2024
Ulcerative Colitis Patients Are at Increased Risk for Adverse Events Following Total Hip Arthroplasty
Oghenesume O, Gouzoulis M, Ratnasamy P, Dhodapkar M, Grauer J, Rubin L. Ulcerative Colitis Patients Are at Increased Risk for Adverse Events Following Total Hip Arthroplasty. The Journal Of Arthroplasty 2024, 40: 1397-1403.e1. PMID: 39515400, DOI: 10.1016/j.arth.2024.10.134.Peer-Reviewed Original ResearchPostoperative adverse eventsAdverse eventsClasses of medicationsElixhauser Comorbidity IndexUlcerative colitisPatient ageTotal hip arthroplastyTotal hip arthroplasty patientsFive-year survivalUlcerative colitis patientsArthroplasty patientsPatient's medication regimenHip arthroplasty patientsDisease ulcerative colitisUC patientsColitis patientsComorbidity indexCorticosteroidsPerioperative periodIncreased riskHip arthroplastyPatientsMedication regimenDisease processMatched groupWhen Perfect Is the Enemy of Good: Results of a RAND Appropriateness Panel on Treat to Target in Asymptomatic Inflammatory Bowel Disease
Systrom H, Rai V, Singh S, Baidoo L, Cheifetz A, Devlin S, Gecse K, Irving P, Kaplan G, Kozuch P, Ullman T, Sparrow M, Melmed G, Siegel C. When Perfect Is the Enemy of Good: Results of a RAND Appropriateness Panel on Treat to Target in Asymptomatic Inflammatory Bowel Disease. The American Journal Of Gastroenterology 2024, 120: 420-430. PMID: 39008539, DOI: 10.14309/ajg.0000000000002964.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseAsymptomatic patientsChanging therapyStable diseaseEndoscopic remissionEndoscopic activityBowel diseaseAsymptomatic inflammatory bowel diseaseRAND/University of California Los Angeles Appropriateness MethodTreat-to-target strategyActive endoscopic diseaseUlcerative colitis patientsCrohn's disease patientsLos Angeles Appropriateness MethodExtensive diseaseDisease extentPatient ageAphthous ulcersRandomized studyEndoscopic diseaseClinical decision-makingColitis patientsAdvanced therapiesTreatment adjustmentAnonymous survey
2023
Real-world Evidence Comparing Tofacitinib and Vedolizumab in Anti-TNF-experienced Patients With Ulcerative Colitis
Adimadhyam S, Lewis J, Simon A, Wolfe A, Smith S, Hou L, Moyneur É, Reynolds J, Toh S, Dobes A, Parlett L, Haynes K, Burris J, Dorand J, Long M, Kappelman M. Real-world Evidence Comparing Tofacitinib and Vedolizumab in Anti-TNF-experienced Patients With Ulcerative Colitis. Inflammatory Bowel Diseases 2023, 30: 554-562. PMID: 37358904, DOI: 10.1093/ibd/izad115.Peer-Reviewed Original ResearchLower treatment persistenceUlcerative colitisTreatment persistenceFollowing secondary outcomesLarge US insurerFirst-line treatmentNecrosis factor inhibitorsTotal abdominal colectomyUlcerative colitis patientsAnti-TNF inhibitorsEvidence of treatmentDiverse US populationReal-world studyAbdominal colectomyCause hospitalizationThromboembolic eventsCardiac eventsCohort studyColitis patientsSecondary outcomesClinical factorsPrimary outcomeAnti-TNFPrimary cohortFactor inhibitors
2022
Tu1429: FREQUENCY AND CHARACTERISTICS OF NUTRITION ASSESSMENT IN HOSPITALIZED ULCERATIVE COLITIS PATIENTS
Levine L, Sharma S, McMillan C, Li D, Gaidos J, Proctor D, Al Bawardy B. Tu1429: FREQUENCY AND CHARACTERISTICS OF NUTRITION ASSESSMENT IN HOSPITALIZED ULCERATIVE COLITIS PATIENTS. Gastroenterology 2022, 162: s-957. DOI: 10.1016/s0016-5085(22)62267-4.Peer-Reviewed Original ResearchHospitalized ulcerative colitis patientsUlcerative colitis patientsColitis patientsNutrition assessmentPatientsDo Cost Limitations of Extended Prophylaxis After Surgery Apply to Ulcerative Colitis Patients?
Leeds IL, Canner JK, DiBrito SR, Safar B. Do Cost Limitations of Extended Prophylaxis After Surgery Apply to Ulcerative Colitis Patients? Diseases Of The Colon & Rectum 2022, 65: 702-712. PMID: 34840290, PMCID: PMC8995329, DOI: 10.1097/dcr.0000000000002056.Peer-Reviewed Original ResearchConceptsMultivariable probabilistic sensitivity analysesUlcerative colitis patientsIncremental cost-effectiveness ratioProbabilistic sensitivity analysesCost-effectiveness ratioDecision analysisColorectal surgery patientsExtended prophylaxisColitis patientsEl análisisSocietal perspectiveLifetime horizonSurgery patientsVenous thromboembolismColitis ulcerosaDecision analysis methodologyUn análisisPostoperative venous thromboembolismRange of scenariosType of thrombosisMain outcome measuresTotal costIndividual risk profileCostSensitivity analysisOUTCOMES OF TOTAL PROCTOCOLECTOMY (TPC) WITH ILEAL POUCH ANAL ANASTOMOSIS (IPAA)
Petrov J, Al-Bawardy B, Gaidos J, Proctor D. OUTCOMES OF TOTAL PROCTOCOLECTOMY (TPC) WITH ILEAL POUCH ANAL ANASTOMOSIS (IPAA). Inflammatory Bowel Diseases 2022, 28: s75-s76. DOI: 10.1093/ibd/izac015.123.Peer-Reviewed Original ResearchIleal pouch-anal anastomosisPouch-anal anastomosisTotal proctocolectomyMedical therapyCrohn's diseaseChronic pouchitisRepeat surgeryAnal anastomosisAnatomic complicationsChronic antibiotic-refractory pouchitisAntibiotic-refractory pouchitisBiopsy-proven inflammationChronic steroid therapyEpisodes of pouchitisPre-pouch ileitisSymptoms of pouchitisAdverse postoperative outcomesRate of complicationsSurgery of choiceUlcerative colitis patientsTreatment of complicationsMulti-center studyThird of subjectsAcute pouchitisAnatomical complications
2021
Ulcerative Colitis Patients Have Reduced Rectal Compliance Compared With Non–Inflammatory Bowel Disease Controls
Krugliak Cleveland N, Rai V, El Jurdi K, Rao S, Giurcanu M, Rubin D. Ulcerative Colitis Patients Have Reduced Rectal Compliance Compared With Non–Inflammatory Bowel Disease Controls. Gastroenterology 2021, 162: 331-333.e1. PMID: 34597674, PMCID: PMC8678316, DOI: 10.1053/j.gastro.2021.09.052.Peer-Reviewed Original ResearchConceptsNon-inflammatory bowel disease controlsUlcerative colitis patientsColitis patientsRectal complianceDisease controlPatientsThe RNA helicase Dhx15 mediates Wnt-induced antimicrobial protein expression in Paneth cells
Wang Y, He K, Sheng B, Lei X, Tao W, Zhu X, Wei Z, Fu R, Wang A, Bai S, Zhang Z, Hong N, Ye C, Tian Y, Wang J, Li M, Zhang K, Li L, Yang H, Li HB, Flavell RA, Zhu S. The RNA helicase Dhx15 mediates Wnt-induced antimicrobial protein expression in Paneth cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2017432118. PMID: 33483420, PMCID: PMC7848544, DOI: 10.1073/pnas.2017432118.Peer-Reviewed Original ResearchConceptsRNA helicasesEssential biological processesPaneth cellsRNA helicase DHX15Antimicrobial protein expressionCell-specific functionsViral RNA sensorsRNA splicingHelicasesUlcerative colitis patientsCell-specific depletionDHX15Complete knockoutKey regulatorBiological processesIntestinal epithelial cellsLethality of miceVivo roleEnteric bacteriaRNA sensorsDextran sodiumColitis patientsLack of evidenceAntimicrobial responsesIntestinal inflammation
2020
Pouchitis in inflammatory bowel disease: a review of diagnosis, prognosis, and treatment
Akiyama S, Rai V, Rubin D. Pouchitis in inflammatory bowel disease: a review of diagnosis, prognosis, and treatment. Intestinal Research 2020, 19: 1-11. PMID: 33138344, PMCID: PMC7873408, DOI: 10.5217/ir.2020.00047.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsIleal pouch-anal anastomosisInflammatory bowel diseaseBowel diseaseRisk factorsUlcerative colitis patientsPouch-anal anastomosisReview of diagnosisDysplasia/cancerNew biological agentsPouchitis developmentRefractory colitisColitis patientsPouch failureRestorative proctocolectomyPouch excisionCrohn's diseaseImpairs qualityTreatment optionsChronic conditionsPouchitisFrequent reasonPatientsDiseaseProctocolectomyPrognosis
2019
A Unique Presentation of Infantile-Onset Colitis and Eosinophilic Disease without Recurrent Infections Resulting from a Novel Homozygous CARMIL2 Variant
Kurolap A, Eshach Adiv O, Konnikova L, Werner L, Gonzaga-Jauregui C, Steinberg M, Mitsialis V, Mory A, Nunberg MY, Wall S, Shaoul R, Overton JD, Shuldiner A, Zohar Y, Paperna T, Snapper S, Shouval D, Baris Feldman H. A Unique Presentation of Infantile-Onset Colitis and Eosinophilic Disease without Recurrent Infections Resulting from a Novel Homozygous CARMIL2 Variant. Journal Of Clinical Immunology 2019, 39: 430-439. PMID: 31079270, DOI: 10.1007/s10875-019-00631-6.Peer-Reviewed Original ResearchMeSH KeywordsAge of OnsetAmino Acid SequenceChildChild, PreschoolColitisDNA Mutational AnalysisEnteritisEosinophiliaExome SequencingGastritisGenetic Association StudiesGenetic Predisposition to DiseaseHomozygoteHumansImmunohistochemistryImmunophenotypingMaleMicrofilament ProteinsModels, MolecularMutationPhenotypeStructure-Activity RelationshipConceptsWhole-exome sequencingImmunological workupWestern blotRecurrent infectionsGastrointestinal diseasesCyTOF analysisRegulatory T cell frequencyEosinophilic gastrointestinal diseasesEosinophilic gastrointestinal disordersT cell frequenciesUlcerative colitis patientsAdaptive immune cellsEvidence of recurrentSigns of immunodeficiencyT cell proliferationT-cell studiesColitis patientsChronic diarrheaImmunodeficiency syndromeTreg generationGastrointestinal disordersImmunological phenotypeImmune populationsImmune cellsSevere infections
2018
Autoimmune Enteropathy in an Ulcerative Colitis Patient
Rodriguez NJ, Gupta N, Gibson J. Autoimmune Enteropathy in an Ulcerative Colitis Patient. ACG Case Reports Journal 2018, 5: e78. PMID: 30465008, PMCID: PMC6224868, DOI: 10.14309/crj.2018.78.Peer-Reviewed Case Reports and Technical NotesOstomy outputChronic active ileitisHigh ostomy outputImmune-mediated changesUlcerative colitis patientsSignificant clinical improvementActive ileitisAutoimmune enteropathyIntravenous solumedrolClinical improvementColitis patientsNegative workupTotal colectomyEnd ileostomyChronic enteritisSevere disordersTacrolimusAutoimmuneSolumedrolColectomyCyclosporineEnteroscopyIleostomyEnteropathyIleitis
2017
Early Surgical Intervention for Acute Ulcerative Colitis Is Associated with Improved Postoperative Outcomes
Leeds IL, Truta B, Parian AM, Chen SY, Efron JE, Gearhart SL, Safar B, Fang SH. Early Surgical Intervention for Acute Ulcerative Colitis Is Associated with Improved Postoperative Outcomes. Journal Of Gastrointestinal Surgery 2017, 21: 1675-1682. PMID: 28819916, PMCID: PMC6201293, DOI: 10.1007/s11605-017-3538-3.Peer-Reviewed Original ResearchConceptsAcute ulcerative colitisEarly surgical interventionUlcerative colitisLength of staySurgical interventionSurgery groupTotal colectomyHospitalization costsEarly operationMedian total hospitalization costModern immunotherapy eraRefractory ulcerative colitisHours of admissionImmediate surgical interventionUlcerative colitis patientsTotal hospitalization costsFurther prospective studiesNational Inpatient SampleImmunotherapy eraColitis patientsHospital outcomesPostoperative complicationsPostoperative outcomesUrgent surgeryComorbid patients
2016
JAK2 Disease-Risk Variants Are Gain of Function and JAK Signaling Threshold Determines Innate Receptor-Induced Proinflammatory Cytokine Secretion in Macrophages
Hedl M, Proctor DD, Abraham C. JAK2 Disease-Risk Variants Are Gain of Function and JAK Signaling Threshold Determines Innate Receptor-Induced Proinflammatory Cytokine Secretion in Macrophages. The Journal Of Immunology 2016, 197: 3695-3704. PMID: 27664279, PMCID: PMC5127452, DOI: 10.4049/jimmunol.1600845.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseAnti-inflammatory cytokinesImmune-mediated diseasesOligomerization domain 2Proinflammatory cytokinesMyeloid cellsJAK2 expressionJAK inhibitorsIntestinal myeloid cellsThymic stromal lymphopoietinUlcerative colitis patientsProinflammatory cytokine secretionPattern recognition receptorsHuman myeloid cellsLower JAK2Cell typesColitis patientsBowel diseaseIL-10IL-22Peripheral macrophagesIL-4Cytokine secretionAA carriersDecreased response
1992
High endothelin-1 immunoreactivity in Crohn's disease and ulcerative colitis
Murch SH, Braegger CP, MacDonald T, Sessa W. High endothelin-1 immunoreactivity in Crohn's disease and ulcerative colitis. The Lancet 1992, 339: 381-385. PMID: 1346658, DOI: 10.1016/0140-6736(92)90077-g.Peer-Reviewed Original ResearchConceptsCrohn's disease patientsInflammatory bowel diseaseDisease patientsUlcerative colitisCrohn's diseaseBowel diseaseEndothelin-1Lamina propriaChronic inflammatory bowel diseaseEndothelin-1 immunoreactivitySubmucosal blood vesselsUlcerative colitis patientsTissue samplesUlcerative colitis groupEndothelin concentrationsImmunological hypersensitivityIntestinal ischaemiaColitis groupColitis patientsEndothelin productionInflammatory cellsPotent vasoconstrictorVascular abnormalitiesDisease groupImmunoreactive cells
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