2024
In-human clinical experience with direct stick embolization of low-flow vascular malformations using a mammalian target of rapamycin inhibitor
Restrepo-Espinosa V, Lee A, Prozora S, Patel P, Nassiri N. In-human clinical experience with direct stick embolization of low-flow vascular malformations using a mammalian target of rapamycin inhibitor. Journal Of Vascular Surgery Venous And Lymphatic Disorders 2024, 13: 101997. PMID: 39515753, PMCID: PMC12014304, DOI: 10.1016/j.jvsv.2024.101997.Peer-Reviewed Original ResearchLow-flow vascular malformationsMTOR inhibitorsClinical successVascular malformationsSide effectsLocalized intravascular coagulopathyOral aphthous ulcersKlippel-Trenaunay syndromeLymphatic malformationsVenous malformationsRe-interventionDelayed complicationsNon-syndromicTechnical successAphthous ulcersIntravascular coagulopathyD-dimerEndovascular treatmentSystemic exposureAdjunctive therapySystemic toxicityFrequent bloodMalformationsSelf-limitingMTOR inhibitionWhen Perfect Is the Enemy of Good: Results of a RAND Appropriateness Panel on Treat to Target in Asymptomatic Inflammatory Bowel Disease
Systrom H, Rai V, Singh S, Baidoo L, Cheifetz A, Devlin S, Gecse K, Irving P, Kaplan G, Kozuch P, Ullman T, Sparrow M, Melmed G, Siegel C. When Perfect Is the Enemy of Good: Results of a RAND Appropriateness Panel on Treat to Target in Asymptomatic Inflammatory Bowel Disease. The American Journal Of Gastroenterology 2024, 120: 420-430. PMID: 39008539, DOI: 10.14309/ajg.0000000000002964.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseAsymptomatic patientsChanging therapyStable diseaseEndoscopic remissionEndoscopic activityBowel diseaseAsymptomatic inflammatory bowel diseaseRAND/University of California Los Angeles Appropriateness MethodTreat-to-target strategyActive endoscopic diseaseUlcerative colitis patientsCrohn's disease patientsLos Angeles Appropriateness MethodExtensive diseaseDisease extentPatient ageAphthous ulcersRandomized studyEndoscopic diseaseClinical decision-makingColitis patientsAdvanced therapiesTreatment adjustmentAnonymous surveyCHANGING THERAPY TO ACHIEVE ENDOSCOPIC HEALING IN ASYMPTOMATIC PATIENTS WITH IBD: WHEN IS PERFECT THE ENEMY OF GOOD?
Systrom H, Rai V, Singh S, Baidoo L, Cheifetz A, Devlin S, Gecse K, Irving P, Kaplan G, Kozuch P, Ullman T, Sparrow M, Melmed G, Siegel C. CHANGING THERAPY TO ACHIEVE ENDOSCOPIC HEALING IN ASYMPTOMATIC PATIENTS WITH IBD: WHEN IS PERFECT THE ENEMY OF GOOD? Inflammatory Bowel Diseases 2024, 30: s83-s83. DOI: 10.1093/ibd/izae020.180.Peer-Reviewed Original ResearchInflammatory bowel diseaseEndoscopic healingAsymptomatic patientsChanging therapyScenarios of patientsCrohn's diseaseUlcerative colitisInflammatory bowel disease specialistsTreat-to-target strategyAsymptomatic IBD patientsPatients aged >Treatment decision-makingStable diseaseEndoscopic improvementClinical remissionExtensive diseaseAnti-TNFEndoscopic progressionDisease extentAphthous ulcersEndoscopic inflammationRandomized studyCurrent therapiesEndoscopic diseaseClinical decision-makingP978 Changing therapy to achieve endoscopic healing in asymptomatic patients with IBD: When is perfect the enemy of good?
Systrom H, Rai V, Singh S, Baidoo L, Cheifetz A, Devlin S, Gecse K, Irving P, Kaplan G, Kozuch P, Ullman T, Sparrow M, Melmed G, Siegel C. P978 Changing therapy to achieve endoscopic healing in asymptomatic patients with IBD: When is perfect the enemy of good? Journal Of Crohn's And Colitis 2024, 18: i1764-i1764. DOI: 10.1093/ecco-jcc/jjad212.1108.Peer-Reviewed Original ResearchInflammatory bowel diseaseInflammatory bowel disease specialistsEndoscopic healingAsymptomatic patientsChanging therapyCrohn's diseaseUlcerative colitisTreat-to-target strategyAsymptomatic IBD patientsInfluence treatment decision-makingPatients aged >RAND/UCLA Appropriateness MethodIn-person meetingsScenarios of patientsTreatment decision-makingStable diseaseEndoscopic improvementClinical remissionExtensive diseaseAnti-TNFEndoscopic progressionDisease extentClinical decision-makingAphthous ulcersEndoscopic inflammation“Deficiency in ELF4, X-Linked”: a Monogenic Disease Entity Resembling Behçet’s Syndrome and Inflammatory Bowel Disease
Olyha S, O’Connor S, Kribis M, Bucklin M, Uthaya Kumar D, Tyler P, Alam F, Jones K, Sheikha H, Konnikova L, Lakhani S, Montgomery R, Catanzaro J, Du H, DiGiacomo D, Rothermel H, Moran C, Fiedler K, Warner N, Hoppenreijs E, van der Made C, Hoischen A, Olbrich P, Neth O, Rodríguez-Martínez A, Lucena Soto J, van Rossum A, Dalm V, Muise A, Lucas C. “Deficiency in ELF4, X-Linked”: a Monogenic Disease Entity Resembling Behçet’s Syndrome and Inflammatory Bowel Disease. Journal Of Clinical Immunology 2024, 44: 44. PMID: 38231408, PMCID: PMC10929603, DOI: 10.1007/s10875-023-01610-8.Peer-Reviewed Original ResearchConceptsDEX patientsClass-switched memory B cellsInborn errors of immunityTreated with anti-inflammatory agentsLow natural killerX-linkedMemory B cellsErrors of immunityCohort of patientsIncreased inflammatory cytokinesLoss-of-function variantsHeterogeneous clinical phenotypesInflammatory bowel diseaseTargeted therapeutic interventionsNatural killerAnti-inflammatory agentsAphthous ulcersTherapeutic responseAutoinflammatory syndromeInflammatory markersClinical manifestationsB cellsBehcet's syndromeGastrointestinal symptomsMechanisms of disease
2023
Vulvar Aphthous Ulcers in Perimenarchal Adolescents after COVID-19 Vaccination: A Multicenter Case Series
Sartor R, Lawson A, Moncada-Madrazo M, Altchek C, Vash-Margita A, Cron J. Vulvar Aphthous Ulcers in Perimenarchal Adolescents after COVID-19 Vaccination: A Multicenter Case Series. Journal Of Pediatric And Adolescent Gynecology 2023, 36: 268-272. PMID: 36708984, PMCID: PMC9876002, DOI: 10.1016/j.jpag.2023.01.003.Peer-Reviewed Original ResearchConceptsCOVID-19 vaccinationAphthous ulcersCase seriesMulticenter case seriesAdolescent gynecology serviceVulvar ulcersDiagnostic workupGynecology serviceTreatment modalitiesPatient presentationDifferential diagnosisClinical experienceUlcersVaccinationTemporal associationFemale adolescentsCOVID-19Novel associationsAdolescentsAssociationOverall coursePresentationComplicationsPatientsVaccine
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