2025
Trends and Key Factors Associated With Racial and Ethnic Differences in Life’s Essential 8 Scores
Yang H, Huang C, Sawano M, Herrin J, Faridi K, Li Z, Spatz E, Krumholz H, Lu Y. Trends and Key Factors Associated With Racial and Ethnic Differences in Life’s Essential 8 Scores. JAMA Network Open 2025, 8: e2516663. PMID: 40531529, PMCID: PMC12177675, DOI: 10.1001/jamanetworkopen.2025.16663.Peer-Reviewed Original ResearchConceptsLife's Essential 8 scoreLife's Essential 8Cross-sectional studyWhite differencesEthnic differencesNational Health and Nutrition Examination SurveyHealth and Nutrition Examination SurveySleep health scoreNutrition Examination SurveyGroup-specific interventionsPrimary positive factorPhysical activityExamination SurveyHealth scoresBlack adultsWhite adultsMain OutcomesAsian adultsOverall scoreEvaluate trendsNicotine exposureEssential 8Blood lipidsAdultsEthnic groups
2024
Changes in Weight Among Individuals With Psychiatric Conditions or Socioeconomic Disadvantage Assigned to Smoke Very Low Nicotine Content Cigarettes
Harfmann R, Heil S, Bunn J, Snell L, Tidey J, Sigmon S, Gaalema D, Lee D, Streck J, Bergeria C, Davis D, Plucinski S, Higgins S. Changes in Weight Among Individuals With Psychiatric Conditions or Socioeconomic Disadvantage Assigned to Smoke Very Low Nicotine Content Cigarettes. Experimental And Clinical Psychopharmacology 2024, 32: 181-188. PMID: 38236223, PMCID: PMC11851335, DOI: 10.1037/pha0000700.Peer-Reviewed Original ResearchOpioid use disorderNicotine reduction policyAffective disordersSocioeconomically disadvantaged womenHigh dosesShort-term adverse consequencesNicotine abstinenceNicotine doseEffects of cigarettesPsychiatric conditionsUse disorderNicotine exposureWeekly assessmentsNicotineGroup of individualsRandomized Controlled TrialsDisordersAssessment of weightDisadvantaged womenFunction of doseCombination groupControlled TrialsDoseSecondary analysisAdverse consequences
2023
Validation of “Life's Essential 8” Metrics With Cardiovascular Structural Status in Children: The PROC Study in China
Shu W, Li M, Xiao H, Amaerjiang N, Khattab N, Zunong J, Guan M, Vermund S, Hu Y. Validation of “Life's Essential 8” Metrics With Cardiovascular Structural Status in Children: The PROC Study in China. Journal Of The American Heart Association 2023, 12: e029077. PMID: 37301752, PMCID: PMC10356051, DOI: 10.1161/jaha.122.029077.Peer-Reviewed Original ResearchConceptsCarotid intima-media thicknessIntima-media thicknessCVH scoreCardiovascular healthLVM indexAbnormal sleep durationChildren's cardiovascular healthOverweight/obesityMin/wkWorse cardiovascular healthChild Cohort StudyM-mode echocardiographyAge/sexLower CVH scoreFollow-up (12- and 24-month) assessmentLipid scoreNormal BPCohort studyFasting GlucosePrimordial preventionNicotine exposureVentricular massPhysical activitySleep durationUS population
2022
The Impact of Reducing Nicotine Content on Adolescent Cigarette Smoking and Nicotine Exposure: Results From a Randomized Controlled Trial
Cassidy R, Tidey J, Jackson K, Cioe P, Murphy S, Krishnan-Sarin S, Hatsukami D, Colby S. The Impact of Reducing Nicotine Content on Adolescent Cigarette Smoking and Nicotine Exposure: Results From a Randomized Controlled Trial. Nicotine & Tobacco Research 2022, 25: 918-927. PMID: 36482794, PMCID: PMC10077938, DOI: 10.1093/ntr/ntac279.Peer-Reviewed Original ResearchConceptsVLNC cigarettesAdolescent daily smokersNNC cigarettesCigarette smokingDaily smokersWeek 3First clinical trialSources of nicotineNicotine contentLow nicotine contentAdolescent cigarette smokingRespiratory symptomsSecondary outcomesPrimary outcomeControlled TrialsNicotine exposureTotal cigarettesIncomplete adherenceNicotine cigarettesClinical trialsAdolescent smokersTwo-armUS FoodControl groupDrug AdministrationChronic oral nicotine exposure decreases aversive taste of nicotine, increases nicotine withdrawal and reinstatement, but cherry flavor does not alter nicotine’s effects in adolescent rats
Bagdas D, Harris L, Addy N. Chronic oral nicotine exposure decreases aversive taste of nicotine, increases nicotine withdrawal and reinstatement, but cherry flavor does not alter nicotine’s effects in adolescent rats. Neuroscience Letters 2022, 793: 137008. PMID: 36476758, PMCID: PMC9948648, DOI: 10.1016/j.neulet.2022.137008.Peer-Reviewed Original ResearchConceptsTaste responsesNicotine concentrationsNicotine exposureNicotine withdrawalNicotine effectsAdolescent ratsChronic exposureOral nicotine exposureTaste reactivityAversive tasteChronic nicotine exposureDevelopment of toleranceLow nicotine concentrationsE-cigarette useE-cigarette flavoringsHigher nicotine concentrationsNicotine abstinenceNicotine useNaïve animalsChronic effectsNicotineRatsAversive responsesDifferent nicotine concentrationsWithdrawalRelating individual differences in the reinforcing value of smoking and dependence severity to nicotine exposure levels in vulnerable populations
Browning K, DeSarno M, Davis D, Streck J, Bergeria C, Harfmann R, Parker M, Heil S, Sigmon S, Gaalema D, Tidey J, Lee D, Tetreault H, Higgins S. Relating individual differences in the reinforcing value of smoking and dependence severity to nicotine exposure levels in vulnerable populations. Preventive Medicine 2022, 165: 107312. PMID: 36272516, PMCID: PMC9986960, DOI: 10.1016/j.ypmed.2022.107312.Peer-Reviewed Original ResearchConceptsNicotine exposure levelsValue of smokingCigarette purchase taskNicotine dependenceVulnerable populationsDependence severityPsychiatric conditionsSocioeconomic disadvantageCo-morbid psychiatric conditionsExposure levelsNicotine dependence severityCigarette smokingNicotine exposureSmoking Dependence MotivesFagerström TestSmokingBrief Wisconsin InventorySeverityDependence MotivesFTNDWisconsin InventoryConsiderable overlapPresent studyPopulationNicotine Pharmacology, Abuse, and Addiction
Miller M, Picciotto M. Nicotine Pharmacology, Abuse, and Addiction. 2022, 4083-4101. DOI: 10.1007/978-3-030-88832-9_157.ChaptersTobacco useDrugs of abuseNeuropsychiatric disordersGreat public health relevanceGreat public health concernMesolimbic dopamine systemPre-clinical studiesPublic health concernPublic health relevanceNicotinic acetylcholine receptorsIonotropic neurotransmitter receptorsPrimary psychoactive componentSubstantial health risksNicotine exposureNicotine actsSustained tobacco useNicotine pharmacologyRewarding effectsNicotine addictionDopamine systemNervous systemNeurotransmitter receptorsNicotine useAcetylcholine receptorsAddictive properties
2021
Sex Differences in the Ventral Tegmental Area and Nucleus Accumbens Proteome at Baseline and Following Nicotine Exposure
Lee AM, Mansuri MS, Wilson RS, Lam TT, Nairn AC, Picciotto MR. Sex Differences in the Ventral Tegmental Area and Nucleus Accumbens Proteome at Baseline and Following Nicotine Exposure. Frontiers In Molecular Neuroscience 2021, 14: 657064. PMID: 34335180, PMCID: PMC8317211, DOI: 10.3389/fnmol.2021.657064.Peer-Reviewed Original ResearchVentral tegmental areaC3H/HeJ miceGlial fibrillary acidic proteinChronic nicotine administrationNicotine administrationProtein abundanceProteomeIsobaric labelingNicotine exposureFemale miceTegmental areaHeJ miceNucleus accumbensNicotine addictionProteinSex differencesSample fractionationPathwayFibrillary acidic proteinTandem mass spectrometryNetwork analysisMouse strainsChronic nicotineMesolimbic systemNicotine reward
2020
A prospective study of the association between rate of nicotine metabolism and alcohol use in tobacco users in the United States
Roberts W, Marotta PL, Verplaetse TL, Peltier MR, Burke C, Ramchandani VA, McKee SA. A prospective study of the association between rate of nicotine metabolism and alcohol use in tobacco users in the United States. Drug And Alcohol Dependence 2020, 216: 108210. PMID: 32805549, PMCID: PMC7609495, DOI: 10.1016/j.drugalcdep.2020.108210.Peer-Reviewed Original ResearchConceptsNicotine metabolite ratioRisk factorsAlcohol useTobacco usersNicotine metabolismTrans-3'-HydroxycotinineWave 1Biochemical risk factorsAlcohol consumption amountCurrent tobacco usersNicotine metabolism rateAssociated health outcomesSex differencesAlcohol use outcomesCigarette smokersNicotine exposureProspective studyOdds ratioTobacco useDrinking statusHealth StudyAlcohol consumptionNicotine useMetabolite ratiosHealth outcomes
2019
High school students’ use of flavored e-cigarette e-liquids for appetite control and weight loss
Morean ME, Bold KW, Kong G, Camenga D, Simon P, Jackson A, Cavallo DA, Krishnan-Sarin S. High school students’ use of flavored e-cigarette e-liquids for appetite control and weight loss. Addictive Behaviors 2019, 102: 106139. PMID: 31704428, PMCID: PMC6948184, DOI: 10.1016/j.addbeh.2019.106139.Peer-Reviewed Original ResearchConceptsE-liquid useAppetite controlWeight-related reasonsWeight lossE-liquidsAdolescent e-cigarette usersE-cigarette initiationE-cigarette usersSubset of adolescentsSchool-based surveyNicotine exposureFlavored e-liquidsSmoking frequencyInclusion criteriaAnalytic sampleVapingNaïve individualsFrequent vapingCurrent usersAdolescentsSchool adolescentsHigh school adolescentsNon-missing dataSmokingControlPerinatal nicotine exposure impairs learning of a skilled forelimb reaching task in male but not female adult mice
Lee AM, Picciotto MR. Perinatal nicotine exposure impairs learning of a skilled forelimb reaching task in male but not female adult mice. Behavioural Brain Research 2019, 367: 176-180. PMID: 30959127, PMCID: PMC6481625, DOI: 10.1016/j.bbr.2019.04.007.Peer-Reviewed Original ResearchConceptsNicotine exposureSingle-pellet reaching taskMotor tasksCortical synaptic plasticityPerinatal nicotine exposureDevelopmental nicotine exposureGross motor functionNicotine-treated animalsNicotine-induced changesFemale adult miceSkilled motor taskGross motor performanceAdverse outcomesMotor cortexFemale miceMale miceMotor functionSkilled forelimbPreclinical studiesControl animalsAdult miceImpaired learningSynaptic plasticityFemale pupsMorphologic changes
2018
Early adolescent nicotine exposure affects later-life hippocampal mu-opioid receptors activity and morphine reward but not physical dependence in male mice
Kota D, Alajaji M, Bagdas D, Selley D, Sim-Selley L, Damaj M. Early adolescent nicotine exposure affects later-life hippocampal mu-opioid receptors activity and morphine reward but not physical dependence in male mice. Pharmacology Biochemistry And Behavior 2018, 173: 58-64. PMID: 30125591, PMCID: PMC6160313, DOI: 10.1016/j.pbb.2018.08.006.Peer-Reviewed Original ResearchConceptsMorphine rewardAdult miceG-protein activityNicotine exposurePhysical dependenceEarly adolescent nicotine exposureAdolescent nicotine treatmentMu-opioid receptor activityAdolescent nicotine exposureCurrent opioid crisisSomatic withdrawal signsMorphine physical dependenceDrug-taking behaviorNicotine treatmentWithdrawal signsWithdrawal symptomsMale miceLong-term effectsLow doseNicotine productsCPP testOpioid crisisReceptor activitySubstance abuseMiceE-cigarettes: Impact of E-liquid Components and Device Characteristics on Nicotine Exposure
DeVito EE, Krishnan-Sarin S. E-cigarettes: Impact of E-liquid Components and Device Characteristics on Nicotine Exposure. Current Neuropharmacology 2018, 16: 438-459. PMID: 29046158, PMCID: PMC6018193, DOI: 10.2174/1570159x15666171016164430.Peer-Reviewed Original ResearchConceptsNicotine exposureE-cigarettesNicotine dependenceEffective smoking cessation toolPrimary addictive componentSmoking cessation toolElectronic cigarette useE-liquidsAddictive componentCessation toolNicotine absorptionNicotine useCigarette usePuff topographyNicotine yieldE-liquid constituentsExposureCigarettesE-cigarette use behaviorsCurrent knowledgeUse behaviorsUnderstanding factorsSmokersFactorsCommon factorsAdolescent Nicotine Exposure Alters GABAA Receptor Signaling in the Ventral Tegmental Area and Increases Adult Ethanol Self-Administration
Thomas A, Ostroumov A, Kimmey B, Taormina M, Holden W, Kim K, Brown-Mangum T, Dani J. Adolescent Nicotine Exposure Alters GABAA Receptor Signaling in the Ventral Tegmental Area and Increases Adult Ethanol Self-Administration. Cell Reports 2018, 23: 68-77. PMID: 29617674, PMCID: PMC5983379, DOI: 10.1016/j.celrep.2018.03.030.Peer-Reviewed Original ResearchConceptsVentral tegmental areaAdolescent nicotine exposureNicotine exposureTegmental areaChloride extrusionLateral ventral tegmental areaSubsequent ethanol intakeVTA GABA neuronsNicotine-treated animalsGlucocorticoid receptor activationGABAA Receptor SignalingEthanol Self‐AdministrationGABA neuronsPathological drinkingVTA GABAAlcohol drinkingEthanol intakeReceptor activationSelf-AdministrationRisk profileGABANeuron responsesAdolescent smokingReceptor signalingReversal potential
2017
Studying the interactive effects of menthol and nicotine among youth: An examination using e-cigarettes
Krishnan-Sarin S, Green BG, Kong G, Cavallo DA, Jatlow P, Gueorguieva R, Buta E, O’Malley S. Studying the interactive effects of menthol and nicotine among youth: An examination using e-cigarettes. Drug And Alcohol Dependence 2017, 180: 193-199. PMID: 28915478, PMCID: PMC5659733, DOI: 10.1016/j.drugalcdep.2017.07.044.Peer-Reviewed Original ResearchConceptsAd lib useE-cigarettesE-cigarette usersStimulant effectsNicotine concentrationsNicotine-containing e-cigarettesNicotine withdrawal symptomsMenthol concentrationRandom counterbalanced orderPositive rewarding effectsNicotine exposureNicotine withdrawalWithdrawal symptomsRewarding effectsMenthol glucuronideHigh menthol concentrationLow dosesNicotine levelsTobacco productsNicotineCounterbalanced orderMaternal smoking and autism spectrum disorder: meta-analysis with population smoking metrics as moderators
Jung Y, Lee AM, McKee SA, Picciotto MR. Maternal smoking and autism spectrum disorder: meta-analysis with population smoking metrics as moderators. Scientific Reports 2017, 7: 4315. PMID: 28659613, PMCID: PMC5489536, DOI: 10.1038/s41598-017-04413-1.Peer-Reviewed Original ResearchConceptsMale smoking prevalenceMaternal smokingNicotine exposureSmoking prevalenceAdult male smoking prevalenceSignificant associationPostnatal nicotine exposureUtero nicotine exposureAutism spectrum disorderRandom-effects modelWorld Health Organization dataMeta-regression analysisSmoking metricsSmoke exposureSecondhand smokingPooled ORsObservational studySpectrum disorderSmokingBrain developmentControl participantsPrevalenceASD riskExposureAssociation
2016
Nicotine Pharmacology, Abuse, and Addiction
Miller M, Picciotto M. Nicotine Pharmacology, Abuse, and Addiction. 2016, 3659-3677. DOI: 10.1007/978-1-4939-3474-4_157.ChaptersTobacco useDrugs of abuseNeuropsychiatric disordersGreat public health relevanceGreat public health concernMesolimbic dopamine systemPre-clinical studiesPublic health concernPublic health relevanceNicotinic acetylcholine receptorsIonotropic neurotransmitter receptorsPrimary psychoactive componentSubstantial health risksNicotine exposureNicotine actsSustained tobacco useNicotine pharmacologyRewarding effectsNicotine addictionDopamine systemNervous systemNeurotransmitter receptorsNicotine useAcetylcholine receptorsAddictive propertiesNicotine concentration of e-cigarettes used by adolescents
Morean ME, Kong G, Cavallo DA, Camenga DR, Krishnan-Sarin S. Nicotine concentration of e-cigarettes used by adolescents. Drug And Alcohol Dependence 2016, 167: 224-227. PMID: 27592270, PMCID: PMC5158305, DOI: 10.1016/j.drugalcdep.2016.06.031.Peer-Reviewed Original ResearchConceptsNicotine usersNicotine e-liquidE-cigarettesNicotine concentrationsE-cigarette usersNicotine-free e-liquidsHigher nicotine concentrationsE-liquidsOwn e-cigaretteCross-sectional surveyLiquid nicotine concentrationHigher nicotine levelsE-cigarette use frequencySmoking statusCigarette smokingMale sexMore smokersNicotine exposureTobacco shopsNicotine levelsSmokersAdolescentsMore malesSexMalesEvaluation of the Nicotinic Acetylcholine Receptor-Associated Proteome at Baseline and Following Nicotine Exposure in Human and Mouse Cortex
McClure-Begley TD, Esterlis I, Stone KL, Lam TT, Grady SR, Colangelo CM, Lindstrom JM, Marks MJ, Picciotto MR. Evaluation of the Nicotinic Acetylcholine Receptor-Associated Proteome at Baseline and Following Nicotine Exposure in Human and Mouse Cortex. ENeuro 2016, 3: eneuro.0166-16.2016. PMID: 27559543, PMCID: PMC4985585, DOI: 10.1523/eneuro.0166-16.2016.Peer-Reviewed Original ResearchConceptsPutative interacting proteinsQuantitative proteomic assessmentProtein-protein interactionsTemporal cortex tissueChaperone familyMood disordersInteracting proteinProtein complexesPresynaptic neurotransmitter releaseNovel etiological mechanismsNicotine exposureProteomic assessmentProteomeNicotinic acetylcholine receptorsMouse cortexProteinHigh-affinity nAChRsΒ2 subunitCortex of miceMaintenance of smokingNew treatment targetsResult of smokingNeurotransmitter releaseAcetylcholine receptorsPrimary functionAn epigenetic mechanism mediates developmental nicotine effects on neuronal structure and behavior
Jung Y, Hsieh LS, Lee AM, Zhou Z, Coman D, Heath CJ, Hyder F, Mineur YS, Yuan Q, Goldman D, Bordey A, Picciotto MR. An epigenetic mechanism mediates developmental nicotine effects on neuronal structure and behavior. Nature Neuroscience 2016, 19: 905-914. PMID: 27239938, PMCID: PMC4925298, DOI: 10.1038/nn.4315.Peer-Reviewed Original Research
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