2022
Gender Differences in Guideline-Directed Medical Therapy for Cardiovascular Disease Among Young Veterans
Dhruva SS, Dziura J, Bathulapalli H, Rosman L, Gaffey AE, Davis MB, Brandt CA, Haskell SG. Gender Differences in Guideline-Directed Medical Therapy for Cardiovascular Disease Among Young Veterans. Journal Of General Internal Medicine 2022, 37: 806-815. PMID: 36042086, PMCID: PMC9481764, DOI: 10.1007/s11606-022-07595-1.Peer-Reviewed Original ResearchConceptsGuideline-directed medical therapyIncident coronary artery diseaseCoronary artery diseaseHeart failureMedical therapyCardiovascular diseaseWomen veteransDiagnosis of HFAldosterone system inhibitorsIncident heart failureAdverse cardiovascular outcomesClinical practice guidelinesRisk of mortalityLevel of evidenceYounger women veteransHF medicationsMultiple pharmacotherapiesAntiplatelet therapyCardiovascular outcomesYounger average ageArtery diseaseCVD careGuideline recommendationsSystem inhibitorsAdverse outcomes
2021
Use of peripheral arterial tonometry in detection of abnormal coronary flow reserve
Gaeta M, Nowroozpoor A, Dziura J, D'Onofrio G, Sinusas AJ, Safdar B. Use of peripheral arterial tonometry in detection of abnormal coronary flow reserve. Microvascular Research 2021, 138: 104223. PMID: 34256085, PMCID: PMC10227886, DOI: 10.1016/j.mvr.2021.104223.Peer-Reviewed Original ResearchConceptsLower coronary flow reserveCoronary flow reserveCoronary microvascular dysfunctionCoronary artery diseaseClinical screening toolPET/CTFlow reserveRubidium-82 positron emission tomography/Large vessel coronary artery diseaseNormal coronary flow reserveTraditional CAD risk factorsVessel coronary artery diseaseAbnormal coronary flow reservePositron emission tomography/Screening toolPeripheral arterial tonometryCAD risk factorsEmission tomography/Presence of calcificationLower RHIHyperemia indexArterial tonometryMicrovascular dysfunctionArtery diseaseAugmentation index
2019
Elevated renalase levels in patients with acute coronary microvascular dysfunction – A possible biomarker for ischemia
Safdar B, Guo X, Johnson C, D'Onofrio G, Dziura J, Sinusas AJ, Testani J, Rao V, Desir G. Elevated renalase levels in patients with acute coronary microvascular dysfunction – A possible biomarker for ischemia. International Journal Of Cardiology 2019, 279: 155-161. PMID: 30630613, PMCID: PMC6482834, DOI: 10.1016/j.ijcard.2018.12.061.Peer-Reviewed Original ResearchConceptsCoronary microvascular dysfunctionFramingham risk scorePET/CTChest painInflammatory markersMicrovascular dysfunctionEmergency departmentRisk scoreRb-82 PET/CTElevated renalase levelsAcute chest painCoronary artery diseaseC-reactive proteinVascular endothelial growth factorAnti-inflammatory proteinTumor necrosis factorEndothelial growth factorAngina historyCMD diagnosisRenalase levelsHypertensive crisisED presentationsHemodynamic instabilityArtery diseaseHeart failure
2018
Prevalence and characteristics of coronary microvascular dysfunction among chest pain patients in the emergency department
Safdar B, D’Onofrio G, Dziura J, Russell RR, Johnson C, Sinusas AJ. Prevalence and characteristics of coronary microvascular dysfunction among chest pain patients in the emergency department. European Heart Journal Acute Cardiovascular Care 2018, 9: 5-13. PMID: 29543037, DOI: 10.1177/2048872618764418.Peer-Reviewed Original ResearchConceptsCoronary microvascular dysfunctionCoronary artery diseaseCardiac positron emission tomography/Positron emission tomography/Chest pain patientsArtery diseaseAcute myocardial infarctionEmission tomography/Chest painMyocardial infarctionMicrovascular dysfunctionPain patientsEmergency departmentTomography/General emergency department populationLower coronary flow reserveNon-obstructive coronary arteriesPrior emergency department visitsTraditional cardiac risk factorsCardiac risk factorsModerate-risk patientsEmergency department visitsEmergency department patientsCoronary flow reserveEmergency department population
2017
Incident Cardiovascular Risk Factors Among Men and Women Veterans After Return From Deployment
Haskell SG, Brandt C, Burg M, Bastian L, Driscoll M, Goulet J, Mattocks K, Dziura J. Incident Cardiovascular Risk Factors Among Men and Women Veterans After Return From Deployment. Medical Care 2017, 55: 948-955. PMID: 28984707, DOI: 10.1097/mlr.0000000000000801.Peer-Reviewed Original ResearchConceptsCardiovascular risk factorsCV risk factorsRisk factorsImpact of sexWomen veteransClinical Modification diagnostic codesIncident cardiovascular risk factorsPrimary care visitsCoronary artery diseaseElectronic health record dataRisk of obesityVeterans Health AdministrationIncident risk factorsHealth record dataMental health conditionsBlack womenNew International ClassificationCare visitsCohort studyArtery diseaseFemale sexDiagnostic codesIncidence rateProtective effectInternational ClassificationDepression is associated with recurrent chest pain with or without coronary artery disease: A prospective cohort study in the emergency department
Kim Y, Soffler M, Paradise S, Jelani QU, Dziura J, Sinha R, Safdar B. Depression is associated with recurrent chest pain with or without coronary artery disease: A prospective cohort study in the emergency department. American Heart Journal 2017, 191: 47-54. PMID: 28888269, DOI: 10.1016/j.ahj.2017.06.003.Peer-Reviewed Original ResearchConceptsRecurrent chest painCoronary artery diseaseAcute chest painChest painProspective cohort studyChest pain centerClinical Anxiety ScaleEmergency departmentPerceived Stress ScalePain centerCohort studyArtery diseaseNonobstructive coronary artery diseaseObstructive coronary artery diseaseChest pain recurrenceED chest painCardiac risk factorsCardiac stress testingPatient Health QuestionnaireSignificant independent predictorsStress testingMultivariable regression modelsPain recurrenceIndependent predictorsPrimary outcomeRanolazine and Microvascular Angina by PET in the Emergency Department: Results From a Pilot Randomized Controlled Trial
Safdar B, D’Onofrio G, Dziura J, Russell RR, Johnson C, Sinusas AJ. Ranolazine and Microvascular Angina by PET in the Emergency Department: Results From a Pilot Randomized Controlled Trial. Clinical Therapeutics 2017, 39: 55-63. PMID: 28081848, PMCID: PMC10345862, DOI: 10.1016/j.clinthera.2016.12.002.Peer-Reviewed Original ResearchConceptsCoronary microvascular dysfunctionCoronary flow reserveCoronary artery diseaseChest painSymptomatic patientsArtery diseasePrimary outcomeEmergency departmentNonobstructive coronary artery diseaseRb-82 positron emission tomographyEffect of ranolazineRate-pressure productEmergency department patientsQTc-prolonging drugsRobust clinical trialsPositron emission tomographyHypertensive urgencyMicrovascular anginaMicrovascular dysfunctionUnderdiagnosed causeControlled TrialsDepartment patientsHeart failureAcute symptomsPressure product
2015
Chest pain syndromes are associated with high rates of recidivism and costs in young United States Veterans
Safdar B, Dziura J, Bathulapalli H, Leslie DL, Skanderson M, Brandt C, Haskell SG. Chest pain syndromes are associated with high rates of recidivism and costs in young United States Veterans. BMC Primary Care 2015, 16: 88. PMID: 26202799, PMCID: PMC4511555, DOI: 10.1186/s12875-015-0287-9.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseUnexplained chest painChest painUCP patientsCAD patientsArtery diseaseRisk factorsReturn visitsSpecific ICD-9 codesVeterans AffairsChest pain syndromeRecurrent chest painReference groupRetrospective cohort studyEvidence-based guidelinesICD-9 codesUnited States veteransDirect total costCAD cohortCause deathCardiac painPain syndromeCohort studyCox regressionEmergency department
2014
Elevated CK-MB with a Normal Troponin Does Not Predict 30-Day Adverse Cardiac Events in Emergency Department Chest Pain Observation Unit Patients
Safdar B, Bezek SK, Sinusas AJ, Russell RR, Klein MR, Dziura JD, D’onofrio G. Elevated CK-MB with a Normal Troponin Does Not Predict 30-Day Adverse Cardiac Events in Emergency Department Chest Pain Observation Unit Patients. Critical Pathways In Cardiology A Journal Of Evidence-Based Medicine 2014, 13: 14-19. PMID: 24526146, DOI: 10.1097/hpc.0000000000000001.Peer-Reviewed Original ResearchConceptsAdverse cardiac eventsCPU patientsNormal troponinAdverse eventsCardiac eventsMultiple logistic regression modelComposite adverse eventsElevated creatinine kinaseObservation unit patientsSerial troponin testingStandardized chart reviewRetrospective cohort studyAcute coronary syndromeNational Death RegistryCoronary artery diseaseLogistic regression modelsPositive troponinPrior CADRenal insufficientCoronary syndromeHemodynamic instabilityChart reviewCohort studyDeath RegistryIschemic electrocardiogram