2009
Glucose dysregulation and hepatic steatosis in obese adolescents: Is there a link?
Cali AM, De Oliveira AM, Kim H, Chen S, Reyes‐Mugica M, Escalera S, Dziura J, Taksali SE, Kursawe R, Shaw M, Savoye M, Pierpont B, Constable RT, Caprio S. Glucose dysregulation and hepatic steatosis in obese adolescents: Is there a link? Hepatology 2009, 49: 1896-1903. PMID: 19434725, PMCID: PMC2692562, DOI: 10.1002/hep.22858.Peer-Reviewed Original ResearchConceptsHepatic fat fractionObese adolescentsHepatic fat contentGlucose dysregulationHepatic steatosisMetabolic syndromeFatty liverInsulin sensitivityTotal fatHigher hepatic fat fractionStandard oral glucose tolerance testOral glucose tolerance testTwo-hour plasma glucoseSubcutaneous fat ratioHomeostasis model assessmentAbdominal fat distributionGlucose tolerance testProinflammatory milieuHMW adiponectinIL-6Insulin resistanceMatsuda indexTolerance testPlasma glucoseFat distribution
2006
Adiponectin in Childhood and Adolescent Obesity and Its Association with Inflammatory Markers and Components of the Metabolic Syndrome
Winer JC, Zern TL, Taksali SE, Dziura J, Cali AM, Wollschlager M, Seyal AA, Weiss R, Burgert TS, Caprio S. Adiponectin in Childhood and Adolescent Obesity and Its Association with Inflammatory Markers and Components of the Metabolic Syndrome. The Journal Of Clinical Endocrinology & Metabolism 2006, 91: 4415-4423. PMID: 16926246, DOI: 10.1210/jc.2006-0733.Peer-Reviewed Original ResearchConceptsC-reactive proteinAdiponectin levelsMetabolic syndromeObese childrenInsulin resistanceChildhood obesityLow high-density lipoprotein cholesterolStandard oral glucose tolerance testBody mass index z-scoreHigh-density lipoprotein cholesterolOral glucose tolerance testHigher CRP levelsChronic inflammatory stateMarkers of inflammationPlasma lipid profileGlucose tolerance testIndex z-scorePotential confounding variablesCRP levelsInflammatory markersLipoprotein ratioHigh triglyceridesLipoprotein cholesterolInflammatory stateProinflammatory cytokines