Daniela Tirziu, PhD
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Appointments
Cardiovascular Medicine
Primary
Titles
Associate Director of Academic Research, Yale Cardiovascular Research Group
Contact Info
Appointments
Cardiovascular Medicine
Primary
Titles
Associate Director of Academic Research, Yale Cardiovascular Research Group
Contact Info
Appointments
Cardiovascular Medicine
Primary
Titles
Associate Director of Academic Research, Yale Cardiovascular Research Group
Contact Info
About
Titles
Senior Research Scientist
Associate Director of Academic Research, Yale Cardiovascular Research GroupBiography
Dr. Tirziu is a Research Scientist and Associate Director of Academic Research (YCRG) who’s oversaw and served as an instrumental member of numerous, innovative advancements in the cardiovascular medicine, specifically in the fields of atherosclerosis, angiogenesis, myocardial hypertrophy, heart failure and medical devices. Dr. Tirziu’s clinical research is focused on the design, reporting and regulatory documentations for interventional cardiovascular device trials, including First-in-Human, CE Mark, IDE/IND Phase III and IV trials and post marketing studies in the US and worldwide. She has made important contributions to clinical research documents, regulatory documents (clinical trial protocols and study reports) and meta-analyses to guide clinical investigation on several novel cardiovascular devices and cerebral embolic protection devices. Dr. Tirziu's research on the basic science front contributed to the understanding of cellular crosstalk in the heart and unraveled a novel molecular mechanism of endothelium-dependent regulation of myocardial hypertrophy and metabolism.
Appointments
Cardiovascular Medicine
Senior Research ScientistPrimary
Other Departments & Organizations
Education & Training
- Research Associate (postdoctoral training)
- Dartmouth Medical School, Dartmouth-Hitchcock Medical Center (2006)
- PhD
- Romanian Academy of Sciences (2000)
Research
Overview
Dr. Tirziu has made substantial contributions to scientifically sound clinical research documents, regulatory documents (clinical trial protocols and study reports) and meta-analyses to guide clinical investigation on several novel cardiovascular devices and cerebral embolic protection devices during transcatheter heart procedures.
On the basic science front, findings from Dr. Tirziu's laboratory showed that stimulation of angiogenesis in the heart promotes cardiomyocyte growth and myocardial hypertrophy through a nitric oxide (NO)-dependent mechanism involving the degradation of regulator of G protein signaling type 4 (RGS4) and de-repression of the Gβγ/PI3Kγ/Akt/mTORC1 pathway with the up-regulation of miR-182 and miR-146b expression in cardiomyocytes.
Medical Subject Headings (MeSH)
Cardiovascular Diseases; Cell Communication; Clinical Trial; Endothelium, Vascular; Endothelium-Dependent Relaxing Factors; Gene Regulatory Networks; Heart Diseases; Heart Failure; MicroRNAs; Publication Characteristics
ORCID
0000-0003-4908-6493
Research at a Glance
Yale Co-Authors
Frequent collaborators of Daniela Tirziu's published research.
Publications Timeline
A big-picture view of Daniela Tirziu's research output by year.
Research Interests
Research topics Daniela Tirziu is interested in exploring.
Alexandra Lansky, MD, FACC, FAHA, FESC
Helen Parise, ScD
Cody Pietras
John K Forrest, MD, FACC, FSCAI
Michael Cleman, MD
S. Elissa Altin, MD
48Publications
1,206Citations
Endothelium, Vascular
Heart Failure
MicroRNAs
Cell Communication
Publications
2024
Determining the Cause of Coronary Vasomotor Disorders in Patients With Ischemia and Nonobstructive Coronary Arteries: Design and Rationale of the DISCOVER INOCA Prospective, Multicenter Registry
Shah S, Tremmel J, Henry T, Smilowitz N, Prasad M, Kobayashi Y, Henry G, Samady H, Samuels B, Lerman A, Moses J, Pietras C, Zhang Z, Tirziu D, Parise H, Cristea E, Chamié D, Grubman D, Henrici K, Matmusaeva E, Latif N, Cigarroa N, Lansky A. Determining the Cause of Coronary Vasomotor Disorders in Patients With Ischemia and Nonobstructive Coronary Arteries: Design and Rationale of the DISCOVER INOCA Prospective, Multicenter Registry. Journal Of The Society For Cardiovascular Angiography & Interventions 2024, 3: 102046. DOI: 10.1016/j.jscai.2024.102046.Peer-Reviewed Original ResearchCitationsAltmetricConceptsCoronary function testingObstructive coronary artery diseaseCoronary artery diseaseNonobstructive coronary arteriesLong-term outcomesFollow-upVasomotor disordersEnd pointsComposite of cardiovascular deathCoronary arteryLong-term follow-upCoronary microvascular dysfunctionDiagnostic coronary angiographyCardiovascular adverse eventsAdverse cardiovascular eventsCoronary vasomotor disordersOptical coherence tomographySymptomatic myocardial bridgingShort-term end pointsAtherosclerotic plaque burdenIschemic heart diseaseLong-term end pointsINOCA patientsAcetylcholine provocationPatient-reported outcome measuresSAFETY AND EFFICACY OF ENDOVASCULAR TREATMENT MODALITIES FOR BELOW-THE-KNEE PERIPHERAL ARTERIAL DISEASE: A SYSTEMATIC REVIEW AND NETWORK META-ANALYSIS
Tirziu D, Saleh A, Huang H, Akhlaghi N, Breen T, Parikh S, Rosenfield K, Armstrong E, Geraghty P, Brodmann M, Adams G, Snyder D, Zilinyi R, Altin S, Parise H, Lansky A. SAFETY AND EFFICACY OF ENDOVASCULAR TREATMENT MODALITIES FOR BELOW-THE-KNEE PERIPHERAL ARTERIAL DISEASE: A SYSTEMATIC REVIEW AND NETWORK META-ANALYSIS. Journal Of The American College Of Cardiology 2024, 83: 843. DOI: 10.1016/s0735-1097(24)02833-x.Peer-Reviewed Original Research
2023
Impact of sex on Transcatheter aortic valve replacement outcomes: Results of a single-center study
See C, Wang Y, Yang Y, Tirziu D, Papoutsidakis N, Francese D, Kaple R, Cleman M, Lansky A, Forrest J. Impact of sex on Transcatheter aortic valve replacement outcomes: Results of a single-center study. International Journal Of Cardiology 2023, 398: 131643. PMID: 38065329, DOI: 10.1016/j.ijcard.2023.131643.Peer-Reviewed Original ResearchCitationsConceptsNew-generation valvesTranscatheter Aortic Valve Replacement OutcomesImpact of sexTAVR outcomesArtery diseaseYale-New Haven HospitalSTS mortality scorePeripheral artery diseaseSingle-center studyCoronary artery diseaseKaplan-Meier curvesLog-rank testNew Haven HospitalSex-based disparitiesSignificant differencesCardiovascular comorbiditiesSAPIEN 3Transfemoral accessSAPIEN XTConsecutive patientsCox modelingMortality scoreEvolut RFemale sexEvolut PROPercutaneous Transluminal Angioplasty for Infrapopliteal Chronic Limb-Threatening Ischemia: A Systematic Review and Meta-analysis of Primary Patency and Binary Restenosis Rates.
Snyder D, Zilinyi R, Pruthi S, George S, Tirziu D, Lansky A, Mintz A, Sethi S, Parikh S. Percutaneous Transluminal Angioplasty for Infrapopliteal Chronic Limb-Threatening Ischemia: A Systematic Review and Meta-analysis of Primary Patency and Binary Restenosis Rates. Journal Of Endovascular Therapy 2023, 15266028231212133. PMID: 38008929, DOI: 10.1177/15266028231212133.Peer-Reviewed Original ResearchCitationsAltmetricConceptsChronic limb-threatening ischemiaPercutaneous transluminal angioplastyBinary restenosis ratePrimary patencyPrimary patency rateBinary restenosisTransluminal angioplastyRestenosis rateFuture RCTsPatency ratesTrial dataChronic limb threatening ischemiaLimb threatening ischemiaLimb-threatening ischemiaRandom-effects modelMeta-analysis demonstrateIntermittent claudicationEndovascular therapyCochrane CENTRALPower calculationMeta-analysis estimatesControl armPatencyRCTsSystematic reviewImpact and Implications of Neurocognitive Dysfunction in the Management of Ischemic Heart Failure
Tirziu D, Kołodziejczak M, Grubman D, Carrión C, Driskell L, Ahmad Y, Petrie M, Omerovic E, Redfors B, Fremes S, Browndyke J, Lansky A. Impact and Implications of Neurocognitive Dysfunction in the Management of Ischemic Heart Failure. Journal Of The Society For Cardiovascular Angiography & Interventions 2023, 2: 101198. DOI: 10.1016/j.jscai.2023.101198.Peer-Reviewed Original ResearchAltmetricConceptsIschemic heart failureHeart failureNeurocognitive dysfunctionCognitive impairmentCoronary Artery Bypass GraftingArtery Bypass GraftingChronic cerebral hypoperfusionCoronary artery bypassPercutaneous coronary interventionPoor cognitive functionArtery bypassBypass GraftingCardiovascular outcomesCerebral hypoperfusionCoronary revascularizationCerebral hypoxiaCoronary interventionNeurologic injuryCardiac outputWorse outcomesBrain damageBrain injuryPatient outcomesInvasive approachPatient managementTCT-627 Binary Restenosis Rates Following Percutaneous Transluminal Angioplasty for Below-the-Knee Chronic Limb-Threatening Ischemia: A Meta-Analysis of Randomized Controlled Trial Data
Snyder D, Zilinyi R, Pruthi S, George S, Tirziu D, Lansky A, Mintz A, Sethi S, Parikh S. TCT-627 Binary Restenosis Rates Following Percutaneous Transluminal Angioplasty for Below-the-Knee Chronic Limb-Threatening Ischemia: A Meta-Analysis of Randomized Controlled Trial Data. Journal Of The American College Of Cardiology 2023, 82: b252-b253. DOI: 10.1016/j.jacc.2023.09.638.Peer-Reviewed Original ResearchAltmetricSupervised Exercise Therapy Versus Percutaneous Transluminal Angioplasty for Claudication by Level of Disease: A Systematic Review and Meta-Analysis
Kapadia S, Huang H, Parise H, Ismayl M, Ahmed Z, Tirziu D, Altin S. Supervised Exercise Therapy Versus Percutaneous Transluminal Angioplasty for Claudication by Level of Disease: A Systematic Review and Meta-Analysis. The American Journal Of Cardiology 2023, 205: 403-405. PMID: 37659260, DOI: 10.1016/j.amjcard.2023.08.044.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsChocolate Touch Versus Lutonix Drug-Coated Balloon for Femoropopliteal Lesions in Diabetes: The Chocolate Touch Study.
Böhme T, Zeller T, Shishehbor M, Werner M, Brodmann M, Parise H, Holden A, Lichtenberg M, Parikh S, Kashyap V, Pietras C, Tirziu D, Beschorner U, Krishnan P, Niazi K, Wali A, Lansky A. Chocolate Touch Versus Lutonix Drug-Coated Balloon for Femoropopliteal Lesions in Diabetes: The Chocolate Touch Study. Journal Of Endovascular Therapy 2023, 15266028231179589. PMID: 37314243, DOI: 10.1177/15266028231179589.Peer-Reviewed Original ResearchCitationsConceptsLutonix drug-coated balloonDrug-coated balloonsPrimary safety endpointDM statusFemoropopliteal diseaseDiabetes mellitusSafety endpointFemoropopliteal lesionsSimilar safetyHigh-risk patient populationFemoropopliteal artery lesionsIschemic rest painNon-DM patientsSymptomatic femoropopliteal lesionsPrimary efficacy endpointMajor adverse eventsTherapy of choiceDrug-Coated BalloonMajor amputationRest painEfficacy endpointPrimary patencyAdverse eventsArtery lesionsDiabetes statusImpact of New-Onset Conduction Disturbances following Transcatheter Aortic Valve Replacement on Outcomes: A Single-Center Study
See C, Wang Y, Huang H, Parise H, Yang Y, Tirziu D, Francese D, Papoutsidakis N, Bader E, Kaple R, Cleman M, Lansky A, Forrest J. Impact of New-Onset Conduction Disturbances following Transcatheter Aortic Valve Replacement on Outcomes: A Single-Center Study. Journal Of Interventional Cardiology 2023, 2023: 5390338. PMID: 37292113, PMCID: PMC10247319, DOI: 10.1155/2023/5390338.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsTranscatheter aortic valve replacementNew-onset conduction disturbancesAortic valve replacementPersistent conduction disturbancesConduction disturbancesValve replacementSurgical aortic valve replacementSingle-center retrospective analysisYale-New Haven HospitalSingle-center studyCause mortality ratesCause mortality riskLong-term outcomesNew Haven HospitalPeriprocedural factorsAortic stenosisConsecutive patientsTAVR proceduresTerm outcomesRetrospective analysisMortality riskMortality ratePatientsOutcomesPatient's ECGAntiplatelet Strategies Following PCI: A Review of Trials Informing Current and Future Therapies
Thomas A, Gitto M, Shah S, Saito Y, Tirziu D, Chieffo A, Stefanini G, Lansky A. Antiplatelet Strategies Following PCI: A Review of Trials Informing Current and Future Therapies. Journal Of The Society For Cardiovascular Angiography & Interventions 2023, 2: 100607. DOI: 10.1016/j.jscai.2023.100607.Peer-Reviewed Original ResearchCitationsAltmetricConceptsDual antiplatelet therapyAntiplatelet regimensPatient-specific risk profileShorter DAPT durationDuration of therapyPercutaneous coronary interventionDAPT strategyIschemic riskAntiplatelet therapyDAPT durationAntiplatelet strategiesCoronary interventionOngoing trialsMajor trialsRecent trialsPractice guidelinesFuture therapiesRisk profileTherapyStent technologyTrialsRegimensNumber of trialsSignificant reductionSignificant changes
Academic Achievements and Community Involvement
honor FAHA
National AwardAmerican Heart AssociationDetails11/11/2013United Stateshonor “Junior Investigator Award”
National AwardThe Society for Vascular Medicine and the North American Vascular Biology OrganizationDetails06/18/2005United Stateshonor “Magna cum laudae”
International AwardRomanian Academy of Sciences, Institute of Cellular Biology and Pathology “Nicolae Simionescu”, RomaniaDetails12/21/2000United Stateshonor “Constantin Velican Award” for research in atherosclerosis and cardiovascular diseases
International AwardRomanian Society for Cell BiologyDetails06/10/1998United States
Links & Media
News
- April 01, 2024
Yale Faculty Present Groundbreaking Clinical Research at the 2024 American College of Cardiology Scientific Sessions
- February 01, 2023
2023 American College of Cardiology late-breaking clinical trials and abstracts from Yale
- July 15, 2021
Discoveries & Impact (July 2021)
- April 29, 2021
ACC 2021: Late-Breaking Studies Highlight New Treatment Protocols