2017
Evaluation of a novel 5-group classification system of sepsis by vasopressor use and initial serum lactate in the emergency department
Swenson KE, Dziura JD, Aydin A, Reynolds J, Wira CR. Evaluation of a novel 5-group classification system of sepsis by vasopressor use and initial serum lactate in the emergency department. Internal And Emergency Medicine 2017, 13: 257-268. PMID: 28132131, DOI: 10.1007/s11739-017-1607-y.Peer-Reviewed Original ResearchConceptsInitial serum lactate levelSerum lactate levelsEmergency departmentLactate elevationVasoplegic shockLactate levelsCryptic shockVasopressor useInfected patientsShock mortalityHigh-risk ED patientsGroup mortality rateInitial serum lactateVasopressor-dependent patientsIdentifiable risk factorsSepsis-3 definitionRisk-stratify patientsHigh-risk subgroupsInitial lactate levelProximal phaseVasopressor dependenceVasopressor requirementHospital outcomesED patientsSerum lactate
2014
Sex Differences in Patient and Provider Response to Elevated Low-Density Lipoprotein Cholesterol
Haskell SG, Bathulapalli H, Pham T, Goulet J, Skanderson M, Driscoll M, Brandt C, Dziura J. Sex Differences in Patient and Provider Response to Elevated Low-Density Lipoprotein Cholesterol. Women's Health Issues 2014, 24: 575-580. PMID: 25213750, DOI: 10.1016/j.whi.2014.06.004.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnticholesteremic AgentsAttitude of Health PersonnelAttitude to HealthDyslipidemiasElectronic Health RecordsFemaleHealthcare DisparitiesHumansLipoproteins, LDLLogistic ModelsMaleMiddle AgedOdds RatioPractice Patterns, Physicians'Risk FactorsSex FactorsTreatment OutcomeUnited StatesConceptsCholesterol controlElevated LDLLow-density lipoprotein cholesterol controlElevated low-density lipoprotein cholesterolLow-density lipoprotein cholesterolProvider responsesAmerican Heart Association recommendationsLipid-lowering medicationsIschemic heart diseaseDiet/lifestyle modificationLifestyle modificationStatin therapyLipoprotein cholesterolPatient factorsPatient sexRisk womenClinical remindersHeart diseaseWomen patientsPatient responseTreatment goalsAssociation recommendationsLDL elevationsMedicationsWomen veterans
2012
Comparison of the Effect on Long-Term Outcomes in Patients With Thoracic Aortic Aneurysms of Taking Versus Not Taking a Statin Drug
Jovin IS, Duggal M, Ebisu K, Paek H, Oprea AD, Tranquilli M, Rizzo J, Memet R, Feldman M, Dziura J, Brandt CA, Elefteriades JA. Comparison of the Effect on Long-Term Outcomes in Patients With Thoracic Aortic Aneurysms of Taking Versus Not Taking a Statin Drug. The American Journal Of Cardiology 2012, 109: 1050-1054. PMID: 22221941, DOI: 10.1016/j.amjcard.2011.11.038.Peer-Reviewed Original ResearchConceptsThoracic aortic aneurysmLong-term outcomesComposite end pointAortic aneurysmAneurysm repairEnd pointImproved long-term outcomesOutcomes of patientsCohort of patientsKaplan-Meier analysisMedian followStatin intakeStatin therapyMedical therapyStatinsFirst presentationPatientsSurvival rateAneurysmsStatin drugsOutcomesTherapyIntakeRepairCohort
2007
Methodological issues in design and analysis of a matched case–control study of a vaccine's effectiveness
Niccolai LM, Ogden LG, Muehlenbein CE, Dziura JD, Vázquez M, Shapiro ED. Methodological issues in design and analysis of a matched case–control study of a vaccine's effectiveness. Journal Of Clinical Epidemiology 2007, 60: 1127-1131. PMID: 17938054, PMCID: PMC2096633, DOI: 10.1016/j.jclinepi.2007.02.009.Peer-Reviewed Original ResearchConceptsCase-control studyTime of vaccinationConditional logistic regression modelsPrelicensure clinical trialsLogistic regression modelsVaricella vaccineVaccine effectivenessVaccine efficacyClinical trialsVaccinationVaccineStudy designRegression modelsEfficacyAgeEffect of timeMethodological issuesTrials
2006
Adiponectin in Childhood and Adolescent Obesity and Its Association with Inflammatory Markers and Components of the Metabolic Syndrome
Winer JC, Zern TL, Taksali SE, Dziura J, Cali AM, Wollschlager M, Seyal AA, Weiss R, Burgert TS, Caprio S. Adiponectin in Childhood and Adolescent Obesity and Its Association with Inflammatory Markers and Components of the Metabolic Syndrome. The Journal Of Clinical Endocrinology & Metabolism 2006, 91: 4415-4423. PMID: 16926246, DOI: 10.1210/jc.2006-0733.Peer-Reviewed Original ResearchConceptsC-reactive proteinAdiponectin levelsMetabolic syndromeObese childrenInsulin resistanceChildhood obesityLow high-density lipoprotein cholesterolStandard oral glucose tolerance testBody mass index z-scoreHigh-density lipoprotein cholesterolOral glucose tolerance testHigher CRP levelsChronic inflammatory stateMarkers of inflammationPlasma lipid profileGlucose tolerance testIndex z-scorePotential confounding variablesCRP levelsInflammatory markersLipoprotein ratioHigh triglyceridesLipoprotein cholesterolInflammatory stateProinflammatory cytokines