2025
Resistance to tuberculin skin test/interferon-gamma release assay conversion among highly TB exposed, HIV infected goldminers in South Africa
Ntshiqa T, Velen K, Ginindza S, Nhlangulela L, Charalambous S, Hawn T, Churchyard G, Boom W, Chihota V, Wallis R. Resistance to tuberculin skin test/interferon-gamma release assay conversion among highly TB exposed, HIV infected goldminers in South Africa. PLOS ONE 2025, 20: e0318819. PMID: 40343976, PMCID: PMC12063869, DOI: 10.1371/journal.pone.0318819.Peer-Reviewed Original ResearchConceptsIsoniazid preventive therapyTuberculin skin testCD4 countQFT-PlusAssociated with lower CD4 countsTST responseQuantiFERON-TB Gold PlusBody mass index >Median CD4 countLow CD4 countExposure to TBRates of HIVLongitudinal cohort studyMedian ageTST/IGRAAntiretroviral treatmentMedian timePreventive therapySkin testFollow-upCohort studyLogistic regressionHIVMonthsAssay conversion
2024
Low concordance between QIAreach QuantiFERON-TB, a novel interferon-gamma release assay, and QuantiFERON-TB Gold Plus, in a population-based survey in Blantyre, Malawi
Rickman H, Phiri M, Mbale H, Horton K, Henrion M, Nightingale E, Seddon J, Corbett E, MacPherson P. Low concordance between QIAreach QuantiFERON-TB, a novel interferon-gamma release assay, and QuantiFERON-TB Gold Plus, in a population-based survey in Blantyre, Malawi. Journal Of Clinical Microbiology 2024, 63: e01323-24. PMID: 39699188, PMCID: PMC11784431, DOI: 10.1128/jcm.01323-24.Peer-Reviewed Original ResearchConceptsInterferon-gamma release assayQuantiFERON-TB Gold PlusPopulation-based surveyQFT-PlusQuantiFERON-TBChildren aged 1Gold PlusRelease assayCross-sectional surveyDiagnostic evaluationMtb infectionPopulation-representative sampleSample of children aged 1Young childrenTime to positivityAged 1Primary careLow-income countriesHigh-burden countriesHigh-burden settingsTB goalsHigh-incidence settingsLow-incomeVolume of venous bloodQFT results
2023
Prevalence of Latent Tuberculosis Infection among Patients Undergoing Regular Hemodialysis in Disenfranchised Communities: A Multicenter Study during COVID-19 Pandemic
Ismail M, Zarriaa N, Osman M, Helfawi S, Kabbara N, Chatah A, Kamaleddine A, Alameddine R, Dabboussi F, Hamze M. Prevalence of Latent Tuberculosis Infection among Patients Undergoing Regular Hemodialysis in Disenfranchised Communities: A Multicenter Study during COVID-19 Pandemic. Medicina 2023, 59: 654. PMID: 37109612, PMCID: PMC10142838, DOI: 10.3390/medicina59040654.Peer-Reviewed Original ResearchConceptsLatent tuberculosis infectionMultivariable logistic regression analysisHD patientsLogistic regression analysisTuberculosis infectionDialysis unitsMulticenter cross-sectional studyQFT-Plus resultsActive tuberculosis diseaseQuantiFERON-TB GoldHospital dialysis unitRisk of mortalityTB control measuresCross-sectional studyRegression analysisCOVID-19 pandemicLow socioeconomic statusLTBI statusQFT-PlusRegular HDRegular hemodialysisElderly patientsLTBI prevalenceHemodialysis patientsPatient transmission
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