Effectiveness of Integrase Strand Transfer Inhibitor–Based Antiretroviral Regimens Among Adults With Human Immunodeficiency Virus: A Collaboration of Cohort Studies in the United States and Canada
Lu H, Cole S, Westreich D, Hudgens M, Adimora A, Althoff K, Silverberg M, Buchacz K, Li J, Edwards J, Rebeiro P, Lima V, Marconi V, Sterling T, Horberg M, Gill M, Kitahata M, Eron J, Moore R. Corrigendum to: Clinical Effectiveness of Integrase Strand Transfer Inhibitor–Based Antiretroviral Regimens Among Adults With Human Immunodeficiency Virus: A Collaboration of Cohort Studies in the United States and Canada. Clinical Infectious Diseases 2022, 74: 755-755. PMID: 35099554, PMCID: PMC8886892, DOI: 10.1093/cid/ciab799.Peer-Reviewed Original Research