2025
Diaphragm dysfunction from phrenic nerve injuries during LVAD or heart transplant: Positive role of diaphragm pacing
Boutros C, Elmo M, Carl N, Abu-Omar Y, Arora R, Elgudin Y, Gray K, Pelletier M, Onders R. Diaphragm dysfunction from phrenic nerve injuries during LVAD or heart transplant: Positive role of diaphragm pacing. JHLT Open 2025, 9: 100281. PMID: 40520816, PMCID: PMC12166398, DOI: 10.1016/j.jhlto.2025.100281.Peer-Reviewed Original ResearchNon-invasive ventilationLeft ventricular assist deviceDiaphragm pacingHeart transplantationMechanical ventilationNerve injurySingle-center cohort studyPhrenic nerve dysfunctionPhrenic nerve injuryLeft ventricular assist device recipientsPhrenic injuryDiaphragm dysfunctionDifficulty weaningNerve dysfunctionNerve injuresCase seriesDiaphragm functionMV weaningDP useAdverse eventsCohort studyVentricular assist deviceHTxExploratory case seriesTransplantation
2024
Assessing Respiratory Function in the Patient with Neuromuscular Disease
Jimenez J, Choi P. Assessing Respiratory Function in the Patient with Neuromuscular Disease. Respiratory Medicine 2024, 37-57. DOI: 10.1007/978-3-031-65335-3_2.Peer-Reviewed Original ResearchSniff nasal inspiratory pressureSlow vital capacityMuscle force testsForced Vital CapacityEvaluation of diaphragm functionVital capacityRespiratory functionAccessory muscle useRespiratory muscle strengthNasal inspiratory pressureAbnormal breathing patternsHistory of symptomsNeuromuscular diseaseLongitudinal assessmentSimple spirometryNoninvasive ventilationDiaphragm functionInspiratory pressurePhysical examinationBlood carbon dioxideBreathing patternPatientsMuscle strengthMuscle useSpirometry
2021
PILOT STUDY OF PERCUTANEOUS TEMPORARY DIAPHRAGM PACING WIRES IN CARDIAC SURGERY PATIENTS AT RISK OF PROLONGED MECHANICAL VENTILATION DURING THE COVID-19 PANDEMIC
Jarrett C, Onders R, Pelletier M, Abu-Omar Y, Baeza C, Elgudin Y, Markowitz A, Vega P, Sabik J. PILOT STUDY OF PERCUTANEOUS TEMPORARY DIAPHRAGM PACING WIRES IN CARDIAC SURGERY PATIENTS AT RISK OF PROLONGED MECHANICAL VENTILATION DURING THE COVID-19 PANDEMIC. Canadian Journal Of Cardiology 2021, 37: s112-s113. PMCID: PMC8523110, DOI: 10.1016/j.cjca.2021.07.213.Peer-Reviewed Original ResearchProlonged mechanical ventilationCardiac surgery patientsCardiac surgeryDiaphragm pacingMechanical ventilationDiaphragm functionSurgery patientsHigh-risk cardiac surgery patientsVentilator induced diaphragm dysfunctionRisk of prolonged mechanical ventilationDecreased ventilation timeLikelihood of extubationPrevent diaphragm atrophyHistory of TIAOpen heart surgeryProlonged mechanical ventilation patientsRelated adverse eventsOutcomes of DPDevice related adverse eventsRandomized Controlled TrialsDiaphragm atrophyDiaphragm dysfunctionProspective trialsMedian timeVentilation timeDiaphragm Pacing in Lung Transplant Patients: To Identify and Treat Diaphragm Function Abnormalities
Onders R, Elgudin Y, Abu-Omar Y, Pelletier M, Schilz R, Chavin K, Sabik J. Diaphragm Pacing in Lung Transplant Patients: To Identify and Treat Diaphragm Function Abnormalities. The Journal Of Heart And Lung Transplantation 2021, 40: s316-s317. DOI: 10.1016/j.healun.2021.01.896.Peer-Reviewed Original ResearchVentilator induced diaphragm dysfunctionPhrenic nerve injuryIntercostal nerve cryoanalgesiaDiaphragm dysfunctionDiaphragm pacingLung transplantationNerve injuryDiaphragm electromyographyDiaphragm functionPost-operativelyMechanical ventilationRecovery of diaphragm functionLung transplant patientsPre-operative conditionDiaphragm recoveryUnilateral DDPhrenic neuropathyRemoval of electrodesTransplant recipientsTransplant patientsDiaphragm activityPost-transplantUnilateral transplantationChest incisionDP therapy
2014
Podocin and Beta Dystroglycan expression to study Podocyte-Podocyte and basement membrane matrix connections in adult protienuric states
Shankar P, Nada R, Joshi K, Kumar A, Rayat C, Sakhuja V. Podocin and Beta Dystroglycan expression to study Podocyte-Podocyte and basement membrane matrix connections in adult protienuric states. Diagnostic Pathology 2014, 9: 40. PMID: 24559085, PMCID: PMC3996081, DOI: 10.1186/1746-1596-9-40.Peer-Reviewed Original ResearchConceptsExpression of podocinSite of injuryStaining patternResistant casesBeta-dystroglycan expressionSteroid-resistant FSGSVirtual slidesThe virtual slide(sPresence of immune depositsCases of FSGSSlit diaphragm functionProtein expression of podocinCases of MCDPrimary site of injuryLoss of immunostainingPrimary podocytopathiesKidney biopsyNo significant differenceDiaphragm functionMethodsAdult patientsControl biopsiesVirtual slide(sImmune depositsModerate stainingWeak stainingDystroglycan expression
2008
Unilateral diaphragm paralysis: etiology, impact, and natural history.
Elefteriades J, Singh M, Tang P, Siegel MD, Kenney B, Pandey A, Kopf GS. Unilateral diaphragm paralysis: etiology, impact, and natural history. The Journal Of Cardiovascular Surgery 2008, 49: 289-95. PMID: 18431352.Peer-Reviewed Original ResearchConceptsUnilateral diaphragm paralysisDiaphragm paralysisChronic obstructive pulmonary diseaseNatural historyBilateral diaphragm paralysisIntact phrenic nerveObstructive pulmonary diseaseSpirometric improvementClinical improvementExpiratory volumePulmonary infectionDiaphragm resectionLeft diaphragmOccasional patientPhrenic nervePulmonary diseaseSurgical explorationDiaphragm functionLower lobeVital capacityClinical recordsClinical spectrumMean durationNeurogenic atrophyBest therapy
2001
Chronic hypoxia modulates diaphragm function in the developing rat
Kass LJ, Bazzy AR. Chronic hypoxia modulates diaphragm function in the developing rat. Journal Of Applied Physiology 2001, 90: 2325-2329. PMID: 11356799, DOI: 10.1152/jappl.2001.90.6.2325.Peer-Reviewed Original ResearchConceptsOne-half relaxation timeNeuromuscular transmissionNerve stimulationChronic hypoxiaContraction timePhrenic nerve-hemidiaphragm preparationAge-matched controlsLower specific forceHypoxic diaphragmDiaphragm functionHemidiaphragm preparationHypoxic ratsHypoxic groupSpecific forceContractile propertiesControl groupRat diaphragmMaturation of mechanismsRatsGreater decreaseStimulationHypoxiaDiaphragmHypoxicDelays maturation
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