2025
Clinical Utility Findings of a Transcriptomic Psoriasis Biologic Test Demonstrate Altered Physician Prescribing Behavior and Improved Patient Outcomes
Strober B, Bukhalo M, Armstrong A, Pariser D, Kircik L, Johnson B, Montgomery P, Dickerson T. Clinical Utility Findings of a Transcriptomic Psoriasis Biologic Test Demonstrate Altered Physician Prescribing Behavior and Improved Patient Outcomes. Dermatology And Therapy 2025, 15: 1787-1796. PMID: 40349264, PMCID: PMC12126387, DOI: 10.1007/s13555-025-01441-y.Peer-Reviewed Original ResearchImprove patient outcomesPatient outcomesPrescribing behaviorStatistical analysis of concordanceTreatment-as-usual armPhysician prescribing behaviorWeek 4Clinical utilityBiologic drug classesDermal biomarker patchPhysician behaviorAnalysis of patientsManagement of patientsManagement of psoriasisUtilization findingsFisher's exact testHealthcare systemMedication changesInclusion of mindfulnessPhysiciansPsoriasis AreaPatient responseProspective studyLesional skinClinical endpointsDeprescribing in Older Adults With Type 2 Diabetes: Associations With Patients' Perspectives: The Diabetes and Aging Study
Parker M, Lipska K, Gilliam L, Grant R, Haider S, Huang E, Jain R, Laiteerapong N, Liu J, Moffet H, Karter A. Deprescribing in Older Adults With Type 2 Diabetes: Associations With Patients' Perspectives: The Diabetes and Aging Study. Journal Of The American Geriatrics Society 2025, 73: 1155-1167. PMID: 39781584, PMCID: PMC11971003, DOI: 10.1111/jgs.19352.Peer-Reviewed Original ResearchKaiser Permanente of Northern CaliforniaPatient perspectiveType 2 diabetesDiabetes medicationsOlder adultsMeasure of relative riskPatient-provider communicationRates of deprescribingLongitudinal cohort studyInfluence deprescribingTargeted deprescribingFrequency of daily dosesHealth literacyMedication for lifeSelf-CareDeprescribingEndocrine Society guidelinesKaiser PermanenteDuration of diabetesOral hypoglycemic agentsMedication changesRelative riskPatient preferencesCohort studySelf-reported perspectives
2024
STABILITY (Symptomatic Review during Biologic Therapy) of Inflammatory Bowel Disease Patients Receiving Infusion Therapy Improves Clinical Outcomes
Morgan K, Morris J, Cai Q, Kilgore P, Cvek U, Trutschl M, Lofton K, Mavuram M, Ramesh P, Dao N, Alhaque A, Alexander J. STABILITY (Symptomatic Review during Biologic Therapy) of Inflammatory Bowel Disease Patients Receiving Infusion Therapy Improves Clinical Outcomes. Pathophysiology 2024, 31: 398-407. PMID: 39189166, PMCID: PMC11348379, DOI: 10.3390/pathophysiology31030030.Peer-Reviewed Original ResearchInflammatory bowel disease patientsInflammatory bowel diseaseFemale IBD patientsMale CD patientsMale IBD patientsCD patientsUC patientsTherapy visitsIBD patientsDisease severityInfusion therapyFemale UC patientsMale UC patientsRetrospective chart reviewIBD-related symptomsPhysician-patient contactLow disease activityPhysician-patient interviewImprove patient outcomesFemale CD patientsCare gapsImproving clinical outcomesDiagnosis dateMedication changesChronic diseasesODD: A Benchmark Dataset for the Natural Language Processing Based Opioid Related Aberrant Behavior Detection.
Kwon S, Wang X, Liu W, Druhl E, Sung M, Reisman J, Li W, Kerns R, Becker W, Yu H. ODD: A Benchmark Dataset for the Natural Language Processing Based Opioid Related Aberrant Behavior Detection. Annual Meeting 2024, 2024: 4338-4359. PMID: 39224833, PMCID: PMC11368170.Peer-Reviewed Original ResearchBenchmark datasetsState-of-the-art natural language processing modelsNatural language processing modelsState-of-the-artLanguage processing modelsAberrant behaviorDetection datasetMacro-average areaBehavior detectionPrecision recall curveDiagnosed opioid dependencePerformance improvementRecall curveDatasetProcess modelExperimental resultsCentral nervous system-relatedOpioid dependenceNervous system-relatedMedication changesOpioidBenchmarksHealth care utilization and behavior changes after workplace genetic testing at a large US health care system
Charnysh E, Pal S, Reader J, Uhlmann W, McCain S, Sanghavi K, Blasco D, Brandt R, Feero W, Ferber R, Giri V, Hendy K, Prince A, Lee C, Roberts J, consortium I, Crumpler N, Leader A, Mathews D, Ryan K, Spector-Bagdady K, Vogle A, Brothers K, Clayton E, Deverka P, Ellis T, Goldenberg A, Mockus S, Morton C, Rueter J, Witham B, Bessey E, Gordon E, Lee L, Roberts J, Saidi F. Health care utilization and behavior changes after workplace genetic testing at a large US health care system. Genetics In Medicine 2024, 26: 101160. PMID: 38733246, PMCID: PMC11566502, DOI: 10.1016/j.gim.2024.101160.Peer-Reviewed Original ResearchHealth behavior changeU.S. healthcare systemHealthcare utilizationIncreased riskAssociated with health behavior changesBehavioral changesHealthcare systemPromote health behavior changeGenetic testingImprove employee healthHeart diseaseSelf-reported dataLogistic regression analysisElectronic surveyMedication changesDescriptive statisticsHealthcarePGx resultsEmployee healthHealth implicationsRegression analysisHealthPGxWorkplaceCancer
2023
Patient perspectives on telemedicine use in rheumatology during the COVID-19 pandemic: survey results from the COVID-19 Global Rheumatology Alliance
Maheswaranathan M, Miller B, Ung N, Sinha R, Harrison C, Egeli B, Degirmenci H, Sirotich E, Liew J, Grainger R, Chock E. Patient perspectives on telemedicine use in rheumatology during the COVID-19 pandemic: survey results from the COVID-19 Global Rheumatology Alliance. Clinical Rheumatology 2023, 43: 543-552. PMID: 37552351, DOI: 10.1007/s10067-023-06717-2.Peer-Reviewed Original ResearchConceptsRheumatic diseasesPerson visitsTelemedicine useMedication changesCOVID-19 pandemicCare of patientsPerspectives of patientsMethodsAn anonymous online surveyPerspectives of telemedicineDisease activityComplete responseMost patientsPatient's perspectiveTelemedicine effectivenessPatientsAnonymous online surveyFree-text responsesSimilar effectivenessDiseaseVisitsTelemedicine usersRheumatologyYounger participantsTelemedicineClinical tasks
2022
Interdisciplinary patient-centred poststroke care in Follow-up After Stroke, Screening and Treatment (FASST) clinic model: a proof-of-concept pilot study
Kim M, Cleymaet S, Kim S, Andres J, Ruchalski C, Kim Y, Azizi S, Sharrief A, Naqvi I. Interdisciplinary patient-centred poststroke care in Follow-up After Stroke, Screening and Treatment (FASST) clinic model: a proof-of-concept pilot study. Integrated Healthcare Journal 2022, 4: e000118. PMID: 37440858, PMCID: PMC10327447, DOI: 10.1136/ihj-2021-000118.Peer-Reviewed Original ResearchRisk factor controlImprove risk factor controlFactor controlPoststroke careInterdisciplinary clinicPoststroke complicationsSecondary stroke preventionPost-stroke careImprove health outcomesHealth-related behaviorsPilot studyPost-stroke complicationsQuality of lifeStroke preventionPharmacist collaborationHealth outcomesFollow-upSocial supportClinical modelStroke physiciansMedication changesFunctional statusOutpatient modelMedication adjustmentsOutcome scoresPrimary care clinicians’ use of deprescribing recommendations: A mixed-methods study
Mecca MC, Zenoni M, Fried TR. Primary care clinicians’ use of deprescribing recommendations: A mixed-methods study. Patient Education And Counseling 2022, 105: 2715-2720. PMID: 35523638, DOI: 10.1016/j.pec.2022.04.013.Peer-Reviewed Original ResearchConceptsMedication-related communicationPrimary care cliniciansMedication reconciliationCare cliniciansThorough medication reconciliationClinical decision support toolChronic disease managementAdherence discussionsMedication appropriatenessHypertension medicationsInappropriate medicationsMedication changesIntervention cliniciansHypertension treatmentPrimary careIntervention groupClinician practiceMedicationsIndividualized reportsCliniciansDeintensificationDisease managementMixed-method studyFeedback reportsReport
2021
OpenSAFELY: impact of national guidance on switching anticoagulant therapy during COVID-19 pandemic
Collaborative T, Curtis HJ, MacKenna B, Walker AJ, Croker R, Mehrkar A, Morton C, Bacon S, Hickman G, Inglesby P, Bates C, Evans D, Ward T, Cockburn J, Davy S, Bhaskaran K, Schultze A, Rentsch CT, Williamson E, Hulme W, Tomlinson L, Mathur R, Drysdale H, Eggo RM, Wong AY, Forbes H, Parry J, Hester F, Harper S, Douglas I, Smeeth L, Goldacre B. OpenSAFELY: impact of national guidance on switching anticoagulant therapy during COVID-19 pandemic. Open Heart 2021, 8: e001784. PMID: 34785588, PMCID: PMC8595296, DOI: 10.1136/openhrt-2021-001784.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnticoagulantsBlood CoagulationBlood Coagulation TestsCOVID-19Drug MonitoringDrug PrescriptionsDrug SubstitutionDrug UtilizationEnglandFactor Xa InhibitorsFemaleHumansMaleMiddle AgedPatient SafetyPractice Guidelines as TopicPractice Patterns, Physicians'Primary Health CareRetrospective StudiesRisk AssessmentRisk FactorsState MedicineWarfarinConceptsWarfarin patientsNational Health ServiceCOVID-19 pandemicNational guidanceCare home residencyINR test resultsRenal function testsFrequent blood testingSafety alertsRoutine clinical dataAtrial fibrillation diagnosisElevated INRMedication changesOral anticoagulantsAnticoagulant therapyCohort studyAppropriate patientsINR testsFunction testsBlood testingPrimary careClinical dataDOACPatientsWarfarinEarly experience of COVID-19 vaccination in adults with systemic rheumatic diseases: results from the COVID-19 Global Rheumatology Alliance Vaccine Survey
Sattui SE, Liew JW, Kennedy K, Sirotich E, Putman M, Moni TT, Akpabio A, Alpízar-Rodríguez D, Berenbaum F, Bulina I, Conway R, Singh AD, Duff E, Durrant KL, Gheita TA, Hill CL, Howard RA, Hoyer BF, Hsieh E, Kibbi L, Kilian A, Kim AH, Liew DFL, Lo C, Miller B, Mingolla S, Nudel M, Palmerlee CA, Singh JA, Singh N, Ugarte-Gil MF, Wallace J, Young KJ, Bhana S, Costello W, Grainger R, Machado PM, Robinson PC, Sufka P, Wallace ZS, Yazdany J, Harrison C, Larché M, Levine M, Foster G, Thabane L, Rider LG, Hausmann JS, Simard JF, Sparks JA. Early experience of COVID-19 vaccination in adults with systemic rheumatic diseases: results from the COVID-19 Global Rheumatology Alliance Vaccine Survey. RMD Open 2021, 7: e001814. PMID: 34493645, PMCID: PMC8424419, DOI: 10.1136/rmdopen-2021-001814.Peer-Reviewed Original ResearchConceptsDisease-modifying antirheumatic drugsPatient-reported adverse eventsSystemic rheumatic diseasesCOVID-19 vaccinationRheumatic disease flareRheumatic diseasesDisease flareCOVID-19 vaccineAdverse eventsVaccine efficacyMuscle/joint painJanssen/JohnsonTime of vaccinationFever/chillsCommon rheumatic diseasePatient-reported dataOxford/AstraZenecaEarly experienceVaccines surveyAntirheumatic drugsMedication changesJoint painMost patientsPfizer-BioNTechRheumatoid arthritis
2019
The quality of medication optimization among patients with transient ischemic attack or minor stroke
Myers J, Bravata D, Sico J, Myers L, Chaturvedi S, Cheng E, Baye F, Zillich A. The quality of medication optimization among patients with transient ischemic attack or minor stroke. JACCP JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY 2019, 3: 36-46. DOI: 10.1002/jac5.1149.Peer-Reviewed Original ResearchTransient ischemic attackVeterans Health AdministrationMedication optimizationMinor strokeEligible patientsIschemic attackEmergency departmentAmerican Heart Association/American Stroke Association guidelinesGreater baseline disease severityAmerican Stroke Association guidelinesMultivariable logistic regression modelRecurrent vascular eventsVHA emergency departmentBaseline disease severityMinor stroke patientsPast medical historyEvidence-based guidelinesHigh-risk populationLogistic regression modelsMedication changesVascular eventsRetrospective cohortStroke patientsIndex eventInpatient staySevere Illness Anxiety Treated by Integrating Inpatient Psychotherapy With Medical Care and Minimizing Reassurance
Higgins-Chen AT, Abdallah SB, Dwyer JB, Kaye AP, Angarita GA, Bloch MH. Severe Illness Anxiety Treated by Integrating Inpatient Psychotherapy With Medical Care and Minimizing Reassurance. Frontiers In Psychiatry 2019, 10: 150. PMID: 30967801, PMCID: PMC6438952, DOI: 10.3389/fpsyt.2019.00150.Peer-Reviewed Case Reports and Technical NotesHealth concernPsychiatric careMedical careCo-morbid hypertensionOutpatient medical visitsHigher healthcare utilizationNumerous health concernsClinical symptom scalesCognitive-behavioral therapy protocolIllness anxiety disorderMedication changesSimilar treatment plansMedication regimenOutpatient managementHealthcare utilizationMedical visitsCase reportInpatient hospitalizationEmergency roomVitamin deficiencyHospitalization criteriaProvider teamOutpatient providersManaging medicationsSymptom ScaleExploring the Less Common Pathogens of Infectious Diarrhea
Toffel S, Velez L, Tremblay E, Shah K, Rand K, Auerbach J, Potter K, Bea S. Exploring the Less Common Pathogens of Infectious Diarrhea. Journal Of Microbiology And Infectious Diseases 2019, 09: 1-9. DOI: 10.5799/jmid.537127.Peer-Reviewed Original ResearchEnteropathogenic E. coliEnteroaggregative Escherichia coliAbdominal painGastrointestinal PanelClinical significanceSingle-institution retrospective chart reviewBioFire FilmArray Gastrointestinal PanelFilmArray Gastrointestinal PanelSpecific clinical significanceRetrospective chart reviewResult of symptomsCases of diarrheaAnalysis of symptomsDis 2019Medication changesChart reviewGI pathogensInfectious diarrheaJ MicrobiolStool samplesHigh prevalenceCommon pathogensPatientsDiarrheaSymptomsAnalysis of the Impact of Antiretroviral Drug Changes on Survival of Patients with Advanced-Stage AIDS with Multidrug-Resistant HIV Infection
Ma R, Jung TH, Peduzzi PN, Brown ST, Kyriakides TC. Analysis of the Impact of Antiretroviral Drug Changes on Survival of Patients with Advanced-Stage AIDS with Multidrug-Resistant HIV Infection. Journal Of The International Association Of Providers Of AIDS Care (JIAPAC) 2019, 18: 2325958219849101. PMID: 31272313, PMCID: PMC6748500, DOI: 10.1177/2325958219849101.Peer-Reviewed Original ResearchConceptsDrug changesCox proportional hazards regression modelKaplan-Meier survival techniqueMultidrug-resistant HIV infectionProportional hazards regression modelsAdvanced-stage AIDSDrug regimen changesSurvival of patientsHazards regression modelsAntiretroviral clinical trialsClinical biomarker dataCause mortalityMedication changesARV regimenHIV infectionImproved survivalRegimen changeClinical outcomesNonclinical reasonsClinical trialsBiomarker changesTreatment historyMultidrug resistanceTherapy strategiesPatients
2018
Home tonometry in childhood glaucoma: clinical indications and physician and parental attitudes
Mali YP, Rotruck JC, Bitner DP, Freedman SF. Home tonometry in childhood glaucoma: clinical indications and physician and parental attitudes. Journal Of American Association For Pediatric Ophthalmology And Strabismus 2018, 22: 319-321.e3. PMID: 29548838, DOI: 10.1016/j.jaapos.2018.01.004.Peer-Reviewed Original ResearchConceptsHome tonometryChildhood glaucomaChildhood glaucoma patientsICare rebound tonometerMedication changesGlaucoma patientsIntraocular pressure monitoringClinical indicationsPressure monitoringRebound tonometryPatientsTonometryRebound tonometerTonometry dataPhysiciansGlaucomaTonometerFinancial concernsParental attitudesSurgery
2013
Primary care physician communication at hospital discharge reduces medication discrepancies
Lindquist LA, Yamahiro A, Garrett A, Zei C, Feinglass JM. Primary care physician communication at hospital discharge reduces medication discrepancies. Journal Of Hospital Medicine 2013, 8: 672-677. PMID: 24311447, DOI: 10.1002/jhm.2098.Peer-Reviewed Original ResearchConceptsMedication discrepanciesHospital dischargePrimary care physician contactHours of dischargeCommunity-dwelling adultsHospital discharge processAcute medicine servicesMedication changesStudy patientsContact patientsPhysician contactHospital readmissionMedication regimensPCP involvementPatient transitionsPhysician communicationPCP contactPCP communicationMedicine servicePatientsPhone interviewsCommunication interventionsHospitalResearch staffSubjects
2009
Impact of antipsychotic medication on family burden in schizophrenia: Longitudinal results of CATIE trial
Perlick DA, Rosenheck RA, Kaczynski R, Swartz MS, Canive JM, Lieberman JA. Impact of antipsychotic medication on family burden in schizophrenia: Longitudinal results of CATIE trial. Schizophrenia Research 2009, 116: 118-125. PMID: 19864114, DOI: 10.1016/j.schres.2009.09.026.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntipsychotic AgentsAttitude to HealthCaregiversCost-Benefit AnalysisDouble-Blind MethodFamilyFemaleHumansLongitudinal StudiesMaleMiddle AgedPsychiatric Status Rating ScalesQuality of LifeRegression AnalysisSchizophreniaSchizophrenic PsychologySeverity of Illness IndexStatistics, NonparametricTreatment OutcomeConceptsSecond-generation antipsychoticsSecond-generation drugsFamily burdenTreatment assignmentInitial treatment assignmentSecond-generation medicationsClinical Antipsychotic TrialsEvidence of superiorityMedication changesCATIE trialInitial medicationPatient's symptomsAntipsychotic medicationAntipsychotic TrialsDaily livingFamily caregiversService useSide effectsMedicationsSecondary analysisPatientsIntervention effectivenessBurden factorsTrialsAntipsychotics
2006
Effectiveness of Switching Antipsychotic Medications
Essock SM, Covell NH, Davis SM, Stroup TS, Rosenheck RA, Lieberman JA. Effectiveness of Switching Antipsychotic Medications. American Journal Of Psychiatry 2006, 163: 2090-2095. PMID: 17151159, DOI: 10.1176/ajp.2006.163.12.2090.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAntipsychotic AgentsBenzodiazepinesCross-Over StudiesDibenzothiazepinesDose-Response Relationship, DrugDouble-Blind MethodDrug Administration ScheduleHumansMiddle AgedOlanzapinePatient DropoutsPsychotherapyQuetiapine FumarateResearch DesignRisperidoneSchizophreniaSchizophrenic PsychologySelection BiasSurvival AnalysisTreatment OutcomeConceptsMedication changesDifferent antipsychoticsCause treatment discontinuationCurrent medication regimensClinical Antipsychotic TrialsPhase 1 analysisPhase 1 findingsBaseline medicationsSwitching medicationsTreatment discontinuationMedication regimensPrimary outcomeMedication effectivenessAntipsychotic medicationAntipsychotic TrialsMedicationsAntipsychoticsClinical situationsOlanzapinePatientsRisperidoneIntervention effectivenessDearth of informationDiscontinuationRandom assignment
2004
The Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) study Approaches to control rate in atrial fibrillation
Olshansky B, Rosenfeld LE, Warner AL, Solomon AJ, O'Neill G, Sharma A, Platia E, Feld GK, Akiyama T, Brodsky MA, Greene HL, Investigators A. The Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) study Approaches to control rate in atrial fibrillation. Journal Of The American College Of Cardiology 2004, 43: 1201-1208. PMID: 15063430, DOI: 10.1016/j.jacc.2003.11.032.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAgedAnti-Arrhythmia AgentsAtrial FibrillationCalcium Channel BlockersCatheter AblationDigoxinDrug Therapy, CombinationElectrocardiography, AmbulatoryFemaleFollow-Up StudiesHeart RateHumansMaleMiddle AgedMultivariate AnalysisPacemaker, ArtificialStroke VolumeTreatment OutcomeConceptsCalcium channel blockersAtrial Fibrillation FollowAtrial fibrillationChannel blockersAFFIRM studyDrug classesFirst drugAdequate rate controlFirst drug classFrequent medication changesRhythm Management (AFFIRM) studyMajority of patientsBeta-adrenergic blockersRate control drugsElectrocardiographic resultsMedication changesWalk testInitial treatmentClinical variablesEfficacy criteriaDrug combinationsHeart rateEffective drugsPatientsMultivariate analysis
1995
The Effects of Exercise on Falls in Elderly Patients: A Preplanned Meta-analysis of the FICSIT Trials
Province M, Hadley E, Hornbrook M, Lipsitz L, Miller J, Mulrow C, Ory M, Sattin R, Tinetti M, Wolf S, Schechtman K, Arfken C, Rossiter-Fornoff J, Stevens V, Wingfield D, Greenlick M, Baker D, Claus E, Horwitz R, Buchner D, Wagner E, de Lateur B, Cress M, Price R, Abrass I, Esselman P, Marguerita T, . C, Mulrow, Gerety M, Cornell J, DeNino L, Kanten D, Kutner N, Green R, McNeely E, Coogler C, Fiatarone M, O'Neill E, Ryan N, Diet T, Clements K, Kehayias J, Roberts S, Evans W, Wallace R, Ross J, Huston J, Kundel C, Sellberg M, Wolfson L, Whipple R, Amerman P, Judge J, Derby C, King M, Tamboli A, Weiss S. The Effects of Exercise on Falls in Elderly Patients: A Preplanned Meta-analysis of the FICSIT Trials. JAMA 1995, 273: 1341-1347. DOI: 10.1001/jama.1995.03520410035023.Peer-Reviewed Original ResearchElderly patientsTreatment armsExercise componentLower extremity weaknessAndersen-Gill extensionEffects of exerciseFall-related injuriesRisk of fallsShort-term exerciseFall outcomesFICSIT TrialsExtremity weaknessMedication changesInjurious fallsIncidence ratiosGeneral exerciseMedical recordsClinical trialsTai ChiDaily livingHigh riskCox modelNursing homesElderly adultsMeta-analysis
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