2024
The Increased Burden of Rare Variants in Four Matrix Metalloproteinase-Related Genes in Childhood Glaucoma Suggests a Complex Genetic Inheritance of the Disease
Tevar A, Aroca-Aguilar J, Bonet-Fernández J, Atienzar-Aroca R, Campos-Mollo E, Méndez-Hernández C, Morales-Fernández L, Palmer I, Coca-Prados M, Martinez-de-la-Casa J, Garcia-Feijoo J, Escribano J. The Increased Burden of Rare Variants in Four Matrix Metalloproteinase-Related Genes in Childhood Glaucoma Suggests a Complex Genetic Inheritance of the Disease. International Journal Of Molecular Sciences 2024, 25: 5757. PMID: 38891949, PMCID: PMC11171635, DOI: 10.3390/ijms25115757.Peer-Reviewed Original ResearchChildhood glaucomaGene variantsIncreased burden of rare variantsChildhood glaucoma patientsEarly-onset glaucomaIrreversible optic neuropathyAnterior eye chamberRare variantsPartial loss-of-function effectsLoss-of-function effectProportion of rare variantsBurden of rare variantsComplex genetic inheritanceGlaucoma patientsGlaucoma typePrimary glaucomaOptic neuropathyMutational burdenAnterior segmentEndoplasmic reticulum stressEye chamberT cellsHEK 293T cellsGlaucomaNext-generation sequencing
2020
Herbal Medicines in Glaucoma Treatment.
Ige M, Liu J. Herbal Medicines in Glaucoma Treatment. The Yale Journal Of Biology And Medicine 2020, 93: 347-353. PMID: 32607093, PMCID: PMC7309662.Peer-Reviewed Original ResearchConceptsCourse of glaucomaIntraocular pressureGlaucoma patientsGlaucoma treatmentRetinal ganglion cell deathHerbal medicineMedical marijuanaGanglion cell deathStandard therapeutic agentsSignificant adverse effectsCurrent standardGinkgo bilobaSurgical therapyGlaucoma managementIrreversible blindnessGlaucomaAlternative medicineLarger studyHerbal remediesTherapeutic agentsAddictive potentialAdverse effectsLonger durationPatientsShort durationOverhead Mounted Optical Coherence Tomography in Childhood Glaucoma Evaluation
Go MS, Barman NR, Kelly MP, House RJ, Rotruck JC, El-Dairi MA, Freedman SF. Overhead Mounted Optical Coherence Tomography in Childhood Glaucoma Evaluation. Journal Of Glaucoma 2020, 29: 742-749. PMID: 32496465, DOI: 10.1097/ijg.0000000000001567.Peer-Reviewed Original ResearchConceptsTotal retinal thicknessPeripapillary retinal nerve fiber layerChildhood glaucoma patientsOptical coherence tomographyChildhood glaucomaRetinal thicknessGCC thicknessGlaucoma patientsCoherence tomographyGanglion cell complex thicknessProspective cross-sectional studyRetinal nerve fiber layerSpectral-domain optical coherence tomographyNerve fiber layerCross-sectional studyAge-matched controlsSpectral-domain OCTYears of ageImproved clinical managementMean image qualityAffected eyeStandard careOptic nerveGlaucoma evaluationComplex thickness
2018
Home tonometry in childhood glaucoma: clinical indications and physician and parental attitudes
Mali YP, Rotruck JC, Bitner DP, Freedman SF. Home tonometry in childhood glaucoma: clinical indications and physician and parental attitudes. Journal Of American Association For Pediatric Ophthalmology And Strabismus 2018, 22: 319-321.e3. PMID: 29548838, DOI: 10.1016/j.jaapos.2018.01.004.Peer-Reviewed Original ResearchConceptsHome tonometryChildhood glaucomaChildhood glaucoma patientsICare rebound tonometerMedication changesGlaucoma patientsIntraocular pressure monitoringClinical indicationsPressure monitoringRebound tonometryPatientsTonometryRebound tonometerTonometry dataPhysiciansGlaucomaTonometerFinancial concernsParental attitudesSurgery
2016
The Ex-PRESS Glaucoma Filtration Device Implantation in Uveitic Glaucoma
Dhanireddy S, Kombo NC, Payal AR, Freitas-Neto CA, Preble J, Foster CS. The Ex-PRESS Glaucoma Filtration Device Implantation in Uveitic Glaucoma. Ocular Immunology And Inflammation 2016, 25: 767-774. PMID: 27230295, DOI: 10.1080/09273948.2016.1175639.Peer-Reviewed Original ResearchConceptsIntraocular pressureUveitic glaucomaGlaucoma medicationsGlaucoma patientsSurgical successEx-PRESS implantationUveitic glaucoma patientsMean intraocular pressureEffective surgical interventionPostoperative examinationPreoperative levelsGlaucoma groupPreoperative examinationDevice implantationSurgical interventionUG groupControl groupMedicationsPatientsGlaucomaMean numberMonthsSignificant reductionEyesImplantationEffect of supine body position on central corneal thickness
Maslin JS, Teng CC, Chadha N, Liu J. Effect of supine body position on central corneal thickness. Clinical And Experimental Ophthalmology 2016, 44: 678-683. PMID: 26991869, DOI: 10.1111/ceo.12742.Peer-Reviewed Original ResearchConceptsCentral corneal thicknessOpen-angle glaucoma patientsSupine body positionHealthy subjectsGlaucoma patientsSupine positioningMin supineCorneal thicknessBody positionLaterality of eyeAngle glaucoma patientsUniversity Eye ClinicCross-sectional studyGlaucoma groupEye clinicSupine positionSitting positionUltrasound pachymeterPatientsSignificant differencesSupineSimilar ratesSubjectsConsecutive measurementsEyes
2015
Marijuana for Glaucoma: A Recipe for Disaster or Treatment?
Sun X, Xu CS, Chadha N, Chen A, Liu J. Marijuana for Glaucoma: A Recipe for Disaster or Treatment? The Yale Journal Of Biology And Medicine 2015, 88: 265-9. PMID: 26339209, PMCID: PMC4553646.Peer-Reviewed Original ResearchConceptsCannabis use disorderIntraocular pressureGlaucoma patientsGlaucoma treatmentAdverse effectsMost glaucoma patientsLower intraocular pressurePsychological adverse effectsTreatment of glaucomaNumerous adverse effectsSignificant adverse effectsWithdrawal symptomsPossible progressionUse disordersUse of marijuanaSubstance abuseMedical marijuanaRare circumstancesFurther studiesTreatmentPatientsGlaucomaCannabinoid moleculesMarijuanaDeleterious effects
2013
Comparative proteomic study in serum of patients with primary open-angle glaucoma and pseudoexfoliation glaucoma
González-Iglesias H, Álvarez L, García M, Escribano J, Rodríguez-Calvo PP, Fernández-Vega L, Coca-Prados M. Comparative proteomic study in serum of patients with primary open-angle glaucoma and pseudoexfoliation glaucoma. Journal Of Proteomics 2013, 98: 65-78. PMID: 24355480, DOI: 10.1016/j.jprot.2013.12.006.Peer-Reviewed Original ResearchConceptsPrimary open-angle glaucomaOpen-angle glaucomaPseudoexfoliation glaucomaGlaucoma patientsInflammatory-related processesSera of patientsForms of glaucomaLarge population studiesPanel of candidatesAge-related blindnessSerum proteinsFunctional pathway analysisClinical manifestationsDietary agentsInflammatory processGlaucoma biomarkersHealthy controlsEarly diagnosisGlaucomaPatientsMajor causeSerumPopulation studiesTwo-dimensional fluorescent difference gel electrophoresisGenetic linkage studies
2010
Horizontal Deviation of Retinal Nerve Fiber Layer Peak Thickness With Stratus Optical Coherence Tomography in Glaucoma Patients and Glaucoma Suspects
Lee JC, Shields MB. Horizontal Deviation of Retinal Nerve Fiber Layer Peak Thickness With Stratus Optical Coherence Tomography in Glaucoma Patients and Glaucoma Suspects. Journal Of Glaucoma 2010, 19: 299-303. PMID: 19528819, DOI: 10.1097/ijg.0b013e3181a990d0.Peer-Reviewed Original ResearchConceptsStratus optical coherence tomographyOptical coherence tomographyGlaucoma patientsGlaucoma suspectsSignificant horizontal deviationHorizontal deviationInferior peaksCoherence tomographySecond cutoff valueRetrospective case seriesFast RNFLCase seriesStratus OCTAnatomic variationsExclusion criteriaClinical practiceCutoff valuePossible associationPatientsNormative databaseFurther studiesLinear regression modelsEyesRegression modelsTomography
2009
Does titration of mitomycin C as an adjunct to trabeculectomy significantly influence the intraocular pressure outcome?
Lee S, Paranhos A, Shields M. Does titration of mitomycin C as an adjunct to trabeculectomy significantly influence the intraocular pressure outcome? Clinical Ophthalmology 2009, 3: 81-87. DOI: 10.2147/opth.s12160132.Peer-Reviewed Original ResearchAdjunctive mitomycin CMitomycin C protocolsAdjunct to trabeculectomyMitomycin CPatient variablesExposure time of mitomycin CRisk factorsConsecutive glaucoma patientsIntraocular pressure outcomesOutcome of trabeculectomyPatient risk factorsSignificant patient variablesIndividual patient variabilityComplex interaction of patientHypotony groupGlaucoma patientsSurgical failureTrabeculectomyRetrospective studySurgical variablesFollow-upOutcome groupPatientsPressure outcomesHypotonyRepeat Selective Laser Trabeculoplasty
Hong BK, Winer JC, Martone JF, Wand M, Altman B, Shields B. Repeat Selective Laser Trabeculoplasty. Journal Of Glaucoma 2009, 18: 180-183. PMID: 19295367, PMCID: PMC2714284, DOI: 10.1097/ijg.0b013e31817eee0b.Peer-Reviewed Original ResearchConceptsSelective laser trabeculoplastyLaser trabeculoplastyMaximum tolerable medical therapyPrior argon laser trabeculoplastyInitial selective laser trabeculoplastyPeak IOP reductionRetrospective chart reviewOpen-angle glaucomaArgon laser trabeculoplastyEquivalent time pointsIntraocular pressure measurementYears of ageSignificant differencesChart reviewGlaucoma patientsIOP reductionMedical therapyGlaucoma surgeryRepeat treatmentFirst treatmentPatientsTrabeculoplastyStudy periodMonthsTime points
2006
Heterozygous CYP1B1 gene mutations in Spanish patients with primary open-angle glaucoma.
López-Garrido MP, Sánchez-Sánchez F, López-Martínez F, Aroca-Aguilar JD, Blanco-Marchite C, Coca-Prados M, Escribano J. Heterozygous CYP1B1 gene mutations in Spanish patients with primary open-angle glaucoma. Molecular Vision 2006, 12: 748-55. PMID: 16862072.Peer-Reviewed Original ResearchMeSH KeywordsAgedAmino Acid SubstitutionAryl Hydrocarbon HydroxylasesCase-Control StudiesConserved SequenceCytochrome P-450 CYP1B1Cytochrome P-450 Enzyme SystemFemaleGene FrequencyGenetic Predisposition to DiseaseGenotypeGlaucoma, Open-AngleHeterozygoteHumansMaleMiddle AgedMutationMutation, MissenseOcular HypertensionPhenotypeSpainConceptsPrimary open-angle glaucomaOcular hypertensionOpen-angle glaucomaCYP1B1 gene mutationsGlaucoma patientsSpanish patientsDevelopment of POAGGene mutationsUnrelated Spanish subjectsOHT subjectsPCR-DNA sequencingPOAG patientsAngle glaucomaPatientsCYP1B1 mutationsGlaucomaSpanish populationSpanish subjectsMissense mutationsDifferent mutationsSignificant changesAmino acid substitutionsSubjectsMutationsAcid substitutions
2003
Expression of cell surface transmembrane carbonic anhydrase genes CA9 and CA12 in the human eye: overexpression of CA12 (CAXII) in glaucoma
Liao S, Ivanov S, Ivanova A, Ghosh S, Cote M, Keefe K, Coca-Prados M, Stanbridge E, Lerman M. Expression of cell surface transmembrane carbonic anhydrase genes CA9 and CA12 in the human eye: overexpression of CA12 (CAXII) in glaucoma. Journal Of Medical Genetics 2003, 40: 257. PMID: 12676895, PMCID: PMC1735430, DOI: 10.1136/jmg.40.4.257.Peer-Reviewed Original ResearchConceptsNon-pigmented ciliary epithelial cellsGlaucoma patientsEpithelium of corneaNPE cell linesNPE cellsAqueous humor productionCultured NPE cellsGlaucoma eyesIntraocular pressureAqueous humor secretionGlaucomatous eyesCAIX expressionCiliary epithelial cellsCAXII expressionEye donorsCA9 mRNANormal eyesPlasma membrane proteinsEmbryonic eye developmentFundamental physiological processesGlaucoma donorsGlaucomaCiliary epitheliumCAIXEpithelial cells
1995
Intraocular pressure response to combined phacoemulsification and trabeculotomy ab externo versus phacoemulsification alone in primary open-angle glaucoma
Gimbel H, Meyer D, DeBroff B, Roux C, Ferensowicz M. Intraocular pressure response to combined phacoemulsification and trabeculotomy ab externo versus phacoemulsification alone in primary open-angle glaucoma. Journal Of Cataract & Refractive Surgery 1995, 21: 653-660. PMID: 8551442, DOI: 10.1016/s0886-3350(13)80561-5.Peer-Reviewed Original ResearchConceptsTrabeculotomy ab externoPrimary open-angle glaucomaOpen-angle glaucomaCombined phacoemulsificationControl groupStudy groupAb externoIntraocular lensPressure-lowering medicationsIncidence of complicationsMean IOP reductionIntraocular pressure controlIntraocular pressure responseIOL implantationIOP reductionSignificant cataractGlaucoma patientsSmall tearsPhacoemulsificationPressure controlDescemet's membraneComplicationsCombined procedurePatientsIOP
1988
Evaluation of Corrected Loss Variance as a Visual Field Index
Liao P, Gollamudi S, Hirsch J. Evaluation of Corrected Loss Variance as a Visual Field Index. Ophthalmologica 1988, 197: 136-143. PMID: 3231420, DOI: 10.1159/000309934.Peer-Reviewed Original ResearchConceptsCorrected loss varianceVisual field indicesLoss varianceField indicesClinical diagnosis of glaucomaDiagnosed glaucoma patientsGlaucoma suspect groupGlaucoma-suspect patientsOctopus visual fieldDiagnosis of glaucomaGroup of patientsVisual fieldGlaucoma groupGlaucoma patientsField lossStudy groupPatientsClinical diagnosisControl groupGlaucomaGroup
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