2022
Practices, attitudes, and confidence related to tobacco treatment interventions in HIV clinics: a multisite cross-sectional survey
Bold KW, Deng Y, Dziura J, Porter E, Sigel KM, Yager JE, Ledgerwood DM, Bernstein SL, Edelman EJ. Practices, attitudes, and confidence related to tobacco treatment interventions in HIV clinics: a multisite cross-sectional survey. Translational Behavioral Medicine 2022, 12: 726-733. PMID: 35608982, PMCID: PMC9260059, DOI: 10.1093/tbm/ibac022.Peer-Reviewed Original ResearchMeSH KeywordsAttitude of Health PersonnelCross-Sectional StudiesHIV InfectionsHumansSmoking CessationTobaccoTobacco UseTobacco Use DisorderUnited StatesConceptsTobacco use disorderHIV clinicHIV cliniciansExact testBrief smoking cessation interventionMultisite cross-sectional surveyHIV clinic settingFirst-line medicationImpact of smokingMedication side effectsClinical practice guidelinesSmoking cessation interventionTobacco treatment interventionsFisher's exact testCross-sectional surveyProvision of careChi-square testAntiretroviral treatmentCounseling patientsTobacco treatmentCessation interventionsClinic settingPractice guidelinesTobacco useProvider characteristics
2021
Development and usability evaluation of VOICES: A digital health tool to identify elder mistreatment
Abujarad F, Ulrich D, Edwards C, Choo E, Pantalon MV, Jubanyik K, Dziura J, D'Onofrio G, Gill TM. Development and usability evaluation of VOICES: A digital health tool to identify elder mistreatment. Journal Of The American Geriatrics Society 2021, 69: 1469-1478. PMID: 33615433, PMCID: PMC8192463, DOI: 10.1111/jgs.17068.Peer-Reviewed Original ResearchAssociation of Race/Ethnicity and Other Demographic Characteristics With Use of Physical Restraints in the Emergency Department
Wong AH, Whitfill T, Ohuabunwa EC, Ray JM, Dziura JD, Bernstein SL, Taylor RA. Association of Race/Ethnicity and Other Demographic Characteristics With Use of Physical Restraints in the Emergency Department. JAMA Network Open 2021, 4: e2035241. PMID: 33492372, PMCID: PMC7835716, DOI: 10.1001/jamanetworkopen.2020.35241.Peer-Reviewed Original Research
2019
Elevated renalase levels in patients with acute coronary microvascular dysfunction – A possible biomarker for ischemia
Safdar B, Guo X, Johnson C, D'Onofrio G, Dziura J, Sinusas AJ, Testani J, Rao V, Desir G. Elevated renalase levels in patients with acute coronary microvascular dysfunction – A possible biomarker for ischemia. International Journal Of Cardiology 2019, 279: 155-161. PMID: 30630613, PMCID: PMC6482834, DOI: 10.1016/j.ijcard.2018.12.061.Peer-Reviewed Original ResearchConceptsCoronary microvascular dysfunctionFramingham risk scorePET/CTChest painInflammatory markersMicrovascular dysfunctionEmergency departmentRisk scoreRb-82 PET/CTElevated renalase levelsAcute chest painCoronary artery diseaseC-reactive proteinVascular endothelial growth factorAnti-inflammatory proteinTumor necrosis factorEndothelial growth factorAngina historyCMD diagnosisRenalase levelsHypertensive crisisED presentationsHemodynamic instabilityArtery diseaseHeart failure
2017
Evaluation of a novel 5-group classification system of sepsis by vasopressor use and initial serum lactate in the emergency department
Swenson KE, Dziura JD, Aydin A, Reynolds J, Wira CR. Evaluation of a novel 5-group classification system of sepsis by vasopressor use and initial serum lactate in the emergency department. Internal And Emergency Medicine 2017, 13: 257-268. PMID: 28132131, DOI: 10.1007/s11739-017-1607-y.Peer-Reviewed Original ResearchConceptsInitial serum lactate levelSerum lactate levelsEmergency departmentLactate elevationVasoplegic shockLactate levelsCryptic shockVasopressor useInfected patientsShock mortalityHigh-risk ED patientsGroup mortality rateInitial serum lactateVasopressor-dependent patientsIdentifiable risk factorsSepsis-3 definitionRisk-stratify patientsHigh-risk subgroupsInitial lactate levelProximal phaseVasopressor dependenceVasopressor requirementHospital outcomesED patientsSerum lactate
2015
Trends in Any and High-Dose Opioid Analgesic Receipt Among Aging Patients With and Without HIV
Becker WC, Gordon K, Jennifer Edelman E, Kerns RD, Crystal S, Dziura JD, Fiellin LE, Gordon AJ, Goulet JL, Justice AC, Fiellin DA. Trends in Any and High-Dose Opioid Analgesic Receipt Among Aging Patients With and Without HIV. AIDS And Behavior 2015, 20: 679-686. PMID: 26384973, PMCID: PMC5006945, DOI: 10.1007/s10461-015-1197-5.Peer-Reviewed Original ResearchReported health conditions in animals residing near natural gas wells in southwestern Pennsylvania
Slizovskiy IB, Conti LA, Trufan SJ, Reif JS, Lamers VT, Stowe MH, Dziura J, Rabinowitz PM. Reported health conditions in animals residing near natural gas wells in southwestern Pennsylvania. Journal Of Environmental Science And Health Part A 2015, 50: 473-481. PMID: 25734823, DOI: 10.1080/10934529.2015.992666.Peer-Reviewed Original ResearchConceptsNatural gas extractionExtraction activitiesHealth impact assessmentHuman health risk assessmentNatural gas extraction activitiesNatural gas wellsHealth risk assessmentGas extraction activitiesGas extractionPotential health risksNatural gas drillingContaminant exposureEnvironmental Health SurveyImpact assessmentAnimal populationsAnimal disease eventsRisk assessmentNearby communitiesHealth risksSouthwestern PennsylvaniaHealth conditionsHealth impactsBackyard animalsAssessment processCommunityAssociation of inpatient and outpatient glucose management with inpatient mortality among patients with and without diabetes at a major academic medical center
Butala NM, Johnson BK, Dziura JD, Reynolds JS, Bozzo JE, Balcezak TJ, Inzucchi SE, Horwitz LI. Association of inpatient and outpatient glucose management with inpatient mortality among patients with and without diabetes at a major academic medical center. Journal Of Hospital Medicine 2015, 10: 228-235. PMID: 25627860, PMCID: PMC4390436, DOI: 10.1002/jhm.2321.Peer-Reviewed Original ResearchConceptsAcademic medical centerGlycemic controlGlucose controlMedical CenterIntensive care unit admissionCross-sectional observational studyCare unit admissionNon-ICU patientsOutpatient glycemic controlCardiovascular risk managementOdds of mortalityLength of stayMajor academic medical centerInpatient glycemic controlDisproportionate reductionHospital mortalityUnit admissionInpatient mortalityICU patientsSurgical patientsDischarge diagnosisNonobstetric patientsGlucose managementObservational studyInpatient discharges
2013
New Media Use by Patients Who Are Homeless: The Potential of mHealth to Build Connectivity
Post LA, Vaca FE, Doran KM, Luco C, Naftilan M, Dziura J, Brandt C, Bernstein S, Jagminas L, D'Onofrio G. New Media Use by Patients Who Are Homeless: The Potential of mHealth to Build Connectivity. Journal Of Medical Internet Research 2013, 15: e195. PMID: 24001876, PMCID: PMC3786002, DOI: 10.2196/jmir.2724.Peer-Reviewed Original ResearchConceptsED patientsHomeless patientsUnmet health care needsCross-sectional observational studyAlcohol/substance abuseEmergency department visitsAdjusted odds ratioHealth care needsStable housingPotential of mHealthDepartment visitsSmoking cessationPrimary careOdds ratioObservational studyCare needsPatientsExperienced homelessnessSubstance abuseMental healthHealth carePoor accessHealth informationSignificant differencesDescriptive statistics
2011
Effect of Contact Lens Power on Optical Coherence Tomography of the Retinal Nerve Fiber Layer
Salchow DJ, Hwang AM, Li FY, Dziura J. Effect of Contact Lens Power on Optical Coherence Tomography of the Retinal Nerve Fiber Layer. Investigative Ophthalmology & Visual Science 2011, 52: 1650-1654. PMID: 21051707, DOI: 10.1167/iovs.10-6118.Peer-Reviewed Original ResearchMeSH KeywordsAdultContact LensesCross-Sectional StudiesFemaleHumansMaleNerve FibersRefractive ErrorsRetinal Ganglion CellsTomography, Optical CoherenceConceptsRNFL thickness measurementsOptical coherence tomographyContact lens powerRNFL thicknessNerve fiber layer thickness measurementsRetinal nerve fiber layer (RNFL) thickness measurementsCoherence tomographyRetinal nerve fiber layerLens powerClock-hour segmentsPeripapillary RNFL thicknessGlobal RNFL thicknessNerve fiber layerRefractive error changesCross-sectional studyGlobal RNFLInferior quadrantTime-domain OCTInferior segmentCorneal planeHealthy subjectsRefractive surgeryStudy subjectsThickness measurementsFiber layer
2010
Renal Ultrasonography in the Evaluation of Acute Kidney Injury: Developing a Risk Stratification Framework
Licurse A, Kim MC, Dziura J, Forman HP, Formica RN, Makarov DV, Parikh CR, Gross CP. Renal Ultrasonography in the Evaluation of Acute Kidney Injury: Developing a Risk Stratification Framework. JAMA Internal Medicine 2010, 170: 1900-1907. PMID: 21098348, DOI: 10.1001/archinternmed.2010.419.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAgedCreatinineCross-Sectional StudiesDecision Support TechniquesFemaleHospitalizationHumansHydronephrosisKidneyLikelihood FunctionsMaleMiddle AgedMultivariate AnalysisPredictive Value of TestsRacial GroupsRecurrenceRetrospective StudiesRisk AssessmentRisk FactorsUltrasonographyUreteral ObstructionUrinary Tract InfectionsConceptsAcute kidney injuryKidney injuryAdult inpatientsIncidental findingPrerenal acute kidney injuryRecurrent urinary tract infectionsMultivariable logistic regression modelYale-New Haven HospitalHistory of hydronephrosisElevated creatinine levelRenal transplant recipientsCongestive heart failureUrinary tract infectionHigh-risk groupLow-risk groupCross-sectional studyLogistic regression modelsNephrotoxic medicationsTransplant recipientsClinical characteristicsCreatinine levelsNonblack raceRenal ultrasonographyTract infectionsHeart failure
2009
Comparison of Neurocognitive Functioning in Children Previously Randomly Assigned to Intrathecal Methotrexate Compared With Triple Intrathecal Therapy for the Treatment of Childhood Acute Lymphoblastic Leukemia
Kadan-Lottick NS, Brouwers P, Breiger D, Kaleita T, Dziura J, Northrup V, Chen L, Nicoletti M, Bostrom B, Stork L, Neglia JP. Comparison of Neurocognitive Functioning in Children Previously Randomly Assigned to Intrathecal Methotrexate Compared With Triple Intrathecal Therapy for the Treatment of Childhood Acute Lymphoblastic Leukemia. Journal Of Clinical Oncology 2009, 27: 5986-5992. PMID: 19884541, PMCID: PMC2793042, DOI: 10.1200/jco.2009.23.5408.Peer-Reviewed Original ResearchMeSH KeywordsAntimetabolites, AntineoplasticAntineoplastic Combined Chemotherapy ProtocolsAttentionChildChild, PreschoolCognitionCross-Sectional StudiesCytarabineFemaleHumansHydrocortisoneInfantInjections, SpinalIntelligence TestsLinear ModelsMaleMemoryMethotrexateNeuropsychological TestsPrecursor Cell Lymphoblastic Leukemia-LymphomaPsychomotor PerformanceTime FactorsTreatment OutcomeUnited StatesConceptsAcute lymphoblastic leukemiaIT therapyIntrathecal methotrexateMethotrexate groupLymphoblastic leukemiaChildhood acute lymphoblastic leukemiaTriple intrathecal therapyPost-therapy periodLong-term neurotoxicityNeurocognitive functioningAssociation of treatmentMajority of childrenCNS prophylaxisFull-scale intelligence quotientIntrathecal therapyNeurologic eventsPsychotropic medicationsVisual-motor integrationTherapy groupAttention/concentrationNeurocognitive evaluationIndex scoreTherapyPatientsMethotrexateA comparison of neurocognitive functioning in children previously randomized to dexamethasone or prednisone in the treatment of childhood acute lymphoblastic leukemia
Kadan-Lottick NS, Brouwers P, Breiger D, Kaleita T, Dziura J, Liu H, Chen L, Nicoletti M, Stork L, Bostrom B, Neglia JP. A comparison of neurocognitive functioning in children previously randomized to dexamethasone or prednisone in the treatment of childhood acute lymphoblastic leukemia. Blood 2009, 114: 1746-1752. PMID: 19546477, PMCID: PMC2738566, DOI: 10.1182/blood-2008-12-186502.Peer-Reviewed Original ResearchConceptsAcute lymphoblastic leukemiaChildhood acute lymphoblastic leukemiaDexamethasone groupLymphoblastic leukemiaNeurocognitive functioningHigher event-free survival rateEvent-free survival rateCentral nervous system penetrationLong-term cognitive functioningPsychotropic drug usePrevious clinical trialsWorse neurocognitive functioningCorticosteroid RandomizationNeurocognitive toxicityPrednisone groupNeurologic complicationsClinical trialsSignificant overall differenceSurvival rateDrug useYounger ageWorse functioningOlder ageDiagnosisMultisite studyThe effect of gender on the prevalence of hypertension in obstructive sleep apnea
Mohsenin V, Yaggi HK, Shah N, Dziura J. The effect of gender on the prevalence of hypertension in obstructive sleep apnea. Sleep Medicine 2009, 10: 759-762. PMID: 19185538, DOI: 10.1016/j.sleep.2008.09.005.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaApnea-hypopnea indexPrevalence of hypertensionSD ageSleep apneaOSA groupContext of OSASeverity of OSAMultiple logistic regression analysisSleep disorder evaluationOdds of hypertensionClinic-based populationSleep apnea severityEffect of genderCross-sectional studyLogistic regression analysisHypertension increasesPrevalent hypertensionSystemic hypertensionObese menHighest quartileApnea severityHypertensionLarge cohortHigh risk
2008
Abdominal Obesity in Older Women: Potential Role for Disrupted Fatty Acid Reesterification in Insulin Resistance
Yeckel CW, Dziura J, DiPietro L. Abdominal Obesity in Older Women: Potential Role for Disrupted Fatty Acid Reesterification in Insulin Resistance. The Journal Of Clinical Endocrinology & Metabolism 2008, 93: 1285-1291. PMID: 18198225, PMCID: PMC2291490, DOI: 10.1210/jc.2007-1875.Peer-Reviewed Original ResearchMeSH KeywordsAbdominal FatAdipose TissueAgedCross-Sectional StudiesFatty AcidsFemaleHumansInsulin ResistanceLipolysisObesityConceptsFatty acid reesterificationPeripheral insulin resistanceAbdominal obesityInsulin resistanceHepatic glucose productionAbdominal adiposityOlder womenGlucose utilizationGeneral Clinical Research CenterBasal hepatic glucose productionGlucose productionFree fatty acid metabolismExcess abdominal adiposityPerturbed glucose metabolismGlucose-lowering medicationsHormone replacement therapyClinical Research CenterPeripheral glucose utilizationGlycerol appearance rateInactive older womenTotal body fatCross-sectional studyAbdominal circumference valuesInsulin-stimulated suppressionFree fatty acid ratio
2007
A Chitinase-like Protein in the Lung and Circulation of Patients with Severe Asthma
Chupp GL, Lee CG, Jarjour N, Shim YM, Holm CT, He S, Dziura JD, Reed J, Coyle AJ, Kiener P, Cullen M, Grandsaigne M, Dombret MC, Aubier M, Pretolani M, Elias JA. A Chitinase-like Protein in the Lung and Circulation of Patients with Severe Asthma. New England Journal Of Medicine 2007, 357: 2016-2027. PMID: 18003958, DOI: 10.1056/nejmoa073600.Peer-Reviewed Original ResearchConceptsSerum YKL-40 levelsYKL-40 levelsSeverity of asthmaYKL-40Chitinase-like proteinsParis cohortOral corticosteroid useCohort of patientsRescue inhaler useSubgroup of patientsCirculation of patientsCorticosteroid useSevere asthmaAirway remodelingClinical characteristicsExpiratory volumeAcidic mammalian chitinasePatient populationHigh serumAsthmaImmunohistochemical analysisPatientsAnimal modelsLocus of expressionMorphometric quantitationHigh Visceral and Low Abdominal Subcutaneous Fat Stores in the Obese Adolescent A Determinant of an Adverse Metabolic Phenotype
Taksali SE, Caprio S, Dziura J, Dufour S, Calí A, Goodman TR, Papademetris X, Burgert TS, Pierpont BM, Savoye M, Shaw M, Seyal AA, Weiss R. High Visceral and Low Abdominal Subcutaneous Fat Stores in the Obese Adolescent A Determinant of an Adverse Metabolic Phenotype. Diabetes 2007, 57: 367-371. PMID: 17977954, DOI: 10.2337/db07-0932.Peer-Reviewed Original ResearchConceptsMetabolic syndromeObese adolescentsInsulin resistanceVisceral fatSubcutaneous fatAdverse metabolic phenotypeC-reactive proteinSevere metabolic complicationsAbdominal subcutaneous fatBMI z-scoreProton magnetic resonance spectroscopyMulti-ethnic cohortFat-free massSubcutaneous fat depotsMagnetic resonance imagingSubcutaneous fat storesMetabolic complicationsTotal adiponectinHepatic fatLiver fatTriglyceride levelsInterleukin-6Visceral depotsOdds ratioC-peptideDegree of Obesity and Glucose Allostasis Are Major Effectors of Glucose Tolerance Dynamics in Obese Youth
Weiss R, Cali AM, Dziura J, Burgert TS, Tamborlane WV, Caprio S. Degree of Obesity and Glucose Allostasis Are Major Effectors of Glucose Tolerance Dynamics in Obese Youth. Diabetes Care 2007, 30: 1845-1850. PMID: 17475938, DOI: 10.2337/dc07-0325.Peer-Reviewed Original ResearchConceptsOral glucose tolerance testDegree of obesityElevated glucose levelsObese youthGlucose toleranceAmbient glycemiaInsulin sensitivityGlucose levelsSecond oral glucose tolerance testBaseline BMI z-scoreGlucose tolerance testBMI z-scoreAltered glucose metabolismCross-sectional analysisTolerance testInsulin sensitizationGlucose metabolismObesityZ-scoreLongitudinal assessmentLongitudinal changesMajor effectorGlycemiaSignificant reduction
2006
Adiponectin in Childhood and Adolescent Obesity and Its Association with Inflammatory Markers and Components of the Metabolic Syndrome
Winer JC, Zern TL, Taksali SE, Dziura J, Cali AM, Wollschlager M, Seyal AA, Weiss R, Burgert TS, Caprio S. Adiponectin in Childhood and Adolescent Obesity and Its Association with Inflammatory Markers and Components of the Metabolic Syndrome. The Journal Of Clinical Endocrinology & Metabolism 2006, 91: 4415-4423. PMID: 16926246, DOI: 10.1210/jc.2006-0733.Peer-Reviewed Original ResearchConceptsC-reactive proteinAdiponectin levelsMetabolic syndromeObese childrenInsulin resistanceChildhood obesityLow high-density lipoprotein cholesterolStandard oral glucose tolerance testBody mass index z-scoreHigh-density lipoprotein cholesterolOral glucose tolerance testHigher CRP levelsChronic inflammatory stateMarkers of inflammationPlasma lipid profileGlucose tolerance testIndex z-scorePotential confounding variablesCRP levelsInflammatory markersLipoprotein ratioHigh triglyceridesLipoprotein cholesterolInflammatory stateProinflammatory cytokinesAge, Rapid-Cycling, and Pharmacotherapy Effects on Ventral Prefrontal Cortex in Bipolar Disorder: A Cross-Sectional Study
Blumberg HP, Krystal JH, Bansal R, Martin A, Dziura J, Durkin K, Martin L, Gerard E, Charney DS, Peterson BS. Age, Rapid-Cycling, and Pharmacotherapy Effects on Ventral Prefrontal Cortex in Bipolar Disorder: A Cross-Sectional Study. Biological Psychiatry 2006, 59: 611-618. PMID: 16414030, DOI: 10.1016/j.biopsych.2005.08.031.Peer-Reviewed Original ResearchConceptsHealthy comparison subjectsWhite matter volumeMagnetic resonance imagingMatter volumeBD patientsHigh-resolution structural magnetic resonance imagingYoung adulthoodStructural magnetic resonance imagingTotal brain volumeCross-sectional studyGray matter volumeAge group interactionVentral prefrontal cortexPharmacotherapy effectsPrefrontal cortex functionIllness featuresBD IProtective effectVolume abnormalitiesHC subjectsComparison subjectsBrain volumeVolume deficitsBipolar disorderRapid initial decline