2009
Early microglial inhibition preemptively mitigates chronic pain development after experimental spinal cord injury.
Tan AM, Zhao P, Waxman SG, Hains BC. Early microglial inhibition preemptively mitigates chronic pain development after experimental spinal cord injury. The Journal Of Rehabilitation Research And Development 2009, 46: 123. PMID: 19533525, DOI: 10.1682/jrrd.2008.03.0048.Peer-Reviewed Original ResearchConceptsSpinal cord injuryMicroglial activationMinocycline treatmentChronic painCord injuryAdult male Sprague-Dawley ratsLumbar dorsal horn neuronsExperimental spinal cord injuryMale Sprague-Dawley ratsDorsal horn neuronsChronic pain developmentDevelopment of painVehicle-treated animalsSprague-Dawley ratsThoracic spinal segmentsNew therapeutic strategiesQuality of lifeMicroglial inhibitionSCI painMinocycline administrationPain developmentEarly administrationPain conditionsMicroglial signalingDays postinjury
2008
Injury Enhances Resistance to Escherichia coli Infection by Boosting Innate Immune System Function
Maung AA, Fujimi S, MacConmara MP, Tajima G, McKenna AM, Delisle AJ, Stallwood C, Onderdonk AB, Mannick JA, Lederer JA. Injury Enhances Resistance to Escherichia coli Infection by Boosting Innate Immune System Function. The Journal Of Immunology 2008, 180: 2450-2458. PMID: 18250454, DOI: 10.4049/jimmunol.180.4.2450.Peer-Reviewed Original ResearchConceptsBurn-injured miceSham miceCecal ligationEnhanced innate immune responseSystemic inflammatory response syndromeInnate immune system functionRelevant sepsis modelSham-injured miceInflammatory response syndromeMac-1 expressionEscherichia coli infectionInnate immune responseSite of infectionImmune system functionPolymicrobial sepsisResponse syndromeOpportunistic infectionsSepsis modelDays postinjuryInjury causesColi infectionImmune responseCommon pathogensMajor injuriesAnimal studies
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