2023
Surgery in the Setting of Metastatic Breast Cancer
Plichta J, Taskindoust M, Greenup R. Surgery in the Setting of Metastatic Breast Cancer. Current Breast Cancer Reports 2023, 15: 37-47. DOI: 10.1007/s12609-023-00476-4.Peer-Reviewed Original ResearchMetastatic breast cancerSurvival benefitBreast cancerSurgical resectionPrimary tumorSelect patient groupsPotential survival benefitPrimary breast tumorsLocoregional treatmentMetastatic diseaseMost patientsPatient groupProspective studyRetrospective studySelect subgroupClinical scenariosBreast tumorsResectionTumorsCancerLimited benefitSurgeryPatientsMixed resultsDisease
2022
Overall survival from a phase II randomized study of ramucirumab plus pembrolizumab versus standard of care for advanced non–small cell lung cancer previously treated with immunotherapy: Lung-MAP nonmatched substudy S1800A.
Reckamp K, Redman M, Dragnev K, Villaruz L, Faller B, Al Baghdadi T, Hines S, Qian L, Minichiello K, Gandara D, Kelly K, Herbst R. Overall survival from a phase II randomized study of ramucirumab plus pembrolizumab versus standard of care for advanced non–small cell lung cancer previously treated with immunotherapy: Lung-MAP nonmatched substudy S1800A. Journal Of Clinical Oncology 2022, 40: 9004-9004. DOI: 10.1200/jco.2022.40.16_suppl.9004.Peer-Reviewed Original ResearchNon-small cell lung cancerAdvanced non-small cell lung cancerProgression-free survivalOverall survivalCell lung cancerProgressive diseaseLung cancerLung-MAPImmune checkpoint inhibitor therapyPlatinum-based doublet therapyRandomized phase II trialVEGF receptor inhibitionCheckpoint inhibitor therapyImproved overall survivalPD-L1 expressionPhase II trialPotential survival benefitDuration of responseLog-rank testStandard of careTumor mutational burdenMajor unmet needAnalysis of survivalMultiple tumor typesCare armAssociation of hyperglycemia and molecular subclass on survival in IDH-wildtype glioblastoma
Liu E, Vasudevaraja V, Sviderskiy V, Feng Y, Tran I, Serrano J, Cordova C, Kurz S, Golfinos J, Sulman E, Orringer D, Placantonakis D, Possemato R, Snuderl M. Association of hyperglycemia and molecular subclass on survival in IDH-wildtype glioblastoma. Neuro-Oncology Advances 2022, 4: vdac163. PMID: 36382106, PMCID: PMC9653172, DOI: 10.1093/noajnl/vdac163.Peer-Reviewed Original ResearchIDH-wt GBMAssociated with poor OSMethylation subclassesOverall survivalPoor OSIDH-wtMolecular subclassesRTK IAssociated with worse survivalAssociated with OSIDH-wildtype glioblastomaPotential survival benefitAssociation of hyperglycemiaAverage glucose valuesAverage glucoseStupp protocolDexamethasone doseMGMT statusSurvival benefitWorse survivalMesenchymal tumorsPerformance statusLow glucose levelsMGMT methylationMolecular subtypes
2021
NCOG-11. ASSOCIATION OF HYPERGLYCEMIA AND TUMOR SUBCLASS ON SURVIVAL IN IDH-WILDTYPE GLIOBLASTOMA
Liu E, Vasudevaraja V, Sviderskiy V, Feng Y, Tran I, Serrano J, Cordova C, Kurz S, Golfinos J, Sulman E, Placantonakis D, Possemato R, Snuderl M. NCOG-11. ASSOCIATION OF HYPERGLYCEMIA AND TUMOR SUBCLASS ON SURVIVAL IN IDH-WILDTYPE GLIOBLASTOMA. Neuro-Oncology 2021, 23: vi154-vi154. PMCID: PMC8598635, DOI: 10.1093/neuonc/noab196.602.Peer-Reviewed Original ResearchIDH-wt glioblastomaAssociated with poor OSMethylation subclassesDexamethasone doseOverall survivalPoor OSIDH-wtMolecular subclassesAssociated with worse survivalRNA expressionIDH-wildtype glioblastomaPotential survival benefitDNA methylation clustersIsocitrate dehydrogenase (IDH)-wildtypeAssociated with survivalClinical next-generation sequencingPlasma glucose measurementsDNA methylation studiesAverage glucoseNext-generation sequencingStupp protocolMGMT statusMesenchymal tumorsPrognostic significanceSurvival benefitAssociation of Convalescent Plasma Therapy With Survival in Patients With Hematologic Cancers and COVID-19
Thompson M, Henderson J, Shah P, Rubinstein S, Joyner M, Choueiri T, Flora D, Griffiths E, Gulati A, Hwang C, Koshkin V, Papadopoulos E, Robilotti E, Su C, Wulff-Burchfield E, Xie Z, Yu P, Mishra S, Senefeld J, Shah D, Warner J, Halmos B, Verma A, Gartrell B, Goel S, Ohri N, Sica R, Thakkar A, Stockerl-Goldstein K, Butt O, Campian J, Fiala M, Monahan R, Zhou A, Bohachek P, Mundt D, Streckfuss M, Tadesse E, Lammers P, Revankar S, Panagiotou O, Egan P, Farmakiotis D, Khan H, Olszewski A, Loaiza-Bonilla A, Del Prete S, Angevine A, Bar M, Lo K, Stratton J, Weinstein P, Caimi P, Barnholtz-Sloan J, Garcia J, Nakayama J, Gupta S, Pennell N, Ahluwalia M, Dawsey S, Nizam A, Lemmon C, Hoppenot C, Li A, Bakouny Z, Bouchard G, Busser F, Conners J, Curran C, Demetri G, Giordano A, Kelleher K, Nohria A, Schmidt A, Shaw G, Van Allen E, Nuzzo P, Xu W, Zon R, Zhang T, Halabi S, Lyman G, Graber J, Grivas P, Khaki A, Loggers E, Lynch R, Nakasone E, Schweizer M, Tachiki L, Vinayak S, Wagner M, Yeh A, Gatson N, Goyal S, Huynh-Le M, Rosenstein L, Clement J, Daher A, Dailey M, Elias R, Hsu E, Menendez A, Rathmann J, Serrano O, Jayaraj A, Gadgeel S, Hawley J, Hershman D, Accordino M, Bhutani D, Schwartz G, Reuben D, Mushtaq S, Bernicker E, Deeken J, Shafer D, Lewis M, Rhodes T, Gill D, Low C, Nagle S, Hayes-Lattin B, McWeeney S, Nemecek E, Zaren H, Smith S, Nagaraj G, Akhtari M, Lau E, Reeves M, Berg S, Elms D, Morgans A, Wehbe F, Altman J, Gurley M, Mulcahy M, Durbin E, Kulkarni A, Nelson H, Shah S, Rosovsky R, Reynolds K, Bardia A, Boland G, Gainor J, Zubiri L, Halfdanarson T, Bekaii-Saab T, Desai A, Mesa R, Bonnen M, Mahadevan D, Ramirez A, Salazar M, Belenkaya R, Philip J, Riely G, Faller B, McKay R, Ajmera A, Cabal A, Shaya J, Weissmann L, Jani C, Chen J, Gatti-Mays M, Jhawar S, Lustberg M, Palmer J, Pillainayagam C, Stover D, Wall S, Williams N, Karivedu V, Addison D, Joshi M, Menon H, Rovito M, Elshoury A, Jabbour S, Shah M, Bashir B, Mahmood S, McNair C, Mico V, Rivera A, Miller C, Cabebe E, Glover M, Jha A, Schapira L, Shah S, Wu J, Subbiah S, Logan B, Kloecker G, Lopes G, Russell K, Stith B, Smits M, Edwin N, Chism D, Owenby S, Doroshow D, Galsky M, Zhu H, Fu J, Fazio A, Patel K, Riess J, Kwon D, Kumar V, Islam J, Wood W, Ahmad S, Grover P, Gulati S, Kharofa J, Marcum M, Park C, Wise-Draper T, Bowles D, Geiger C, Bishnoi R, Markham M, Shah C, Acoba J, Rho Y, Feldman L, Hoskins K, Gantt G, Khan M, Nguyen R, Pasquinelli M, Schwartz C, Venepalli N, Vikas P, Kasi A, Fecher L, Friese C, Mavromatis B, Zaman Q, Bijjula R, Cheng A, Davis E, French B, Gillaspie E, Hausrath D, Hennessy C, Hsu C, Johnson D, Li X, Reid S, Rini B, Shyr Y, Slosky D, Solorzano C, Tucker M, Vega-Luna K, Wang L, Enriquez K, Sun T, Carducci T, Puc M, Van Loon S, Goldsmith K, Rice R, Cabalona W, Pilar C, Barrow McCollough B, Peddi P, Rosen L, Bilen M, Ravindranathan D, Hafez N, Herbst R, LoRusso P, Masters T, Stratton C. Association of Convalescent Plasma Therapy With Survival in Patients With Hematologic Cancers and COVID-19. JAMA Oncology 2021, 7: 1167-1175. PMID: 34137799, PMCID: PMC8377563, DOI: 10.1001/jamaoncol.2021.1799.Peer-Reviewed Original ResearchConvalescent plasma recipientsConvalescent plasma treatmentConvalescent plasma therapyMechanical ventilatory supportHematologic cancersPlasma recipientsVentilatory supportCohort studyHazard ratioPlasma therapyMAIN OUTCOMECOVID-19Intensive care unit admissionProportional hazards regression analysisPropensity scoreUntreated control patientsCare unit admissionRetrospective cohort studySevere COVID-19Potential survival benefitHazards regression analysisMulti-institutional cohortSecondary subgroup analysisIntensive care unitPotential confounding factors
2020
Neoadjuvant therapy in locally advanced colon cancer: a meta-analysis and systematic review
Cheong C, Nistala K, Ng C, Syn N, Chang H, Sundar R, Yang S, Chong C. Neoadjuvant therapy in locally advanced colon cancer: a meta-analysis and systematic review. Journal Of Gastrointestinal Oncology 2020, 11: 847-857. PMID: 33209481, PMCID: PMC7657836, DOI: 10.21037/jgo-20-220.Peer-Reviewed Original ResearchLocally advanced colon cancerAdvanced colon cancerR0 resection rateDisease-free survivalNeoadjuvant chemotherapyColon cancerNeoadjuvant therapyRandomized Controlled TrialsOverall survivalResection rateAdjuvant chemotherapyChina Knowledge Resource Integrated DatabaseSurvival benefit of neoadjuvant chemotherapyBenefit of neoadjuvant chemotherapyRisk of peri-operative complicationsObservational studyObservational study of patientsAdverse effects of chemotherapyPeri-operative complicationsPotential survival benefitMeta-analysisEffects of chemotherapyStudy of patientsFOxTROT trialUpfront operation
2018
Hospital Variation in the Utilization and Implementation of Targeted Temperature Management in Out-of-Hospital Cardiac Arrest
Khera R, Humbert A, Leroux B, Nichol G, Kudenchuk P, Scales D, Baker A, Austin M, Newgard CD, Radecki R, Vilke GM, Sawyer KN, Sopko G, Idris AH, Wang H, Chan PS, Kurz MC. Hospital Variation in the Utilization and Implementation of Targeted Temperature Management in Out-of-Hospital Cardiac Arrest. Circulation Cardiovascular Quality And Outcomes 2018, 11: e004829. PMID: 30571336, DOI: 10.1161/circoutcomes.118.004829.Peer-Reviewed Original ResearchConceptsTargeted temperature managementHospital cardiac arrestCardiac arrestMedian rateResuscitation Outcomes Consortium sitesHospital cardiac arrest patientsImproved functional survivalMedian hospital rateClass I recommendationPotential survival benefitResuscitation Outcomes ConsortiumNon-traumatic outCardiac arrest patientsTemperature managementPatterns of utilizationConsecutive adultsHospital arrivalProspective cohortSurvival benefitArrest patientsHospital variationI recommendationMean ageOutcomes ConsortiumResuscitation guidelines
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